Brazilin isolated from Caesalpinia sappan L. inhibits rheumatoid arthritis activity in a type-II collagen induced arthritis mouse model.

Abstract:

BACKGROUND:Caesalpinia sappan L. extracts exhibit great therapeutic potential, and have been shown to have analgesic and anti-inflammatory properties. This study aimed to understand the anti-rheumatoid activity of brazilin that was isolated from ethyl acetate extract of C. sappan L. The evaluations were conducted in mice with type-II collagen-induced arthritis (CIA). METHODS:Brazilin was purified via preparative HPLC and identified by mass spectrometry and 1H/13C NMR analysis. DBA/1J mice were divided into four groups (n=10). Three groups of mice received intradermal injections of inducer bovine type-II collagen (BTIIC; 2 mg/ml in 0.05 ml acetic acid) and 0.1 ml of booster complete Freund's adjuvant (CFA). A second injection of BTIIC with booster incomplete Freund's adjuvant (ICFA) was given subsequently after 21 days. On 22nd day, purified brazilin (10 mg/kg body weight) or the disease-modifying anti-rheumatic drug methotrexate (3 mg/kg body weight) was administered intraperitoneally daily or every three days for 21 days, respectively to two groups of mice. At the 42nd day, mice sera were collected, and the levels of pro-inflammatory cytokines and stress enzyme markers in serum were measured using standard immunoassay methods. The microstructure and morphometric analyses of the bones were assessed using high-resolution microfocal computed tomography. RESULTS:Brazilin isolated from C. sappan reduced the arthritis index score and the extent of acute inflammatory paw edema in CIA-mice. The bone mineral density was significantly (p<0.05) lower in only-CIA mice, and appeared to increase commensurate with methotrexate and brazilin administration. Brazilin prevented joint destruction, surface erosion, and enhanced bone formation as revealed by microstructural examinations. Brazilin markedly attenuated mouse CIA and reduced the serum levels of inflammatory cytokines including TNF-α, IL-1β, and IL-6. CONCLUSIONS:Brazilin purified from C. sappan L. shows protective efficacy in CIA mouse, and may be useful to treat chronic inflammatory disorders including rheumatoid arthritis.

authors

Jung EG,Han KI,Hwang SG,Kwon HJ,Patnaik BB,Kim YH,Han MD

doi

10.1186/s12906-015-0648-x

subject

Has Abstract

pub_date

2015-04-22 00:00:00

pages

124

issn

1472-6882

pii

10.1186/s12906-015-0648-x

journal_volume

15

pub_type

杂志文章
  • Retraction Note: Optimized extraction, composition, antioxidant and antimicrobial activities of exo and intracellular polysaccharides from submerged culture of Cordyceps cicadae.

    abstract::The editor has retracted this article [1] due to overlap with a previously published article [2]. Both articles also appear to use the same image representing different fungal mycelial growths. S.K. Sharma and N.S. Atri do not agree to this retraction. N. Gautam has not responded to correspondence from the editor abou...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,撤回出版物

    doi:10.1186/s12906-018-2344-0

    authors: Sharma SK,Gautam N,Atri NS

    更新日期:2018-10-16 00:00:00

  • Gene expression profiling reveals underlying molecular mechanism of hepatoprotective effect of Phyllanthus niruri on thioacetamide-induced hepatotoxicity in Sprague Dawley rats.

    abstract:BACKGROUND:The liver plays an essential role in the body by regulating several important metabolic functions. Liver injury is associated with the distortion of these functions causing many health problems. Pharmaceutical drugs treat liver disorders but cause further damage to it. Hence, herbal drugs are used worldwide ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-160

    authors: Amin ZA,Alshawsh MA,Kassim M,Ali HM,Abdulla MA

    更新日期:2013-07-05 00:00:00

  • Acupuncture as a therapeutic treatment option for threatened miscarriage.

    abstract:BACKGROUND:Threatened miscarriage involves vaginal bleeding in a pregnancy that remains viable. This is a common early pregnancy complication with increased risk factors for early pregnancy loss, preterm premature rupture of membranes (PPROM), preterm delivery, low birth weight babies and maternal antepartum haemorrhag...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-12-20

    authors: Betts D,Smith CA,Hannah DG

    更新日期:2012-03-22 00:00:00

  • Current status of Kampo medicine curricula in all Japanese medical schools.

    abstract:BACKGROUND:There have been a few but not precise surveys of the current status of traditional Japanese Kampo education at medical schools in Japan. Our aim was to identify problems and suggest solutions for a standardized Kampo educational model for all medical schools throughout Japan. METHODS:We surveyed all 80 medi...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-12-207

    authors: Arai M,Katai S,Muramatsu S,Namiki T,Hanawa T,Izumi S

    更新日期:2012-11-02 00:00:00

  • Moxibustion for cancer-related fatigue: study protocol for a randomized controlled trial.

    abstract:BACKGROUND:Cancer-related fatigue is one of the most common symptoms experienced by cancer patients, and it diminishes their quality of life. However, there is currently no confirmed standard treatment for cancer-related fatigue, and thus, many patients who suffer cancer-related fatigue seek complementary and alternati...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/s12906-017-1856-3

    authors: Kim M,Kim JE,Lee HY,Kim AR,Park HJ,Kwon OJ,Kim EJ,Park YC,Seo BK,Cho JH,Kim JH

    更新日期:2017-07-05 00:00:00

  • Current challenges and future directions for naturopathic medicine in Australia: a qualitative examination of perceptions and experiences from grassroots practice.

    abstract:BACKGROUND:Naturopaths are an increasingly significant part of the healthcare sector in Australia, yet despite their significant role there has been little research on this practitioner group. Currently the naturopathic profession in Australia is undergoing a period of rapid professional growth and change. However, to ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-15

    authors: Wardle JL,Adams J,Lui CW,Steel AE

    更新日期:2013-01-14 00:00:00

  • Treatments of pelvic girdle pain in pregnant women: adverse effects of standard treatment, acupuncture and stabilising exercises on the pregnancy, mother, delivery and the fetus/neonate.

    abstract:BACKGROUND:Previous publications indicate that acupuncture is efficient for the treatment of pelvic girdle pain, PGP, in pregnant women. However, the use of acupuncture for PGP is rare due to insufficient documentation of adverse effects of this treatment in this specific condition. The aim of the present work was to a...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1472-6882-8-34

    authors: Elden H,Ostgaard HC,Fagevik-Olsen M,Ladfors L,Hagberg H

    更新日期:2008-06-26 00:00:00

  • Anti-allodynic effect of intrathecal processed Aconitum jaluense is associated with the inhibition of microglial activation and P2X7 receptor expression in spinal cord.

    abstract:BACKGROUND:For their analgesic and anti-arthritic effects, Aconitum species have been used in folk medicine in some East Asian countries. Although their analgesic effect is attributed to its action on voltage-dependent sodium channels, they also suppress purinergic receptor expression in dorsal root ganglion neurons in...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1201-2

    authors: Yang J,Park KS,Yoon JJ,Bae HB,Yoon MH,Choi JI

    更新日期:2016-07-13 00:00:00

  • Induction of apoptosis and G2/M arrest by ampelopsin E from Dryobalanops towards triple negative breast cancer cells, MDA-MB-231.

    abstract:BACKGROUND:Several compounds isolated from Dryobalanops have been reported to exhibit cytotoxic effects to several cancer cell lines. This study investigated the cytotoxic effects, cell cycle arrest and mode of cell death in ampelopsin E-treated triple negative cells, MDA-MB-231. METHODS:Cytotoxicity of ampelopsin E, ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1328-1

    authors: Rahman NA,Yazan LS,Wibowo A,Ahmat N,Foo JB,Tor YS,Yeap SK,Razali ZA,Ong YS,Fakurazi S

    更新日期:2016-09-08 00:00:00

  • Establishing key components of yoga interventions for musculoskeletal conditions: a Delphi survey.

    abstract:BACKGROUND:Evidence suggests yoga is a safe and effective intervention for the management of physical and psychosocial symptoms associated with musculoskeletal conditions. However, heterogeneity in the components and reporting of clinical yoga trials impedes both the generalization of study results and the replication ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-196

    authors: Ward L,Stebbings S,Sherman KJ,Cherkin D,Baxter GD

    更新日期:2014-06-18 00:00:00

  • Chlorella sorokiniana induces mitochondrial-mediated apoptosis in human non-small cell lung cancer cells and inhibits xenograft tumor growth in vivo.

    abstract:BACKGROUND:Lung cancer is one of the leading causes of cancer related deaths worldwide. Marine microalgae are a source of biologically active compounds and are widely consumed as a nutritional supplement in East Asian countries. It has been reported that Chlorella or Chlorella extracts have various beneficial pharmacol...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1611-9

    authors: Lin PY,Tsai CT,Chuang WL,Chao YH,Pan IH,Chen YK,Lin CC,Wang BY

    更新日期:2017-02-01 00:00:00

  • Enzyme inhibitory and antioxidant activities of traditional medicinal plants: potential application in the management of hyperglycemia.

    abstract:BACKGROUND:Traditional Indian and Australian medicinal plant extracts were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of hyperglycemia and type 2 diabetes. The antioxidant activities were also assessed. METHODS:The eval...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-12-77

    authors: Gulati V,Harding IH,Palombo EA

    更新日期:2012-06-19 00:00:00

  • Potential biological efficacy of Pinus plant species against oxidative, inflammatory and microbial disorders.

    abstract:BACKGROUND:Traditionally, Pine has been used to treat oxidative and inflammatory disorders. The study was aimed to investigate biological potential of phytoconstituents of Pinus plant species: Pinus roxburghii, Pinus wallichiana and Pinus gerardiana using in-vitro antioxidant, anti-inflammatory and antimicrobial method...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1011-6

    authors: Sharma A,Goyal R,Sharma L

    更新日期:2016-01-28 00:00:00

  • Moxibustion for cephalic version: a feasibility randomised controlled trial.

    abstract:BACKGROUND:Moxibustion (a type of Chinese medicine which involves burning a herb close to the skin) has been used to correct a breech presentation. Evidence of effectiveness and safety from systematic reviews is encouraging although significant heterogeneity has been found among trials. We assessed the feasibility of c...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1472-6882-11-81

    authors: Do CK,Smith CA,Dahlen H,Bisits A,Schmied V

    更新日期:2011-09-26 00:00:00

  • Individualised medicine from the perspectives of patients using complementary therapies: a meta-ethnography approach.

    abstract:BACKGROUND:Personalised (or individualised) medicine in the days of genetic research refers to molecular biologic specifications in individuals and not to a response to individual patient needs in the sense of person-centred medicine. Studies suggest that patients often wish for authentically person-centred care and pe...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,meta分析

    doi:10.1186/1472-6882-13-124

    authors: Franzel B,Schwiegershausen M,Heusser P,Berger B

    更新日期:2013-06-03 00:00:00

  • The hepatoprotective activity of olive oil and Nigella sativa oil against CCl4 induced hepatotoxicity in male rats.

    abstract:BACKGROUND:Liver disease is the major cause of serious health problem leading to morbidity and mortality worldwide and the problem has increased in search for hepatotherapeutic agents from plants. The present study was designed to compare the probable hepatoprotective activity of olive oil and N. sativa oil on CCl4 ind...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1422-4

    authors: Al-Seeni MN,El Rabey HA,Zamzami MA,Alnefayee AM

    更新日期:2016-11-04 00:00:00

  • Rural Australian community pharmacists' views on complementary and alternative medicine: a pilot study.

    abstract:BACKGROUND:Complementary and alternative medicines (CAMs) are being used increasingly across the world. In Australia, community pharmacists are a major supplier of these products but knowledge of the products and interactions with other medicines is poor. Information regarding the use of CAMs by metropolitan pharmacist...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-11-103

    authors: Bushett NJ,Dickson-Swift VA,Willis JA,Wood P

    更新日期:2011-10-28 00:00:00

  • Antitumor effect of Quercetin on Y79 retinoblastoma cells via activation of JNK and p38 MAPK pathways.

    abstract:BACKGROUND:Quercetin (QCT) is a flavonol present in many vegetables, it is proved to show chemo preventive effect against lung, cervical, prostate, breast and colon cancer due to its anti-inflammatory, anti-tumor and anti-oxidant property. Looking into the reported chemo-preventive effect we speculated antitumor activi...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-2023-6

    authors: Liu H,Zhou M

    更新日期:2017-12-13 00:00:00

  • Effects of Gelam and Acacia honey acute administration on some biochemical parameters of Sprague Dawley rats.

    abstract:BACKGROUND:Since ancient times, honey has been used for medicinal purposes in many cultures; it is one of the oldest and most enduring substances used in wound management. Scientific evidence for its efficacy is widely studied, but systemic safety studies are still lacking. It is essential to study the impact of consum...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-146

    authors: Samat S,Nor NA,Nor Hussein F,Ismail WI

    更新日期:2014-05-04 00:00:00

  • Optimization of extraction parameters of PTP1β (protein tyrosine phosphatase 1β), inhibitory polyphenols, and anthocyanins from Zea mays L. using response surface methodology (RSM).

    abstract:BACKGROUND:Protein tyrosine phosphatase expressed in insulin-sensitive tissues (such as liver, muscle, and adipose tissue) has a key role in the regulation of insulin signaling and pathway activation, making protein tyrosine phosphatase a promising target for the treatment of type 2 diabetes mellitus and obesity and re...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1296-5

    authors: Hwang SH,Kwon SH,Wang Z,Kim TH,Kang YH,Lee JY,Lim SS

    更新日期:2016-08-26 00:00:00

  • Neuroprotective effect of Aronia melanocarpa extract against glutamate-induced oxidative stress in HT22 cells.

    abstract:BACKGROUND:Glutamate (an endogenous excitatory neurotransmitter) at high concentrations contributes to the development of neurodegenerative diseases. Aronia melanocarpa (A. melanocarpa) berries contain anthocyanins and have high antioxidant activities. In this study, we evaluated whether A. melanocarpa berries could pr...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1716-1

    authors: Lee HY,Weon JB,Ryu G,Yang WS,Kim NY,Kim MK,Ma CJ

    更新日期:2017-04-11 00:00:00

  • Chemical analysis, inhibition of biofilm formation and biofilm eradication potential of Euphorbia hirta L. against clinical isolates and standard strains.

    abstract:BACKGROUND:The frequent occurrences of antibiotic-resistant biofilm forming pathogens have become global issue since various measures that had been taken to curb the situation led to failure. Euphorbia hirta, is a well-known ethnomedicinal plant of Malaysia with diverse biological activities. This plant has been used w...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-346

    authors: Perumal S,Mahmud R

    更新日期:2013-12-09 00:00:00

  • Cyanidin-3-rutinoside acts as a natural inhibitor of intestinal lipid digestion and absorption.

    abstract:BACKGROUND:Cyanidin-3-rutinoside (C3R), a naturally occurring anthocyanin, possesses anti-oxidant, anti-hyperglycemic, anti-glycation and cardioprotective properties. However, its mechanisms responsible for anti-hyperlipidemic activity have not been fully identified. The aim of the study was to investigate the lipid-lo...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-019-2664-8

    authors: Thilavech T,Adisakwattana S

    更新日期:2019-09-05 00:00:00

  • Topical application of Acheflan on rat skin injury accelerates wound healing: a histopathological, immunohistochemical and biochemical study.

    abstract:BACKGROUND:Dermal wound healing involves a cascade of complex events including angiogenesis and extracellular matrix remodeling. Several groups have focused in the study of the skin wound healing activity of natural products. The phytomedicine Acheflan®, and its main active constituent is the oil from Cordia verbenacea...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0745-x

    authors: Perini JA,Angeli-Gamba T,Alessandra-Perini J,Ferreira LC,Nasciutti LE,Machado DE

    更新日期:2015-06-30 00:00:00

  • Trypanocidal activity of ethanolic extracts of Commiphora swynnertonii Burtt on Trypanosoma congolense.

    abstract:BACKGROUND:African trypanosomosis is the disease caused by extracellular protozoan parasites of the genus Trypanosoma transmitted by tsetse flies. The current study has evaluated the trypanocidal activity of Commiphora swynnertonii extracts on Trypanosoma congolense. METHODS:The effect of ethanolic stem bark and resin...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1191-0

    authors: Nagagi YP,Silayo RS,Kweka EJ

    更新日期:2016-07-08 00:00:00

  • Perceptions, use and attitudes of pharmacy customers on complementary medicines and pharmacy practice.

    abstract:BACKGROUND:Complementary medicines (CMs) are popular amongst Australians and community pharmacy is a major supplier of these products. This study explores pharmacy customer use, attitudes and perceptions of complementary medicines, and their expectations of pharmacists as they relate to these products. METHODS:Pharmac...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-10-38

    authors: Braun LA,Tiralongo E,Wilkinson JM,Spitzer O,Bailey M,Poole S,Dooley M

    更新日期:2010-07-20 00:00:00

  • Sasang constitutional types for the risk prediction of metabolic syndrome: a 14-year longitudinal prospective cohort study.

    abstract:BACKGROUND:To examine whether the use of Sasang constitutional (SC) types, such as Tae-yang (TY), Tae-eum (TE), So-yang (SY), and So-eum (SE) types, increases the accuracy of risk prediction for metabolic syndrome. METHODS:From 2001 to 2014, 3529 individuals aged 40 to 69 years participated in a longitudinal prospecti...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1936-4

    authors: Lee S,Lee SK,Kim JY,Cho N,Shin C

    更新日期:2017-09-02 00:00:00

  • DanQi Pill protects against heart failure through the arachidonic acid metabolism pathway by attenuating different cyclooxygenases and leukotrienes B4.

    abstract:BACKGROUND:Chinese herbal formulae are composed of complex components and produce comprehensive pharmacological effects. Unlike chemical drugs that have only one clear single target, the components of Chinese herbal formulae have multiple channels and targets. How to discover the pharmacological targets of Chinese herb...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-67

    authors: Wang Y,Li C,Liu Z,Shi T,Wang Q,Li D,Wu Y,Han J,Guo S,Tang B,Wang W

    更新日期:2014-02-20 00:00:00

  • In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii.

    abstract:BACKGROUND:The aim of this research was to determine the intensity and mechanisms of the cytotoxic actions of five extracts isolated from the endemic plant species Helichrysum zivojinii Černjavski & Soška (family Asteraceae) against specific cancer cell lines. In order to evaluate the sensitivity of normal immunocompet...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-36

    authors: Matić IZ,Aljančić I,Žižak Ž,Vajs V,Jadranin M,Milosavljević S,Juranić ZD

    更新日期:2013-02-18 00:00:00

  • The ameliorating effects of long-term electroacupuncture on cardiovascular remodeling in spontaneously hypertensive rats.

    abstract:BACKGROUND:The purpose of this study was to investigate the inhibitory effects of long-term electroacupuncture at BaiHui (DU20) and ZuSanLi (ST36) on cardiovascular remodeling in spontaneously hypertensive rats (SHR) and underlying mechanisms. METHODS:6-weeks-old SHR or Wistar male rats were randomly, divided into 6 g...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-118

    authors: Huo ZJ,Li Q,Tian GH,Zhou CM,Wei XH,Pan CS,Yang L,Bai Y,Zhang YY,He K,Wang CS,Li ZG,Han JY

    更新日期:2014-04-01 00:00:00