The effects of Cordyceps sinensis phytoestrogen on estrogen deficiency-induced osteoporosis in ovariectomized rats.


BACKGROUND:Isoflavones are naturally occurring plant chemicals belonging to the "phytoestrogen" class. The aim of the present study was to examine the effects of isoflavones obtained from Cordyceps sinensis (CSIF) on development of estrogen deficiency-induced osteoporosis in ovariectomized rats. METHODS:After the rats were treated orally with CSIF, serum alkaline phosphatase (ALP), tartarate resistant acid phosphatase (TRAP), serum osteocalcin (OC), homocysteine (HCY), C-terminal crosslinked telopeptides of collagen type I (CTX), estradiol and interferonγ (IFN-γ) level were examined. At the same time, the urine calcium, plasma calcium, plasma phosphorus and the mass of uterus, thymus and body were also examined. RESULTS:The beneficial effects of CSIF on improvement of osteoporosis in rats were attributable mainly to decrease ALP activity, TRAP activity, CTX level and IFN-γ level. At the same time, CSIF also increase the OC and estradiol level in ovariectomized osteopenic rats. The histological examination clearly showed that dietary CSIF can prevent bone loss caused by estrogen deficiency. CONCLUSION:The significant estrogenic activity of CSIF demonstrated that CSIF has significant estrogenic effects in OVX rats.


Zhang DW,Wang ZL,Qi W,Zhao GY




Has Abstract


2014-12-13 00:00:00










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    authors: Ali N,Ali Shah SW,Shah I,Ahmed G,Ghias M,Khan I,Ali W

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    authors: Lin M,Li L,Li L,Pokhrel G,Qi G,Rong R,Zhu T

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    journal_title:BMC complementary and alternative medicine

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    authors: Chua KH,Lee TH,Nagandran K,Md Yahaya NH,Lee CT,Tjih ET,Abdul Aziz R

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    journal_title:BMC complementary and alternative medicine

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    journal_title:BMC complementary and alternative medicine

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    authors: Bakr RO,El-Naa MM,Zaghloul SS,Omar MM

    更新日期:2017-01-17 00:00:00

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    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章


    authors: Han C,Li F,Tian S,Liu Y,Xiao H,Wu X,Zhang W,Zhang W,Mao M

    更新日期:2018-11-26 00:00:00

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    pub_type: 杂志文章


    authors: BenSaad LA,Kim KH,Quah CC,Kim WR,Shahimi M

    更新日期:2017-01-14 00:00:00

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    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章


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