How should HIV resources be allocated? Lessons learnt from applying Optima HIV in 23 countries.

Abstract:

INTRODUCTION:With limited funds available, meeting global health targets requires countries to both mobilize and prioritize their health spending. Within this context, countries have recognized the importance of allocating funds for HIV as efficiently as possible to maximize impact. Over the past six years, the governments of 23 countries in Africa, Asia, Eastern Europe and Latin America have used the Optima HIV tool to estimate the optimal allocation of HIV resources. METHODS:Each study commenced with a request by the national government for technical assistance in conducting an HIV allocative efficiency study using Optima HIV. Each study team validated the required data, calibrated the Optima HIV epidemic model to produce HIV epidemic projections, agreed on cost functions for interventions, and used the model to calculate the optimal allocation of available funds to best address national strategic plan targets. From a review and analysis of these 23 country studies, we extract common themes around the optimal allocation of HIV funding in different epidemiological contexts. RESULTS AND DISCUSSION:The optimal distribution of HIV resources depends on the amount of funding available and the characteristics of each country's epidemic, response and targets. Universally, the modelling results indicated that scaling up treatment coverage is an efficient use of resources. There is scope for efficiency gains by targeting the HIV response towards the populations and geographical regions where HIV incidence is highest. Across a range of countries, the model results indicate that a more efficient allocation of HIV resources could reduce cumulative new HIV infections by an average of 18% over the years to 2020 and 25% over the years to 2030, along with an approximately 25% reduction in deaths for both timelines. However, in most countries this would still not be sufficient to meet the targets of the national strategic plan, with modelling results indicating that budget increases of up to 185% would be required. CONCLUSIONS:Greater epidemiological impact would be possible through better targeting of existing resources, but additional resources would still be required to meet targets. Allocative efficiency models have proven valuable in improving the HIV planning and budgeting process.

journal_name

J Int AIDS Soc

authors

Stuart RM,Grobicki L,Haghparast-Bidgoli H,Panovska-Griffiths J,Skordis J,Keiser O,Estill J,Baranczuk Z,Kelly SL,Reporter I,Kedziora DJ,Shattock AJ,Petravic J,Hussain SA,Grantham KL,Gray RT,Yap XF,Martin-Hughes R,Bened

doi

10.1002/jia2.25097

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

e25097

issue

4

issn

1758-2652

journal_volume

21

pub_type

杂志文章,评审
  • When are declines in condom use while using PrEP a concern? Modelling insights from a Hillbrow, South Africa case study.

    abstract:INTRODUCTION:Oral pre-exposure prophylaxis (PrEP) is a promising new prevention approach for those most at risk of HIV infection. However, there are concerns that behavioural disinhibition, specifically reductions in condom use, might limit PrEP's protective effect. This study uses the case of female sex workers (FSWs)...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/IAS.20.1.21744

    authors: Grant H,Mukandavire Z,Eakle R,Prudden H,B Gomez G,Rees H,Watts C

    更新日期:2017-09-20 00:00:00

  • Telaprevir combination therapy in HCV/HIV co-infected patients (INSIGHT study): sustained virologic response at 12 weeks final analysis.

    abstract:INTRODUCTION:We report the SVR12 final analysis of a phase 3 study of telaprevir in combination with peginterferon (P)/ribavirin (R) in HCV-genotype 1, treatment-naïve and -experienced patients with HCV/HIV co-infection (INSIGHT). MATERIALS AND METHODS:Patients receiving stable, suppressive HIV antiretroviral (ARV) th...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/IAS.17.4.19626

    authors: Montes M,Nelson M,Girard PM,Sasadeusz J,Horban A,Grinsztejn B,Zakharova N,Rivero A,Lathouwers E,Janssen K,Ouwerkerk-Mahadevan S,Witek J

    更新日期:2014-11-02 00:00:00

  • "We don't need services. We have no problems": exploring the experiences of young people who inject drugs in accessing harm reduction services.

    abstract:INTRODUCTION:Evidence suggests that people who inject drugs often begin their drug use and injecting practices in adolescence, yet there are limited data available on the HIV epidemic and the responses for this population. The comprehensive package of interventions for the prevention, treatment and care of HIV infectio...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/IAS.18.2.19442

    authors: Krug A,Hildebrand M,Sun N

    更新日期:2015-02-26 00:00:00

  • Uptake of HIV self-testing and linkage to treatment among men who have sex with men (MSM) in Nigeria: A pilot programme using key opinion leaders to reach MSM.

    abstract:INTRODUCTION:HIV self-testing (HIVST) offers an alternative to facility-based HIV testing services, particularly for populations such as men who have sex with men (MSM) who may fear accessing testing due to stigma, discrimination and criminalization. Innovative HIV testing approaches are needed to meet the goal of 90% ...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1002/jia2.25124

    authors: Tun W,Vu L,Dirisu O,Sekoni A,Shoyemi E,Njab J,Ogunsola S,Adebajo S

    更新日期:2018-07-01 00:00:00

  • Tuberculosis: opportunities and challenges for the 90-90-90 targets in HIV-infected children.

    abstract:INTRODUCTION:In 2014 the Joint United Nations Programme on HIV/AIDS defined the ambitious 90-90-90 targets for 2020, in which 90% of people living with HIV must be diagnosed, 90% of those diagnosed should be on sustained therapy and 90% of those on therapy should have an undetectable viral load. Children are considered...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章,评审

    doi:10.7448/IAS.18.7.20236

    authors: Rabie H,Frigati L,Hesseling AC,Garcia-Prats AJ

    更新日期:2015-12-02 00:00:00

  • Pharmacokinetics-based adherence measures for antiretroviral therapy in HIV-infected Kenyan children.

    abstract:BACKGROUND:Traditional medication adherence measures do not account for the pharmacokinetic (PK) properties of the drugs, potentially misrepresenting true therapeutic exposure. METHODS:In a population of HIV-infected Kenyan children on antiretroviral therapy including nevirapine (NVP), we used a one-compartment model ...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/IAS.20.1.21157

    authors: Tu W,Nyandiko WM,Liu H,Slaven JE,Scanlon ML,Ayaya SO,Vreeman RC

    更新日期:2017-06-15 00:00:00

  • The impact of criminalization of HIV non-disclosure on the healthcare engagement of women living with HIV in Canada: a comprehensive review of the evidence.

    abstract:INTRODUCTION:In 2012, the Supreme Court of Canada ruled that people living with HIV (PLWH) must disclose their HIV status to sexual partners prior to sexual activity that poses a "realistic possibility" of HIV transmission for consent to sex to be valid. The Supreme Court deemed that the duty to disclose could be avert...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章,评审

    doi:10.7448/IAS.18.1.20572

    authors: Patterson SE,Milloy MJ,Ogilvie G,Greene S,Nicholson V,Vonn M,Hogg R,Kaida A

    更新日期:2015-12-22 00:00:00

  • How far are we from viral hepatitis elimination service coverage targets?

    abstract:INTRODUCTION:In 2016, the Global Health Sector Strategy (GHSS) on viral hepatitis called for elimination of viral hepatitis as a major public health threat by 2030 (i.e. 90% reduction in incidence and 65% in mortality). In 2017, WHO's first-ever Global Hepatitis Report presented the baseline values for each of the core...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章,评审

    doi:10.1002/jia2.25050

    authors: Hutin YJ,Bulterys M,Hirnschall GO

    更新日期:2018-04-01 00:00:00

  • India-US collaboration to prevent adolescent HIV infection: the feasibility of a family-based HIV-prevention intervention for rural Indian youth.

    abstract:BACKGROUND:Despite the centrality of family in Indian society, relatively little is known about family-based communication concerning sexual behaviour and HIV/AIDS in rural Indian families. To date, very few family-based adolescent HIV-prevention interventions have been developed for rural Indian youth. This study cond...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1186/1758-2652-12-35

    authors: Soletti AB,Guilamo-Ramos V,Burnette D,Sharma S,Bouris A

    更新日期:2009-11-19 00:00:00

  • Routine viral load monitoring in HIV-infected infants and children in low- and middle-income countries: challenges and opportunities.

    abstract:INTRODUCTION:The objective of this commentary is to review considerations for implementing routine viral load (VL) monitoring programmes for HIV-infected infants and children living in low- and middle-income countries (LMIC). Since 2013, the World Health Organization (WHO) guidelines recommend VL testing as the preferr...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1002/jia2.25001

    authors: Arpadi SM,Shiau S,De Gusmao EP,Violari A

    更新日期:2017-11-01 00:00:00

  • Transmission route and reasons for HIV testing among recently diagnosed HIV patients in HIV-TR cohort, 2011-2012.

    abstract:INTRODUCTION:Routes of transmission and reasons for HIV testing are important epidemiologic data to analyze the epidemic and to tailor the response to AIDS. The aim of this study was to analyze reasons for testing and transmission ways of HIV among recently diagnosed HIV patients registered in the multicenter HIV-TR co...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/IAS.17.4.19595

    authors: Dokuzoguz B,Korten V,Gökengin D,Fincanci M,Yildirmak T,Kes UN,Tasdelen Fisgin N,Inan D,Eraksoy H,Akalin H

    更新日期:2014-11-02 00:00:00

  • How does living with HIV impact on women's mental health? Voices from a global survey.

    abstract:INTRODUCTION:Women living with HIV experience a disproportionate burden of mental health issues. To date, global guidelines contain insufficient guidance on mental health support, particularly regarding perinatal care. The aim of this article is to describe the extent and impact of mental health issues as experienced b...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/IAS.18.6.20289

    authors: Orza L,Bewley S,Logie CH,Crone ET,Moroz S,Strachan S,Vazquez M,Welbourn A

    更新日期:2015-12-01 00:00:00

  • Viral escape in the CNS with multidrug-resistant HIV-1.

    abstract:INTRODUCTION:HIV-1 viral escape in the cerebrospinal fluid (CSF) despite viral suppression in plasma is rare [1,2]. We describe the case of a 50-year-old HIV-1 infected patient who was diagnosed with HIV-1 in 1995. Antiretroviral therapy (ART) was started in 1998 with a CD4 T cell count of 71 cells/ìL and HIV-viremia o...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/IAS.17.4.19745

    authors: Béguelin C,Vázquez M,Bertschi M,Yerly S,de Jong D,Rauch A,Cusini A

    更新日期:2014-11-02 00:00:00

  • The case for viral load testing in adolescents in resource-limited settings.

    abstract:INTRODUCTION:The success of HIV treatment programmes globally has resulted in children with perinatally acquired HIV reaching adolescence in large numbers. The number of adolescents living with HIV is growing further due to persisting high HIV incidence rates among adolescents in low- and middle-income settings, partic...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章,评审

    doi:10.1002/jia2.25002

    authors: Marcus R,Ferrand RA,Kranzer K,Bekker LG

    更新日期:2017-11-01 00:00:00

  • Integrating care for non-communicable diseases into routine HIV services: key considerations for policy design in sub-Saharan Africa.

    abstract:INTRODUCTION:There is great interest for integrating care for non-communicable diseases (NCDs) into routine HIV services in sub-Saharan Africa (SSA) due to the steady rise of the number of people who are ageing with HIV. Suggested health system approaches for intervening on these comorbidities have mostly been normativ...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1002/jia2.25508

    authors: Kintu A,Sando D,Okello S,Mutungi G,Guwatudde D,Menzies NA,Danaei G,Verguet S

    更新日期:2020-06-01 00:00:00

  • Eliminating hepatitis C virus as a public health threat among HIV-positive men who have sex with men: a multi-modelling approach to understand differences in sexual risk behaviour.

    abstract:INTRODUCTION:Outbreaks of hepatitis C virus (HCV) infections among HIV-positive men who have sex with men (MSM) have been observed globally. Using a multi-modelling approach we estimate the time and number of direct-acting antiviral treatment courses required to achieve an 80% reduction in HCV prevalence among HIV-posi...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1002/jia2.25059

    authors: Scott N,Stoové M,Wilson DP,Keiser O,El-Hayek C,Doyle J,Hellard M

    更新日期:2018-01-01 00:00:00

  • Tim-3 blocking rescue macrophage and T cell function against Mycobacterium tuberculosis infection in HIV+ patients.

    abstract:INTRODUCTION:T cell immunoglobulin and mucin domain (Tim) 3 and programmed death 1 (PD-1) are co-inhibitory receptors involved in the so-called T cell exhaustion, and in vivo blockade of these molecules restores T cell dysfunction. High expression of Tim-3 and PD-1 is induced after chronic antigen-specific stimulation ...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/IAS.18.1.20078

    authors: Sada-Ovalle I,Ocaña-Guzman R,Pérez-Patrigeón S,Chávez-Galán L,Sierra-Madero J,Torre-Bouscoulet L,Addo MM

    更新日期:2015-10-19 00:00:00

  • Online interventions to address HIV and other sexually transmitted and blood-borne infections among young gay, bisexual and other men who have sex with men: a systematic review.

    abstract:INTRODUCTION:Globally, young gay, bisexual and other men who have sex with men (gbMSM) continue to experience disproportionately high rates of HIV and other sexually transmitted and blood-borne infections (STBBIs). As such, there are strong public health imperatives to evaluate innovative prevention, treatment and care...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章,评审

    doi:10.1002/jia2.25017

    authors: Knight R,Karamouzian M,Salway T,Gilbert M,Shoveller J

    更新日期:2017-11-01 00:00:00

  • Approaches to transitioning women into and out of prevention of mother-to-child transmission of HIV services for continued ART: a systematic review.

    abstract:INTRODUCTION:Women living with HIV are required to transition into the prevention of mother-to-child transmission of HIV (PMTCT) services when they become pregnant and back to ART services after delivery. Transition can be a vulnerable time when many women are lost from HIV care yet there is little guidance on the opti...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章,评审

    doi:10.1002/jia2.25633

    authors: Phillips TK,Teasdale CA,Geller A,Ng'eno B,Mogoba P,Modi S,Abrams EJ

    更新日期:2021-01-01 00:00:00

  • Transactional sex and risk for HIV infection in sub-Saharan Africa: a systematic review and meta-analysis.

    abstract:INTRODUCTION:Young women aged 15 to 24 years in sub-Saharan Africa continue to be disproportionately affected by HIV. A growing number of studies have suggested that the practice of transactional sex may in part explain women's heightened risk, but evidence on the association between transactional sex and HIV has not y...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章,meta分析,评审

    doi:10.7448/IAS.19.1.20992

    authors: Wamoyi J,Stobeanau K,Bobrova N,Abramsky T,Watts C

    更新日期:2016-11-02 00:00:00

  • HIV knowledge trends during an era of rapid antiretroviral therapy scale-up: an analysis of 33 sub-Saharan African countries.

    abstract:INTRODUCTION:Population-level improvements in knowledge about HIV may reduce the stigma attached to HIV and ensure maximal uptake of HIV prevention initiatives. The extent to which levels of HIV knowledge in the general population of sub-Saharan Africa have changed in the current era of antiretroviral therapy (ART) sca...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1002/jia2.25169

    authors: Chan BT,Tsai AC

    更新日期:2018-07-01 00:00:00

  • Barriers and facilitators to linkage to ART in primary care: a qualitative study of patients and providers in Blantyre, Malawi.

    abstract:INTRODUCTION:Linkage from HIV testing and counselling (HTC) to initiation of antiretroviral therapy (ART) is suboptimal in many national programmes in sub-Saharan Africa, leading to delayed initiation of ART and increased risk of death. Reasons for failure of linkage are poorly understood. METHODS:Semi-structured qual...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/IAS.15.2.18020

    authors: MacPherson P,MacPherson EE,Mwale D,Bertel Squire S,Makombe SD,Corbett EL,Lalloo DG,Desmond N

    更新日期:2012-12-31 00:00:00

  • Index and targeted community-based testing to optimize HIV case finding and ART linkage among men in Zambia.

    abstract:INTRODUCTION:Current healthcare systems fail to provide adequate HIV services to men. In Zambia, 25% of adult men living with HIV were unaware of their HIV status in 2018, and 12% of those who were unaware of their HIV statu were not receiving antiretroviral therapy (ART) due to pervasive barriers to HIV testing servic...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1002/jia2.25520

    authors: Mwango LK,Stafford KA,Blanco NC,Lavoie MC,Mujansi M,Nyirongo N,Tembo K,Sakala H,Chipukuma J,Phiri B,Nzangwa C,Mwandila S,Nkwemu KC,Saadani A,Mwila A,Herce ME,Claassen CW

    更新日期:2020-06-01 00:00:00

  • Acute retroviral syndrome and high baseline viral load are predictors of rapid HIV progression among untreated Argentinean seroconverters.

    abstract:BACKGROUND:Diagnosis of primary HIV infection (PHI) has important clinical and public health implications. HAART initiation at this stage remains controversial. METHODS:Our objective was to identify predictors of disease progression among Argentinean seroconverters during the first year of infection, within a multicen...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1186/1758-2652-14-40

    authors: Socías ME,Sued O,Laufer N,Lázaro ME,Mingrone H,Pryluka D,Remondegui C,Figueroa MI,Cesar C,Gun A,Turk G,Bouzas MB,Kavasery R,Krolewiecki A,Pérez H,Salomón H,Cahn P,Grupo Argentino de Seroconversión Study Group.

    更新日期:2011-08-10 00:00:00

  • Risk of death among those awaiting treatment for HIV infection in Zimbabwe: adolescents are at particular risk.

    abstract:INTRODUCTION:Mortality among HIV-positive adults awaiting antiretroviral therapy (ART) has previously been found to be high. Here, we compare adolescent pre-ART mortality to that of adults in a public sector HIV care programme in Bulawayo, Zimbabwe. METHODS:In this retrospective cohort study, we compared adolescent pr...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/IAS.18.1.19247

    authors: Shroufi A,Ndebele W,Nyathi M,Gunguwo H,Dixon M,Saint-Sauveur JF,Taziwa F,Viñoles MC,Ferrand RA

    更新日期:2015-02-23 00:00:00

  • Fostering successful and sustainable collaborations to advance implementation science: the adolescent HIV prevention and treatment implementation science alliance.

    abstract:INTRODUCTION:HIV continues to devastate the adolescent population in sub-Saharan Africa (SSA). The complex array of interpersonal, social, structural and system-level obstacles specific to adolescents have slowed progress in prevention and treatment of HIV in this population. The field of implementation science holds p...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1002/jia2.25572

    authors: Sturke R,Vorkoper S,Bekker LG,Ameyan W,Luo C,Allison S,Walker D,Kapogiannis B,Guay L

    更新日期:2020-09-01 00:00:00

  • Acceptability of PrEP among HIV negative Portuguese men who have sex with men that attended 2014 Lisbon pride fair.

    abstract:INTRODUCTION:Consistent use of PrEP reduces HIV transmission from sexual practices amongst men who have sex with men (MSM) up to 92% [1]. Lisbon MSM cohort study estimates point that 59.3% of their participants at entrance (1593 HIV negative MSM enrolled between April 2011 and May 2013) were eligible for PrEP [2], acco...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/IAS.17.4.19734

    authors: Rocha LM,Campos MJ,Brito J,Fuertes R,Rojas J,Pinto N,Mendão L,Esteves J

    更新日期:2014-11-02 00:00:00

  • XVII International AIDS Conference: From Evidence to Action - Clinical and biomedical prevention science.

    abstract:: The question of whether to initiate ART at higher CD4+ cell counts than currently recommended by World Health Organization (WHO) treatment guidelines received much attention at the XVII International AIDS Conference (AIDS 2008). If studies presented at the conference ultimately lead to a revision of WHO treatment gui...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1186/1758-2652-12-S1-S4

    authors: Mascolini M,Kort R,Gilden D

    更新日期:2009-10-06 00:00:00

  • Testing the efficacy of an HIV stigma reduction intervention with medical students in Puerto Rico: the SPACES project.

    abstract:INTRODUCTION:Stigma associated with HIV has been documented as a barrier for accessing quality health-related services. When the stigma manifests in the health care setting, people living with HIV receive substandard services or even be denied care altogether. Although the consequences of HIV stigma have been documente...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章,随机对照试验

    doi:10.7448/IAS.16.3.18670

    authors: Varas-Díaz N,Neilands TB,Cintrón-Bou F,Marzán-Rodríguez M,Santos-Figueroa A,Santiago-Negrón S,Marques D,Rodríguez-Madera S

    更新日期:2013-11-13 00:00:00

  • The role of family planning in achieving safe pregnancy for serodiscordant couples: commentary from the United States government's interagency task force on family planning and HIV service integration.

    abstract:INTRODUCTION:People living with HIV (PLHIV) have the right to exercise voluntary choices about their health, including their reproductive health. This commentary discusses the integral role that family planning (FP) plays in helping PLHIV, including those in serodiscordant relationships, achieve conception safely. The ...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章,评审

    doi:10.7448/IAS.20.2.21312

    authors: Mason J,Medley A,Yeiser S,Nightingale VR,Mani N,Sripipatana T,Abutu A,Johnston B,Watts DH

    更新日期:2017-03-08 00:00:00