Abstract：
:Pretreatment of ethyl acetate extract of Phellinus rimosus (Berk) Pilat protected cisplatin induced nephrotoxicity in mice. Single dose of the extract (25 and 50 mg/kg body weight) decreased cisplatin induced serum creatinine and urea levels. The cisplatin depleted renal antioxidant defence system, such as activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and concentration of reduced glutathione (GSH), were restored by the treatment of the extract. The enhanced renal antioxidant defence system prevented cisplatin induced tissue lipid peroxidation. The experimental results suggest that ethyl acetate extract of P. rimosus protected cisplatin induced nephrotoxicity, possibly by enhancing renal antioxidant status. The extract did not interfere with the antitumor efficacy of cisplatin.
journal_name
J Exp Clin Cancer Resjournal_title
Journal of experimental & clinical cancer research : CRauthors
Ajith TA,Jose N,Janardhanan KKkeywords:
subject
Has Abstractpub_date
2002-06-01 00:00:00pages
213-7issue
2eissn
0392-9078issn
1756-9966journal_volume
21pub_type
杂志文章abstract：:The continuous growth of a solid tumor is contingent upon the induction and formation of new vascular structures (angiogenesis). Several studies have established a close correlation between the microvessel density (MVD) of a tumor and its growth capacity. Therefore, a non-invasive method to accurately assess tumor MVD...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:The efficacy of currently developed methods for gene transfer into mammalian cells depends primarily on the transfection technique, and also on the type of targeted cells. Considering the importance of gene transfer in the creation of gene therapies, our study was aimed at the assessment of transfection capacity of re...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：BACKGROUND:Retinoic acid-inducible gene-I (Rig-I) is an intracellular viral RNA receptor, which specifically recognizes double-stranded viral RNA initiating antiviral innate immunity. Increasing evidences showed that Rig-I had broader roles in antibacterial immunity and cancer protection. However, the potential roles a...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-016-0471-3
更新日期：2017-01-05 00:00:00
abstract：:Increased expression of sialyl Lewis antigens, sLe(a) and sLe(x), is frequent during malignant transformation and tumor progression of gastrointestinal cancers and it is assumed to be correlated with the increased metastatic potential of tumor cells and, consequently, with poor patient survival. To determine the influ...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:To assess the relationship between serum concentrations of proinflammatory cytokines and prognosis of non small cell lung cancer (NSCLC), we evaluated the serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1-beta (IL-1-beta) and interleukin-6 (IL-6) in 60 patients with untreated advanced NSCLC. Mean ...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：BACKGROUND:There is no consensus regarding the secondary cytoreduction surgery (CRS) in recurrent ovarian cancer patients. The present study aims to determine the value of secondary CRS and the eligible subgroup for this procedure. METHODS:96 platinum-sensitive recurrent ovarian cancer patients were recruited from Jia...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/1756-9966-32-61
更新日期：2013-09-02 00:00:00
abstract：:The aim of this study was to assess the efficiency of the radioguided localization and excision technique using radiopharmaceuticals injected directly or close to occult breast lesions. We studied thirty-two consecutive patients with thirty-six occult breast lesions detected mammographically or ultrasonically categori...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 临床试验,杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis. The inhibition of this key enzyme in the mevalonate pathway leads to suppression of cell proliferation and induction of apoptosis. However, the molecular mechanism of apoptosis induct...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/1756-9966-30-74
更新日期：2011-08-10 00:00:00
abstract：BACKGROUND:Oxaliplatin belongs to the platinum-based drug family and has shown promise in treating cancer by binding to DNA to induce cytotoxicity. However, individual patients show diverse therapeutic responses toward oxaliplatin due to yet-unknown underlying mechanisms. We recently established that oxaliplatin also e...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-018-0837-9
更新日期：2018-07-20 00:00:00
abstract：BACKGROUND:Accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been described for different types of cancers and might be associated with cancer risk and disease outcome. We used a population-based series of esophageal squamous cell carcinoma (ESCC) ...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/1756-9966-29-155
更新日期：2010-11-26 00:00:00
abstract：BACKGROUND:Coiled-Coil Domain Containing 88A (CCDC88A) was identified as a substrate of the serine/threonine kinase Akt that is capable of binding to the actin cytoskeleton. The aim of this study was to investigate the potential role of CCDC88A in the migration and invasiveness of pancreatic ductal adenocarcinoma (PDAC...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-016-0466-0
更新日期：2016-12-05 00:00:00
abstract：BACKGROUND:Colon cancer represents one of the leading causes of gastrointestinal tumors in industrialized countries, and its incidence appears to be increasing at an alarming rate. Accumulating evidence has unveiled the contributory roles of cancer stem cells (CSCs) in tumorigenicity, recurrence, and metastases. The fu...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-020-01704-w
更新日期：2020-10-28 00:00:00
abstract：INTRODUCTION:Women with ductal hyperplasia including usual ductal hyperplasia (UDH) and atypical ductal hyperplasia (ADH) have an increased risk of developing invasive ductal carcinoma (IDC) of breast. The importance of several molecular markers in breast cancer has been of considerable interest during recent years suc...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/1756-9966-29-112
更新日期：2010-08-16 00:00:00
abstract：BACKGROUND:Pancreatic ductal adenocarcinoma is one of the leading causes of cancer-related death worldwide. Immune checkpoint blockade therapy, including anti-PD-1 and anti-PD-L1, is a new therapeutic strategy for cancer treatment but the monotherapy with PD-L1 inhibitors for pancreatic cancer is almost ineffective for...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-019-1044-z
更新日期：2019-02-01 00:00:00
abstract：:Identifying appropriate preclinical cancer models remains a major challenge in increasing the efficiency of drug development. A potential strategy to improve patient outcomes could be selecting the 'right' treatment in preclinical studies performed in patient-derived xenografts (PDXs) obtained by direct implants of su...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章,评审
doi：10.1186/s13046-016-0462-4
更新日期：2016-12-05 00:00:00
abstract：BACKGROUND:The epithelial-to-mesenchymal transition (EMT) accompanied by the downregulation of E-cadherin has been thought to promote metastasis. Cyclooxygenase-2 (Cox-2) is presumed to contribute to cancer progression through its multifaceted function, and recently its inverse relationship with E-cadherin was suggeste...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/1756-9966-33-40
更新日期：2014-05-10 00:00:00
abstract：:We report the long-term results of a series of patients affected by advanced epithelial ovarian cancer treated with the PEC combination (cisplatin 60 mg/m2, epirubicin 60 mg/m2 and cyclophosphamide 750 mg/m2, all at day 1, every 21 days). Response was evaluated after three cycles, and treatment continued in responsive...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：:Tumours involving the scrotum are rare and primary malignant melanoma is among the rarest of these lesions. Between 1949 and 1996 only 7 cases have been reported. We present two cases of scrotal melanoma. The current recommendations and management strategies are discussed on the basis of a review of the literature. ...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章,评审
doi：
更新日期：1998-03-01 00:00:00
abstract：:The number of colorectal tumors per mouse induced by 1,2-dimethylhydrazine in transgenic (Tg) mice carrying human c-Ha-ras genes was significantly reduced by ingestion of apple pectin (AP) or a culture condensate of Bifidobacterium longum(MB) compared with a control diet and non-Tg mice. However, there were no differe...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND:Bone metastasis is a leading cause of morbidity and mortality in advanced prostate cancer (PCa). Downexpression of miR-133a-3p has been found to contribute to the progression, recurrence and distant metastasis in PCa. However, clinical significance of miR-133a-3p in bone metastasis of PCa, and the biological...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-018-0813-4
更新日期：2018-07-18 00:00:00
abstract：:Occult carcinoma cells in peripheral blood of breast cancer (BC) patients is generally associated with poor disease prognosis. Reverse transcriptase-polymerase chain reaction (RT-PCR) is a sensitive method for revealing rare circulating cancer cells. The target mRNA must be carefully chosen, as it must be expressed on...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2005-06-01 00:00:00
abstract：:Over the past 20 years, fiberoptic endoscopy, followed by video-endoscopy, has taken on an increasingly important role in the diagnostics and therapy for digestive tract diseases. Especially in the field of oncology, endoscopy is fundamental not only for the diagnosis and staging of diseases of the gastroenteric tract...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章,评审
doi：
更新日期：1999-03-01 00:00:00
abstract：BACKGROUND:The bromodomain and extra-terminal domain (BET) inhibitor is a type of anti-tumor agent, currently being evaluated in phase I and II clinical trials for cancer therapy. It can decrease MYC expression levels and cause effective anti-tumor effects in diverse human cancers. However, its cytotoxic effect and rel...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-019-1082-6
更新日期：2019-02-15 00:00:00
abstract：BACKGROUND:Investigation of the expression of an intestinal stem cell marker in esophageal adenocarcinomas (EAC) with and without Barrett's Esophagus (BE), with respect to a cancer stem cell (CSC) hypothesis. MATERIALS AND METHODS:Expression of a putative intestinal stem cell marker LgR5 was analyzed in esophageal can...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/1756-9966-30-23
更新日期：2011-02-23 00:00:00
abstract：:This study was carried out statistically to evaluate the present situation of carcinoids and related endocrine variants in the uterine cervix. A total of 205 patients who had been reported on in world-wide literature were divided into two groups; one, as a carcinoid group, consisting of 81 patients with carcinoids, 49...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
abstract：UNLABELLED:Stem cells are a relevant source of information about cellular differentiation, molecular processes and tissue homeostasis, but also one of the most putative biological tools to treat degenerative diseases. This review focuses on human stem cells clinical and experimental applications. Our aim is to take a c...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章,评审
doi：10.1186/1756-9966-30-9
更新日期：2011-01-17 00:00:00
abstract：BACKGROUND:Yes-associated protein (YAP), an essential component of Hippo pathway, was identified as an oncoprotein which participated in the progression of various malignancies. However, its role in chronic myeloid leukemia (CML) remains to be further clarified. METHODS:The expression of YAP in CML cells was determine...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-016-0414-z
更新日期：2016-09-06 00:00:00
abstract：BACKGROUND:Novel therapies tailored to the molecular composition of esophageal squamous cell carcinoma (ESCC) are needed to improve patient survival. We investigated the regulatory network of long intergenic non-protein coding RNA, regulator of reprogramming (linc-ROR) and sex-determining region Y-box 9 (SOX9), and the...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-017-0658-2
更新日期：2017-12-13 00:00:00
abstract：BACKGROUND:Glucose-6-phospate dehydrogenase (G6PD) is the limiting enzyme of the pentose phosphate pathway (PPP) correlated to cancer progression and drug resistance. We previously showed that G6PD inhibition leads to Endoplasmic Reticulum (ER) stress often associated to autophagy deregulation. The latter can be induce...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-019-1164-5
更新日期：2019-04-12 00:00:00
abstract：BACKGROUND:Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Nevertheless, its effects on colorectal cancer (CRC) remain poorly defined. In this study, we aim to demonstrate the biological function of ANGPT...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-017-0548-7
更新日期：2017-06-12 00:00:00
