Abstract:
BACKGROUND:Natural products display numerous therapeutic properties (e.g., antibacterial activity), providing the population with countless benefits. Therefore, the search for novel biologically active, naturally occurring compounds is extremely important. The present paper describes the antibacterial action of the Copaifera langsdorffii oleoresin and ten compounds isolated from this oleoresin against multiresistant bacteria; it also reports the antiproliferative activity of the Copaifera langsdorffii oleoresin and (-)-copalic acid. METHODS:MICs and MBCs were used to determine the antibacterial activity. Time-kill curve assays provided the time that was necessary for the bacteria to die. The Minimum Inhbitory Concentration of Biofilm (CIMB50) of the compounds that displayed the best results was calculated. Cytotoxicity was measured by using the XTT assay. RESULTS:The diterpene (-)-copalic acid was the most active antibacterial and afforded promising Minimum Inhibitory Concentration (MIC) values for most of the tested strains. Determination of the bactericidal kinetics against some bacteria revealed that the bactericidal effect emerged within six hours of incubation for Streptococcus pneumoniae. Concerning the antibiofilm action of this diterpene, its MICB50 was twofold larger than its CBM against S. capitis and S. pneumoniae. The XTT assay helped to evaluate the cytotoxic effect; results are expressed as IC50. The most pronounced antiproliferative effect arose in tumor cell lines treated with (-)-copalic acid; the lowest IC50 value was found for the human glioblastoma cell line. CONCLUSIONS:The diterpene (-)-copalic acid is a potential lead for the development of new selective antimicrobial agents to treat infections caused by Gram-positive multiresistant microorganisms, in both the sessile and planktonic mode. This diterpene is also a good candidate to develop anticancer drugs.
journal_name
BMC Complement Altern Medjournal_title
BMC complementary and alternative medicineauthors
Abrão F,de Araújo Costa LD,Alves JM,Senedese JM,de Castro PT,Ambrósio SR,Veneziani RC,Bastos JK,Tavares DC,Martins CHdoi
10.1186/s12906-015-0961-4subject
Has Abstractpub_date
2015-12-21 00:00:00pages
443issn
1472-6882pii
10.1186/s12906-015-0961-4journal_volume
15pub_type
杂志文章abstract:BACKGROUND:Asclepias curassavica Linn. is a traditional medicinal plant used by tribal people in the western ghats, India, to treat piles, gonorrhoea, roundworm infestation and abdominal tumours. We have determined the protective effect of beta-sitosterol isolated from A. curassavica in colon cancer, using in vitro and...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-10-24
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abstract:BACKGROUND:Protein tyrosine phosphatase expressed in insulin-sensitive tissues (such as liver, muscle, and adipose tissue) has a key role in the regulation of insulin signaling and pathway activation, making protein tyrosine phosphatase a promising target for the treatment of type 2 diabetes mellitus and obesity and re...
journal_title:BMC complementary and alternative medicine
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doi:10.1186/s12906-016-1296-5
更新日期:2016-08-26 00:00:00
abstract:BACKGROUND:Pyrexia, algesia and inflammation are associated with several pathological conditions. Synthetic drugs available for the treatment of these conditions cause multiple unwanted effects. Several studies are ongoing worldwide to find natural healing agents with better safety profile. The current study was thus a...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-12-59
更新日期:2012-05-02 00:00:00
abstract:BACKGROUND:Type 2 diabetes mellitus is a major health threat worldwide. Cosmos caudatus is one of the medicinal plants used to treat type 2 diabetes. Therefore, this study aims to determine the effectiveness and safety of C. caudatus in patients with type 2 diabetes. Metabolomic approach will be carried out to compare ...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章,随机对照试验
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更新日期:2016-02-27 00:00:00
abstract:BACKGROUND:Many diseases are associated with oxidative stress caused by free radicals. Current research is directed towards finding naturally-occurring antioxidants of plant origin. The aim of the present study was to evaluate the in vitro antioxidant activities of Spondias pinnata stem bark extract. METHODS:A 70% met...
journal_title:BMC complementary and alternative medicine
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doi:10.1186/1472-6882-8-63
更新日期:2008-12-09 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-017-1911-0
更新日期:2017-08-15 00:00:00
abstract:BACKGROUND:Isoflavones are naturally occurring plant chemicals belonging to the "phytoestrogen" class. The aim of the present study was to examine the effects of isoflavones obtained from Cordyceps sinensis (CSIF) on development of estrogen deficiency-induced osteoporosis in ovariectomized rats. METHODS:After the rats...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-14-484
更新日期:2014-12-13 00:00:00
abstract:BACKGROUND:Flavonoid-rich aqueous fraction of methanolic extract of Hibiscus sabdariffa calyx was evaluated for its anti-hepatotoxic activities in streptozotocin-induced diabetic Wistar rats. METHODS:Diabetes Mellitus was induced in Wistar rats by a single i.p injection of 80 mg/kg b.w. streptozotocin (STZ) dissolved ...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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journal_title:BMC complementary and alternative medicine
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更新日期:2018-03-07 00:00:00
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journal_title:BMC complementary and alternative medicine
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更新日期:2019-09-14 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-12-137
更新日期:2012-08-24 00:00:00
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journal_title:BMC complementary and alternative medicine
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更新日期:2013-09-10 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章,随机对照试验
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更新日期:2012-07-16 00:00:00
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doi:10.1186/1472-6882-14-196
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journal_title:BMC complementary and alternative medicine
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journal_title:BMC complementary and alternative medicine
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journal_title:BMC complementary and alternative medicine
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journal_title:BMC complementary and alternative medicine
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更新日期:2012-01-13 00:00:00
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更新日期:2017-12-13 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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更新日期:2012-08-29 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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更新日期:2017-12-16 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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pub_type: 杂志文章,meta分析,评审
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journal_title:BMC complementary and alternative medicine
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更新日期:2015-03-03 00:00:00
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journal_title:BMC complementary and alternative medicine
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更新日期:2019-12-11 00:00:00
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journal_title:BMC complementary and alternative medicine
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