Abstract：
BACKGROUND:In Shaanxi province, China, the aqueous extract of Rubia cordifolia's aerial part (AERCAP) is traditionally used to manage diarrhea. However, there is no scientific evidence to verify the safety and efficacy of its use. The aim of this study was to investigate the anti-diarrheal and anti-inflammatory effects of AERCAP by using a rodent model. METHODS:The anti-diarrheal effects were studied by senna leaf-induced diarrheal and intestinal transit experiments in mice. The anti-inflammatory activity was investigated by trinitrobenzenesulfonic acid (TNBS)-induced colonic inflammation in rats. RESULTS:The results indicated that AERCAP delayed the onset of semi-solid feces, reduced the evacuation index (EI) in senna leaf-induced diarrheal in mice, and inhibited the propulsive movement in castor oil-induced intestinal transit but not in the normal intestinal transit test. The results were compared with the standard anti-diarrheal drug loperamide. Additionally, oral treatment with AERCAP significantly decreased the macroscopic damage area, improved the microscopic structure, and reduced the malondialdehyde (MDA) content, IL-1β and TNF-α levels in colonic tissue compared with the TNBS control group in rats. CONCLUSIONS:AERCAP exhibited anti-diarrheal and anti-inflammatory activities in a rodent model. The study validated the traditional use of the plant in Chinese herbal medicine as a valuable natural remedy for the treatment of diarrhea.
journal_name
BMC Complement Altern Medjournal_title
BMC complementary and alternative medicineauthors
Gong XP,Sun YY,Chen W,Guo X,Guan JK,Li DY,Du Gdoi
10.1186/s12906-016-1527-9subject
Has Abstractpub_date
2017-01-05 00:00:00pages
20issue
1issn
1472-6882pii
10.1186/s12906-016-1527-9journal_volume
17pub_type
杂志文章abstract：BACKGROUND:Melastoma malabathricum L. (family Melastomaceae; MM) and Muntingia calabura L. (family Elaeocarpaceae; MC) have been separately reported to possess gastroprotective activity. In an attempt to develop a pharmaceutical product with antiulcer potential, the synergistic gastroprotective activity of methanolic e...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-017-1992-9
更新日期：2017-11-09 00:00:00
abstract：BACKGROUND:Plant medicinal extracts may be claimed to prevent or cure chemical intoxications. Few of these are tested for their mechanisms of actions in vivo and for their cellular impacts. In 2011, we demonstrated that hepatic cell mortality induced by environmentally realistic levels of the widely used herbicide Roun...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-016-1226-6
更新日期：2016-07-22 00:00:00
abstract：BACKGROUND:The study was part of a nationwide evaluation of complementary and alternative medicine (CAM) in Swiss primary care. The aim of the study was to compare patient-physician relationships and the respective patient-reported relief of symptoms between CAM and conventional primary care (COM). METHODS:A comparati...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-10-63
更新日期：2010-11-04 00:00:00
abstract：BACKGROUND:Multiple sclerosis (MS) is a complex autoimmune disease mediated by an immune response to central nervous system antigens. Modern immunomodulatory therapies, however, do not ameliorate many of the symptoms, such as pain and depression. Patients thus seek alternative treatments, such as acupuncture, although ...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章,随机对照试验
doi：10.1186/1472-6882-12-209
更新日期：2012-11-05 00:00:00
abstract：BACKGROUND:Naturopaths and Western herbal medicine (WHM) practitioners were surveyed to identify their extent, experience and roles within the community pharmacy setting and to explore their attitudes to integration of complementary medicine (CM) practitioners within the pharmacy setting. METHOD:Practising naturopaths...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-11-41
更新日期：2011-05-23 00:00:00
abstract：BACKGROUND:The use of edible plants is an integral part of dietary behavior in the West region of Cameroon. Dorstenia psilurus (Moraceae) is widely used as spice and as medicinal plant for the treatment of several diseases in Cameroon. The aim of this study is to investigate the cytotoxic and apoptotic potential of met...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-13-223
更新日期：2013-09-10 00:00:00
abstract：BACKGROUND:The use of CAM by pregnant women is very popular in developed countries. The trend is increasing globally and lack of evidence of safety particularly when used during pregnancy may lead to complications. Pregnancy is a vulnerable period especially during the first trimester. There is scarcity of empirical ev...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-017-1689-0
更新日期：2017-04-04 00:00:00
abstract：BACKGROUND:Mind-body practices are frequently used by people living with HIV to reduce symptoms and improve wellbeing. These include Tai Chi, Qigong, yoga, meditation, and all types of relaxation. Although there is substantial research on the efficacy of mind-body practices in people living with HIV, there is no summar...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-019-2502-z
更新日期：2019-06-11 00:00:00
abstract：BACKGROUND:Complementary and Alternative Medicine use and how it impacts health care utilization in the United States Military is not well documented. Using data from the Millennium Cohort Study we describe the characteristics of CAM users in a large military population and document their health care needs over a 12-mo...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-11-27
更新日期：2011-04-11 00:00:00
abstract：BACKGROUND:The traditional use of the oleo-gum-resin of Commiphora guidottii Chiov. ex. Guid., which is commonly called scented myrrh, for topical treatment of wound is well documented. The major objective of the present study was to investigate the essential oil and resin obtained from C. guidottii for their potential...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-015-0813-2
更新日期：2015-08-18 00:00:00
abstract：BACKGROUND:Saliva is fundamental to our oral health and our well-being. Many factors can impair saliva secretion, such as adverse effects of prescribed medication, auto-immune diseases (for example Sjögren's syndrome) and radiotherapy for head and neck cancers. Several studies have suggested a positive effect of acupun...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章,评审
doi：10.1186/s12906-018-2124-x
更新日期：2018-02-13 00:00:00
abstract：BACKGROUND:Phyllanthus amarus (Schum & Thonn), a plant belonging to the family of Euphorbiaceae is used in Ivorian traditional medicine to treat cardiovascular disorders such as hypertension. However, although this plant has been described as a diuretic agent, the underlying mechanism remains unclear. Therefore, the ai...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-018-2158-0
更新日期：2018-03-15 00:00:00
abstract：BACKGROUND:Few studies have investigated the prevalence and characteristics of potentially inappropriate Kampo medication use among elderly ambulatory patients taking any prescribed Kampo medications. METHODS:A retrospective cross-sectional study was conducted using electronic medical records. All patients aged 65 yea...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-018-2228-3
更新日期：2018-05-11 00:00:00
abstract：BACKGROUND:Renal ischemia-reperfusion injury (IRI) increases the rates of acute kidney failure, delayed graft function, and early mortality after kidney transplantation. The pathophysiology involved includes oxidative stress, mitochondrial dysfunction, and immune-mediated injury. The anti-oxidation, anti-apoptosis, and...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-14-19
更新日期：2014-01-13 00:00:00
abstract：BACKGROUND:The aim of this study was to find the prevalence of potential drug-herb interactions in patients with chronic diseases and identify factors associated with these interactions if present. METHOD:The study was a questionnaire based cross-sectional study. It was conducted at a number of governmental primary he...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-015-0764-7
更新日期：2015-07-11 00:00:00
abstract：BACKGROUND:Brazilian green propolis is produced by mixing secretions from Africanized honey bees with exudate, mainly from Baccharis dracunculifolia. Brazilian propolis is especially rich in flavonoids and cinammic acid derivatives, and it has been widely used in folk medicine owing to its anti-inflammatory, anti-viral...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-018-2198-5
更新日期：2018-05-02 00:00:00
abstract：BACKGROUND:Verbascum thapsus is used in tribal medicine as an antispasmodic, anti-tubercular agent and wormicide. In this study, we investigated the antispasmodic and anthelmintic activities of crude aqueous methanolic extract of the plant. METHODS:V. thapsus extracts were tested against roundworms (Ascaridia galli) a...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-12-29
更新日期：2012-03-30 00:00:00
abstract：BACKGROUND:Increased platelet aggregation is implicated in the pathogenesis of ischemic stroke and anti-platelet strategy may contribute to its therapy. Panaxatriol saponin (PTS), the main components extracted from Panax notoginseng, has been shown to be efficacious in the prevention and treatment of ischemic stroke in...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-016-1160-7
更新日期：2016-06-08 00:00:00
abstract：BACKGROUND:The fruit of Cyrtocarpa procera is used to treat stomach diseases by people living in San Rafael, Coxcatlan, Puebla. This work investigated the antibacterial, antioxidant, cytotoxic and anti-inflammatory activities of the fruit produced by this species. METHODS:Methanol extract was obtained by maceration. A...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-015-0602-y
更新日期：2015-03-21 00:00:00
abstract：BACKGROUND:The use of complementary and alternative medicine (CAM) persists, despite the availability of conventional medicine (CM), modernisation, globalisation, technological advancement, and limited scientific evidence supporting CAM. People with cardiovascular diseases often use CAM, despite possible major adverse ...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-015-0610-y
更新日期：2015-03-31 00:00:00
abstract：BACKGROUND:Soshiho-tang (SST, Xiao-chai-hu-tang in Chinese and Sho-saiko-to in Japanese), an oriental herbal formula, is used for treatment of chronic liver diseases. Although many researchers have studied the pharmacological properties of SST, information about its safety and toxicity is limited. Therefore, we evaluat...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-12-266
更新日期：2012-12-27 00:00:00
abstract：BACKGROUND:Complementary and Alternative Medicine (CAM) is increasingly popular with cancer patients and yet information provision or discussion about CAM by health professionals remains low. Previous research suggests that patients may fear clinicians' 'disapproval' if they raise the subject of CAM, and turn to other ...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-7-25
更新日期：2007-08-04 00:00:00
abstract：BACKGROUND:The present investigation was aimed at evaluating the hypoglycemic and hypolipidemic properties of the aqueous and methanolic extracts from Bersama engleriana leaves in streptozotocin/nicotinamide (STZ-NA)-induced type 2 diabetic rats. METHODS:Animals were orally treated for 4 consecutive weeks with Bersama...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-12-264
更新日期：2012-12-26 00:00:00
abstract：BACKGROUND:Resveratrol, a polyphenol from grapes and red wine has many health beneficial effects, including protection against cardiovascular and neurodegenerative diseases and cancer. However, our group and others have provided evidence for a dual cancer promoting or inhibitory role for resveratrol in breast cancer, d...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-13-6
更新日期：2013-01-08 00:00:00
abstract：BACKGROUND:Senecio serratuloides DC is used in folk medicine for treating hypertension, skin disorders, internal and external sores, rashes, burns and wounds. This study aimed at investigating the antihypertensive effects of the hydroethanol extract of S. serratuloides (HESS) in N-Nitro-L-arginine methyl ester (L-NAME)...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-019-2463-2
更新日期：2019-02-28 00:00:00
abstract：BACKGROUND:African trypanosomosis is the disease caused by extracellular protozoan parasites of the genus Trypanosoma transmitted by tsetse flies. The current study has evaluated the trypanocidal activity of Commiphora swynnertonii extracts on Trypanosoma congolense. METHODS:The effect of ethanolic stem bark and resin...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-016-1191-0
更新日期：2016-07-08 00:00:00
abstract：BACKGROUND:The Consolidated Standards for Reporting Trials (CONSORT) are aimed to standardize clinical trial reporting. Our objective is to compare the quality of randomized clinical trials (RCTs) of traditional Chinese medicine (TCM) published in 2005-2009 and 2011-2012 according to the current CONSORT statements and ...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章,评审
doi：10.1186/1472-6882-14-362
更新日期：2014-09-26 00:00:00
abstract：BACKGROUND:P-113 (AKRHHGYKRKFH-NH2) is a 12-amino-acid histidine-rich peptide derived from histatin 5 that is highly degradable in high salt concentrations and biological fluids such as serum, plasma and saliva. Nal-P-113, a novel antimicrobial peptide whose histidine residues are replaced by the bulky amino acids β-na...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-017-1931-9
更新日期：2017-08-29 00:00:00
abstract：BACKGROUND:This study was designed to evaluate the effects of electroacupuncture-like stimulation at Baihui (GV20) and Dazhui (GV14) acupoints (EA at acupoints) following mild cerebral ischemia-reperfusion (I/R) injury. Furthermore, we investigated whether brain-derived neurotrophic factor (BDNF)-mediated activation of...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-14-92
更新日期：2014-03-07 00:00:00
abstract：BACKGROUND:Breast cancer is the most common type of malignancy in women worldwide. Euphorbia humifusa Willd (EuH) is a plant that is widely used as a traditional medicine. However, no systemic studies on the anti-cancer effects of EuH have been reported. The aim of this study is to evaluate the anti-metastatic effect o...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-016-1404-6
更新日期：2016-10-24 00:00:00
