Sequential broncho-alveolar lavages reflect distinct pulmonary compartments: clinical and research implications in lung transplantation.

abstract：BACKGROUND:Nintedanib is an approved therapy for idiopathic pulmonary fibrosis (IPF). Some patients treated with nintedanib experience weight loss. Exploratory data suggest that low body mass index or weight loss are associated with worse outcomes in patients with IPF. We investigated whether BMI at baseline or weight ...

journal_title：Respiratory research

authors： Jouneau S,Crestani B,Thibault R,Lederlin M,Vernhet L,Valenzuela C,Wijsenbeek M,Kreuter M,Stansen W,Quaresma M,Cottin V

更新日期：2020-11-25 00:00:00

abstract：BACKGROUND:Airway smooth muscle contraction is critical for maintenance of appropriate airway tone, and has been implicated in asthma pathogenesis. Smooth muscle contraction requires an "engine" (myosin activation) and a "transmission system" (actin cytoskeletal remodeling). However, the mechanisms that control actin r...

journal_title：Respiratory research

authors： Wang Y,Rezey AC,Wang R,Tang DD

更新日期：2018-01-05 00:00:00

abstract：BACKGROUND:Systemic sclerosis (SSc) is a rare connective tissue disease with a heterogeneous clinical course. Interstitial lung disease (ILD) is a common manifestation of SSc and a leading cause of death. MAIN BODY:All patients newly diagnosed with SSc should receive a comprehensive clinical evaluation, including asse...

journal_title：Respiratory research

authors： Cottin V,Brown KK

更新日期：2019-01-18 00:00:00

abstract：BACKGROUND:The long-term efficacy and safety of aclidinium bromide, a novel, long-acting muscarinic antagonist, were investigated in patients with moderate to severe chronic obstructive pulmonary disease (COPD). METHODS:In two double-blind, 52-week studies, ACCLAIM/COPD I (n=843) and II (n=804), patients were randomis...

journal_title：Respiratory research

authors： Jones PW,Rennard SI,Agusti A,Chanez P,Magnussen H,Fabbri L,Donohue JF,Bateman ED,Gross NJ,Lamarca R,Caracta C,Gil EG

更新日期：2011-04-26 00:00:00

abstract：BACKGROUND:Inspiratory activity is a prerequisite for successful application of patient triggered ventilation such as proportional assist ventilation (PAV). It has recently been reported that surfactant instillation increases the activity of slowly adapting pulmonary stretch receptors (PSRs) followed by a shorter inspi...

journal_title：Respiratory research

authors： Sindelar R,Rieger-Fackeldey E,Jonzon A,Schaller P,Schulze A,Sedin G

更新日期：2006-03-10 00:00:00

abstract：BACKGROUND:In order to find novel noninvasive biomarkers with high accuracy for the screening of early-stage non-small cell lung cancer (NSCLC), we investigate the predictive power of 5 microRNAs (miR-20a, miR-145, miR-21, miR223 and miR-221) as potential biomarkers in early-stage NSCLC. METHODS:In training set, 25 ea...

journal_title：Respiratory research

authors： Geng Q,Fan T,Zhang B,Wang W,Xu Y,Hu H

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:Extended culture of monocytes and fibroblasts in three-dimensional collagen gels leads to degradation of the gels (see linked study in this issue, "Fibroblasts and monocytes contract and degrade three-dimensional collagen gels in extended co-culture"). The current study, therefore, was designed to evaluate p...

journal_title：Respiratory research

authors： Zhu Y,Liu X,Sköld CM,Wang H,Kohyama T,Wen FQ,Ertl RF,Rennard SI

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Macrolides reduce exacerbations in patients with COPD. Their effects on health status has not been assessed as primary outcome and is less clear. This study assessed the effects of prophylactic azithromycin on cough-specific health status in COPD-patients with chronic productive cough. METHODS:In this rando...

journal_title：Respiratory research

authors： Berkhof FF,Doornewaard-ten Hertog NE,Uil SM,Kerstjens HA,van den Berg JW

更新日期：2013-11-14 00:00:00

abstract：BACKGROUND:An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerbation rates in clinical trials over time. A more systematic understanding would help to improve the design and interpretation of COPD trials. ...

journal_title：Respiratory research

authors： Andreas S,Röver C,Heinz J,Straube S,Watz H,Friede T

更新日期：2019-08-16 00:00:00

abstract：BACKGROUND:Preserved Ratio Impaired Spirometry (PRISm), defined as a reduced FEV1 in the setting of a preserved FEV1/FVC ratio, is highly prevalent and is associated with increased respiratory symptoms, systemic inflammation, and mortality. Studies investigating quantitative chest tomographic features, genetic associat...

journal_title：Respiratory research

authors： Wan ES,Castaldi PJ,Cho MH,Hokanson JE,Regan EA,Make BJ,Beaty TH,Han MK,Curtis JL,Curran-Everett D,Lynch DA,DeMeo DL,Crapo JD,Silverman EK,COPDGene Investigators.

更新日期：2014-08-06 00:00:00

abstract：BACKGROUND:Pulmonary sarcoidosis is an inflammatory disease, characterized by an accumulation of CD4+ lymphocytes and the formation of non-caseating epithelioid cell granulomas in the lungs. The disease either resolves spontaneously or develops into a chronic disease with fibrosis. The neurotrophins nerve growth factor...

journal_title：Respiratory research

authors： Dagnell C,Grunewald J,Kramar M,Haugom-Olsen H,Elmberger GP,Eklund A,Olgart Höglund C

更新日期：2010-11-08 00:00:00

abstract：BACKGROUND:Exposure to crystalline silica is considered to increase the risk of lung fibrosis. The primary effector cell, the myofibroblast, plays an important role in the deposition of extracellular matrix (ECM). DNA methylation change is considered to have a potential effect on myofibroblast differentiation. Therefor...

journal_title：Respiratory research

authors： Li J,Yao W,Zhang L,Bao L,Chen H,Wang D,Yue Z,Li Y,Zhang M,Hao C

更新日期：2017-05-12 00:00:00

abstract：BACKGROUND:Discrepancy exists amongst studies investigating the effect of comorbid heart failure (HF) on the morbidity and mortality of chronic obstructive pulmonary disease (COPD) patients. METHODS:MEDLINE and Embase were searched using a pre-specified search strategy for studies comparing hospitalisation, rehospital...

journal_title：Respiratory research

authors： Axson EL,Ragutheeswaran K,Sundaram V,Bloom CI,Bottle A,Cowie MR,Quint JK

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:Platelet-derived growth factor A (PDGF-A) signals solely through PDGF-Ralpha, and is required for fibroblast proliferation and transdifferentiation (fibroblast to myofibroblast conversion) during alveolar development, because pdgfa-null mice lack both myofibroblasts and alveoli. However, these PDGF-A-mediate...

journal_title：Respiratory research

authors： Kimani PW,Holmes AJ,Grossmann RE,McGowan SE

更新日期：2009-11-25 00:00:00

abstract：:In many model systems, cystic fibrosis (CF) phenotype airway epithelial cells in culture respond to P. aeruginosa with greater interleukin (IL)-8 and IL-6 secretion than matched controls. In order to test whether this excess inflammatory response results from the reported increased adherence of P. aeruginosa to the CF...

journal_title：Respiratory research

authors： Kube DM,Fletcher D,Davis PB

更新日期：2005-07-11 00:00:00

abstract：BACKGROUND:Obstructive sleep apnoea (OSA) and morbid obesity (MO), defined by a body mass index ≥35 kg/m2, are two closely related conditions. Recent studies suggest that circulating microRNA (miRNA) plays a potential role in the physiopathology of both conditions. To date, circulating miRNA expression has been studied...

journal_title：Respiratory research

authors： Lázaro J,Clavería P,Cabrejas C,Fernando J,Daga B,Ordoñez B,Segura S,Sanz-Rubio D,Marín JM

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:The collagen gel contraction assay measures gel size to assess the contraction of cells embedded in collagen gel matrices. Using the assay with lung fibroblasts is useful in studying the lung tissue remodeling process in wound healing and disease development. However, the involvement of bronchial epithelial ...

journal_title：Respiratory research

authors： Ishikawa S,Ishimori K,Ito S

更新日期：2017-11-22 00:00:00

abstract：:The pulmonary innate immune system is heavily implicated in the perpetual airway inflammation and impaired host defense characterizing Chronic Obstructive Pulmonary Disease (COPD). The airways of patients suffering from COPD are infiltrated by various immune and inflammatory cells including macrophages, neutrophils, T...

journal_title：Respiratory research

authors： Haczku A

更新日期：2012-09-19 00:00:00

abstract：BACKGROUND:WNT/β-catenin signaling plays an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF); however, the role of WNT10A via transforming growth factor (TGF)-β signaling remains unclear. METHODS:We evaluated the expression of WNT10A and TGF-β in bleomycin (BLM)-treated mice and the interactio...

journal_title：Respiratory research

authors： Oda K,Yatera K,Izumi H,Ishimoto H,Yamada S,Nakao H,Hanaka T,Ogoshi T,Noguchi S,Mukae H

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:Various signals are known to participate in the pathogenesis of lung fibrosis. Our aim was to determine which signal is predominantly mobilized in the early inflammatory phase and thereafter modulates the development of lung fibrosis. METHODS:Mice received a single dose of 3 mg/kg body weight of bleomycin (...

journal_title：Respiratory research

authors： Kobayashi T,Tanaka K,Fujita T,Umezawa H,Amano H,Yoshioka K,Naito Y,Hatano M,Kimura S,Tatsumi K,Kasuya Y

更新日期：2015-08-20 00:00:00

abstract：BACKGROUND:Aim of this prospective study was to compare clinical and genetic findings in children with idiopathic or heritable pulmonary arterial hypertension (I/HPAH) with children affected with congenital heart defects associated PAH (CHD-APAH). METHODS:Prospectively included were 40 consecutive children with invasi...

journal_title：Respiratory research

authors： Pfarr N,Fischer C,Ehlken N,Becker-Grünig T,López-González V,Gorenflo M,Hager A,Hinderhofer K,Miera O,Nagel C,Schranz D,Grünig E

更新日期：2013-01-09 00:00:00

abstract：BACKGROUND:Airway clearance techniques (ACTs) are an important aspect of the treatment of children with chronic obstructive lung diseases. Unfortunately, a sound evidence base is lacking and airway clearance strategies are largely based on clinical expertise. One of the reasons for the limited evidence is the lack of a...

journal_title：Respiratory research

authors： Lauwers E,Ides K,Van Hoorenbeeck K,Verhulst S

更新日期：2020-08-17 00:00:00

abstract：BACKGROUND:Surfactant protein D (SP-D) and Mannose Binding Lectin (MBL) are collectins that have opsonic and immunoregulatory functions, are found in lung fluid and interact with the human immunodeficiency virus (HIV). We compared collectin levels in lung fluid and serum from HIV infected and normal subjects to determi...

journal_title：Respiratory research

authors： Jambo KC,French N,Zijlstra E,Gordon SB

更新日期：2007-06-13 00:00:00

abstract：BACKGROUND:For decades, there is an unresolved debate about adequate prescription of antibiotics for patients suffering from exacerbations of chronic obstructive pulmonary disease (COPD). The aim of this systematic review was to analyse randomised controlled trials investigating the clinical benefit of antibiotics for ...

journal_title：Respiratory research

authors： Puhan MA,Vollenweider D,Latshang T,Steurer J,Steurer-Stey C

更新日期：2007-04-04 00:00:00

abstract：BACKGROUND:Chitosan, a polymer derived from chitin, has been used for nasal drug delivery because of its biocompatibility, biodegradability and bioadhesiveness. Theophylline is a drug that reduces the inflammatory effects of allergic asthma but is difficult to administer at an appropriate dosage without causing adverse...

journal_title：Respiratory research

authors： Lee DW,Shirley SA,Lockey RF,Mohapatra SS

更新日期：2006-08-24 00:00:00

abstract：BACKGROUND:Airway epithelial barrier function is maintained by the formation of tight junctions (TJs) and adherens junctions (AJs). Inhalation of cigarette smoke causes airway epithelial barrier dysfunction and may contribute to the pathogenesis of chronic lung diseases such as asthma and chronic obstructive pulmonary ...

journal_title：Respiratory research

authors： Tatsuta M,Kan-O K,Ishii Y,Yamamoto N,Ogawa T,Fukuyama S,Ogawa A,Fujita A,Nakanishi Y,Matsumoto K

更新日期：2019-11-09 00:00:00

abstract：BACKGROUND:Alveolar macrophages are professional phagocytes that remove microbial pathogens inhaled into the lung. The phagocytic ability is compromised in chronic obstructive pulmonary disease (COPD). However, the molecular mechanisms underlying this defect in phagocytosis are not clearly defined. MATERIALS AND METHO...

journal_title：Respiratory research

authors： Tanno A,Fujino N,Yamada M,Sugiura H,Hirano T,Tanaka R,Sano H,Suzuki S,Okada Y,Ichinose M

更新日期：2020-01-28 00:00:00

abstract：BACKGROUND:In idiopathic pulmonary fibrosis loss of alveolar epithelium induces inflammation of the pulmonary tissue followed by accumulation of pathogenic myofibroblasts leading eventually to respiratory failures. In animal models inflammatory and resident cells have been demonstrated to contribute to pulmonary fibros...

journal_title：Respiratory research

authors： Blyszczuk P,Germano D,Stein S,Moch H,Matter CM,Beck-Schimmer B,Lüscher TF,Eriksson U,Kania G

更新日期：2011-09-26 00:00:00

abstract：BACKGROUND:Bronchiectasis is defined as a permanent dilation of the airways arising from chronic bronchial inflammation/infection. In 50% of cases, no etiology can be identified. Recently, the role of the epithelial sodium channel ENaC has been pointed out in the pathophysiology of cystic fibrosis, a disease due to mut...

journal_title：Respiratory research

authors： Fajac I,Viel M,Sublemontier S,Hubert D,Bienvenu T

更新日期：2008-05-28 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a progressive and irreversible chronic inflammatory disease of the lung. The nature of the immune reaction in COPD raises the possibility that IL-17 and related cytokines may contribute to this disorder. This study analyzed the expression of IL-17A and IL-17F a...

journal_title：Respiratory research

authors： Chang Y,Nadigel J,Boulais N,Bourbeau J,Maltais F,Eidelman DH,Hamid Q

更新日期：2011-04-10 00:00:00