Abstract:
BACKGROUND:Cystic echinococcosis (CE) is a near cosmopolitan zoonosis caused by the larval stage of the dog tapeworm Echinococcus granulosus. E. granulosus infection induces a polarized T-helper type 2 (Th2) systematic immune response in its intermediate hosts. However, it is not known whether the infection modulates lung inflammation by regulating local immune response. In this study, we examined the effects of E. granulosus infection on mouse ovalbumin (OVA)-induced asthma model. METHODS:BALB/c mice were intraperitoneally transplanted with 50 small E. granulosus cysts cultured in vitro. At 3 months post-inoculation, the mice were sensitized and challenged with ovalbumin (OVA). For histopathological studies, hematoxylin eosin and periodic acid schiff staining was used to examine the inflammatory cells infiltration and goblet cells hyperplasia, respectively. Cytokine levels were measured by mouse cytometric bead array (CBA) Kit and quantitative RT-PCR and other molecular biological approaches. Airway hyperresponsiveness was assessed in response to increasing doses of methacholine. Serum immunoglobulins were determined by ELISA. RESULTS:E. granulosus infection significantly increased Th2 and Treg cytokine levels in serum and lung tissues, but down-regulated the expression of IL-5 in the lungs and IL-17A in serum and lung tissues of asthmatic mice sensitized and challenged with OVA. Histological staining of lung tissues showed that E. granulosus infection significantly reduced the severity of OVA-induced airway inflammation including reduction of eosinophil cell infiltration and mucus production. The E. granulosus infection also reduced eosinophil accumulation induced by OVA in bronchoalveolar lavage fluid (BALF) and also ameliorated airway hyperresponsiveness, a hallmark symptom of asthma. CONCLUSIONS:E. granulosus infection remarkably reduces the severity of OVA-induced airway inflammation likely through enhancing IL-10 and down-regulation of IL-5 and IL-17A.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Wang H,Li J,Pu H,Hasan B,Ma J,Jones MK,Zheng K,Zhang X,Ma H,McManus DP,Lin R,Wen H,Zhang Wdoi
10.1186/s13071-014-0522-6subject
Has Abstractpub_date
2014-11-20 00:00:00pages
522issn
1756-3305pii
s13071-014-0522-6journal_volume
7pub_type
杂志文章abstract:BACKGROUND:Infections with soil-transmitted helminths and pathogenic intestinal protozoa pose a considerable public health burden, particularly in low- and middle-income countries, including Nepal. We assessed the extent of intestinal parasite infections among schoolchildren in two districts of Nepal and determined und...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3105-0
更新日期:2018-09-29 00:00:00
abstract:BACKGROUND:Thymidylate synthase is a housekeeping gene, designated ancient due to its role in DNA synthesis and ubiquitous phyletic distribution. The genomic sequences were characterized coding for thymidylate synthase in two species of the genus Trichinella, an encapsulating T. spiralis and a non-encapsulating T. pseu...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-175
更新日期:2014-04-09 00:00:00
abstract:BACKGROUND:Lymphatic filariasis (LF) is a mosquito-borne parasitic disease and a major cause of disability worldwide. It is one of the neglected tropical diseases identified by the World Health Organization for elimination as a public health problem by 2020. Maps displaying disease distribution are helpful tools to ide...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3097-9
更新日期:2018-09-17 00:00:00
abstract:BACKGROUND:Understanding the dispersal dynamics of invasive mosquito species is fundamental to improve vector surveillance and to target control efforts. Aedes albopictus has been deemed a poor flyer as its range of active dispersal is generally assumed to be limited to a few hundred metres, while laboratory studies su...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3837-5
更新日期:2019-12-12 00:00:00
abstract:BACKGROUND:The myxosporean parasite Parvicapsula pseudobranchicola commonly infects farmed Atlantic salmon in northern Norway. Heavy infections are associated with pseudobranch lesions, runting and mortality in the salmon populations. The life-cycle of the parasite is unknown, preventing controlled challenge experiment...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2583-9
更新日期:2018-01-06 00:00:00
abstract:BACKGROUND:Human and animal fascioliasis poses serious public health problems in South America. In Venezuela, livestock infection represents an important veterinary problem whereas there appear to be few human cases reported, most of which are passively detected in health centres. However, results of recent surveys sug...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-200
更新日期:2011-10-14 00:00:00
abstract:BACKGROUND:Eimeria species are parasitic protozoa that cause coccidiosis, an intestinal disease commonly characterised by malabsorption, diarrhoea and haemorrhage that is particularly important in chickens. Vaccination against chicken coccidiosis is effective using wild-type or attenuated live parasite lines. The devel...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1756-2
更新日期:2016-08-23 00:00:00
abstract:BACKGROUND:Parasitic infections may cause significant effects on behavior, learning, and memory of the host. In the brain of mice heavily infected with Angiostrongylus cantonensis, severe damage has been observed in the hippocampus. This component has been considered to have associations with spatial learning and memor...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04230-y
更新日期:2020-08-10 00:00:00
abstract::Major efforts are currently underway to develop novel, complementary methods to combat mosquito-borne diseases. Mosquito genetic control strategies (GCSs) have become an increasingly important area of research on account of their species-specificity, track record in targeting agricultural insect pests, and their envir...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/s13071-018-3222-9
更新日期:2018-12-24 00:00:00
abstract:BACKGROUND:Anaplasma phagocytophilum is an emerging tick-borne zoonotic pathogen of increased interest worldwide which has been detected in northern Africa. Anaplasma platys is also present in this region and could possibly have a zoonotic potential. However, only one recent article reports on the human esposure to A. ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2148-y
更新日期:2017-04-24 00:00:00
abstract:: The recently developed Multiple Displacement Amplification technique (MDA) allows for the production of a large quantity of high quality genomic DNA from low amounts of the original DNA. The goal of this study was to evaluate the performance of the MDA technique to amplify genomic DNA of siphonapterids that have been...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-3-86
更新日期:2010-09-15 00:00:00
abstract:BACKGROUND:The prevalence of bovine babesiosis caused by Babesia divergens has been declining during the past decades in northeastern Hungary, and no cases have been observed since 2008. Infections of cattle with B. major and Theileria buffeli were hitherto reported in southern and western Europe. In other parts of the...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-434
更新日期:2014-09-11 00:00:00
abstract:BACKGROUND:Cysteine peptidases of clan CA, family C1 account for a major part of proteolytic activity in the haematophagous monogenean Eudiplozoon nipponicum. The full spectrum of cysteine cathepsins is, however, unknown and their particular biochemical properties, tissue localisation, and involvement in parasite-host ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2666-2
更新日期:2018-03-06 00:00:00
abstract:BACKGROUND:Thelazia callipaeda is transmitted by Phortica variegata, a drosophilid that feeds on lachrymal secretions of mammals. Scientific information on human thelaziosis is still relatively limited, mainly for physicians and ophthalmologists. Indeed, the literature is full of misleading information on the transmiss...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0881-7
更新日期:2015-05-14 00:00:00
abstract:BACKGROUND:During a Plasmodium infection, exposure of human host immune cells to both the asexual and the sexual stages of the parasite elicit immune responses. These responses may be protective and prevent the development of high parasitaemia and its associated clinical symptoms, or block the transmission of malaria t...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2607-5
更新日期:2018-01-05 00:00:00
abstract:BACKGROUND:Sand flies (Diptera: Psychodidae) are the vectors of Leishmania parasites, the causative agents of leishmaniasis. Cutaneous leishmaniasis is an increasing public health problem in the Republic of Suriname and is mainly caused by Leishmania (Vianna) guyanensis, but L. (V.) braziliensis, L. (L.) amazonensis, a...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-318
更新日期:2013-11-04 00:00:00
abstract:BACKGROUND:Toxoplasma gondii is an intracellular protozoan parasite that infects a wide variety of warm-blooded hosts, including humans. Limited information about T. gondii infection in bats is available in China. The objective of the present study was to determine prevalence and genetic characterization of T. gondii i...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-014-0558-7
更新日期:2014-12-03 00:00:00
abstract:BACKGROUND:Control of the mosquito vector Culex pipiens with insecticides is the main way to control arboviruses that the species can transmit such as West Nile virus (WNV) and Rift Valley fever virus (RVFV). However, its efficiency has been hampered by the emergence of insecticide resistance. Little is known about the...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2625-y
更新日期:2018-01-22 00:00:00
abstract:BACKGROUND:An accurate diagnosis of soil-transmitted helminthiasis is important for individual patient management, for drug efficacy evaluation and for monitoring control programmes. The Kato-Katz technique is the most widely used method detecting soil-transmitted helminth eggs in faecal samples. However, detailed anal...
journal_title:Parasites & vectors
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13071-015-0702-z
更新日期:2015-02-05 00:00:00
abstract:BACKGROUND:Reunion Island regularly faces outbreaks of epizootic haemorrhagic disease (EHD) and bluetongue (BT), two viral diseases transmitted by haematophagous midges of the genus Culicoides (Diptera: Ceratopogonidae) to ruminants. To date, five species of Culicoides are recorded in Reunion Island in which the first ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3812-1
更新日期:2019-11-27 00:00:00
abstract:BACKGROUND:Anopheles sinensis is one of the most important malaria vectors in Asian countries. The rapid spread of insecticide resistance has become a major obstacle for insecticide-based strategies for vector control. Therefore, it is necessary to prepare an insecticide-resistant strain of An. sinensis to further unde...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-014-0582-7
更新日期:2014-12-11 00:00:00
abstract:BACKGROUND:Schistosomiasis primarily affects poor and neglected communities due to their lack of safe water and sanitation facilities. In an effort to improve intervention strategies, the present study investigated the association of socio-demographic characteristics of women with their existing knowledge, perceptions ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3668-4
更新日期:2019-09-23 00:00:00
abstract:BACKGROUND:Arthropod-borne diseases are some of the most rapidly spreading diseases. Reducing the vector population is currently the only effective way to reduce case numbers. Central metabolic pathways are potential targets to control vector populations, but have not been well explored to this aim. The information ava...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1391-y
更新日期:2016-02-25 00:00:00
abstract:BACKGROUND:Lymphatic filariasis and onchocerciasis are debilitating diseases caused by filarial nematodes. Disease pathogenesis is induced by inflammatory responses following the death of the parasite. Wolbachia endosymbionts of filariae are potent inducers of innate and adaptive inflammation and bacterial lipoproteins...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-3-99
更新日期:2010-10-14 00:00:00
abstract:BACKGROUND:Northeastern Italy is a hotspot for several tick-borne pathogens, transmitted to animals and humans mainly by Ixodes ricinus. Here we compare the results of molecular monitoring of ticks and zoonotic TBPs over a six-year period, with the monitoring of red foxes (Vulpes vulpes) in an endemic area. RESULTS:In...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2726-7
更新日期:2018-03-20 00:00:00
abstract:BACKGROUND:Invasive mosquito species (IMS) of the genus Aedes are a cause of increasing concern in Europe owing to their ability to vector important human viral diseases. Entomological surveillance to early detect alien mosquito and flavivirus circulation in Liguria, northwest Italy, has been carried out since 2011. R...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3589-2
更新日期:2019-07-05 00:00:00
abstract:BACKGROUND:Animal trypanosomosis is endemic in Nigeria, while the human disease caused by Trypanosoma brucei gambiense is rarely reported nowadays after efforts to bring it under control in the 20th century. The University of Nigeria Veterinary Teaching Hospital (UNVTH) is a reference centre located within the Nsukka a...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3680-8
更新日期:2019-08-27 00:00:00
abstract:BACKGROUND:Tick infestation is the major problem for animal health that causes substantial economic losses, particularly in tropical and subtropical countries. To better understand the spatial distribution of tick species and risk factors associated with tick prevalence in livestock in Pakistan, ticks were counted and ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2138-0
更新日期:2017-04-19 00:00:00
abstract:BACKGROUND:Many cases of cutaneous leishmaniasis (CL) have been recorded in the Jenin District based on their clinical appearance. Here, their parasites have been characterized in depth. METHODS:Leishmanial parasites isolated from 12 human cases of CL from the Jenin District were cultured as promastigotes, whose DNA w...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-121
更新日期:2012-06-18 00:00:00
abstract:BACKGROUND:In this study for the first time, a Dientamoeba fragilis protein profile by MALDI-TOF MS was created in order to identify specific markers for the application of this technology in the laboratory diagnosis of dientamoebiasis. In particular, one D. fragilis reference strain was used to create a reference spec...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2597-3
更新日期:2018-01-04 00:00:00