Abstract:
INTRODUCTION:Pain is an expected and appropriate experience following traumatic musculoskeletal injury. By contrast, chronic pain and disability are unhelpful yet common sequelae of trauma-related injuries. Presently, the mechanisms that underlie the transition from acute to chronic disabling post-traumatic pain are not fully understood. Such knowledge would facilitate the development and implementation of precision rehabilitation approaches that match interventions to projected risk of recovery, with the aim of preventing poor long-term outcomes. The aim of this study is to identify a set of predictive factors to identify patients at risk of developing ongoing post-traumatic pain and disability following acute musculoskeletal trauma. To achieve this, we will use a unique and comprehensive combination of patient-reported outcome measures, psychophysical testing and biomarkers. METHODS AND ANALYSIS:A prospective observational study will recruit two temporally staggered cohorts (n=250 each cohort; at least 10 cases per candidate predictor) of consecutive patients with acute musculoskeletal trauma aged ≥16 years, who are emergency admissions into a Major Trauma Centre in the United Kingdom, with an episode inception defined as the traumatic event. The first cohort will identify candidate predictors to develop a screening tool to predict development of chronic and disabling pain, and the second will allow evaluation of the predictive performance of the tool (validation). The outcome being predicted is an individual's absolute risk of poor outcome measured at a 6-month follow-up using the Chronic Pain Grade Scale (poor outcome ≥grade II). Candidate predictors encompass the four primary mechanisms of pain: nociceptive (eg, injury location), neuropathic (eg, painDETECT), inflammatory (biomarkers) and nociplastic (eg, quantitative sensory testing). Concurrently, patient-reported outcome measures will assess general health and psychosocial factors (eg, pain self-efficacy). Risk of poor outcome will be calculated using multiple variable regression analysis. ETHICS AND DISSEMINATION:Approved by the NHS Research Ethics Committee (17/WA/0421).
journal_name
BMJ Openjournal_title
BMJ openauthors
Rushton AB,Evans DW,Middlebrook N,Heneghan NR,Small C,Lord J,Patel JM,Falla Ddoi
10.1136/bmjopen-2017-017876subject
Has Abstractpub_date
2018-04-28 00:00:00pages
e017876issue
4issn
2044-6055pii
bmjopen-2017-017876journal_volume
8pub_type
杂志文章相关文献
BMJ Open文献大全abstract:INTRODUCTION:The Afghanistan war (2003-2014) was a unique period in military medicine. Many service personnel survived injuries of a severity that would have been fatal at any other time in history; the long-term health outcomes of such injuries are unknown. The ArmeD SerVices TrAuma and RehabilitatioN OutComE (ADVANCE...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-037850
更新日期:2020-10-30 00:00:00
abstract:OBJECTIVE:Concerns have been raised regarding the quality and completeness of abstract reporting in evidence reviews, but this had not been evaluated in meta-analyses of diagnostic accuracy. Our objective was to evaluate reporting quality and completeness in abstracts of systematic reviews with meta-analyses of depress...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-012867
更新日期:2016-11-18 00:00:00
abstract:INTRODUCTION:Bone metastasis (BM) in patients with primary lung cancer poses a serious health problem. Numerous risk factors have been hypothesised to predict BM in these patients, but research studies are of mutable quality, and may not be of value in clinical evaluation. METHODS AND ANALYSIS:We will search a number ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005202
更新日期:2014-07-24 00:00:00
abstract:OBJECTIVE:Illness perception has been shown to have significant influence on the well-being and coping strategies of persons living with chronic medical conditions. Understanding of how women living with breast cancer cognitively and emotionally represent their illness and coping strategies used is likely to help in de...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033019
更新日期:2020-07-14 00:00:00
abstract:INTRODUCTION:Sarcomas are rare tumours of connective tissue. The exact overall incidence of sarcomas is unknown due to diagnostic difficulties and the various histological subtypes (over 80 subtypes). However, the apparent increasing incidence of sarcomas suggests environmental causes such as pesticides. Except for som...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2019-030013
更新日期:2019-06-18 00:00:00
abstract:OBJECTIVES:(1) Summarise chest ultrasound accuracy to diagnose radiological consolidation, referenced to chest CT in patients with acute respiratory failure (ARF). (2) Directly compared ultrasound with chest X-ray. SETTING:Hospitalised patients. PARTICIPANTS:Studies were eligible if adult participants in respiratory ...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2015-007838
更新日期:2015-05-19 00:00:00
abstract:OBJECTIVES:To determine the validity and reliability of the Spiritual Care Competency Scale (SCCS) among nurses in China. DESIGN:Methodological research. METHODS:After the SCCS was translated into Chinese, the validity and reliability of the Chinese version of the SCCS (C-SCCS) were evaluated using a convenience samp...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030497
更新日期:2019-10-10 00:00:00
abstract:OBJECTIVES:Literature on associations between female genital mutilation/cutting (FGM/C) and fistula points to a common belief that FGM/C predisposes women to developing fistula. This study explores this association using nationally representative survey data. DESIGN:A secondary statistical analysis of cross-sectional ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-025355
更新日期:2019-07-29 00:00:00
abstract:OBJECTIVES:To identify rates of potentially preventable complications for dementia patients compared with non-dementia patients. DESIGN:Retrospective cohort design using hospital discharge data for dementia patients, case matched on sex, age, comorbidity and surgical status on a 1 : 4 ratio to non-dementia patients. ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-002770
更新日期:2013-06-20 00:00:00
abstract:INTRODUCTION:Postintensive care syndrome (PICS) is defined as a new or worsening impairment in cognition, mental health and physical function after critical illness. There is little evidence regarding treatment of patients with PICS; new directions for effective treatment strategies are urgently needed. Early physiothe...
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2016-013828
更新日期:2017-03-01 00:00:00
abstract:INTRODUCTION:Low vision and blindness adversely affect education and independence of children and young people. New 'assistive' technologies such as tablet computers can display text in enlarged font, read text out to the user, allow speech input and conversion into typed text, offer document and spreadsheet processing...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2017-015939
更新日期:2017-06-21 00:00:00
abstract:OBJECTIVE:Mild traumatic brain injury (mTBI) has been insufficiently researched, and its definition remains elusive. Investigators are confronted by heterogeneity in patients, mechanism of injury and outcomes. Findings are thus often limited in generalisability and clinical application. Serum protein biomarkers are inc...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2017-017848
更新日期:2017-09-27 00:00:00
abstract:OBJECTIVES:To develop an algorithm that aims to provide guidance and awareness for choosing multiple study designs in systematic reviews of healthcare interventions. DESIGN:Method study: (1) To summarise the literature base on the topic. (2) To apply the integration of various study types in systematic reviews. (3) To...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-007540
更新日期:2015-08-19 00:00:00
abstract:OBJECTIVES:This study compared the impact of two different 8-week mindfulness based courses (.b Foundations and Mindfulness-Based Stress Reduction (MBSR)), delivered to school teachers, on quantitative (stress, anxiety and depression) and qualitative (experience, acceptability and implementation) outcomes. DESIGN:A mi...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-025686
更新日期:2019-07-04 00:00:00
abstract:OBJECTIVES:To determine the sex-specific prevalence, inequality and factors associated with healthcare utilisation for diabetes mellitus (DM), hypertension and comorbidity among the adult population of Bangladesh. STUDY DESIGN:This study analysed cross-sectional nationwide Bangladesh Demographic and Health Survey data...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-029364
更新日期:2019-09-17 00:00:00
abstract:OBJECTIVE:To determine whether neuromuscular blocking agents (NMBAs) can decrease the mortality of patients with acute respiratory distress syndrome (ARDS) and improve their clinical outcomes. DESIGN:Systematic review, meta-analysis and meta-regression. DATA SOURCES:PubMed, Embase, Cochrane Library, Web of Science an...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-037737
更新日期:2020-11-19 00:00:00
abstract:INTRODUCTION:Air and noise pollution are emerging environmental health hazards in African cities, with potentially complex spatial and temporal patterns. Limited local data are a barrier to the formulation and evaluation of policies to reduce air and noise pollution. METHODS AND ANALYSIS:We designed a year-long measur...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-035798
更新日期:2020-08-20 00:00:00
abstract:INTRODUCTION:Self-management and remaining physically active are first-line recommendations for the care of patients with low back pain (LBP). With a lifetime prevalence of up to 85%, novel approaches to support behavioural self-management are needed. Internet interventions may provide accessible support for self-manag...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-040543
更新日期:2020-08-20 00:00:00
abstract:INTRODUCTION:Trauma to the nail bed is the most common surgically treated paediatric hand injury. The majority of surgeons replace the nail plate after repairing the nail bed despite a lack of evidence to do so. Replacing the nail plate may be associated with increased postoperative infection. We will investigate the i...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-031552
更新日期:2019-12-04 00:00:00
abstract:INTRODUCTION:Ageing-related processes such as cellular senescence are believed to underlie the accumulation of diseases in time, causing (co)morbidity, including cancer, thromboembolism and stroke. Interfering with these processes may delay, stop or reverse morbidity. The aim of this study is to investigate the link be...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-039560
更新日期:2020-12-17 00:00:00
abstract:OBJECTIVES:This study aimed to investigate the epidemiological characteristics and preliminarily explore possible risk factors of physical activity-related injury (PARI) occurrences among Chinese university students via a multicentre mixed survey. DESIGN:Cross-sectional study. PARTICIPANTS:A total of 4758 undergradua...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2018-021845
更新日期:2018-09-21 00:00:00
abstract:OBJECTIVES:To compare the clinical, socioeconomic and demographic characteristics of individuals diagnosed with Neisseria gonorrhoeae (NG) in the community using a concomitant nucleic acid amplification test (NAAT, AptimaCombo2) as part of the (community-based) UK Chlamydia Screening Programme (CSP), with those diagnos...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-004862
更新日期:2014-03-14 00:00:00
abstract:INTRODUCTION:Obese patients with type 2 diabetes undergoing bariatric surgery experience significant and lasting weight loss and improved glycaemic control. However, bariatric surgical procedures such as Roux-en-Y gastric bypass are irreversible and associated with considerable short-term and long-term risks. The EndoB...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003417
更新日期:2013-09-13 00:00:00
abstract:BACKGROUND:Birth weight is a critical indicator of neonatal health and foretells people's health in adolescence and even adulthood. Some researchers have warned against the adverse effects on babies' birth weight of exposure to pollutants in interior decoration or oil paint by odour intake. This study evaluated the eff...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-013700
更新日期:2017-08-21 00:00:00
abstract:OBJECTIVES:Medical and healthcare organisations-including the national cancer support and helpline organisation that is the subject of this study-are expected to collect and monitor information about the ethnicity of their client populations. Information about ethnicity is important for a variety of reasons, including ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-002676
更新日期:2013-06-28 00:00:00
abstract:BACKGROUND:In areas where HIV and intestinal schistosomiasis are highly endemic, co-infections of the two diseases in a single human host are frequent. Evidence in adult populations indicates that HIV and intestinal schistosomiasis are associated with negative health impacts. However, the topic of HIV and schistosomias...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-029749
更新日期:2019-07-24 00:00:00
abstract:OBJECTIVE:Lean interventions aim to improve quality of healthcare by reducing waste and facilitate flow in work processes. There is conflicting evidence on the outcomes of lean thinking, with quantitative and qualitative studies often contradicting each other. We suggest that reviewing the literature within the approac...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2013-003873
更新日期:2014-01-15 00:00:00
abstract:BACKGROUND:To date, delirium prevalence and incidence in acute hospitals has been estimated from pooled findings of studies performed in distinct patient populations. OBJECTIVE:To determine delirium prevalence across an acute care facility. DESIGN:A point prevalence study. SETTING:A large tertiary care, teaching hos...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001772
更新日期:2013-01-07 00:00:00
abstract:INTRODUCTION:Evidence from individual longitudinal studies suggests that anxiety and depression may impact quality of life. However, systematic reviews synthesising current evidence have mainly focused on specific samples. Thus, the aim of this study is to synthesise evidence from longitudinal studies on the associatio...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-027218
更新日期:2019-03-04 00:00:00
abstract:OBJECTIVES:Pressures on healthcare systems due to COVID-19 has impacted patients without COVID-19 with surgery disproportionally affected. This study aims to understand the impact on the initial management of patients with brain tumours by measuring changes to normal multidisciplinary team (MDT) decision making. DESIG...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-040898
更新日期:2020-08-16 00:00:00