Abstract:
BACKGROUND:Ucche (Momordica charantia L. var. muricata (Willd.) Chakravarty) has been reported to possess many benefits and medicinal properties. However, the protective effect of ucche against carbon tetrachloride (CCl4) induced hepatotoxicity have not been clarified fully yet. The aim of the present study was to investigate the effects of ucche on oxidative stress and inflammation in liver of CCl4 treated rats. METHODS:Female Long Evans rats were administered with CCl4 orally (1 ml/kg) twice a week for 2 weeks and were supplemented with freshly prepared crashed ucche (10% wt/wt of diet) with powdered chaw food. Both plasma and liver tissues were analyzed for AST, ALT and ALP activities. Oxidative stress parameters were measure by determining malondialdehyde (MDA), nitric oxide (NO), advanced protein oxidation product (APOP), and reduced glutathione (GSH) concentrations and catalase activities in plasma and liver tissues. Moreover, inflammation and tissue fibrosis were confirmed by histological staining of liver tissue sections. RESULTS:Our data suggest that ucche significantly prevented CCl4-induced hepatotoxicity, indicated by both diagnostic indicators of liver damage (serum transferases activities) and histopathological analysis. Moreover, CCl4 administration induced profound elevation of reactive oxygen species (ROS) production and oxidative stress, as evidenced by increasing lipid peroxidation level and depletion of antioxidant enzymes in liver. Fresh ucche supplementation prevented the oxidative stresses and improved antioxidant enzyme function. Furthermore, fresh ucche supplementation reduced hepatic inflammatory cell infiltration, iron deposition and fibrosis in liver of CCl4 treated rats. CONCLUSION:In conclusion, these results suggested that the inhibition of CCl4-induced inflammation by ucche is due at least in part to its anti-oxidant activity and its ability to modulate the inflammation and fibrosis in liver.
journal_name
BMC Complement Altern Medjournal_title
BMC complementary and alternative medicineauthors
Sagor AT,Chowdhury MR,Tabassum N,Hossain H,Rahman MM,Alam MAdoi
10.1186/s12906-015-0636-1subject
Has Abstractpub_date
2015-04-11 00:00:00pages
115issn
1472-6882pii
10.1186/s12906-015-0636-1journal_volume
15pub_type
杂志文章abstract:BACKGROUND:Sea buckthorn (Elaeagnus rhamnoides (L.) A. Nelson, SBT) is a valuable plant because of its medical and therapeutic potential. Different bioactive compounds in SBT berries are of special interest to various researchers. However, not only sea buckthorn berries, but also leaves of this plant (both fresh and dr...
journal_title:BMC complementary and alternative medicine
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journal_title:BMC complementary and alternative medicine
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journal_title:BMC complementary and alternative medicine
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journal_title:BMC complementary and alternative medicine
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pub_type: 杂志文章,meta分析
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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journal_title:BMC complementary and alternative medicine
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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