Abstract：
BACKGROUND:Pancreatic fibrosis is a prominent histopathological characteristic of chronic pancreatitis and plausibly a dynamic process of transition to the development of pancreatic ductal adenocarcinoma. Conversely, the activation of pancreatic stellate cells (PSCs) has been recently suggested as the key initiating step in pancreatic fibrosis. As natural polyphenols had been largely applied in complementary therapies in the past decade, in this study, we aimed to investigate which groups of phenolic compounds exert promising inhibitory actions on fibrogenesis as there are few effective strategies for the treatment of pancreatic fibrosis to date. METHODS:We examined the anti-fibrotic effects of a variety of herbal constituents using a cellular platform, the LTC-14 cells, which retained essential characteristics and morphologies of primary PSCs, by means of various biochemical assays including cell viability test, real-time polymerase chain reaction and Western blotting analysis. RESULTS:Among a number of commonly used herbal constituents, we found that the application of rhein, emodin, curcumin and resveratrol significantly suppressed the mRNA and protein levels of several fibrotic mediators namely alpha-smooth muscle actin, type I collagen and fibronectin in LTC-14 cells against transforming growth factor-beta stimulation. Though the values of cytotoxicity varied, the mechanism of the anti-fibrotic action of these four phenolic compounds was principally associated with a decrease in the activation of the nuclear factor-kappaB signaling pathway. CONCLUSIONS:Our findings suggest that the mentioned phenolic compounds may serve as anti-fibrotic agents in PSC-relating disorders and pathologies, particularly pancreatic fibrosis.
journal_name
BMC Complement Altern Medjournal_title
BMC complementary and alternative medicineauthors
Lin Z,Zheng LC,Zhang HJ,Tsang SW,Bian ZXdoi
10.1186/s12906-015-0789-ysubject
Has Abstractpub_date
2015-07-30 00:00:00pages
259issn
1472-6882pii
10.1186/s12906-015-0789-yjournal_volume
15pub_type
杂志文章abstract：BACKGROUND:Acupuncture is not considered a conventional therapy for post-stroke sequelae but it might have some additional positive effects on early rehabilitation. We conducted this trial to determine whether acupuncture has additional effects in early comprehensive rehabilitation for acute ischemic stroke and dysfunc...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/s12906-016-1193-y
更新日期：2016-07-18 00:00:00
abstract：BACKGROUND:Neurotoxin-Nna (NT), an analgesic peptide separated from the venom of Naja naja atra, has reported to have an exceptional specificity to block transmission of the nerve impulse by binding to the α- subunit of the nicotinic acetylcholine receptor in the membrane. However, little information is available on th...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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abstract：BACKGROUND:Acetaminophen (APAP)-induced toxicity is a predominant cause of acute hepatic and renal failure. In both humans and rodents toxicity begins with a reactive metabolite that binds to proteins. This leads to mitochondrial dysfunction and nuclear DNA fragmentation resulting in necrotic cell death. Pleurotus ostr...
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abstract：BACKGROUND:Previous animal studies have shown that Curcuma longa (turmeric) improves liver function. Turmeric may thus be a promising ingredient in functional foods aimed at improving liver function. The purpose of the study is to investigate the hepatoprotective effect of fermented turmeric powder (FTP) on liver funct...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章,随机对照试验
doi：10.1186/1472-6882-13-58
更新日期：2013-03-08 00:00:00
abstract：BACKGROUND:Picralima nitida Stapf (Apocynaceae) is a medicinal plant used traditionally in Cameroon to cure various ailments such as gastrointestinal disorders and dysentery. This study reports the in vitro and in vivo anti-shigellosis activity of the methanol extract of this plant on rats. METHODS:The antimicrobial a...
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abstract：BACKGROUND:Traditional Indian and Australian medicinal plant extracts were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of hyperglycemia and type 2 diabetes. The antioxidant activities were also assessed. METHODS:The eval...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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更新日期：2012-06-19 00:00:00
abstract：BACKGROUND:Infertility and gonadal dysfunction are well known side-effects by cancer treatment in males. In particularly, chemotherapy and radiotherapy induced testicular damage, resulting in prolonged azoospermia. However, information regarding therapeutics to treat spermatogenesis disturbance after cancer treatment i...
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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更新日期：2013-07-19 00:00:00
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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abstract：BACKGROUND:The use of complementary and alternative medicine (CAM) continues to increase in Taiwan. This study examined the use of CAM and beliefs about CAM as expressed by patients with traumatic brain injury (TBI) in Taiwan. METHODS:TBI patients and their accompanying relatives were interviewed by using a structured...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-12-211
更新日期：2012-11-06 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-9-11
更新日期：2009-04-23 00:00:00
abstract：BACKGROUND:Staphylococcus aureus is the pathogen most often and prevalently involved in skin and soft tissue infections. In recent decades outbreaks of methicillin-resistant S. aureus (MRSA) have created major problems for skin therapy, and burn and wound care units. Topical antimicrobials are most important component ...
journal_title：BMC complementary and alternative medicine
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更新日期：2012-08-16 00:00:00
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pub_type： 杂志文章
doi：10.1186/s12906-018-2349-8
更新日期：2018-10-29 00:00:00
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journal_title：BMC complementary and alternative medicine
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doi：10.1186/s12906-018-2176-y
更新日期：2018-04-03 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：BMC complementary and alternative medicine
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