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Neuroprotective effect of Demethoxycurcumin, a natural derivative of Curcumin on rotenone induced neurotoxicity in SH-SY 5Y Neuroblastoma cells.

Abstract：

BACKGROUND:Mitochondrial dysfunction and oxidative stress are the main toxic events leading to dopaminergic neuronal death in Parkinson's disease (PD) and identified as vital objective for therapeutic intercession. This study investigated the neuro-protective effects of the demethoxycurcumin (DMC), a derivative of curcumin against rotenone induced neurotoxicity. METHODS:SH-SY5Y neuroblastoma cells are divided into four experimental groups: untreated cells, cells incubated with rotenone (100 nM), cells treated with DMC (50 nM) + rotenone (100 nM) and DMC alone treated. 24 h after treatment with rotenone and 28 h after treatment with DMC, cell viability was assessed using the MTT assay, and levels of ROS and MMP, plus expression of apoptotic protein were analysed. RESULTS:Rotenone induced cell death in SH-SY5Y cells was significantly reduced by DMC pretreatment in a dose-dependent manner, indicating the potent neuroprotective effects of DMC. Rotenone treatment significantly increases the levels of ROS, loss of MMP, release of Cyt-c and expression of pro-apoptotic markers and decreases the expression of anti-apoptotic markers. CONCLUSIONS:Even though the results of the present study indicated that the DMC may serve as a potent therapeutic agent particularly for the treatment of neurodegenerative diseases like PD, further pre-clinical and clinical studies are required.

journal_name

BMC Complement Altern Med

journal_title

BMC complementary and alternative medicine

authors

Ramkumar M,Rajasankar S,Gobi VV,Dhanalakshmi C,Manivasagam T,Justin Thenmozhi A,Essa MM,Kalandar A,Chidambaram R

doi

10.1186/s12906-017-1720-5

subject

Has Abstract

pub_date

2017-04-18 00:00:00

pages

217

issue

1

issn

1472-6882

pii

10.1186/s12906-017-1720-5

journal_volume

17

pub_type

杂志文章

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