Abstract：
BACKGROUND:The goal of this study is to determine if Rhodiola Crenulata (RC) has protective effects on mice hearts with severe sleep apnea model. METHODS:Sixty-four C57BL/6 J mice 5-6 months old were distributed into 4 groups i.e. Control group (21% O2, 24 h per day, 8 weeks, n=16); Hypoxia group (Hypoxia: 7% O2 60 s, 20% O2 alternating 60 s, 8 h per day, 8 weeks, n=16); Hypoxia+90RC and Hypoxia+270RC group (Hypoxia for 1st 4 weeks and hypoxia pretreated 90 mg/Kg and 270 mg/Kg Rhodiola Crenulata by oral gavage per day for 2nd 4 weeks, each n=16). Excised hearts from 4 groups of mice were analyzed for heart weight index changes using H&E staining, TUNEL-positive assays and Western Blotting protein. RESULTS:Cardiac widely dispersed TUNEL-positive apoptotic cells in mice hearts were less in Hypoxia+RC90 and Hypoxia+RC270 than those in Hypoxia. Compared with Hypoxia, the protein levels of Fas ligand, Fas death receptors, Fas-Associated Death Domain (FADD), activated caspase 8, and activated caspase 3 (Fas dependent apoptotic pathways) were decreased in Hypoxia+RC90, Hypoxia+RC270. The protein levels of Bad, Bax, t-Bid, activated caspase 9, activated caspase 3 (mitochondria dependent apoptotic pathway) were less in Hypoxia+RC90, Hypoxia+RC270 than those in hypoxia. The protein levels of Bcl2, Bcl-xL, p-Bad (Bcl2-realted anti-apoptotic pathway) and VEGF, p-PI3k, p-AKT (VEGF-related pro-survival pathway) were higher in Hypoxia+RC90, Hypoxia+RC270 than those in hypoxia. CONCLUSIONS:Our findings suggest that Rhodiola Crenulata have protective effects on chronic intermittent hypoxia-induced cardiac widely dispersed apoptosis via Fas-dependent and mitochondria-dependent apoptotic and VEGF-related pro-survival pathway.
journal_name
BMC Complement Altern Medjournal_title
BMC complementary and alternative medicineauthors
Lai MC,Lin JG,Pai PY,Lai MH,Lin YM,Yeh YL,Cheng SM,Liu YF,Huang CY,Lee SDdoi
10.1186/s12906-015-0698-0subject
Has Abstractpub_date
2015-06-25 00:00:00pages
198issn
1472-6882pii
10.1186/s12906-015-0698-0journal_volume
15pub_type
杂志文章abstract：BACKGROUND:In 2011 there was a strengthening of European Union (EU) legislation on the licencing of herbal products which, in the UK, resulted in the introduction of the Traditional Herbal Registration (THR) scheme. This scheme sets out standards for the safety and quality of herbal medicines and includes the provision...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-019-2494-8
更新日期：2019-04-11 00:00:00
abstract：BACKGROUND:Bee honey is a functional food which has a unique composition, antimicrobial properties and bifidogenic effect. In order to assess whether honey can inhibit the toxic effect of mycotoxins, the present study was undertaken. METHODS:Production of biomass and toxins by Aspergillus parasiticus and Aspergillus o...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-6-6
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abstract：BACKGROUND:Medicinal plants are rich source of traditional herbal medicine around the globe. Most of the plant's therapeutic properties are due to the presence of secondary bioactive compounds. METHODS:The present study analyzed the High Pressure Liquid Chromatography (HPLC) fractions of Puncia granatum (peel) extract...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-017-1766-4
更新日期：2017-05-03 00:00:00
abstract：BACKGROUND:Throughout the world, patients with chronic diseases/illnesses use complementary and alternative medicines (CAM). The use of CAM is also substantial among patients with diseases/illnesses of unknown aetiology. Chronic fatigue syndrome (CFS), also termed myalgic encephalomyelitis (ME), is no exception. Hence,...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章,评审
doi：10.1186/1472-6882-11-87
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abstract：BACKGROUND:Caesalpinia sappan L. extracts exhibit great therapeutic potential, and have been shown to have analgesic and anti-inflammatory properties. This study aimed to understand the anti-rheumatoid activity of brazilin that was isolated from ethyl acetate extract of C. sappan L. The evaluations were conducted in mi...
journal_title：BMC complementary and alternative medicine
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更新日期：2015-04-22 00:00:00
abstract：BACKGROUND:Previous publications indicate that acupuncture is efficient for the treatment of pelvic girdle pain, PGP, in pregnant women. However, the use of acupuncture for PGP is rare due to insufficient documentation of adverse effects of this treatment in this specific condition. The aim of the present work was to a...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章,随机对照试验
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更新日期：2008-06-26 00:00:00
abstract：BACKGROUND:Suo Quan Wan (SQW) is a Chinese traditional prescription that has been used in clinical treatment of lower urinary tract symptoms for centuries. However, scientific basis of SQW efficacy and mechanism is still needed. This study investigated the effect of SQW on bladder function and transient receptor potent...
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abstract：BACKGROUND:Postmenopausal women experience estrogen deficiency-related menopausal symptoms (e.g., hot flashes and mood swings) and a dramatic increase in the incidence of chronic diseases. Although estrogen-replacement therapy (ERT) can reduce mortality from cardiovascular disease and improve osteoporosis and menopausa...
journal_title：BMC complementary and alternative medicine
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doi：10.1186/1472-6882-12-260
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journal_title：BMC complementary and alternative medicine
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doi：10.1186/s12906-015-0601-z
更新日期：2015-03-19 00:00:00
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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更新日期：2015-05-22 00:00:00
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journal_title：BMC complementary and alternative medicine
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更新日期：2012-05-20 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-13-71
更新日期：2013-04-02 00:00:00
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更新日期：2013-11-09 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-12-3
更新日期：2012-01-13 00:00:00
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journal_title：BMC complementary and alternative medicine
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更新日期：2012-07-13 00:00:00
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doi：10.1186/1472-6882-13-342
更新日期：2013-12-04 00:00:00
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journal_title：BMC complementary and alternative medicine
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更新日期：2017-08-24 00:00:00
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pub_type： 杂志文章
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更新日期：2015-10-07 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章,已发布勘误
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更新日期：2019-11-07 00:00:00
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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更新日期：2016-03-22 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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更新日期：2016-01-28 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-019-2458-z
更新日期：2019-02-21 00:00:00
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更新日期：2018-02-02 00:00:00
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journal_title：BMC complementary and alternative medicine
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更新日期：2014-12-02 00:00:00
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journal_title：BMC complementary and alternative medicine
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doi：10.1186/s12906-017-1750-z
更新日期：2017-04-26 00:00:00
