Electroacupuncture versus diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial.

Abstract:

BACKGROUND:The purpose of this study was to compare the efficacy of electroacupuncture (EA), diclofenac and their combination in symptomatic treatment of osteoarthritis (OA) of the knee. METHODS:This study was a randomized, single-blind, placebo controlled trial. The 193 out-patients with OA of the knee were randomized into four groups: placebo, diclofenac, EA and combined (diclofenac plus EA). Paracetamol tablets were prescribed as a rescue analgesic during the study. The patients were evaluated after a run-in period of one week (week 0) and again at the end of the study (week 4). The clinical assessments included the amount of paracetamol taken/week, visual analog scale (VAS), Western Ontario and McMaster Universities (WOMAC) OA Index, Lequesne's functional index, 50 feet-walk time, and the orthopedist's and patient's opinion of change. RESULTS:One hundred and eighty six patients completed the study. The improvement of symptoms (reduction in mean changes) in most outcome parameters was greatest in the EA group. The proportions of responders and patients with an overall opinion of "much better" were also greatest in the EA group. The improvement in VAS was significantly different between the EA and placebo group as well as the EA and diclofenac group. The improvement in Lequesne's functional index also differed significantly between the EA and placebo group. In addition, there was a significant improvement in WOMAC pain index between the combined and placebo group. CONCLUSION:EA is significantly more effective than placebo and diclofenac in the symptomatic treatment of OA of the knee in some circumstances. However, the combination of EA and diclofenac treatment was no more effective than EA treatment alone.

authors

Sangdee C,Teekachunhatean S,Sananpanich K,Sugandhavesa N,Chiewchantanakit S,Pojchamarnwiputh S,Jayasvasti S

doi

10.1186/1472-6882-2-3

keywords:

subject

Has Abstract

pub_date

2002-03-21 00:00:00

pages

3

issn

1472-6882

journal_volume

2

pub_type

临床试验,杂志文章,随机对照试验
  • Flavones from Erythrina falcata are modulators of fear memory.

    abstract:BACKGROUND:Flavonoids, which have been identified in a variety of plants, have been demonstrated to elicit beneficial effects on memory. Some studies have reported that flavonoids derived from Erythrina plants can provide such beneficial effects on memory. The aim of this study was to identify the flavonoids present in...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-288

    authors: de Oliveira DR,Zamberlam CR,Gaiardo RB,Rêgo GM,Cerutti JM,Cavalheiro AJ,Cerutti SM

    更新日期:2014-08-05 00:00:00

  • Evaluation of antimicrobial activity of chondrillasterol isolated from Vernonia adoensis (Asteraceae).

    abstract:BACKGROUND:Bacteria have developed resistance to most of the current antibiotics. There is evidence suggesting that plant-derived compounds have a potential for interacting with biological processes. One of the plants commonly used in African ethnomedicine is Vernonia adoensis from the Asteraceae family. The leaves of ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-019-2657-7

    authors: Mozirandi W,Tagwireyi D,Mukanganyama S

    更新日期:2019-09-06 00:00:00

  • Effects of whole-body ELECTROMYOSTIMULATION on health and performance: a systematic review.

    abstract:BACKGROUND:Whole-body electrical myostimulation (WB-EMS) is a relatively recent training methodology that has been extraordinarily used in recent years. However, there is a lack of consensus on the effectiveness of WB-EMS in the situations in which its use has been largely popularized. The objective of this systematic ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12906-019-2485-9

    authors: Pano-Rodriguez A,Beltran-Garrido JV,Hernández-González V,Reverter-Masia J

    更新日期:2019-04-24 00:00:00

  • Proficiencies of Artemisia scoparia against CCl4 induced DNA damages and renal toxicity in rat.

    abstract:BACKGROUND:Artemisia scoparia is traditionally used in the local system of medicine in kidney disorders. This study aimed at scrutinizing the nephroprotective prospective of A. scoparia methanol extract against carbon tetrachloride (CCl4) provoked DNA damages and oxidative stress in kidneys of rat. METHODS:Dried aeria...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1137-6

    authors: Sajid M,Khan MR,Shah NA,Ullah S,Younis T,Majid M,Ahmad B,Nigussie D

    更新日期:2016-05-27 00:00:00

  • Neuroprotective effect of Demethoxycurcumin, a natural derivative of Curcumin on rotenone induced neurotoxicity in SH-SY 5Y Neuroblastoma cells.

    abstract:BACKGROUND:Mitochondrial dysfunction and oxidative stress are the main toxic events leading to dopaminergic neuronal death in Parkinson's disease (PD) and identified as vital objective for therapeutic intercession. This study investigated the neuro-protective effects of the demethoxycurcumin (DMC), a derivative of curc...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1720-5

    authors: Ramkumar M,Rajasankar S,Gobi VV,Dhanalakshmi C,Manivasagam T,Justin Thenmozhi A,Essa MM,Kalandar A,Chidambaram R

    更新日期:2017-04-18 00:00:00

  • Homeopathy for mental fatigue: lessons from a randomized, triple blind, placebo-controlled cross-over clinical trial.

    abstract:BACKGROUND:Difficulty in controlling attention can lead to mental fatigue in the healthy population. We identified one trial reporting a benefit in patients' attention using a homeopathic formula preparation. One component of the preparation was potassium phosphate, widely available off the shelf as Kali phos 6x for co...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1472-6882-12-167

    authors: Dean ME,Karsandas R,Bland JM,Gooch D,MacPherson H

    更新日期:2012-10-01 00:00:00

  • Individualised medicine from the perspectives of patients using complementary therapies: a meta-ethnography approach.

    abstract:BACKGROUND:Personalised (or individualised) medicine in the days of genetic research refers to molecular biologic specifications in individuals and not to a response to individual patient needs in the sense of person-centred medicine. Studies suggest that patients often wish for authentically person-centred care and pe...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,meta分析

    doi:10.1186/1472-6882-13-124

    authors: Franzel B,Schwiegershausen M,Heusser P,Berger B

    更新日期:2013-06-03 00:00:00

  • Immunomodulatory effect of water soluble extract separated from mycelium of Phellinus linteus on experimental atopic dermatitis.

    abstract:BACKGROUND:Complementary and alternative medicine (CAM) is becoming a popular treatment for modulating diverse immune disorders. Phellinus linteus (P. linteus) as one of the CAMs has been used to modulate cancers, inflammation and allergic activities. However, little evidence has been shown about its underlying mechani...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-12-159

    authors: Hwang JS,Kwon HK,Kim JE,Rho J,Im SH

    更新日期:2012-09-18 00:00:00

  • Anti-inflammatory activity of extracts of Bushen-Qiangdu-Zhilv decoction, a Chinese medicinal formula, in M1-polarized RAW264.7.

    abstract:BACKGROUND:Bushen-Qiangdu-Zhilv Decoction (BQZ) is one of famous traditional Chinese medical formula for treating ankylosing spondylitis (AS). However, the mechanisms underlying effects of BQZ remains unknown. Pro-inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-1, play an important role in AS...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-268

    authors: Huang RY,Lin JH,He XH,Li X,Lu CL,Zhou YY,Cai J,He YT

    更新日期:2014-07-28 00:00:00

  • Effectiveness and safety of moxibustion for primary insomnia: a systematic review and meta-analysis.

    abstract:BACKGROUND:Primary insomnia is a widespread and refractory disease. Moxibustion therapy for insomnia shows some advantages compared with conventional therapies. This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to evaluate the effectiveness and safety of moxibustion therapy f...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/s12906-016-1179-9

    authors: Sun YJ,Yuan JM,Yang ZM

    更新日期:2016-07-13 00:00:00

  • Supplementation of fresh ucche (Momordica charantia L. var. muricata Willd) prevented oxidative stress, fibrosis and hepatic damage in CCl4 treated rats.

    abstract:BACKGROUND:Ucche (Momordica charantia L. var. muricata (Willd.) Chakravarty) has been reported to possess many benefits and medicinal properties. However, the protective effect of ucche against carbon tetrachloride (CCl4) induced hepatotoxicity have not been clarified fully yet. The aim of the present study was to inve...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0636-1

    authors: Sagor AT,Chowdhury MR,Tabassum N,Hossain H,Rahman MM,Alam MA

    更新日期:2015-04-11 00:00:00

  • Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells.

    abstract:BACKGROUND:Flavonoid-rich extracts from the mature roots of Scutellaria baicalensis have been shown to exhibit antiproliferative effects on various cancer cell lines. We assessed the ability of an ethanolic extract of S. baicalensis root to inhibit the proliferation of malignant glioma cells. METHODS:Cell lines derive...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-6-27

    authors: Scheck AC,Perry K,Hank NC,Clark WD

    更新日期:2006-08-16 00:00:00

  • Moon phases and moon signs do not influence morbidity, mortality and long-term survival, after living donor kidney transplantation.

    abstract:BACKGROUND:Approximately 11% of the German population are convinced that certain moon phases and moon signs may impact their health and the onset and clinical course of diseases. Before elective surgery, a considerable number of patients look to optimize the timing of the procedure based on the lunar cycle. Especially ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1944-4

    authors: Kleespies A,Mikhailov M,Khalil PN,Pratschke S,Khandoga A,Stangl M,Illner WD,Angele MK,Jauch KW,Guba M,Werner J,Rentsch M

    更新日期:2017-09-04 00:00:00

  • Growth environment and organ specific variation in in-vitro cytoprotective activities of Picea mariana in PC12 cells exposed to glucose toxicity: a plant used for treatment of diabetes symptoms by the Cree of Eeyou Istchee (Quebec, Canada).

    abstract:BACKGROUND:The Cree of Eeyou Istchee (James Bay area of northern Quebec) suffer from a high rate of diabetes and its complications partly due to the introduction of the western lifestyle within their culture. As part of a search for alternative medicine based on traditional practice, this project evaluates the biologic...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-019-2550-4

    authors: Downing AD,Eid HM,Tang A,Ahmed F,Harris CS,Haddad PS,Johns T,Arnason JT,Bennett SAL,Cuerrier A

    更新日期:2019-06-18 00:00:00

  • Potential biological efficacy of Pinus plant species against oxidative, inflammatory and microbial disorders.

    abstract:BACKGROUND:Traditionally, Pine has been used to treat oxidative and inflammatory disorders. The study was aimed to investigate biological potential of phytoconstituents of Pinus plant species: Pinus roxburghii, Pinus wallichiana and Pinus gerardiana using in-vitro antioxidant, anti-inflammatory and antimicrobial method...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1011-6

    authors: Sharma A,Goyal R,Sharma L

    更新日期:2016-01-28 00:00:00

  • Usage and appraisal of educational media by homeopathic therapists - a cross sectional survey.

    abstract:BACKGROUND:During recent years the market for homeopathic education media has increasingly diversified with old (books, seminars) and new media (video-seminars, pc-programs, homeo-wiki and internet-courses). However, little is known about homeopaths' preferences in using educational media and their requirements of this...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-12-95

    authors: Escher M,Vollmar HC,Holling A,Raak C,Ostermann T

    更新日期:2012-07-13 00:00:00

  • Bioassay-guided isolation of active anti-adipogenic compound from royal jelly and the study of possible mechanisms.

    abstract:BACKGROUND:Royal jelly (RJ) has been used traditionally for dietary, cosmetic and health purposes for a long time in different parts of the world. Scientific studies have also shown its numerous health-promoting properties including hypoglycemic and anti-hypercholesterolemic action. In this study, we investigated the a...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-018-2423-2

    authors: Pandeya PR,Lamichhane R,Lee KH,Kim SG,Lee DH,Lee HK,Jung HJ

    更新日期:2019-01-29 00:00:00

  • Retraction Note: Optimized extraction, composition, antioxidant and antimicrobial activities of exo and intracellular polysaccharides from submerged culture of Cordyceps cicadae.

    abstract::The editor has retracted this article [1] due to overlap with a previously published article [2]. Both articles also appear to use the same image representing different fungal mycelial growths. S.K. Sharma and N.S. Atri do not agree to this retraction. N. Gautam has not responded to correspondence from the editor abou...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,撤回出版物

    doi:10.1186/s12906-018-2344-0

    authors: Sharma SK,Gautam N,Atri NS

    更新日期:2018-10-16 00:00:00

  • Prevalence of the potentially inappropriate Kampo medications to be used with caution among elderly patients taking any prescribed Kampo medications at a single centre in Japan: a retrospective cross-sectional study.

    abstract:BACKGROUND:Few studies have investigated the prevalence and characteristics of potentially inappropriate Kampo medication use among elderly ambulatory patients taking any prescribed Kampo medications. METHODS:A retrospective cross-sectional study was conducted using electronic medical records. All patients aged 65 yea...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-018-2228-3

    authors: Komagamine J,Hagane K

    更新日期:2018-05-11 00:00:00

  • In vitro determination of the anti-aging potential of four southern African medicinal plants.

    abstract:BACKGROUND:Aging is an inevitable process for all living organisms. During this process reactive oxygen species generation is increased which leads to the activation of hyaluronidase, collagenase and elastase, which can further contribute to skin aging. Four southern African medicinal plants; Clerodendrum glabrum, Scho...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-304

    authors: Ndlovu G,Fouche G,Tselanyane M,Cordier W,Steenkamp V

    更新日期:2013-11-05 00:00:00

  • Efficacy and safety of acupuncture for dizziness and vertigo in emergency department: a pilot cohort study.

    abstract:BACKGROUND:Dizziness and vertigo account for roughly 4% of chief symptoms in the emergency department (ED). Pharmacological therapy is often applied for these symptoms, such as vestibular suppressants, anti-emetics and benzodiazepines. However, every medication is accompanied with unavoidable side-effects. There are se...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0704-6

    authors: Chiu CW,Lee TC,Hsu PC,Chen CY,Chang SC,Chiang JY,Lo LC

    更新日期:2015-06-09 00:00:00

  • Anti-inflammatory effects of Sanguisorbae Radix water extract on the suppression of mast cell degranulation and STAT-1/Jak-2 activation in BMMCs and HaCaT keratinocytes.

    abstract:BACKGROUND:Sanguisorbae Radix (SR) is a well-known herbal medicine used to treat inflammatory disease and skin burns in Asia. In addition, it is used to treat many types of allergic skin diseases, including urticaria, eczema, and allergic dermatitis. SR has been reported to exhibit anti-wrinkle, anti-oxidant, and anti-...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1317-4

    authors: Yang JH,Yoo JM,Cho WK,Ma JY

    更新日期:2016-09-06 00:00:00

  • Leishmanicidal, cytotoxicity and wound healing potential of Arrabidaea chica Verlot.

    abstract:BACKGROUND:Leishmaniasis includes a wide complex of diseases that affect humans and other mammals, and can range from a mild cutaneous form to a severe visceral type. The safety of the standard treatment using pentavalent antimony is a concern due to its toxic effects. The search for alternative, effective and less tox...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0973-0

    authors: Cortez de Sá J,Almeida-Souza F,Mondêgo-Oliveira R,Oliveira Idos S,Lamarck L,Magalhães Ide F,Ataídes-Lima AF,Ferreira Hda S,Abreu-Silva AL

    更新日期:2016-01-04 00:00:00

  • DisArticle: a web server for SVM-based discrimination of articles on traditional medicine.

    abstract:BACKGROUND:Much research has been done in Northeast Asia to show the efficacy of traditional medicine. While MEDLINE contains many biomedical articles including those on traditional medicine, it does not categorize those articles by specific research area. The aim of this study was to provide a method that searches for...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1596-4

    authors: Kim SK,Nam S,Kim S

    更新日期:2017-01-28 00:00:00

  • Ethanol extract of Poria cocos reduces the production of inflammatory mediators by suppressing the NF-kappaB signaling pathway in lipopolysaccharide-stimulated RAW 264.7 macrophages.

    abstract:BACKGROUND:Poria cocos Wolf, a medicinal fungus, is widely used in traditional medicines in East Asian countries owing to its various therapeutic potentials. Although several studies have demonstrated the anti-inflammatory activity of this fungus, its underlying mechanisms have not yet been clearly defined. METHODS:In...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-101

    authors: Jeong JW,Lee HH,Han MH,Kim GY,Hong SH,Park C,Choi YH

    更新日期:2014-03-15 00:00:00

  • Brazilin isolated from Caesalpinia sappan L. inhibits rheumatoid arthritis activity in a type-II collagen induced arthritis mouse model.

    abstract:BACKGROUND:Caesalpinia sappan L. extracts exhibit great therapeutic potential, and have been shown to have analgesic and anti-inflammatory properties. This study aimed to understand the anti-rheumatoid activity of brazilin that was isolated from ethyl acetate extract of C. sappan L. The evaluations were conducted in mi...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0648-x

    authors: Jung EG,Han KI,Hwang SG,Kwon HJ,Patnaik BB,Kim YH,Han MD

    更新日期:2015-04-22 00:00:00

  • Health care utilization among complementary and alternative medicine users in a large military cohort.

    abstract:BACKGROUND:Complementary and Alternative Medicine use and how it impacts health care utilization in the United States Military is not well documented. Using data from the Millennium Cohort Study we describe the characteristics of CAM users in a large military population and document their health care needs over a 12-mo...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-11-27

    authors: White MR,Jacobson IG,Smith B,Wells TS,Gackstetter GD,Boyko EJ,Smith TC,Millennium Cohort Study Team.

    更新日期:2011-04-11 00:00:00

  • Effect of DanQi Pill on PPARα, lipid disorders and arachidonic acid pathway in rat model of coronary heart disease.

    abstract:BACKGROUND:Danqi pill (DQP) is one of the most widely prescribed formulas and has been shown to have remarkable protective effect on coronary heart disease (CHD). However, its regulatory effects on lipid metabolism disorders haven't been comprehensively studied so far. We aimed to explore the effects of DQP on Peroxiso...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1083-3

    authors: Chang H,Wang Q,Shi T,Huo K,Li C,Zhang Q,Wang G,Wang Y,Tang B,Wang W,Wang Y

    更新日期:2016-03-22 00:00:00

  • New Canadian natural health product regulations: a qualitative study of how CAM practitioners perceive they will be impacted.

    abstract:BACKGROUND:New Canadian policy to regulate natural health products (NHPs), such as herbs and vitamins were implemented on January 1st, 2004. We explored complementary and alternative medicine (CAM) practitioners' perceptions of how the new regulations may affect their practices and relationships with patients/consumers...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-6-18

    authors: Moss K,Boon H,Ballantyne P,Kachan N

    更新日期:2006-05-10 00:00:00

  • Huatuo Zaizao pill promotes functional recovery and neurogenesis after cerebral ischemia-reperfusion in rats.

    abstract:BACKGROUND:Ischemic stroke is the third leading cause of death in adults worldwide and is the first leading cause of long-term disability. Neurogenesis plays an important role in promoting behavioral recovery after stroke. Huatuo Zaizao pill (HT), a traditional Chinese medicine, has been used clinically in China to pro...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1516-z

    authors: Duan S,Wang T,Zhang J,Li M,Lu C,Wang L,Zou Y,Fu F

    更新日期:2017-01-05 00:00:00