Rate of adherence to urate-lowering therapy among patients with gout: a systematic review and meta-analysis.

Abstract:

INTRODUCTION:Reported adherence to urate-lowering therapy (ULT) in gout varies widely (17%-83.5%). Variability may partly be due to different adherence measurement methods. This review aimed to quantify ULT adherence in adult patients with gout. METHODS:This analysis examined studies in PubMed, Web of Science, CNKI Scholar and WanFang databases from inception to January 2017. Papers were selected by inclusion and exclusion criteria in the context. Random-effect meta-analysis estimated adherence. RESULTS:22 studies were found by the inclusion criteria, which involved 1 37 699 patients with gout. Four ways to define adherence were reported. Meta-analysis revealed that the overall adherence rate was 47% (95% CI 42% to 52%, I2=99.7%). Adherence rate to ULT was 42% (95% CI 37% to 47%, I2=99.8%) for prescription claims, 71% (95% CI 63% to 79%) for pill count, 66% (95% CI 50% to 81%, I2=86.3%) for self-report and 63% (95% CI 42% to 83%, I2=82.9%) for interview, respectively. The influential factor on adherence rate was country of origin. CONCLUSIONS:Among adult patients with gout, overall adherence rate to ULT was as low as 47%, which suggested that clinicians should pay more attention to medication adherence in patients with gout to effectively improve adherence to ULT.

journal_name

BMJ Open

journal_title

BMJ open

authors

Yin R,Li L,Zhang G,Cui Y,Zhang L,Zhang Q,Fu T,Cao H,Li L,Gu Z

doi

10.1136/bmjopen-2017-017542

subject

Has Abstract

pub_date

2018-04-10 00:00:00

pages

e017542

issue

4

issn

2044-6055

pii

bmjopen-2017-017542

journal_volume

8

pub_type

杂志文章,meta分析

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