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Patient-derived xenografts: a relevant preclinical model for drug development.

Abstract：

:Identifying appropriate preclinical cancer models remains a major challenge in increasing the efficiency of drug development. A potential strategy to improve patient outcomes could be selecting the 'right' treatment in preclinical studies performed in patient-derived xenografts (PDXs) obtained by direct implants of surgically resected tumours in mice. These models maintain morphological similarities and recapitulate molecular profiling of the original tumours, thus representing a useful tool in evaluating anticancer drug response. In this review, we will present the state-of-art use of PDXs as a reliable strategy to predict clinical findings. The main advantages and limitations will also be discussed.

journal_name

J Exp Clin Cancer Res

journal_title

Journal of experimental & clinical cancer research : CR

authors

Pompili L,Porru M,Caruso C,Biroccio A,Leonetti C

doi

10.1186/s13046-016-0462-4

subject

Has Abstract

pub_date

2016-12-05 00:00:00

pages

189

issue

1

eissn

0392-9078

issn

1756-9966

pii

10.1186/s13046-016-0462-4

journal_volume

35

pub_type

杂志文章,评审

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