Abstract:
BACKGROUND:Parasitic infections may cause significant effects on behavior, learning, and memory of the host. In the brain of mice heavily infected with Angiostrongylus cantonensis, severe damage has been observed in the hippocampus. This component has been considered to have associations with spatial learning and memory in humans and vertebrates. This study was designed to determine the impairments in behavior, learning, and memory in BALB/c and C57BL/6 mice heavily infected with the parasite. METHODS:Each mouse was inoculated with 50 third-stage larvae of A. cantonensis. After infection, daily changes in weight and dietary consumption, worm recoveries and survival rates were determined. The forced swimming test, open field test, and Morris water maze test were employed to evaluate depression- and anxiety-like behavior as well as impairments in spatial learning and memory, respectively. RESULTS:The worm recovery rate in the BALB/c mice was significantly lower than that of C57BL/6 mice from day 14 post-infection. The survival rate in infected BALB/c mice decreased to 0% by day 25 whereas those with swim-training survived three more days. On day 42, the C57BL/6 mice had a survival rate of 85.7% in the swimming group and 70% in the non-swimming group. Significant differences were found in weight between infected and non-infected BALB/c and C57BL/6 mice from day 13 and day 12, respectively with corresponding changes in their dietary consumption. Depression-like behavior was found in the infected BALB/c mice but not in C57BL/6 mice. However, anxiety-like behavior was found to occur only in C57BL/6 mice. Impaired spatial learning and memory were also found in the two strains of mice which occurred from day 14 post-infection. CONCLUSIONS:Results of this study indicate that A. cantonensis causes depression, anxiety, and impairments in spatial learning and memory in heavily infected mice. Moreover, significantly higher severity was observed in the Th-2 dominant BALB/c mice.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Jhan KY,Lai GJ,Chang PK,Tang RY,Cheng CJ,Chen KY,Wang LCdoi
10.1186/s13071-020-04230-ysubject
Has Abstractpub_date
2020-08-10 00:00:00pages
405issue
1issn
1756-3305pii
10.1186/s13071-020-04230-yjournal_volume
13pub_type
杂志文章abstract:BACKGROUND:Bovine besnoitiosis, caused by the protozoan Besnoitia besnoiti, reduces productivity and fertility of affected herds. Besnoitiosis continues to expand in Europe and no effective control tools are currently available. Experimental models are urgently needed. Herein, we describe for the first time the kinetic...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1405-9
更新日期:2016-02-29 00:00:00
abstract:BACKGROUND:This study evaluated the exposure of dogs to three different Ehrlichia spp. in the south and central regions of the United States where vector-borne disease prevalence has been previously difficult to ascertain, particularly beyond the metropolitan areas. METHODS:Dog blood samples (n = 8,662) were submitted...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-29
更新日期:2012-02-08 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-246
更新日期:2012-10-31 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3200-2
更新日期:2018-12-04 00:00:00
abstract:BACKGROUND:Infections with soil-transmitted helminths and pathogenic intestinal protozoa pose a considerable public health burden, particularly in low- and middle-income countries, including Nepal. We assessed the extent of intestinal parasite infections among schoolchildren in two districts of Nepal and determined und...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3105-0
更新日期:2018-09-29 00:00:00
abstract:BACKGROUND:There is a continuing need for novel approaches to tick control in dogs. One such approach lies in the ability of lotilaner (Credelio™), an isoxazoline with a rapid onset of action, to provide sustained efficacy against ticks. Two studies were undertaken to confirm lotilaner's efficacy, at the minimum dose r...
journal_title:Parasites & vectors
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13071-017-2477-x
更新日期:2017-11-01 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-274
更新日期:2014-06-19 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-283
更新日期:2013-09-27 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1890-x
更新日期:2016-12-09 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3739-6
更新日期:2019-10-22 00:00:00
abstract:BACKGROUND:Bioclimatic variables play an integral part in the life-cycle of Ctenocephalides felis, the most common flea found on companion animals. It is essential that we understand the effects of climate on C. felis distribution as fleas are a major veterinary and public health concern. This study investigated the cu...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3399-6
更新日期:2019-03-22 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3472-1
更新日期:2019-05-16 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04134-x
更新日期:2020-05-19 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0760-2
更新日期:2015-03-03 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-136
更新日期:2012-07-09 00:00:00
abstract:BACKGROUND:During a Plasmodium infection, exposure of human host immune cells to both the asexual and the sexual stages of the parasite elicit immune responses. These responses may be protective and prevent the development of high parasitaemia and its associated clinical symptoms, or block the transmission of malaria t...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2607-5
更新日期:2018-01-05 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-211
更新日期:2011-11-04 00:00:00
abstract:BACKGROUND:The action of chemical compounds on the Palaearctic tick D. reticulatus (Fabricius) (Acari: Amblyomminae) has been poorly investigated so far. Therefore, the effects of application of permethrin on engorged D. reticulatus females have been assessed, and the survival rate for the different developmental stage...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-18
更新日期:2014-01-10 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-1055-3
更新日期:2015-09-04 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0745-1
更新日期:2015-03-23 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2017-10-25 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-145
更新日期:2014-03-31 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-129
更新日期:2011-07-05 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-3-2
更新日期:2010-01-11 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-36
更新日期:2012-02-13 00:00:00
abstract:BACKGROUND:Parasitic flatworms (Trematoda: Digenea) represent one of the most remarkable examples of drastic morphological diversity among the stages within a life cycle. Which genes are responsible for extreme differences in anatomy, physiology, behavior, and ecology among the stages? Here we report a comparative tran...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04424-4
更新日期:2020-11-10 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3279-5
更新日期:2019-01-24 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-217
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Even though male-biased parasitism is common in mammals, little effort has been made to evaluate whether higher parasitic burden in males results in an extra biological cost, and thus a decrease in fitness. Body condition impairment and the augmentation of oxidative stress can be used as indicators of the co...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2060-5
更新日期:2017-04-21 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-420
更新日期:2014-09-04 00:00:00