Tranexamic Acid versus Placebo to Prevent Blood Transfusion during Radical Cystectomy for Bladder Cancer (TACT): Study Protocol for a Randomized Controlled Trial.

abstract：BACKGROUND:Trials of complex interventions are associated with high costs and burdens in terms of paperwork, management, data collection, validation, and intervention fidelity assessment occurring across multiple sites. Traditional data collection methods rely on paper-based forms, where processing can be time-consumin...

journal_title：Trials

authors： Drew CJ,Poile V,Trubey R,Watson G,Kelson M,Townson J,Rosser A,Hood K,Quinn L,Busse M

更新日期：2016-11-17 00:00:00

abstract：BACKGROUND:Despite efforts to improve the accuracy and transparency of the design, conduct, and reporting of randomised controlled trials (RCTs), deficiencies remain. Such deficiencies contribute to significant, avoidable waste of health research investment and impede reproducibility. This study aimed to synthesise and...

journal_title：Trials

authors： Clyne B,Boland F,Murphy N,Murphy E,Moriarty F,Barry A,Wallace E,Devine T,Smith SM,Devane D,Murphy A,Fahey T

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Care management interventions in the German health-care system have been evaluated with promising results, but further research is necessary to explore their full potential in the context of multi-morbidity. Our aim in this trial is to assess the efficacy of a primary care practice network-based care managem...

journal_title：Trials

authors： Bozorgmehr K,Szecsenyi J,Ose D,Besier W,Mayer M,Krisam J,Jacke CO,Salize HJ,Brandner R,Schmitt S,Kiel M,Kamradt M,Freund T

更新日期：2014-06-21 00:00:00

abstract：BACKGROUND:The costs of medical research are a concern. Clinical Trials Units (CTUs) need to better understand variations in the costs of their activities. METHODS:Representatives of ten CTUs and two grant-awarding bodies pooled their experiences in discussions over 1.5 years. Five of the CTUs provided estimates of, a...

journal_title：Trials

authors： Hind D,Reeves BC,Bathers S,Bray C,Corkhill A,Hayward C,Harper L,Napp V,Norrie J,Speed C,Tremain L,Keat N,Bradburn M

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:Coronary artery disease is the leading cause of morbidity and mortality in patients with type 2 diabetes. Screening for asymptomatic coronary artery disease with treatment by means of revascularization seems to be an appealing option for prevention. The utility of such a strategy has never been challenged in...

journal_title：Trials

authors： Turrini F,Messora R,Giovanardi P,Tondi S,Magnavacchi P,Cavani R,Tosoni G,Cappelli C,Pellegrini E,Romano S,Baldini A,Zennaro RG,Bondi M

更新日期：2009-12-23 00:00:00

abstract：OBJECTIVES:Patients with diabetes are - compared to people without diabetes - at increased risk of worse outcomes from COVID-19 related pneumonia during hospitalization. We aim to investigate whether telemetric continuous glucose monitoring (CGM) in quarantined hospitalized patients with diabetes and confirmed SARS-CoV...

journal_title：Trials

authors： Klarskov CK,Lindegaard B,Pedersen-Bjergaard U,Kristensen PL

更新日期：2020-11-25 00:00:00

abstract：RATIONALE:In critically ill patients receiving invasive mechanical ventilation (MV), research supports the use of daily screening to identify patients who are ready to undergo a spontaneous breathing trial (SBT) followed by conduct of an SBT. However, once daily (OD) screening is poorly aligned with the continuous care...

journal_title：Trials

authors： Burns KEA,Rizvi L,Cook DJ,Seely AJE,Rochwerg B,Lamontagne F,Devlin JW,Dodek P,Mayette M,Tanios M,Gouskos A,Kay P,Mitchell S,Kiedrowski KC,Hill NS,Canadian Critical Care Trials Group.

更新日期：2019-10-11 00:00:00

abstract：BACKGROUND:There are marked disparities between pre-school children in key skills affecting school readiness, disparities that commonly persist and influence children's later academic achievements, employment, and adjustment. Much of this disparity is linked to socio-economic disadvantage and its impact on the home lea...

journal_title：Trials

authors： Murray L,Jennings S,Mortimer A,Prout A,Melhuish E,Hughes C,Duncan J,Holmes J,Dishington C,Cooper PJ

更新日期：2018-08-22 00:00:00

abstract：BACKGROUND:Meta-analyses of randomized controlled trials (RCTs) have shown that exercise has beneficial effects on quality of life (QoL) in patients with breast cancer. However, these effects were often small. Blinding in an exercise trial is not possible, which has the possible disadvantage of difficult accrual, drop-...

journal_title：Trials

authors： Gal R,Monninkhof EM,Groenwold RHH,van Gils CH,van den Bongard DHJG,Peeters PHM,Verkooijen HM,May AM

更新日期：2017-10-27 00:00:00

abstract：BACKGROUND:Metabolic acidosis is more common with advancing chronic kidney disease, and has been associated with impaired physical function, impaired bone health, accelerated decline in kidney function and increased vascular risk. Although oral sodium bicarbonate is widely used to correct metabolic acidosis, there exis...

journal_title：Trials

authors： Witham MD,Band MM,Littleford RC,Avenell A,Soiza RL,McMurdo ME,Sumukadas D,Ogston SA,Lamb EJ,Hampson G,McNamee P,BiCARB Study Group.

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:In 2007, the Chinese Science Division of the State Administration of Traditional Chinese Medicine(TCM) convened a special conference to discuss quality control for TCM clinical research. Control and assurance standards were established to guarantee the quality of clinical research. This paper provides practi...

journal_title：Trials

authors： Zhao L,Liang FR,Li Y,Zhang FW,Zheng H,Wu X

更新日期：2009-12-27 00:00:00

abstract：BACKGROUND:Age-related muscle wasting has been strongly implicated with falls and fractures in the elderly, but it has also been associated with cognitive decline and dementia. Progressive resistance training (PRT) and adequate dietary protein are recognised as important contributors to the maintenance of muscle health...

journal_title：Trials

authors： Daly RM,Gianoudis J,Prosser M,Kidgell D,Ellis KA,O'Connell S,Nowson CA

更新日期：2015-08-08 00:00:00

abstract：BACKGROUND:Studies exploring parents' trial experiences generally relate to their understanding of the consent process and the development of researcher strategies to facilitate recruitment and retention. The aim was to better understand parents' experience of being part of a trial at the time and their perceptions of ...

journal_title：Trials

authors： Harvey M,Nongena P,Edwards D,Redshaw M

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The prevalence of depression in young people is increasing. The predominant co-morbidities of juvenile depression include sleep disturbances and persistent problems with the sleep-wake rhythm, which have shown to influence treatment outcomes negatively. Severe mood dysregulation is another condition that inc...

journal_title：Trials

authors： Bogen S,Legenbauer T,Bogen T,Gest S,Jensch T,Schneider S,Holtmann M

更新日期：2013-06-17 00:00:00

abstract：BACKGROUND:Recommendations for good clinical practice have been reported to be difficult to apply in real life by primary care clinicians. This could be because the clinical trials at the origin of the guidelines are based on explanatory trials, conducted under ideal conditions not reflecting the reality of primary car...

journal_title：Trials

authors： Ettori-Ajasse I,Tatin E,Forbes G,Eldridge S,Dibao-Dina C

更新日期：2020-03-19 00:00:00

abstract：BACKGROUND:Halitosis is an unpleasant breath odour that can interfere with the professional life, social life and quality of life of people who suffer from it. A modality of treatment that has been increasing in dentistry is antimicrobial photodynamic therapy (aPDT). Bixa orellana, popularly known as "urucum" is a plan...

journal_title：Trials

authors： Gonçalves MLL,da Mota ACC,Deana AM,Guedes GH,Cavalcante LAS,Prates RA,Horliana ACRT,Pavani C,Motta LJ,Bitencourt GB,Fernandes KPS,Salgueiro MDCC,Mesquita-Ferrari RA,da Silva DFT,França CM,Bussadori SK

更新日期：2018-10-29 00:00:00

abstract：BACKGROUND:Tinnitus is the perception of a sound in the absence of an objective physical source. Up to now, there is no generally accepted view how these phantom sounds come about, and also no efficient treatment. Patients are turning to complementary or alternative medical therapies, such as acupuncture. Based on the ...

journal_title：Trials

authors： Shi GX,Han LL,Liu LY,Li QQ,Liu CZ,Wang LP

更新日期：2012-11-23 00:00:00

abstract：:Tuberculosis (TB) remains a major killer amongst the infectious diseases. Current treatment involves a four-drug regimen for at least 6 months. New drugs and regimens are required to shorten treatment duration, reduce toxicity and combat drug resistance, but the optimal methodology to define the critical path for nove...

journal_title：Trials

authors： Bonnett LJ,Davies GR

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:The application of artificial intelligence (AI) in healthcare is an area of immense interest. The high profile of 'AI in health' means that there are unusually strong drivers to accelerate the introduction and implementation of innovative AI interventions, which may not be supported by the available evidence...

journal_title：Trials

authors： Ibrahim H,Liu X,Rivera SC,Moher D,Chan AW,Sydes MR,Calvert MJ,Denniston AK

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:The application of neuroendoscopy in intraventricular hemorrhage (IVH) has attracted more and more attention in recent years. Studies have shown that the use of neuroendoscopy for IVH evacuation has advantages over external ventricular drainage (EVD) alone. However, the cases of most current research are sma...

journal_title：Trials

authors： Zhu J,Tang C,Cong Z,Yang J,Cai X,Liu Y,Ma C

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:Verrucae are a common, infectious and sometimes painful problem. The optimal treatment for verrucae is unclear due to a lack of high quality randomised controlled trials. The primary objective of this study is to compare the clinical effectiveness of two common treatments for verrucae: cryotherapy using liqu...

journal_title：Trials

authors： Cockayne ES,EVERT Trial Team.

更新日期：2010-02-08 00:00:00

abstract：:Periconceptional supplementation could extend the period over which maternal and fetal nutrition is improved, but there are many challenges facing early-life intervention studies. Periconceptional trials differ from pregnancy supplementation trials, not only because of the very early or pre-gestational timing of nutri...

journal_title：Trials

authors： Brabin BJ,Gies S,Owens S,Claeys Y,D'Alessandro U,Tinto H,Brabin L

更新日期：2016-01-30 00:00:00

abstract：BACKGROUND:Psychosis is a serious mental illness that typically emerges during early adulthood. The disorder is characterized by inactivity, cognitive deficits and the need for ongoing support. Regular exercise has mood enhancing and anxiolytic effects that could benefit this patient group. To date, few studies have ex...

journal_title：Trials

authors： Forsell Y,Hallgren M,Mattson M,Ekblom O,Lavebratt C

更新日期：2015-12-04 00:00:00

abstract：BACKGROUND:Exploration and modelling of heterogeneous treatment effects as a function of baseline covariates is an important aspect of precision medicine in randomised controlled trials (RCTs). Randomisation generally guarantees the internal validity of an RCT, but heterogeneity in treatment effect can reduce external ...

journal_title：Trials

authors： Watson JA,Holmes CC

更新日期：2020-05-07 00:00:00

abstract：BACKGROUND:There has been longstanding interesting in cognitive training for older adults with cognitive impairment. In this study, we will investigate the effects of working memory training, and explore augmentation strategies that could possibly consolidate the effects in older adults with mild neurocognitive disorde...

journal_title：Trials

authors： Cheng CP,Chan SS,Mak AD,Chan WC,Cheng ST,Shi L,Wang D,Lam LC

更新日期：2015-10-24 00:00:00

abstract：:After publication of our article [1] we became aware that several sections of text in our Methods section were copied from a previously published article [2]. ...

journal_title：Trials

authors： Langella LG,Silva PFC,Costa-Santos L,Gonçalves MLL,Motta LJ,Deana AM,Fernandes KPS,Mesquita-Ferrari RA,Bussadori SK

更新日期：2018-12-24 00:00:00

abstract：BACKGROUND:Pragmatic randomised controlled trials (RCTs) are considered essential to determine effective interventions for routine clinical practice, but many fail to recruit participants efficiently, and some really important RCTs are not undertaken because recruitment is thought to be too difficult. The 'QuinteT Recr...

journal_title：Trials

authors： Donovan JL,Rooshenas L,Jepson M,Elliott D,Wade J,Avery K,Mills N,Wilson C,Paramasivan S,Blazeby JM

更新日期：2016-06-08 00:00:00

abstract：BACKGROUND:Metabolic syndrome (MetS) has been identified as a major contributor to the development of cardiovascular disease (CVD). Current recommendations for dietary management of people with MetS involve quantitative and qualitative modifications of food intake, such as high consumption of vegetables, fruits, and wh...

journal_title：Trials

authors： Ramprasath VR,Thandapilly SJ,Yang S,Abraham A,Jones PJ,Ames N

更新日期：2015-10-31 00:00:00

abstract：BACKGROUND:More than 60,000 people have health problems due to chemical weapons exposure during the Iran-Iraq war. Respiratory consequences of mustard gas exposure are common and disabling; medical interventions have limited effect. Patients complain of cough, sputum, breathlessness and exercise limitation. We hypothes...

journal_title：Trials

authors： Sedighi Moghadam MR,Ghanei M,Kenn K,Hopkinson NS

更新日期：2019-02-14 00:00:00

abstract：BACKGROUND:A growing body of evidence shows the short-term benefits of breastfeeding, which include protection against infections, allergies, and lung diseases. However, evidence on the long-term benefits of breastfeeding is scarce and often conflicting. The BReastfeeding Attitude and Volume Optimization (BRAVO) trial ...

journal_title：Trials

authors： Savitri AI,Idris NS,Indawati W,Saldi SR,Amelia D,Baharuddin M,Sastroasmoro S,Grobbee DE,Uiterwaal CS

更新日期：2016-06-02 00:00:00