Amelioration of cisplatin induced nephrotoxicity in mice by ethyl acetate extract of a polypore fungus, Phellinus rimosus.

Abstract:

:Pretreatment of ethyl acetate extract of Phellinus rimosus (Berk) Pilat protected cisplatin induced nephrotoxicity in mice. Single dose of the extract (25 and 50 mg/kg body weight) decreased cisplatin induced serum creatinine and urea levels. The cisplatin depleted renal antioxidant defence system, such as activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and concentration of reduced glutathione (GSH), were restored by the treatment of the extract. The enhanced renal antioxidant defence system prevented cisplatin induced tissue lipid peroxidation. The experimental results suggest that ethyl acetate extract of P. rimosus protected cisplatin induced nephrotoxicity, possibly by enhancing renal antioxidant status. The extract did not interfere with the antitumor efficacy of cisplatin.

journal_name

J Exp Clin Cancer Res

authors

Ajith TA,Jose N,Janardhanan KK

keywords:

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

213-7

issue

2

eissn

0392-9078

issn

1756-9966

journal_volume

21

pub_type

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