Antihypertensive effects of the hydro-ethanol extract of Senecio serratuloides DC in rats.

Abstract:

BACKGROUND:Senecio serratuloides DC is used in folk medicine for treating hypertension, skin disorders, internal and external sores, rashes, burns and wounds. This study aimed at investigating the antihypertensive effects of the hydroethanol extract of S. serratuloides (HESS) in N-Nitro-L-arginine methyl ester (L-NAME) induced hypertension in rats. METHODS:Acute toxicity of HESS was first determined to provide guidance on doses to be used in this study. Lorke's method was used to determine safety of the extract in mice. Female Wistar rats were treated orally once daily with L-NAME (40 mg/kg) for 4 weeks and then concomitantly with L-NAME (20 mg/kg) and plant extract (150 and 300 mg/kg), captopril (20 mg/kg) or saline as per assigned group for 2 weeks followed by a 2-week period of assigned treatments only. Blood pressure was monitored weekly. Lipid profile, nitric oxide, renin and angiotensin II concentrations were determined in serum while mineralocorticoid receptor concentration was quantified in the kidney homogenate. Nitric oxide (NO) concentration was determined in serum and cardiac histology performed. RESULTS:HESS was found to be non-toxic, having a LD50 greater than 5000 mg/kg. Blood pressure increased progressively in all animals from the second week of L-NAME treatment. HESS treatment significantly and dose-dependently lowered systolic blood pressure (p < 0.001), diastolic blood pressure (p < 0.01), low density lipoprotein cholesterol (p < 0.01) and triglycerides (p < 0.01). It significantly prevented L-NAME induced decrease in serum angiotensin II (p < 0.01), high density lipoprotein cholesterol (p < 0.001) and serum nitric oxide concentrations (p < 0.001). HESS also significantly (p < 0.01) prevented collagen deposition in cardiac tissue. CONCLUSION:The hydro-ethanol extract of Senecio serratuloides showed antihypertensive, antihyperlipidemic and cardioprotective effects in rats thus confirming its usefulness in traditional antihypertensive therapy and potential for antihypertensive drug development.

authors

Tata CM,Sewani-Rusike CR,Oyedeji OO,Gwebu ET,Mahlakata F,Nkeh-Chungag BN

doi

10.1186/s12906-019-2463-2

subject

Has Abstract

pub_date

2019-02-28 00:00:00

pages

52

issue

1

issn

1472-6882

pii

10.1186/s12906-019-2463-2

journal_volume

19

pub_type

杂志文章
  • Non-alcoholic fatty liver disease among sasang constitutional types: a population-based study in Korea.

    abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and is highly prevalent in populations with metabolic conditions such as obesity and type II diabetes. Specific types of Sasang constitution can act as a risk factor for metabolic diseases, but there are no studies ad...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0925-8

    authors: Lee SK,Yoon DW,Lee SW,Kim JY,Kim JK,Shin C

    更新日期:2015-11-07 00:00:00

  • What do clinicians want? Interest in integrative health services at a North Carolina academic medical center.

    abstract:BACKGROUND:Use of complementary medicine is common, consumer driven and usually outpatient focused. We wished to determine interest among the medical staff at a North Carolina academic medical center in integrating diverse therapies and services into comprehensive care. METHODS:We conducted a cross sectional on-line s...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-7-5

    authors: Kemper KJ,Dirkse D,Eadie D,Pennington M

    更新日期:2007-02-09 00:00:00

  • Activity guided isolation and modification of juglone from Juglans regia as potent cytotoxic agent against lung cancer cell lines.

    abstract:BACKGROUND:Juglans regia has been found to exhibit significant anticancer activity against various human cancer cell lines. This study was undertaken to isolate the active chemical constituent (Juglone) and to investigate its cytotoxic activity along with its various analogs against different human cancer cell lines. ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0920-0

    authors: Zhang XB,Zou CL,Duan YX,Wu F,Li G

    更新日期:2015-11-03 00:00:00

  • Cytotoxicity effect of degraded and undegraded kappa and iota carrageenan in human intestine and liver cell lines.

    abstract:BACKGROUND:Carrageenan is a linear sulphated polysaccharide extracted from red seaweed of the Rhodophyceae family. It has broad spectrum of applications in biomedical and biopharmaceutical field. In this study, we determined the cytotoxicity of degraded and undegraded carrageenan in human intestine (Caco-2; cancer and ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-508

    authors: Ariffin SH,Yeen WW,Abidin IZ,Abdul Wahab RM,Ariffin ZZ,Senafi S

    更新日期:2014-12-17 00:00:00

  • Prevention of advanced glycation end-products formation in diabetic rats through beta-cell modulation by Aegle marmelos.

    abstract:BACKGROUND:Although the anti-diabetic activity of Aegle marmelos (AM) is known, however, its anti-glycation activity is not reported yet. In this study, we have investigated its anti-glycation activity under in vitro and in vivo conditions and determined possible mechanism(s) in streptozotocin-induced diabetic rats. M...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1743-y

    authors: Hafizur RM,Momin S,Fatima N

    更新日期:2017-04-21 00:00:00

  • Protective effect of Danggui (Radix Angelicae Sinensis) on angiotensin II-induced apoptosis in H9c2 cardiomyoblast cells.

    abstract:BACKGROUND:Danggui (Radix Angelicae Sinensis) is an herb often used in Traditional Chinese medicine. It is used to promote blood flow and has been used in the treatment of myocardial ischemia-reperfusion injury in animal models. Angiotensin II (Ang II) has been shown to play important roles in mediating cardiovascular ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-358

    authors: Huang CY,Kuo WW,Kuo CH,Tsai FJ,Liu PY,Hsieh DJ

    更新日期:2014-09-25 00:00:00

  • Treatments of pelvic girdle pain in pregnant women: adverse effects of standard treatment, acupuncture and stabilising exercises on the pregnancy, mother, delivery and the fetus/neonate.

    abstract:BACKGROUND:Previous publications indicate that acupuncture is efficient for the treatment of pelvic girdle pain, PGP, in pregnant women. However, the use of acupuncture for PGP is rare due to insufficient documentation of adverse effects of this treatment in this specific condition. The aim of the present work was to a...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1472-6882-8-34

    authors: Elden H,Ostgaard HC,Fagevik-Olsen M,Ladfors L,Hagberg H

    更新日期:2008-06-26 00:00:00

  • Effects of Tangshen Formula on urinary and plasma liver-type fatty acid binding protein levels in patients with type 2 diabetic kidney disease: post-hoc findings from a multi-center, randomized, double-blind, placebo-controlled trial investigating the eff

    abstract:BACKGROUND:Tangshen Formula (TSF) is a traditional Chinese medicine for the treatment of diabetic kidney disease (DKD). Liver-type fatty acid binding protein (L-FABP) is expressed in various tissues, including the kidney, where it is known as urinary L-FABP. Other studies demonstrated that urinary L-FABP may be a usefu...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/s12906-016-1228-4

    authors: Yang X,Zhang B,Lu X,Yan M,Wen Y,Zhao T,Li P

    更新日期:2016-07-26 00:00:00

  • The acute diuretic effect of an ethanolic fraction of Phyllanthus amarus (Euphorbiaceae) in rats involves prostaglandins.

    abstract:BACKGROUND:Phyllanthus amarus (Schum & Thonn), a plant belonging to the family of Euphorbiaceae is used in Ivorian traditional medicine to treat cardiovascular disorders such as hypertension. However, although this plant has been described as a diuretic agent, the underlying mechanism remains unclear. Therefore, the ai...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-018-2158-0

    authors: Yao AN,Kamagaté M,Amonkan AK,Chabert P,Kpahé F,Koffi C,Kouamé MN,Auger C,Kati-Coulibaly S,Schini-Kerth V,Die-Kakou H

    更新日期:2018-03-15 00:00:00

  • Isolation, characterization and antimicrobial evaluation of a novel compound N-octacosan 7β ol, from Fumaria parviflora Lam.

    abstract:BACKGROUND:Fumaria parviflora Lam. (Fumaraceae) is widely used in traditional as well as folkloric system of medicine from ancient. It is commonly known as 'Pitpapra' or 'Shahtrah' in Indian traditional system of medicine and used for treating numerous ailments like diarrhea, fever, influenza, blood purifier and other ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-98

    authors: Jameel M,Islamuddin M,Ali A,Afrin F,Ali M

    更新日期:2014-03-12 00:00:00

  • Neuroprotective effect of Demethoxycurcumin, a natural derivative of Curcumin on rotenone induced neurotoxicity in SH-SY 5Y Neuroblastoma cells.

    abstract:BACKGROUND:Mitochondrial dysfunction and oxidative stress are the main toxic events leading to dopaminergic neuronal death in Parkinson's disease (PD) and identified as vital objective for therapeutic intercession. This study investigated the neuro-protective effects of the demethoxycurcumin (DMC), a derivative of curc...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1720-5

    authors: Ramkumar M,Rajasankar S,Gobi VV,Dhanalakshmi C,Manivasagam T,Justin Thenmozhi A,Essa MM,Kalandar A,Chidambaram R

    更新日期:2017-04-18 00:00:00

  • In vitro biological assessment of Berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects.

    abstract:BACKGROUND:Berberis vulgaris is a well known plant with traditional herbal medical history. The aims of this study was to bioscreen and compare the in vitro biological activity (antioxidant, cholinergic, antidaibetic and the anticancer) of barberry crude extract and berberine active compound. METHODS:The effect of B. ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-218

    authors: Abd El-Wahab AE,Ghareeb DA,Sarhan EE,Abu-Serie MM,El Demellawy MA

    更新日期:2013-09-05 00:00:00

  • Pingchuan formula improves asthma via restoration of the Th17/Treg balance in a mouse model.

    abstract:BACKGROUND:Pingchuan Formula (PCF) is a traditional Chinese recipe. PCF improves chronic airway inflammation by correcting the imbalance of T-helper cell ratio. The purpose of this study was to investigate the effect of PCF on pathological changes in the lungs of asthmatic mice in terms of Treg/Th17 balance. METHODS:A...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0755-8

    authors: Liu F,Yu J,Bai L,Xue Z,Zhang X

    更新日期:2015-07-16 00:00:00

  • Effect of dietary honey on intestinal microflora and toxicity of mycotoxins in mice.

    abstract:BACKGROUND:Bee honey is a functional food which has a unique composition, antimicrobial properties and bifidogenic effect. In order to assess whether honey can inhibit the toxic effect of mycotoxins, the present study was undertaken. METHODS:Production of biomass and toxins by Aspergillus parasiticus and Aspergillus o...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-6-6

    authors: Ezz El-Arab AM,Girgis SM,Hegazy EM,Abd El-Khalek AB

    更新日期:2006-03-14 00:00:00

  • Kinsenoside inhibits the inflammatory mediator release in a type-II collagen induced arthritis mouse model by regulating the T cells responses.

    abstract:BACKGROUND:Anoectochilus formosanus has been used as a Chinese folk medicine and is known as the "King of medicine" in Chinese society due to its versatile pharmacological effects such as anti-hypertension, anti-diabetes, anti-heart disease, anti-lung and liver diseases, anti-nephritis and anti-Rheumatoid arthritis. Ki...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1054-8

    authors: Hsiao HB,Hsieh CC,Wu JB,Lin H,Lin WC

    更新日期:2016-02-25 00:00:00

  • Anti-diarrheal and anti-inflammatory activities of aqueous extract of the aerial part of Rubia cordifolia.

    abstract:BACKGROUND:In Shaanxi province, China, the aqueous extract of Rubia cordifolia's aerial part (AERCAP) is traditionally used to manage diarrhea. However, there is no scientific evidence to verify the safety and efficacy of its use. The aim of this study was to investigate the anti-diarrheal and anti-inflammatory effects...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1527-9

    authors: Gong XP,Sun YY,Chen W,Guo X,Guan JK,Li DY,Du G

    更新日期:2017-01-05 00:00:00

  • Screening of anti-dengue activity in methanolic extracts of medicinal plants.

    abstract:BACKGROUND:Dengue fever regardless of its serotypes has been the most prevalent arthropod-borne viral diseases among the world population. The development of a dengue vaccine is complicated by the antibody-dependent enhancement effect. Thus, the development of a plant-based antiviral preparation promises a more potenti...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-12-3

    authors: Tang LI,Ling AP,Koh RY,Chye SM,Voon KG

    更新日期:2012-01-13 00:00:00

  • TRPV1 channel inhibition contributes to the antinociceptive effects of Croton macrostachyus extract in mice.

    abstract:BACKGROUND:Previous study showed that extracts from Croton macrostachyus (Euphorbiaceae) exhibit analgesic effects in acute pain models. The present study evaluates the antinociceptive properties of the methanol/methylene chloride extract (MECM) of the stem bark of this plant using mice models of persistent inflammator...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0816-z

    authors: Nguelefack TB,Dutra RC,Paszcuk AF,de Andrade EL,Calixto JB

    更新日期:2015-08-25 00:00:00

  • Critical pharmacokinetic and pharmacodynamic drug-herb interactions in rats between warfarin and pomegranate peel or guava leaves extracts.

    abstract:BACKGROUND:In-depth information of potential drug-herb interactions between warfarin and herbal compounds with suspected anticoagulant blood thinning effects is needed to raise caution of concomitant administration. The current study aimed to investigate the impact of co-administration of pomegranate peel and guava lea...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-019-2436-5

    authors: Alnaqeeb M,Mansor KA,Mallah EM,Ghanim BY,Idkaidek N,Qinna NA

    更新日期:2019-01-24 00:00:00

  • Effects of electroacupuncture on recovery of the electrophysiological properties of the rabbit gastrocnemius after contusion: an in vivo animal study.

    abstract:BACKGROUND:Our preliminary studies indicated that electroacupuncture (EA) at the ST36 and Ashi acupoints could promote regeneration of the rabbit gastrocnemius (GM) by improving microcirculation perfusion, promoting the recovery of myofiber structures, and inhibiting excessive fibrosis. However, the effects of EA on re...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0601-z

    authors: Liu S,Wang R,Luo D,Xu Q,Xiao C,Lin P,Yu Z,Zhao X,Cai R,Ma J,Zhang Q,Wang Y

    更新日期:2015-03-19 00:00:00

  • Chemopreventive potential of beta-Sitosterol in experimental colon cancer model--an in vitro and In vivo study.

    abstract:BACKGROUND:Asclepias curassavica Linn. is a traditional medicinal plant used by tribal people in the western ghats, India, to treat piles, gonorrhoea, roundworm infestation and abdominal tumours. We have determined the protective effect of beta-sitosterol isolated from A. curassavica in colon cancer, using in vitro and...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-10-24

    authors: Baskar AA,Ignacimuthu S,Paulraj GM,Al Numair KS

    更新日期:2010-06-04 00:00:00

  • Flavones from Erythrina falcata are modulators of fear memory.

    abstract:BACKGROUND:Flavonoids, which have been identified in a variety of plants, have been demonstrated to elicit beneficial effects on memory. Some studies have reported that flavonoids derived from Erythrina plants can provide such beneficial effects on memory. The aim of this study was to identify the flavonoids present in...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-288

    authors: de Oliveira DR,Zamberlam CR,Gaiardo RB,Rêgo GM,Cerutti JM,Cavalheiro AJ,Cerutti SM

    更新日期:2014-08-05 00:00:00

  • KOTMIN13, a Korean herbal medicine alleviates allergic inflammation in vivo and in vitro.

    abstract:BACKGROUND:The ethanol extract of KOTMIN13, composed of Inula japonica Flowers, Trichosanthes kirilowii Semen, Peucedanum praeruptorum Radix, and Allium macrostemon Bulbs, was investigated for its anti-asthmatic and anti-allergic activities. METHODS:The anti-asthmatic effects of KOTMIN13 were evaluated on ovalbumin (O...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1155-4

    authors: Lee E,Kim SG,Park NY,Park HH,Jeong KT,Choi J,Lee IH,Lee H,Kim KJ,Lee E

    更新日期:2016-06-06 00:00:00

  • Profiling of phenolic compounds and their antioxidant and anticancer activities in pandan (Pandanus amaryllifolius Roxb.) extracts from different locations of Malaysia.

    abstract:BACKGROUND:Phytochemicals and antioxidants from plant sources are of increasing interest to consumers because of their roles in the maintenance of human health. Most of the secondary metabolites of herbs are used in a number of pharmaceutical products. METHODS:Secondary metabolites composition and content of five flav...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-341

    authors: Ghasemzadeh A,Jaafar HZ

    更新日期:2013-12-01 00:00:00

  • Fungal 7-epi-10-deacetyltaxol produced by an endophytic Pestalotiopsis microspora induces apoptosis in human hepatocellular carcinoma cell line (HepG2).

    abstract:BACKGROUND:Paclitaxel (taxol) is a potent anticancer drug that is used in the treatment of a wide variety of cancerous. In the present study, we identified a taxol derivative named 7-epi-10-deacetyltaxol (EDT) from the culture of an endophytic fungus Pestalotiopsis microspora isolated from the bark of Taxodium mucronat...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1993-8

    authors: Subban K,Singh S,Subramani R,Johnpaul M,Chelliah J

    更新日期:2017-11-28 00:00:00

  • Efficacy and safety of acupuncture for functional constipation: a randomised, sham-controlled pilot trial.

    abstract:BACKGROUND:The prevalence of functional constipation (FC) is 3-27%, and FC has been reported to cause discomfort in daily life and various complications. The treatment for FC depends on laxatives, and thus, effective and non-toxic alternative treatments are needed. METHODS:We conducted a randomised, sham-controlled pa...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12906-018-2243-4

    authors: Lee HY,Kwon OJ,Kim JE,Kim M,Kim AR,Park HJ,Cho JH,Kim JH,Choi SM

    更新日期:2018-06-15 00:00:00

  • Fisetin and polymeric micelles encapsulating fisetin exhibit potent cytotoxic effects towards ovarian cancer cells.

    abstract:BACKGROUND:The anti-tumor activities of Natural compounds and their derivatives are of great interest to pharmaceutical industries. Fisetin is one of prospective natural compounds in this regard but unfortunately with poor hydrophilicity. METHODS:The effects of unmodified and modified fisetin in cultured ovarian cance...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-018-2127-7

    authors: Xiao X,Zou J,Fang Y,Meng Y,Xiao C,Fu J,Liu S,Bai P,Yao Y

    更新日期:2018-03-15 00:00:00

  • Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity.

    abstract:BACKGROUND:Originating from Africa, India, and the Middle East, frankincense oil has been important both socially and economically as an ingredient in incense and perfumes for thousands of years. Frankincense oil is prepared from aromatic hardened gum resins obtained by tapping Boswellia trees. One of the main componen...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-9-6

    authors: Frank MB,Yang Q,Osban J,Azzarello JT,Saban MR,Saban R,Ashley RA,Welter JC,Fung KM,Lin HK

    更新日期:2009-03-18 00:00:00

  • Antifungal, anti-inflammatory and cytotoxicity activities of three varieties of labisia pumila benth: from microwave obtained extracts.

    abstract:BACKGROUND:Labisia pumila, locally known as Kacip Fatimah, is a forest-floor plant that has tremendous potential in the herbal industry. It is one of the five herbal plants identified by the government as one of the national key economic areas to be developed for commercial purposes. There are three varieties of L. pum...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-20

    authors: Karimi E,Jaafar HZ,Ahmad S

    更新日期:2013-01-24 00:00:00

  • Effects of comprehensive therapy based on traditional Chinese medicine patterns in stable chronic obstructive pulmonary disease: a four-center, open-label, randomized, controlled study.

    abstract:BACKGROUND:Traditional Chinese medicine (TCM) has been used to treat chronic obstructive pulmonary disease (COPD) for many years. This study aimed to evaluate the efficacy and safety of the comprehensive therapy based on the three common TCM patterns in stable COPD patients. METHODS:A four-center, open-label randomize...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1472-6882-12-197

    authors: Li SY,Li JS,Wang MH,Xie Y,Yu XQ,Sun ZK,Ma LJ,Zhang W,Zhang HL,Cao F,Pan YC

    更新日期:2012-10-29 00:00:00