The case for viral load testing in adolescents in resource-limited settings.

abstract：INTRODUCTION:Mortality among HIV-positive adults awaiting antiretroviral therapy (ART) has previously been found to be high. Here, we compare adolescent pre-ART mortality to that of adults in a public sector HIV care programme in Bulawayo, Zimbabwe. METHODS:In this retrospective cohort study, we compared adolescent pr...

journal_title：Journal of the International AIDS Society

authors： Shroufi A,Ndebele W,Nyathi M,Gunguwo H,Dixon M,Saint-Sauveur JF,Taziwa F,Viñoles MC,Ferrand RA

更新日期：2015-02-23 00:00:00

abstract：INTRODUCTION:Although RTS as HIV Diagnosis was considered cost effectiveness [1], overall budget may be unaffordable for some countries. We explore Incremental cost per NDHI associated with different TS. MATERIALS AND METHODS:From a health care perspective, using direct costs and Euros currency, we calculated budget a...

journal_title：Journal of the International AIDS Society

authors： Gomez-Ayerbe C,Elías MJ,Muriel A,Elías PP,Cano A,Diaz A,Moreno A,Casado JL,Santos C,Martinez-Colubi M,Uranga A,Dronda F,Moreno S

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Countries in the West and Central African regions struggle to offer quality HIV care at scale, despite HIV prevalence being relatively low. In these challenging operating environments, basic health care needs are multiple, systems are highly fragile and conflict disrupts health care. Médecins Sans Frontièr...

journal_title：Journal of the International AIDS Society

authors： Ssonko C,Gonzalez L,Mesic A,da Fonseca MS,Achar J,Safar N,Martin B,Wong S,Casas EC

更新日期：2017-07-21 00:00:00

abstract：INTRODUCTION:Women living with HIV (WLWH) are reportedly at increased risk of invasive cervical cancer (ICC). WLWH in Denmark attend the National ICC screening program less often than women in the general population. We aimed to estimate the incidence of cervical dysplasia and ICC in WLWH in Denmark. METHODS:We studie...

journal_title：Journal of the International AIDS Society

authors： Thorsteinsson K,Ladelund S,Jensen-Fangel S,Katzenstein TL,Johansen IS,Pedersen G,Junge J,Helleberg M,Storgaard M,Obel N,Lebech AM

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:This was a descriptive non-interventional study in HIV-1-infected patients treated with DRV/r conducted in the clinical setting, with a single-arm prospective design. The primary objective was to collect data on utilization of darunavir/ritonavir (DRV/r) under the conditions described in the marketing auth...

journal_title：Journal of the International AIDS Society

authors： Antinori A,Galli M,Gianotti N,Mussini C,Quirino T,Sterrantino K,Mancusi D,Termini R

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:International investment in the response to HIV and AIDS has plateaued and its future level is uncertain. With many countries committed to ending the epidemic, it is essential to allocate available resources efficiently over different response periods to maximize impact. The objective of this study is to p...

journal_title：Journal of the International AIDS Society

authors： Shattock AJ,Kerr CC,Stuart RM,Masaki E,Fraser N,Benedikt C,Gorgens M,Wilson DP,Gray RT

更新日期：2016-02-23 00:00:00

abstract：INTRODUCTION:Although individual HIV rapid diagnostic tests (RDTs) show good performance in evaluations conducted by WHO, reports from several African countries highlight potentially significant performance issues. Despite widespread use of RDTs for HIV diagnosis in resource-constrained settings, there has been no syst...

journal_title：Journal of the International AIDS Society

authors： Kosack CS,Page AL,Beelaert G,Benson T,Savane A,Ng'ang'a A,Andre B,Zahinda JB,Shanks L,Fransen K

更新日期：2017-03-24 00:00:00

abstract：INTRODUCTION:Changes in combination antiretroviral therapy (cART) throughout childhood challenge the continuity of paediatric HIV treatment. This study aimed to evaluate the prevalence of treatment interruption (TI), including lamivudine (3TC) monotherapy, and the relationship of TI to virologic and immunologic paramet...

journal_title：Journal of the International AIDS Society

authors： Rakhmanina N,Lam KS,Hern J,Young HA,Walters A,Castel AD

更新日期：2016-10-27 00:00:00

abstract：INTRODUCTION:The relative efficacy of different antiretroviral (ART) regimens has been extensively evaluated in the context of clinical trials, using HIV viral load (VL) measurements at pre-specified timepoints after ART onset. However, data from real-life studies using combined longitudinal measurements of cumulative ...

journal_title：Journal of the International AIDS Society

authors： Pascom AR,Pinho RE,Rick F,Veras NM,Perini FB,Meireles MV,Pereira GF,Benzaken AS,Avelino-Silva VI

更新日期：2019-11-01 00:00:00

abstract：INTRODUCTION:Disruption in bone homeostasis with increased osteoclastic resorption may lead to osteoporosis. HIV tat has been found to increase differentiation of precursor cells into osteoclast (OC) (1). Presence of soluble HIV proteins in virally suppressed HIV patients on ART may drive a bone resorption phenotype. W...

journal_title：Journal of the International AIDS Society

authors： Chew N,Tan E,Li L,Lim R

更新日期：2014-11-02 00:00:00

abstract：BACKGROUND:The majority of new HIV infections are acquired through heterosexual transmission. There is urgent need for prevention methods to compliment behavior change and condom use. Topical microbicide represent a potential strategy for reduction of HIV transmission in women. METHODS:Monthly Colposcopy evaluations w...

journal_title：Journal of the International AIDS Society

authors： Chirenje ZM,Mâsse BR,Maslankowski LA,Ramjee G,Coletti AS,Tembo TN,Magure TM,Soto-Torres L,Kelly C,Hillier S,Karim A

更新日期：2012-08-27 00:00:00

abstract：INTRODUCTION:Vaginal tenofovir (TFV) 1% gel may reduce incident HIV-1 and herpes simplex virus 2 infection. Pregnancy may increase risk of HIV acquisition, and incident HIV in pregnancy potentiates perinatal HIV transmission. Our objective was to investigate the safety and pharmacokinetics of seven days of TFV 1% vagin...

journal_title：Journal of the International AIDS Society

authors： Beigi RH,Noguchi LM,Montgomery E,Biggio J,Hendrix CW,Marzinke MA,Dai JY,Pan J,Kunjara Na Ayudhya R,Schwartz JL,Isaacs K,Piper JM,Watts DH

更新日期：2016-09-21 00:00:00

abstract：INTRODUCTION:The long-term effects of an intensified induction regimen are unknown. In this pilot, randomized, prospective study we evaluate the effect of a short-term four-drugs induction regimen in patients with high baseline viral load. METHODS:Naive patients with HIV-RNA>100.000 copies/ml receiving TDF+FTC+EFV+RAL...

journal_title：Journal of the International AIDS Society

authors： Maggiolo F,Masini G,Astuti N,Di Filippo E,Benatti S,Valenti D,Callegaro AP,Rizzi M

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Infection with HIV subtype A has been associated with poorer neurocognitive outcomes compared to HIV subtype D in Ugandan children not eligible for antiretroviral therapy (ART). In this study, we sought to determine whether subtype-specific differences are also observed among children receiving ART. MATER...

journal_title：Journal of the International AIDS Society

authors： Bangirana P,Ruel TD,Boivin MJ,Pillai SK,Giron LB,Sikorskii A,Banik A,Achan J

更新日期：2017-10-01 00:00:00

abstract：INTRODUCTION:Treatment as prevention has mobilized new opportunities in preventing HIV transmission and has led to bold new UNAIDS targets in testing, treatment coverage and transmission reduction. These will require not only an increase in investment but also a deeper understanding of the dynamics of combining behavio...

journal_title：Journal of the International AIDS Society

authors： Brown G,Reeders D,Dowsett GW,Ellard J,Carman M,Hendry N,Wallace J

更新日期：2015-12-14 00:00:00

abstract：INTRODUCTION:Rilpivirine (RPV) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) that was recently approved for the treatment of antiretroviral-naïve individuals with HIV-1 viral load of <100,000 copies/ml. As transmission of the drug resistance mutations to this NNRTI may affect treatment o...

journal_title：Journal of the International AIDS Society

authors： Parczewski M,Urbańska A,Maciejewska K,Witak-Jȩdra M,Leszczyszyn-Pynka M

更新日期：2014-04-17 00:00:00

abstract：INTRODUCTION:The 48-week interim analysis of the MODAT study showed that confirmed virologic failure (CVF) was more frequent in patients simplifying to ATV/r monotherapy compared to maintaining ATV/r-based triple therapy. The DSMB recommended stopping study enrollment but continuing follow-up of enrolled patients. We p...

journal_title：Journal of the International AIDS Society

authors： Spagnuolo V,Galli L,Bigoloni A,Nozza S,Monforte Ad,Antinori A,Di Biagio A,Rusconi S,Guaraldi G,Di Giambenedetto S,Lazzarin A,Castagna A

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Qualitative research on antiretroviral therapy (ART) adherence interventions can provide a deeper understanding of intervention facilitators and barriers. This systematic review aims to synthesize qualitative evidence of interventions for improving ART adherence and to inform patient-centred policymaking. ...

journal_title：Journal of the International AIDS Society

authors： Ma Q,Tso LS,Rich ZC,Hall BJ,Beanland R,Li H,Lackey M,Hu F,Cai W,Doherty M,Tucker JD

更新日期：2016-10-17 00:00:00

abstract：INTRODUCTION:Policies for rationing antiretroviral therapy (ART) have been subject to on-going ethical debates. Introduced in Malawi in 2011, Option B+ prioritized HIV-positive pregnant women for lifelong ART regardless of the underlying state of their immune system, shifting the logic of allocation away from medical e...

journal_title：Journal of the International AIDS Society

authors： Yeatman S,Trinitapoli J

更新日期：2017-03-08 00:00:00

abstract：INTRODUCTION:Low bone mineral density (BMD) and osteoporosis are prevalent in HIV-infected patients and were associated with HIV infection and tenofovir-containing ART. MATERIALS AND METHODS:The GUSTA study (GUided Simplification with Tropism Assay) is a two-arm, prospective, multicenter, 1:1 randomized controlled tri...

journal_title：Journal of the International AIDS Society

authors： Bianco C,Rossetti B,Gagliardini R,Lamonica S,Fanti L,Lombardi F,Cauda R,Di Giambenedetto S,De Luca A

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Women living with HIV are required to transition into the prevention of mother-to-child transmission of HIV (PMTCT) services when they become pregnant and back to ART services after delivery. Transition can be a vulnerable time when many women are lost from HIV care yet there is little guidance on the opti...

journal_title：Journal of the International AIDS Society

authors： Phillips TK,Teasdale CA,Geller A,Ng'eno B,Mogoba P,Modi S,Abrams EJ

更新日期：2021-01-01 00:00:00

abstract：INTRODUCTION:For many women living with HIV (WLWH), the disclosure of positive status can lead to either an extension of former violence or new conflict specifically associated with HIV status disclosure. This study aims to explore the following about WLWH: 1. the women's experiences of intimate partner violence (IPV) ...

journal_title：Journal of the International AIDS Society

authors： Colombini M,James C,Ndwiga C,Integra team.,Mayhew SH

更新日期：2016-03-31 00:00:00

abstract：: The HIV/AIDS epidemic continues to be a major issue facing Botswana, with overall adult HIV prevalence estimated to be 25.7 percent in 2007. This paper estimates the cost and impact of the draft Ministry of Health male circumcision strategy using the UNAIDS/WHO Decision-Makers' Programme Planning Tool (DMPPT). Demogr...

journal_title：Journal of the International AIDS Society

authors： Bollinger LA,Stover J,Musuka G,Fidzani B,Moeti T,Busang L

更新日期：2009-05-27 00:00:00

abstract：INTRODUCTION:The majority of new HIV infections occur through mucosal transmission. The availability of readily applicable and accessible platforms for anti-retroviral (ARV) delivery is critical for the prevention of HIV acquisition through sexual transmission in both women and men. There is a compelling need for devel...

journal_title：Journal of the International AIDS Society

authors： Crakes KR,Herrera C,Morgan JL,Olstad K,Hessell AJ,Ziprin P,LiWang PJ,Dandekar S

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:Achieving UNAIDS 90-90-90 targets is a crucial step towards ending the AIDS epidemic. Many countries have published estimates of care cascades, although often with methodological limitations. We describe an approach that used the national HIV registry as a starting-point to determine the HIV care cascade a...

journal_title：Journal of the International AIDS Society

authors： Ho ZJM,Huang F,Wong CS,Chua L,Ma S,Chen MI,Lee VJ

更新日期：2019-07-01 00:00:00

abstract：INTRODUCTION:To be used most effectively, pre-exposure prophylaxis (PrEP) should be prioritized to those at high risk of acquisition and would ideally be aligned with time periods of increased exposure. Identifying such time periods is not always straightforward, however. Gaza Province in southern Mozambique is charact...

journal_title：Journal of the International AIDS Society

authors： Cremin I,Morales F,Jewell BL,O'Reilly KR,Hallett TB

更新日期：2015-07-20 00:00:00

abstract：INTRODUCTION:T cell immunoglobulin and mucin domain (Tim) 3 and programmed death 1 (PD-1) are co-inhibitory receptors involved in the so-called T cell exhaustion, and in vivo blockade of these molecules restores T cell dysfunction. High expression of Tim-3 and PD-1 is induced after chronic antigen-specific stimulation ...

journal_title：Journal of the International AIDS Society

authors： Sada-Ovalle I,Ocaña-Guzman R,Pérez-Patrigeón S,Chávez-Galán L,Sierra-Madero J,Torre-Bouscoulet L,Addo MM

更新日期：2015-10-19 00:00:00

abstract：INTRODUCTION:Since June 2016, the national HIV programme in Malawi has adopted Universal Test and Treat (UTT) guidelines requiring that all persons who test HIV positive will be referred to start antiretroviral therapy (ART). Although there is strong evidence from clinical trials that early initiation of ART leads to r...

journal_title：Journal of the International AIDS Society

authors： Alhaj M,Amberbir A,Singogo E,Banda V,van Lettow M,Matengeni A,Kawalazira G,Theu J,Jagriti MR,Chan AK,van Oosterhout JJ

更新日期：2019-02-01 00:00:00

abstract：INTRODUCTION:There are limited data characterizing the burden of HIV among men who have sex with men (MSM) in Malawi. Epidemiologic research and access to HIV prevention, treatment and care services have been traditionally limited in Malawi by criminalization and stigmatization of same-sex practices. To inform the deve...

journal_title：Journal of the International AIDS Society

authors： Wirtz AL,Jumbe V,Trapence G,Kamba D,Umar E,Ketende S,Berry M,Strömdahl S,Beyrer C,Baral SD

更新日期：2013-12-02 00:00:00

abstract：INTRODUCTION:Evidence suggests that people who inject drugs often begin their drug use and injecting practices in adolescence, yet there are limited data available on the HIV epidemic and the responses for this population. The comprehensive package of interventions for the prevention, treatment and care of HIV infectio...

journal_title：Journal of the International AIDS Society

authors： Krug A,Hildebrand M,Sun N

更新日期：2015-02-26 00:00:00