Electroacupuncture-like stimulation at Baihui and Dazhui acupoints exerts neuroprotective effects through activation of the brain-derived neurotrophic factor-mediated MEK1/2/ERK1/2/p90RSK/bad signaling pathway in mild transient focal cerebral ischemia in

Abstract:

BACKGROUND:This study was designed to evaluate the effects of electroacupuncture-like stimulation at Baihui (GV20) and Dazhui (GV14) acupoints (EA at acupoints) following mild cerebral ischemia-reperfusion (I/R) injury. Furthermore, we investigated whether brain-derived neurotrophic factor (BDNF)-mediated activation of extracellular signal-regulated kinase (ERK)1/2 signaling pathway is involved in the neuroprotection induced by EA at acupoints. METHODS:Rats were subjected to middle cerebral artery occlusion (MCAo) for 15 min followed by reperfusion for 3 d. EA at acupoints was applied 1 d postreperfusion then once daily for 2 consecutive days. RESULTS:Following the application of EA at acupoints, initiated 1 d postreperfusion, we observed significant reductions in the cerebral infarct area, neurological deficit scores, active caspase-3 protein expression, and apoptosis in the ischemic cortex after 3 d of reperfusion. We also observed markedly upregulated BDNF, phospho-Raf-1 (pRaf-1), phospho-MEK1/2 (pMEK1/2), phospho-ERK1/2 (pERK1/2), phospho-90 kDa ribosomal S6 kinase (pp90RSK), and phospho-Bad (pBad) expression, and restored neuronal nuclear antigen (NeuN) expression. Pretreatment with the MEK1/2 inhibitor U0126 abrogated the effects of EA at acupoints on cerebral infarct size, neurological deficits, active caspase-3 protein, and apoptosis in the ischemic cortex after 3 d of reperfusion. Pretreatment with U0126 also abrogated the effects of EA at acupoints on pMEK1/2, pERK1/2, pp90RSK, pBad, and NeuN expression, but did not influence BDNF and pRaf-1 expression. CONCLUSION:Overall, our study results indicated that EA at acupoints, initiated 1 d postreperfusion, upregulates BDNF expression to provide BDNF-mediated neuroprotection against caspase-3-dependent neuronal apoptosis through activation of the Raf-1/MEK1/2/ERK1/2/p90RSK/Bad signaling cascade after 3 d of reperfusion in mild MCAo.

authors

Cheng CY,Lin JG,Su SY,Tang NY,Kao ST,Hsieh CL

doi

10.1186/1472-6882-14-92

subject

Has Abstract

pub_date

2014-03-07 00:00:00

pages

92

issn

1472-6882

pii

1472-6882-14-92

journal_volume

14

pub_type

杂志文章
  • The inhibitory effect of tongxieyaofang on rats with post infectious irritable bowel syndrome through regulating colonic par-2 receptor.

    abstract:BACKGROUND:The aims of this study were to evaluate the effect and mechanism of a traditional Chinese medicine formula: Tongxieyaofang (TXYF) on Rats with Post Infectious Irritable Bowel Syndrome (PI-IBS). METHODS:SD male rats in adult were used to model PI-IBS and treated with TXYF at three dosage for 14 consecutive d...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-246

    authors: Hu X,Zhang X,Han B,Bei W

    更新日期:2013-10-02 00:00:00

  • Role of ellagic acid in regulation of apoptosis by modulating novel and atypical PKC in lymphoma bearing mice.

    abstract:BACKGROUND:Protein kinase C regulates various cellular processes including cell proliferation, cell adhesion, apoptosis, angiogenesis, invasion, and metastasis. Activation of different PKC isozymes results in distinct cellular responses. Novel PKCs are mainly involved in apoptotic process. Atypical PKC subfamily plays ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0810-5

    authors: Mishra S,Vinayak M

    更新日期:2015-08-15 00:00:00

  • In vitro evaluation of the α-glucosidase inhibitory potential of methanolic extracts of traditionally used antidiabetic plants.

    abstract:BACKGROUND:Different plant parts of Roylea cinerea (D. Don) Baill. (Lamiaceae), Clematis grata Wall. (Ranunculaceae), Cornus capitata Wall. (Cornaceae) are traditionally used in the management of diabetes and various other diseases. METHOD:The air-dried plant parts from different plants were coarsely powdered and mace...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-019-2482-z

    authors: Bhatia A,Singh B,Arora R,Arora S

    更新日期:2019-03-25 00:00:00

  • Molecular insights into the anti-cancer properties of traditional Tibetan medicine Yukyung Karne.

    abstract:BACKGROUND:Yukyung karne (YK) is a traditional Tibetan formulation used for many centuries for the treatment of ovarian cancer. However, the pharmacological basis of its anticancer property is not well understood. In the present study, the anticancer property of YK was investigated in cell culture. METHODS:The growth ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-380

    authors: Choedon T,Dolma D,Mathan G,Kumar V

    更新日期:2014-10-07 00:00:00

  • Antioxidant and cytotoxic activities of Dendrobium moniliforme extracts and the detection of related compounds by GC-MS.

    abstract:BACKGROUND:The medicinal orchid Dendrobium moniliforme contains water-soluble polysaccharides, phenanthrenes, bibenzyl derivatives, and polyphenol compounds. This study explored the antioxidant and cytotoxic activities of D. moniliforme extracts and detected their bioactive compounds. METHODS:Plant material was collec...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-018-2197-6

    authors: Paudel MR,Chand MB,Pant B,Pant B

    更新日期:2018-04-23 00:00:00

  • Cytotoxic and antimicrobial activities of endophytic fungi isolated from Bacopa monnieri (L.) Pennell (Scrophulariaceae).

    abstract:BACKGROUND:Endophytes, which reside in plant tissues, have the potential to produce novel metabolites with immense benefits for health industry. Cytotoxic and antimicrobial activities of endophytic fungi isolated from Bacopa monnieri (L.) Pennell were investigated. METHODS:Endophytic fungi were isolated from the Bacop...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-52

    authors: Katoch M,Singh G,Sharma S,Gupta N,Sangwan PL,Saxena AK

    更新日期:2014-02-11 00:00:00

  • Evaluation of the antiplasmodial properties of selected plants in southern Ethiopia.

    abstract:BACKGROUND:The majority of the Ethiopian population is at risk of malaria largely caused by Plasmodium falciparum. The resistance of the parasite to existing drugs is the main challenge in the control of the disease and thus new therapeutic drugs are required. In Ethiopia, people use different plant species to treat ma...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0976-x

    authors: Asnake S,Teklehaymanot T,Hymete A,Erko B,Giday M

    更新日期:2015-12-23 00:00:00

  • Complementary and alternative medicine use among patients with cancer in Mongolia: a National hospital survey.

    abstract:BACKGROUND:Complementary and alternative medicine (CAM) use is popular in former Soviet Central Asian countries including Mongolia. However, no studies are available on CAM use among patients with cancer in countries of this region. The aim of this research is to describe the prevalence and patterns of CAM use by patie...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1576-8

    authors: Oyunchimeg B,Hwang JH,Ahmed M,Choi S,Han D

    更新日期:2017-01-19 00:00:00

  • Inhibitory effect of aqueous Dandelion extract on HIV-1 replication and reverse transcriptase activity.

    abstract:BACKGROUND:Acquired immunodeficiency syndrome (AIDS), which is caused by the human immunodeficiency virus (HIV), is an immunosuppressive disease that results in life-threatening opportunistic infections. The general problems in current therapy include the constant emergence of drug-resistant HIV strains, adverse side e...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-11-112

    authors: Han H,He W,Wang W,Gao B

    更新日期:2011-11-14 00:00:00

  • Inhibitory effect of Yukmijihwang-tang, a traditional herbal formula against testosterone-induced benign prostatic hyperplasia in rats.

    abstract:BACKGROUND:Yukmijihwang-tang, a traditional herbal formula, has been used for treating disorder, diabetic mellitus and neurosis in China (Liu-wei-di-huang-tang in Chinese), Japan (Lokumijio-to in Japanese) and Korea for many years. In this study, we investigated the effects of Yukmijihwang-tang water extract (YJT) on t...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-12-48

    authors: Shin IS,Lee MY,Ha HK,Seo CS,Shin HK

    更新日期:2012-04-20 00:00:00

  • Trypanocidal activity of ethanolic extracts of Commiphora swynnertonii Burtt on Trypanosoma congolense.

    abstract:BACKGROUND:African trypanosomosis is the disease caused by extracellular protozoan parasites of the genus Trypanosoma transmitted by tsetse flies. The current study has evaluated the trypanocidal activity of Commiphora swynnertonii extracts on Trypanosoma congolense. METHODS:The effect of ethanolic stem bark and resin...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1191-0

    authors: Nagagi YP,Silayo RS,Kweka EJ

    更新日期:2016-07-08 00:00:00

  • Dichrostachys cinerea (L.) Wight et Arn (Mimosaceae) hydro-alcoholic extract action on the contractility of tracheal smooth muscle isolated from guinea-pig.

    abstract:BACKGROUND:Dichrostachys cinerea (L.) Wight et Arn. (Mimosaceae) is largely used in ethno-medically across Africa, and mainly employed for the treatment of asthma in Ivory Coast and Gabon. The paper analyses the relaxation induced by the methanolic extract of D. cinerea (Edici) in the guinea-pig trachea preparations (G...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-11-23

    authors: Aworet-Samseny RR,Souza A,Kpahé F,Konaté K,Datté JY

    更新日期:2011-03-17 00:00:00

  • Isolation, characterization and antimicrobial evaluation of a novel compound N-octacosan 7β ol, from Fumaria parviflora Lam.

    abstract:BACKGROUND:Fumaria parviflora Lam. (Fumaraceae) is widely used in traditional as well as folkloric system of medicine from ancient. It is commonly known as 'Pitpapra' or 'Shahtrah' in Indian traditional system of medicine and used for treating numerous ailments like diarrhea, fever, influenza, blood purifier and other ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-98

    authors: Jameel M,Islamuddin M,Ali A,Afrin F,Ali M

    更新日期:2014-03-12 00:00:00

  • Fungal 7-epi-10-deacetyltaxol produced by an endophytic Pestalotiopsis microspora induces apoptosis in human hepatocellular carcinoma cell line (HepG2).

    abstract:BACKGROUND:Paclitaxel (taxol) is a potent anticancer drug that is used in the treatment of a wide variety of cancerous. In the present study, we identified a taxol derivative named 7-epi-10-deacetyltaxol (EDT) from the culture of an endophytic fungus Pestalotiopsis microspora isolated from the bark of Taxodium mucronat...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1993-8

    authors: Subban K,Singh S,Subramani R,Johnpaul M,Chelliah J

    更新日期:2017-11-28 00:00:00

  • Acacia honey accelerates in vitro corneal ulcer wound healing model.

    abstract:BACKGROUND:The study aimed to evaluate the effects of Acacia honey (AH) on the migration, differentiation and healing properties of the cultured rabbit corneal fibroblasts. METHODS:Stromal derived corneal fibroblasts from New Zealand White rabbit (n = 6) were isolated and cultured until passage 1. In vitro corneal ulc...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1248-0

    authors: Abd Ghafar N,Ker-Woon C,Hui CK,Mohd Yusof YA,Wan Ngah WZ

    更新日期:2016-07-29 00:00:00

  • Effectiveness Guidance Document (EGD) for acupuncture research - a consensus document for conducting trials.

    abstract:BACKGROUND:There is a need for more Comparative Effectiveness Research (CER) to strengthen the evidence base for clinical and policy decision-making. Effectiveness Guidance Documents (EGD) are targeted to clinical researchers. The aim of this EGD is to provide specific recommendations for the design of prospective acup...

    journal_title:BMC complementary and alternative medicine

    pub_type: 共识发展会议,杂志文章

    doi:10.1186/1472-6882-12-148

    authors: Witt CM,Aickin M,Baca T,Cherkin D,Haan MN,Hammerschlag R,Hao JJ,Kaplan GA,Lao L,McKay T,Pierce B,Riley D,Ritenbaugh C,Thorpe K,Tunis S,Weissberg J,Berman BM,Effectiveness Guidance Documents Collaborators.

    更新日期:2012-09-06 00:00:00

  • The effects of the court-type Thai traditional massage on anatomical relations, blood flow, and skin temperature of the neck, shoulder, and arm.

    abstract:BACKGROUND:Court-type Thai traditional massage (CTTM) has specific major signal points (MaSP) for treating musculoskeletal conditions. The objectives of this study are to investigate the anatomical surfaces and structures of MaSPs, and to examine blood flow (BF) and skin temperature (ST) changes after applying pressure...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1282-y

    authors: Plakornkul V,Vannabhum M,Viravud Y,Roongruangchai J,Mutirangura P,Akarasereenont P,Laohapand T

    更新日期:2016-09-15 00:00:00

  • Polyphenols of Salix aegyptiaca modulate the activities of drug metabolizing and antioxidant enzymes, and level of lipid peroxidation.

    abstract:BACKGROUND:Salix aegyptiaca is known for its medicinal properties mainly due to the presence of salicylate compounds. However, it also contains other beneficial phytochemicals such as gallic acid, quercetin, rutin and vanillin. The aim of the study was to examine the redox potential, antioxidant and anti-inflammatory a...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-018-2143-7

    authors: Nauman M,Kale RK,Singh RP

    更新日期:2018-03-07 00:00:00

  • The effects of Gamijinhae-tang on elastase/lipopolysaccharide-induced lung inflammation in an animal model of acute lung injury.

    abstract:BACKGROUND:Gamijinhae-tang (GJHT) has long been used in Korea to treat respiratory diseases. The therapeutic effect of GJHT is likely associated with its anti-inflammatory activity. However, the precise mechanisms underlying its effects are unknown. This study was conducted to evaluate the protective effects of GJHT in...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-176

    authors: Sohn SH,Jang H,Kim Y,Jang YP,Cho SH,Jung H,Jung S,Bae H

    更新日期:2013-07-16 00:00:00

  • Proficiencies of Artemisia scoparia against CCl4 induced DNA damages and renal toxicity in rat.

    abstract:BACKGROUND:Artemisia scoparia is traditionally used in the local system of medicine in kidney disorders. This study aimed at scrutinizing the nephroprotective prospective of A. scoparia methanol extract against carbon tetrachloride (CCl4) provoked DNA damages and oxidative stress in kidneys of rat. METHODS:Dried aeria...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1137-6

    authors: Sajid M,Khan MR,Shah NA,Ullah S,Younis T,Majid M,Ahmad B,Nigussie D

    更新日期:2016-05-27 00:00:00

  • All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy.

    abstract:BACKGROUND:Radiotherapy is of critical importance in the treatment of breast cancer. However, not all patients derive therapeutic benefit and some breast cancers are resistant to the treatment, and are thus evidenced with prospective distant metastatic spread and local recurrence. In this study, we investigated the pot...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1088-y

    authors: Yan Y,Li Z,Xu X,Chen C,Wei W,Fan M,Chen X,Li JJ,Wang Y,Huang J

    更新日期:2016-03-31 00:00:00

  • Antimicrobial activities of endophytic fungi obtained from the arid zone invasive plant Opuntia dillenii and the isolation of equisetin, from endophytic Fusarium sp.

    abstract:BACKGROUND:Opuntia dillenii is an invasive plant well established in the harsh South-Eastern arid zone of Sri Lanka. Evidence suggests it is likely that the endophytic fungal populations of O. dillenii assist the host in overcoming biotic and abiotic stress by producing biologically active metabolites. With this in min...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0722-4

    authors: Ratnaweera PB,de Silva ED,Williams DE,Andersen RJ

    更新日期:2015-07-10 00:00:00

  • Huatuo Zaizao pill promotes functional recovery and neurogenesis after cerebral ischemia-reperfusion in rats.

    abstract:BACKGROUND:Ischemic stroke is the third leading cause of death in adults worldwide and is the first leading cause of long-term disability. Neurogenesis plays an important role in promoting behavioral recovery after stroke. Huatuo Zaizao pill (HT), a traditional Chinese medicine, has been used clinically in China to pro...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1516-z

    authors: Duan S,Wang T,Zhang J,Li M,Lu C,Wang L,Zou Y,Fu F

    更新日期:2017-01-05 00:00:00

  • Ethanol extract of Poria cocos reduces the production of inflammatory mediators by suppressing the NF-kappaB signaling pathway in lipopolysaccharide-stimulated RAW 264.7 macrophages.

    abstract:BACKGROUND:Poria cocos Wolf, a medicinal fungus, is widely used in traditional medicines in East Asian countries owing to its various therapeutic potentials. Although several studies have demonstrated the anti-inflammatory activity of this fungus, its underlying mechanisms have not yet been clearly defined. METHODS:In...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-101

    authors: Jeong JW,Lee HH,Han MH,Kim GY,Hong SH,Park C,Choi YH

    更新日期:2014-03-15 00:00:00

  • Effect of new polyherbal formulations DF1911, DF2112 and DF2813 on CFA induced inflammation in rat model.

    abstract:BACKGROUND:Aim of the present study was to evaluate anti-inflammatory activity of newly developed polyherbal formulations DF1911, DF2112 and DF2813. These newly developed formulations are modifications of Dashamoola, a well known Ayurvedic formulation, along with addition of new plants. METHODS:Complete Freund's adjuv...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1711-6

    authors: Nagarkar B,Jagtap S

    更新日期:2017-04-04 00:00:00

  • Flavones from Erythrina falcata are modulators of fear memory.

    abstract:BACKGROUND:Flavonoids, which have been identified in a variety of plants, have been demonstrated to elicit beneficial effects on memory. Some studies have reported that flavonoids derived from Erythrina plants can provide such beneficial effects on memory. The aim of this study was to identify the flavonoids present in...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-288

    authors: de Oliveira DR,Zamberlam CR,Gaiardo RB,Rêgo GM,Cerutti JM,Cavalheiro AJ,Cerutti SM

    更新日期:2014-08-05 00:00:00

  • Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic activities against Anisakis simplex and Hymenolepis nana of yakuchinone A from Alpinia oxyphylla.

    abstract:BACKGROUND:Alpinia oxyphylla is a common remedy in traditional Chinese medicine. Yakuchinone A is a major constituent of A. oxyphylla and exhibits anti-inflammatory, antitumor, antibacterial, and gastric protective activities. METHODS:Antioxidant and antitumor characteristics of yakuchinone A in skin cancer cells as w...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-237

    authors: Lin RJ,Yen CM,Chou TH,Chiang FY,Wang GH,Tseng YP,Wang L,Huang TW,Wang HC,Chan LP,Ding HY,Liang CH

    更新日期:2013-09-26 00:00:00

  • Complementary traditional Chinese medicine use in Children with cerebral palsy: a nationwide retrospective cohort study in Taiwan.

    abstract:BACKGROUND:Complementary traditional Chinese medicine (TCM) has been used to treat patients with cerebral palsy (CP). However, large-scale surveys examining its use in the treatment of CP and associated disorders are lacking. METHODS:We enrolled 11,218 patients ≤ 18 years of age with CP in the Taiwanese National Healt...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1668-5

    authors: Liao HH,Yen HR,Muo CH,Lee YC,Wu MY,Chou LW,Sun MF,Chang TT

    更新日期:2017-03-14 00:00:00

  • Synergistic effects and related bioactive mechanism of Potentilla fruticosa L. leaves combined with Ginkgo biloba extracts studied with microbial test system (MTS).

    abstract:BACKGROUND:Potentilla fruticosa, also called "Jinlaomei" and "Gesanghua", is widely used as folk herbs in traditional Tibetan medicine in China to treat inflammations, wounds, certain forms of cancer, diarrhoea, diabetes and other ailments. Previous research found P. fruticosa leaf extract (C-3) combined with Ginkgo bi...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1485-2

    authors: Liu ZH,Wang DM,Fan SF,Li DW,Luo ZW

    更新日期:2016-12-01 00:00:00

  • Perceptions of traditional Chinese medicine for chronic disease care and prevention: a cross-sectional study of Chinese hospital-based health care professionals.

    abstract:BACKGROUND:In China, demands for disease prevention and health care and the prevalence of chronic non-communicable diseases have increased. TCM and general hospitals are increasingly utilizing TCM strategies for chronic non-communicable disease care and prevention. This study aimed to investigate health care profession...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-018-2273-y

    authors: Fan X,Meng F,Wang D,Guo Q,Ji Z,Yang L,Ogihara A

    更新日期:2018-07-06 00:00:00