Abstract：
BACKGROUND:Pyrexia, algesia and inflammation are associated with several pathological conditions. Synthetic drugs available for the treatment of these conditions cause multiple unwanted effects. Several studies are ongoing worldwide to find natural healing agents with better safety profile. The current study was thus aimed at evaluating antipyretic, analgesic and anti-inflammatory activities of the methanolic extract of whole plant of V. betonicifolia (VBME). METHODS:VBME was employed to assess antipyretic activity in yeast induced hyperthermia. Analgesic profile was ascertained in acetic acid induced writhing, hot plat and tail immersion test. Nevertheless, the anti-inflammatory activity was tested in carrageenan induced paw edema and histamine induced inflammatory tests. BALB/c mice were used at test doses of 100, 200 and 300 mg/kg body weight intra peritoneally (i.p). RESULTS:In yeast induced pyrexia, VBME demonstrated dose dependently (78.23%) protection at 300 mg/kg, similar to standard drug, paracetamol (90%) at 150 mg/kg i.p. VBME showed a dose dependent analgesia in various pain models i.e. acetic acid, hot plat and tail immersion having 78.90%, 69.96% and 68.58% protection respectively at 300 mg/kg. However, the analgesic action of VBME was completely antagonized by the injection of naloxone like opiate antagonists. Similarly carrageenan and histamine induces inflammation was significantly antagonized by VBME, 66.30% and 60.80% respectively at 300 mg/kg. CONCLUSIONS:It is concluded that VBME has marked antipyretic, analgesic and anti-inflammatory activities in various animal models and this strongly supports the ethnopharmacological uses of Viola betonicifolia as antipyretic, analgesic and anti-inflammatory plant.
journal_name
BMC Complement Altern Medjournal_title
BMC complementary and alternative medicineauthors
Muhammad N,Saeed M,Khan Hdoi
10.1186/1472-6882-12-59subject
Has Abstractpub_date
2012-05-02 00:00:00pages
59issn
1472-6882pii
1472-6882-12-59journal_volume
12pub_type
杂志文章abstract：BACKGROUND:Flavonoid-rich extracts from the mature roots of Scutellaria baicalensis have been shown to exhibit antiproliferative effects on various cancer cell lines. We assessed the ability of an ethanolic extract of S. baicalensis root to inhibit the proliferation of malignant glioma cells. METHODS:Cell lines derive...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-6-27
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abstract：BACKGROUND:Samsoeum has long been used in Korea and other Asian countries as a traditional medicine to treat various diseases. In the present study, we investigated the antiasthma effect of the herbal medicine Samsoeum water extract (SSEW) using an in vivo ovalbumin (OVA)-induced asthmatic model. METHODS:Female BALB/c...
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journal_title：BMC complementary and alternative medicine
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更新日期：2013-07-05 00:00:00
abstract：BACKGROUND:Gentiana floribunda was investigated for the possible hypotensive and vasodilator activities in an attempt to rationalize its traditional use in hypertension. METHODS:The crude extract of Gentiana floribunda (Gf.Cr) was studied in anaesthetized rats and isolated thoracic aorta tissues. RESULTS:Gf.Cr which ...
journal_title：BMC complementary and alternative medicine
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更新日期：2012-08-11 00:00:00
abstract：BACKGROUND:The young shoots of Rubus idaeus are traditionally used as a herbal remedy in common cold, fever and flu-like infections yet there is no research concerning this plant material. The aim of the study was to evaluate the chemical composition and biological properties of raspberry shoots from 11 cultivar variet...
journal_title：BMC complementary and alternative medicine
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abstract：BACKGROUND:Evidence suggests yoga is a safe and effective intervention for the management of physical and psychosocial symptoms associated with musculoskeletal conditions. However, heterogeneity in the components and reporting of clinical yoga trials impedes both the generalization of study results and the replication ...
journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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更新日期：2007-08-04 00:00:00
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journal_title：BMC complementary and alternative medicine
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更新日期：2014-04-01 00:00:00
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更新日期：2018-06-18 00:00:00
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更新日期：2014-12-15 00:00:00
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更新日期：2014-01-13 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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更新日期：2012-03-27 00:00:00
abstract：BACKGROUND:Pleurotus sajor-caju (P. sajor-caju) has been extremely useful in the prevention of diabetes mellitus due to its low fat and high soluble fiber content for thousands of years. Insulin resistance is a key component in the development of diabetes mellitus which is caused by inflammation. In this study, we aime...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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更新日期：2012-12-21 00:00:00
abstract：BACKGROUND:Breast cancer is the most common type of malignancy in women worldwide. Euphorbia humifusa Willd (EuH) is a plant that is widely used as a traditional medicine. However, no systemic studies on the anti-cancer effects of EuH have been reported. The aim of this study is to evaluate the anti-metastatic effect o...
journal_title：BMC complementary and alternative medicine
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更新日期：2016-10-24 00:00:00
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journal_title：BMC complementary and alternative medicine
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更新日期：2013-07-17 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-12-4
更新日期：2012-01-16 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2014-06-30 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-10-63
更新日期：2010-11-04 00:00:00
