Abstract：
BACKGROUND:Electroacupuncture (EA) has been applied to treat and prevent diseases for years. However, molecular events happened in both the acupunctured site and the internal organs after EA stimulation have not been clarified. METHODS:Here we applied transcriptomic analysis to explore the gene expression signatures after EA stimulation. Mice were applied EA stimulation at ST36 for 15 min and nine tissues were collected three hours later for microarray analysis. RESULTS:We found that EA affected the expression of genes not only in the acupunctured site but also in the internal organs. EA commonly affected biological networks involved in cytoskeleton and cell adhesion, and also regulated unique process networks in specific organs, such as γ-aminobutyric acid-ergic neurotransmission in brain and inflammation process in lung. In addition, EA affected the expression of genes related to various diseases, such as neurodegenerative diseases in brain and obstructive pulmonary diseases in lung. CONCLUSIONS:This report applied, for the first time, a global comprehensive genome-wide approach to analyze the gene expression profiling of acupunctured site and internal organs after EA stimulation. The connection between gene expression signatures, biological processes, and diseases might provide a basis for prediction and explanation on the therapeutic potentials of acupuncture in organs.
journal_name
BMC Complement Altern Medjournal_title
BMC complementary and alternative medicineauthors
Wu JS,Lo HY,Li CC,Chen FY,Hsiang CY,Ho TYdoi
10.1186/s12906-017-1911-0subject
Has Abstractpub_date
2017-08-15 00:00:00pages
406issue
1issn
1472-6882pii
10.1186/s12906-017-1911-0journal_volume
17pub_type
杂志文章abstract：BACKGROUND:Anoectochilus formosanus has been used as a Chinese folk medicine and is known as the "King of medicine" in Chinese society due to its versatile pharmacological effects such as anti-hypertension, anti-diabetes, anti-heart disease, anti-lung and liver diseases, anti-nephritis and anti-Rheumatoid arthritis. Ki...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-016-1054-8
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-12-29
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journal_title：BMC complementary and alternative medicine
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abstract：BACKGROUND:Cnidii Rhizoma is the dried root stem of Cnidium officinale Makino. Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms of CR on RANKL-induced osteoclastogenesis pathway remain to be elucidated. In this study, we inves...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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pub_type： 杂志文章,meta分析
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-13-20
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journal_title：BMC complementary and alternative medicine
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pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章,随机对照试验
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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更新日期：2016-05-27 00:00:00
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journal_title：BMC complementary and alternative medicine
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更新日期：2014-07-09 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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更新日期：2014-04-23 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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更新日期：2015-03-21 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章,随机对照试验
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更新日期：2018-01-31 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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更新日期：2016-07-29 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-018-2147-3
更新日期：2018-03-09 00:00:00
