Abstract:
BACKGROUND:More than 46 species of mammals can be naturally infected with Schistosoma japonicum in the mainland of China. Mice are permissive and may act as the definitive host of the life cycle. In contrast, rats are less susceptible to S. japonicum infection, and are considered to provide an unsuitable micro-environment for parasite growth and development. Since little is known of what effects this micro-environment has on the parasite itself, we have in the present study utilised a S. japonicum oligonucleotide microarray to compare the gene expression differences of 10-day-old schistosomula maintained in Wistar rats with those maintained in BALB/c mice. RESULTS:In total 3,468 schistosome genes were found to be differentially expressed, of which the majority (3,335) were down-regulated (≤ 2 fold) and 133 were up-regulated (≥ 2 fold) in schistosomula from Wistar rats compared with those from BALB/c mice. Gene ontology (GO) analysis revealed that of the differentially expressed genes with already established functions or close homology to well characterized genes in another organisms, many are related to important biological functions or molecular processes. Among the genes that were down-regulated in schistosomula from Wistar rats, some were associated with metabolism, signal transduction and development. Of these genes related to metabolic processes, areas including translation, protein and amino acid phosphorylation, proteolysis, oxidoreductase activities, catalytic activities and hydrolase activities, were represented. KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis of differential expressed genes indicated that of the 328 genes that had a specific KEGG pathway annotation, 324 were down-regulated and were mainly associated with metabolism, growth, redox pathway, oxidative phosphorylation, the cell cycle, ubiquitin-mediated proteolysis, protein export and the MAPK (mitogen-activated protein kinases) signaling pathway. CONCLUSIONS:This work presents the first large scale gene expression study identifying the differences between schistosomula maintained in mice and those maintained in rats, and specifically highlights differential expression that may impact on the survival and development of the parasite within the definitive host. The research presented here provides valuable information for the better understanding of schistosome development and host-parasite interactions.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Peng J,Han H,Gobert GN,Hong Y,Jiang W,Wang X,Fu Z,Liu J,Shi Y,Lin Jdoi
10.1186/1756-3305-4-155subject
Has Abstractpub_date
2011-08-05 00:00:00pages
155issn
1756-3305pii
1756-3305-4-155journal_volume
4pub_type
杂志文章abstract:BACKGROUND:Toxocara canis is the causative agent of toxocariasis of humans and other animals. This parasitic nematode (roundworm) has a complex life cycle, in which substantial developmental changes and switches occur. As small non-coding RNAs (sRNAs) are key regulators of gene expression in a wide range of organisms, ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1508-3
更新日期:2016-04-23 00:00:00
abstract:BACKGROUND:The merozoite of the zoonotic Plasmodium knowlesi invades human erythrocytes via the binding of its Duffy binding protein (PkDBPαII) to the Duffy antigen on the eythrocytes. The Duffy antigen has two immunologically distinct forms, Fya and Fyb. In this study, the erythrocyte-binding assay was used to quantit...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3118-8
更新日期:2018-09-26 00:00:00
abstract:BACKGROUND:Liver fibrosis is an excessive wound-healing reaction that requires the participation of inflammatory cells and hepatic stellate cells (HSCs). The pathogenesis of liver fibrosis caused by viruses and alcohol has been well characterized, but the molecular mechanisms underlying liver fibrosis induced by the li...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2228-z
更新日期:2017-06-17 00:00:00
abstract:BACKGROUND:Rickettsia spp. are obligate intracellular bacteria and well known as transmitted by arthropods. These pathogens have a broad geographic distribution and a high degree of biological and clinical diversity. This study was conducted to determine the prevalence and molecular characterization of Rickettsia spp. ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1423-7
更新日期:2016-03-12 00:00:00
abstract:BACKGROUND:Co-infections of multiple parasite species in hosts may lead to interspecific associations and subsequently shape the structure of a parasite community. However, few studies have focused on these associations in highly abundant parasite species or, in particular, investigated how the associations develop wit...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-85
更新日期:2011-05-20 00:00:00
abstract:BACKGROUND:The South-to-North Water Diversion Project (SNWDP) is the largest national water conservancy project in China. However, the Eastern Route Project (ERP) of SNWDP will refer to the habitats of Oncomelania hupensis, the intermediate host of Schistosoma japonicum. The present study was aimed at investigating the...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-52
更新日期:2012-03-20 00:00:00
abstract:BACKGROUND:Agrochemicals have been widely used in Pakistan for several years. This exposes mosquito populations, particularly those present around agricultural settings, to an intense selection pressure for insecticide resistance. The aim of the present study was to investigate the toxicity of representative agrochemic...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-146
更新日期:2011-07-22 00:00:00
abstract::In the more than 100 years since its discovery, our knowledge of Toxoplasma biology has improved enormously. The evolution of molecular biology, immunology and genomics has had profound influences on our understanding of this ubiquitous bug. However, it could be argued that in science today the adage "seeing is believ...
journal_title:Parasites & vectors
pub_type: 历史文章,杂志文章,评审
doi:10.1186/1756-3305-6-334
更新日期:2013-11-22 00:00:00
abstract:BACKGROUND:Control of the mosquito vector Culex pipiens with insecticides is the main way to control arboviruses that the species can transmit such as West Nile virus (WNV) and Rift Valley fever virus (RVFV). However, its efficiency has been hampered by the emergence of insecticide resistance. Little is known about the...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2625-y
更新日期:2018-01-22 00:00:00
abstract:BACKGROUND:Recent studies demonstrate that insect-specific viruses can influence the ability of their mosquito hosts to become infected with and transmit arboviruses of medical and veterinary importance. The aim of this study was to evaluate the interactions between Anopheles gambiae densovirus (AgDNV) (Parvoviridae) (...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04072-8
更新日期:2020-04-22 00:00:00
abstract:BACKGROUND:The bacteria Anaplasma platys and Ehrlichia canis and the protozoan Leishmania infantum are vector-borne agents that cause canine vector-borne diseases, some of which are zoonotic. The present survey investigated the prevalence of Anaplasma, Ehrlichia and Leishmania in red foxes (Vulpes vulpes) from Portugal...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0756-y
更新日期:2015-03-23 00:00:00
abstract:BACKGROUND:Diagnostics provide a means to measure progress toward disease elimination. Many countries in Africa are approaching elimination of onchocerciasis after successful implementation of mass drug administration programs as well as vector control. An understanding of how markers for infection such as skin snip mi...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1623-1
更新日期:2016-06-13 00:00:00
abstract:BACKGROUND:Mutation of the voltage-gated sodium channel (VGSC) gene, or knockdown resistance (kdr) gene, is an important resistance mechanism against DDT and pyrethroids for dengue vector Aedes albopictus. A phenylalanine to serine (F1534S), leucine (F1534L) and cysteine (F1534C) substitution were detected in many Ae. ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3829-5
更新日期:2019-12-26 00:00:00
abstract:BACKGROUND:Correct species identification of blow flies is a crucial step for understanding their biology, which can be used not only for designing fly control programs, but also to determine the minimum time since death. Identification techniques are usually based on morphological and molecular characters. However, th...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2163-z
更新日期:2017-05-10 00:00:00
abstract:BACKGROUND:Whipworms (Nematoda: Trichuridae), among the most common soil-transmitted helminths (STHs), can cause the socioeconomically important disease trichuriasis in various mammalian hosts including humans and non-human primates. For many years, Trichuris from non-human primates has been assigned to the same specie...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3100-5
更新日期:2018-09-20 00:00:00
abstract:BACKGROUND:Chagas disease control programmes have decreased the prevalence of Chagas disease in Latin America. Together with migration to urban areas and increase in life expectancy, a new scenario for Chagas disease has emerged in Brazil with most patients currently elderly individuals living in urban areas. However, ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2929-y
更新日期:2018-06-19 00:00:00
abstract:BACKGROUND:Preventive chemotherapy with donated anthelminthic drugs is the cornerstone for the control of helminthiases. However, reinfection can occur rapidly in the absence of clean water and sanitation coupled with unhygienic behaviour. The purpose of this study was to assess the effect of an integrated package of i...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2642-x
更新日期:2018-02-27 00:00:00
abstract:BACKGROUND:Sand flies (Diptera: Psychodidae) are the vectors of Leishmania parasites, the causative agents of leishmaniasis. Cutaneous leishmaniasis is an increasing public health problem in the Republic of Suriname and is mainly caused by Leishmania (Vianna) guyanensis, but L. (V.) braziliensis, L. (L.) amazonensis, a...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-318
更新日期:2013-11-04 00:00:00
abstract:BACKGROUND:Landscape structure can affect pathogen prevalence and persistence with consequences for human and animal health. Few studies have examined how reservoir host species traits may interact with landscape structure to alter pathogen communities and dynamics. Using a landscape of islands and mainland sites we in...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3200-2
更新日期:2018-12-04 00:00:00
abstract:BACKGROUND:The action of chemical compounds on the Palaearctic tick D. reticulatus (Fabricius) (Acari: Amblyomminae) has been poorly investigated so far. Therefore, the effects of application of permethrin on engorged D. reticulatus females have been assessed, and the survival rate for the different developmental stage...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-18
更新日期:2014-01-10 00:00:00
abstract:BACKGROUND:Bluetongue virus (BTV) is transmitted by Culicoides biting midges and causes bluetongue (BT), a clinical disease observed primarily in sheep. BT has a detrimental effect on subsistence farmers in India, where hyperendemic outbreaks impact on smallholdings in the southern states of the country. In this study,...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-1992-0
更新日期:2017-01-31 00:00:00
abstract:BACKGROUND:Trichinella nematodes are globally distributed food-borne pathogens, in which Trichinella spiralis is the most common species in China. Microsatellites are a powerful tool in population genetics and phylogeographic analysis. However, only a few microsatellite markers were reported in T. spiralis. Thus, there...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-3929-2
更新日期:2020-02-11 00:00:00
abstract:BACKGROUND:In the past, immune responses to several Brugia malayi immunodominant antigens have been characterized in filaria-infected populations; however, little is known regarding Wolbachia proteins. We earlier cloned and characterized few B. malayi (trehalose-6-phosphate phosphatase, Bm-TPP and heavy chain myosin, B...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1963-x
更新日期:2017-01-24 00:00:00
abstract:BACKGROUND:Leishmaniasis remains a major public health problem in African nations, including Morocco, where little is known about the vertebrate reservoirs involved in the causal parasites' transmission cycles. The present study investigates the role of rodent species as potential reservoirs of Leishmania spp. in centr...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2398-8
更新日期:2017-10-02 00:00:00
abstract:BACKGROUND:During infection with Leishmania donovani, parasite control is linked to the systemic Th1 immune response, but in infected organs (liver, spleen and bone marrow), the response differs according to the micro-environment. The pleiomorphic cytokine interleukin-33 (IL-33) exerts various roles during infection, e...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04190-3
更新日期:2020-06-22 00:00:00
abstract:BACKGROUND:Survival to dry season conditions of sub-Saharan savannahs is a major challenge for insects inhabiting such environments, especially regarding the desiccation threat they are exposed to. While extensive literature about insect seasonality has revealed morphologic, metabolic and physiological changes in many ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-1289-0
更新日期:2016-01-07 00:00:00
abstract:BACKGROUND:Blastocystis spp. are the most prevalent intestinal eukaryotes identified in humans, with at least 17 genetic subtypes (ST) based on genes coding for the small-subunit ribosomal RNA (18S). It has been argued that the 18S gene should not be the marker of choice to discriminate between STs of these strains bec...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3141-9
更新日期:2018-10-29 00:00:00
abstract::Rickettsioses are among the oldest known infectious diseases. In spite of this, and of the extensive research carried out, many aspects of the biology and epidemiology of tick-borne rickettsiae are far from being completely understood. Their association with arthropod vectors, the importance of vertebrates as reservoi...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/s13071-018-2856-y
更新日期:2018-04-24 00:00:00
abstract:BACKGROUND:Plasmodium ovale is widely distributed across tropical regions and has two closely related but distinct species, namely P. ovale curtisi and P. ovale wallikeri. Combining genetic characterization with the immunogenicity of merozoite surface protein-8 (MSP-8) supports considering MSP-8 as a candidate target f...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3412-0
更新日期:2019-04-11 00:00:00
abstract:BACKGROUND:The strongylid nematode Haemonchus contortus is a parasite of major concern for modern livestock husbandry because hostile environmental conditions may induce diapause in the early fourth-stage larvae. METHODS:A new gene Hc-daf-22 was identified which is the homologue of Ce-daf-22 and human SCPx. Genome wal...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1704-1
更新日期:2016-07-29 00:00:00