Abstract：
BACKGROUND:Gualou Xiebai Decoction (GXD) is a well-known traditional Chinese recipe. It has been used to treat cardiovascular disorders for nearly two thousand years. But there is a lack of reports on cardiac fibrosis and underlying mechanism. METHODS:Myocardial infarction was performed by ligation of left anterior descending coronary artery (LAD) in male Wistar rats. Rats with myocardial infarction were treated with GXD (1.14 g/kg, 4.53 g/kg) daily for 4 weeks. Cardiac function was evaluated by echocardiography. Hemodynamic parameters and infarct size were measured in each group. Myocardial enzymes were examined by biochemical tests. Inflammatory cytokines were assessed by ELISA, and interrelated proteins were detected by western blot. RESULTS:Cardiac function was significantly improved in GXD-treatment rats after myocardial infarction (MI), which was accompanied with decreased infarct size. Administration of GXD to myocardial fibrosis rats significantly ameliorated the activities of AST, LDH and CK-MB in serum. The increase in inflammatory factors (TNF-α, IL-1β) were markedly reduced upon GXD treatment. Furthermore, the inflammatory mediators (NF-κB p65, TNF-α, MCP-1) were down-regulated by GXD in the myocardial fibrosis rats. CONCLUSIONS:Treatment with GXD improved cardiac function induced by myocardial fibrosis by inhibiting expression of inflammatory mediators associated with NF-κB.
journal_name
BMC Complement Altern Medjournal_title
BMC complementary and alternative medicineauthors
Ding YF,Peng YR,Shen H,Shu L,Wei YJdoi
10.1186/s12906-016-1012-5subject
Has Abstractpub_date
2016-02-04 00:00:00pages
49issn
1472-6882pii
10.1186/s12906-016-1012-5journal_volume
16pub_type
杂志文章abstract：BACKGROUND:Aim of the present study was to evaluate anti-inflammatory activity of newly developed polyherbal formulations DF1911, DF2112 and DF2813. These newly developed formulations are modifications of Dashamoola, a well known Ayurvedic formulation, along with addition of new plants. METHODS:Complete Freund's adjuv...
journal_title：BMC complementary and alternative medicine
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更新日期：2017-04-04 00:00:00
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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更新日期：2017-08-15 00:00:00
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更新日期：2001-01-01 00:00:00
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更新日期：2013-01-08 00:00:00
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更新日期：2013-10-12 00:00:00
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更新日期：2015-07-22 00:00:00
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更新日期：2018-07-09 00:00:00
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更新日期：2017-09-04 00:00:00
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