Estrogen-like activity of aqueous extract from Agrimonia pilosa Ledeb. in MCF-7 cells.

Abstract:

BACKGROUND:Postmenopausal women experience estrogen deficiency-related menopausal symptoms (e.g., hot flashes and mood swings) and a dramatic increase in the incidence of chronic diseases. Although estrogen-replacement therapy (ERT) can reduce mortality from cardiovascular disease and improve osteoporosis and menopausal symptoms, its side effects have limited recent use. This study investigated the estrogen-like activity of aqueous extract from Agrimonia pilosa Ledeb. METHODS:The estrogenic activity of A. pilosa was investigated by using several in vitro assays. The binding activity of A. pilosa on estrogen receptors was examined using a fluorescence polarization-based competitive binding assay. The proliferative activity of A. pilosa was also examined using MCF-7 cells. Furthermore, the effect of A. pilosa on the expression of 3 estrogen-dependent genes was assessed. RESULTS:Using liquid chromatography-mass spectrometry, the 3 major peaks of A. pilosa aqueous extract were identified as apigenin-hexose, luteolin-glucuronide, and apigenin-glucuronide. The aqueous extract induced the proliferation of estrogen receptor-positive MCF-7 cells (p < 0.05). A. pilosa-stimulated proliferation was blocked on adding the estrogen antagonist ICI 182,780. Moreover, A. pilosa treatment increased the mRNA expression of the estrogen-responsive genes pS2 and PR (p < 0.05). CONCLUSIONS:These results suggest A. pilosa can be used to improve estrogen deficiency-related menopausal symptoms or to treat diseases in postmenopausal women.

authors

Lee YM,Kim JB,Bae JH,Lee JS,Kim PS,Jang HH,Kim HR

doi

10.1186/1472-6882-12-260

subject

Has Abstract

pub_date

2012-12-21 00:00:00

pages

260

issn

1472-6882

pii

1472-6882-12-260

journal_volume

12

pub_type

杂志文章
  • Hydro-ethanolic leaf extract of Ziziphus abyssinica Hochst Ex A. Rich (Rhamnaceae) exhibits anti-nociceptive effects in murine models.

    abstract:BACKGROUND:Despite substantial advances in pain research and treatment, millions of people continue to suffer from pain and this has been attributed mainly to the unavailability of effective and safer analgesics. The use of plants as medicines is still widespread and plants constitute a large source of novel phytocompo...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1750-z

    authors: Boakye-Gyasi E,Henneh IT,Abotsi WKM,Ameyaw EO,Woode E

    更新日期:2017-04-26 00:00:00

  • Beneficial effect of compound essential oil inhalation on central fatigue.

    abstract:BACKGROUNDS:Although the physical and mental enhancement effect of essential oils have been proved, the beneficial effect of essential oil in central fatigue remains unclear. In this study, we extracted essential oils from nine aromatic plants to make a compound essential oil, and detected the therapeutic effect of cen...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-018-2375-6

    authors: Han C,Li F,Tian S,Liu Y,Xiao H,Wu X,Zhang W,Zhang W,Mao M

    更新日期:2018-11-26 00:00:00

  • Curcumin as a permeability enhancer enhanced the antihyperlipidemic activity of dietary green tea extract.

    abstract:BACKGROUND:Green tea has polyphenols like flavonoids and catechins; mainly epigallocatechin-3-gallate (EGCG), epicatechin gallate (ECG), epigallocatechin (EGC) and epicatechin (EC), out of which EGCG is of higher abundance. EGCG has shown preventive role in hypercholesterolemia. However, due to low oral bioavailability...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-019-2545-1

    authors: Pandit AP,Joshi SR,Dalal PS,Patole VC

    更新日期:2019-06-13 00:00:00

  • Kinsenoside inhibits the inflammatory mediator release in a type-II collagen induced arthritis mouse model by regulating the T cells responses.

    abstract:BACKGROUND:Anoectochilus formosanus has been used as a Chinese folk medicine and is known as the "King of medicine" in Chinese society due to its versatile pharmacological effects such as anti-hypertension, anti-diabetes, anti-heart disease, anti-lung and liver diseases, anti-nephritis and anti-Rheumatoid arthritis. Ki...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1054-8

    authors: Hsiao HB,Hsieh CC,Wu JB,Lin H,Lin WC

    更新日期:2016-02-25 00:00:00

  • Abalone visceral extract inhibit tumor growth and metastasis by modulating Cox-2 levels and CD8+ T cell activity.

    abstract:BACKGROUND:Abalone has long been used as a valuable food source in East Asian countries. Although the nutritional importance of abalone has been reported through in vitro and in vivo studies, there is little evidence about the potential anti-tumor effects of abalone visceral extract. The aim of the present study is to ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-10-60

    authors: Lee CG,Kwon HK,Ryu JH,Kang SJ,Im CR,Ii Kim J,Im SH

    更新日期:2010-10-20 00:00:00

  • Effects of whole-body ELECTROMYOSTIMULATION on health and performance: a systematic review.

    abstract:BACKGROUND:Whole-body electrical myostimulation (WB-EMS) is a relatively recent training methodology that has been extraordinarily used in recent years. However, there is a lack of consensus on the effectiveness of WB-EMS in the situations in which its use has been largely popularized. The objective of this systematic ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12906-019-2485-9

    authors: Pano-Rodriguez A,Beltran-Garrido JV,Hernández-González V,Reverter-Masia J

    更新日期:2019-04-24 00:00:00

  • Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity.

    abstract:BACKGROUND:Originating from Africa, India, and the Middle East, frankincense oil has been important both socially and economically as an ingredient in incense and perfumes for thousands of years. Frankincense oil is prepared from aromatic hardened gum resins obtained by tapping Boswellia trees. One of the main componen...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-9-6

    authors: Frank MB,Yang Q,Osban J,Azzarello JT,Saban MR,Saban R,Ashley RA,Welter JC,Fung KM,Lin HK

    更新日期:2009-03-18 00:00:00

  • The effects of Gamijinhae-tang on elastase/lipopolysaccharide-induced lung inflammation in an animal model of acute lung injury.

    abstract:BACKGROUND:Gamijinhae-tang (GJHT) has long been used in Korea to treat respiratory diseases. The therapeutic effect of GJHT is likely associated with its anti-inflammatory activity. However, the precise mechanisms underlying its effects are unknown. This study was conducted to evaluate the protective effects of GJHT in...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-176

    authors: Sohn SH,Jang H,Kim Y,Jang YP,Cho SH,Jung H,Jung S,Bae H

    更新日期:2013-07-16 00:00:00

  • Native musk and synthetic musk ketone strongly induced the growth repression and the apoptosis of cancer cells.

    abstract:BACKGROUND:Musk is widely used in clinical practice for its anti-cancer properties. Here, we treated various types of cancer using musk to determine which cancers are sensitive to musk treatment. We also compared effects of native musk and synthetic musk ketone in cancer cells. Furthermore, we investigated mechanisms u...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1493-2

    authors: Xu L,Cao Y

    更新日期:2016-12-08 00:00:00

  • Psychophysical responses in patients receiving a mock laser within context of an acupuncture clinical trial: an interoceptive perspective.

    abstract:BACKGROUND:The psychophysical responses induced by verum acupuncture are characterized by a constellation of unique subjective sensory responses commonly termed De Qi. Furthermore, a variety of sham interventions have been used as a control for acupuncture clinical trials. Indeed, one such control has been mock laser w...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/s12906-017-1859-0

    authors: Razavy S,Gadau M,Zhang SP,Wang FC,Bangrazi S,Berle C,Harahap M,Li T,Li WH,Zaslawski C

    更新日期:2017-07-03 00:00:00

  • Effects of JSOG-6 on protection against bone loss in ovariectomized mice through regulation of osteoblast differentiation and osteoclast formation.

    abstract:BACKGROUND:JSOG-6 is used as a traditional medicine to relieve the symptoms associated with inflammation, rheumatism, and osteoporosis in Korea. In the present study, we investigated the effects of JSOG-6 on bone loss prevention both in in vitro and in vivo as well as its underlying mechanism of action. METHODS:Protec...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-184

    authors: Chung HJ,Cho L,Shin JS,Lee J,Ha IH,Park HJ,Lee SK

    更新日期:2014-06-06 00:00:00

  • Knowledge and exposure to complementary and alternative medicine in paediatric doctors: a questionnaire survey.

    abstract:BACKGROUND:Complementary and alternative medicines are increasingly used by the general population. A survey was conducted to ascertain the knowledge of Complementary and Alternative Medicines (CAMs) amongst paediatric physicians, and whether seniority increases the likelihood of its use being considered in consultatio...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-7-38

    authors: Fountain-Polley S,Kawai G,Goldstein A,Ninan T

    更新日期:2007-11-29 00:00:00

  • Anti-adipogenic effects of the traditional herbal formula Dohongsamul-tang in 3T3-L1 adipocytes.

    abstract:BACKGROUND:Blood stasis syndrome (BSS) is a general pattern identification and refers to pathological stagnation of blood circulation, dysfunction of endothelial cells or metabolic disorder in traditional Korean medicine (TKM). Dohongsamul-Tang (DHSMT) is a well-known traditional herbal formula which used for treatment...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-2038-z

    authors: Shim EH,Lee H,Lee MS,You S

    更新日期:2017-12-19 00:00:00

  • Dichrostachys cinerea (L.) Wight et Arn (Mimosaceae) hydro-alcoholic extract action on the contractility of tracheal smooth muscle isolated from guinea-pig.

    abstract:BACKGROUND:Dichrostachys cinerea (L.) Wight et Arn. (Mimosaceae) is largely used in ethno-medically across Africa, and mainly employed for the treatment of asthma in Ivory Coast and Gabon. The paper analyses the relaxation induced by the methanolic extract of D. cinerea (Edici) in the guinea-pig trachea preparations (G...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-11-23

    authors: Aworet-Samseny RR,Souza A,Kpahé F,Konaté K,Datté JY

    更新日期:2011-03-17 00:00:00

  • The effect of freeze-dried Carica papaya leaf juice treatment on NS1 and viremia levels in dengue fever mice model.

    abstract:BACKGROUND:Carica papaya leaf juice (CPLJ) was well known for its thrombocytosis activity in rodents and dengue patients. However, the effect of CPLJ treatment on other parameters that could contribute to dengue pathogenesis such as nonstructural protein 1 (NS1) production and viremia level have never been highlighted ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-018-2390-7

    authors: Mohd Abd Razak MR,Mohmad Misnan N,Md Jelas NH,Norahmad NA,Muhammad A,Ho TCD,Jusoh B,Sastu UR,Zainol M,Wasiman MI,Muhammad H,Thayan R,Syed Mohamed AF

    更新日期:2018-12-05 00:00:00

  • Anti-inflammatory effects of Neurotoxin-Nna, a peptide separated from the venom of Naja naja atra.

    abstract:BACKGROUND:Neurotoxin-Nna (NT), an analgesic peptide separated from the venom of Naja naja atra, has reported to have an exceptional specificity to block transmission of the nerve impulse by binding to the α- subunit of the nicotinic acetylcholine receptor in the membrane. However, little information is available on th...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-86

    authors: Ruan Y,Yao L,Zhang B,Zhang S,Guo J

    更新日期:2013-04-15 00:00:00

  • Fungal vincristine from Eutypella spp - CrP14 isolated from Catharanthus roseus induces apoptosis in human squamous carcinoma cell line -A431.

    abstract:BACKGROUND:Catharanthus roseus, a medicinal plant, is known to produce secondary metabolites, vincristine and vinblastine, which are terpenoid indole alkaloids. Previously we have reported that Eutypella spp - CrP14 isolated from stem cutting of this plant had shown significant antiproliferative activity when tested in...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1299-2

    authors: Kuriakose GC,Palem PP,Jayabaskaran C

    更新日期:2016-08-22 00:00:00

  • In vitro antimicrobial activity of plants used in traditional medicine in Gurage and Silti Zones, south central Ethiopia.

    abstract:BACKGROUND:To overcome the escalating problems associated with infectious diseases and drug resistance, discovery of new antimicrobials is crucial. The present study aimed to carry out in vitro antimicrobial analysis of 15 medicinal plant species selected according to their traditional medicinal uses in Gurage and Silt...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0822-1

    authors: Teka A,Rondevaldova J,Asfaw Z,Demissew S,Van Damme P,Kokoska L,Vanhove W

    更新日期:2015-08-18 00:00:00

  • Comprehensive evaluation of gene expression signatures in response to electroacupuncture stimulation at Zusanli (ST36) acupoint by transcriptomic analysis.

    abstract:BACKGROUND:Electroacupuncture (EA) has been applied to treat and prevent diseases for years. However, molecular events happened in both the acupunctured site and the internal organs after EA stimulation have not been clarified. METHODS:Here we applied transcriptomic analysis to explore the gene expression signatures a...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1911-0

    authors: Wu JS,Lo HY,Li CC,Chen FY,Hsiang CY,Ho TY

    更新日期:2017-08-15 00:00:00

  • Mind-body practices for people living with HIV: a systematic scoping review.

    abstract:BACKGROUND:Mind-body practices are frequently used by people living with HIV to reduce symptoms and improve wellbeing. These include Tai Chi, Qigong, yoga, meditation, and all types of relaxation. Although there is substantial research on the efficacy of mind-body practices in people living with HIV, there is no summar...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-019-2502-z

    authors: Ramirez-Garcia MP,Gagnon MP,Colson S,Côté J,Flores-Aranda J,Dupont M

    更新日期:2019-06-11 00:00:00

  • Chemical analysis, inhibition of biofilm formation and biofilm eradication potential of Euphorbia hirta L. against clinical isolates and standard strains.

    abstract:BACKGROUND:The frequent occurrences of antibiotic-resistant biofilm forming pathogens have become global issue since various measures that had been taken to curb the situation led to failure. Euphorbia hirta, is a well-known ethnomedicinal plant of Malaysia with diverse biological activities. This plant has been used w...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-346

    authors: Perumal S,Mahmud R

    更新日期:2013-12-09 00:00:00

  • Antimicrobial activity against oral pathogens and immunomodulatory effects and toxicity of geopropolis produced by the stingless bee Melipona fasciculata Smith.

    abstract:BACKGROUND:Native bees of the tribe Meliponini produce a distinct kind of propolis called geopropolis. Although many pharmacological activities of propolis have already been demonstrated, little is known about geopropolis, particularly regarding its antimicrobial activity against oral pathogens. The present study aimed...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-11-108

    authors: Liberio SA,Pereira AL,Dutra RP,Reis AS,Araújo MJ,Mattar NS,Silva LA,Ribeiro MN,Nascimento FR,Guerra RN,Monteiro-Neto V

    更新日期:2011-11-04 00:00:00

  • Anti-platelet activity of panaxatriol saponins is mediated by suppression of intracellular calcium mobilization and ERK2/p38 activation.

    abstract:BACKGROUND:Increased platelet aggregation is implicated in the pathogenesis of ischemic stroke and anti-platelet strategy may contribute to its therapy. Panaxatriol saponin (PTS), the main components extracted from Panax notoginseng, has been shown to be efficacious in the prevention and treatment of ischemic stroke in...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1160-7

    authors: Qi H,Huang Y,Yang Y,Dou G,Wan F,Zhang W,Yang H,Wang L,Wu C,Li L

    更新日期:2016-06-08 00:00:00

  • A new, easy-to-make pectin-honey hydrogel enhances wound healing in rats.

    abstract:BACKGROUND:Honey, alone or in combination, has been used for wound healing since ancient times and has reemerged as a topic of interest in the last decade. Pectin has recently been investigated for its use in various biomedical applications such as drug delivery, skin protection, and scaffolding for cells. The aim of t...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1769-1

    authors: Giusto G,Vercelli C,Comino F,Caramello V,Tursi M,Gandini M

    更新日期:2017-05-16 00:00:00

  • Increased first and second pulse harmonics in Tai Chi Chuan practitioners.

    abstract:BACKGROUND:Tai Chi Chuan (TCC) is known to be a good calisthenics for people. This study examined the relationship between pulse harmonics and autonomic nervous modulation in TCC practitioners. METHODS:Power spectral measures of right pulse wave and heart rate variability (HRV) measures were compared between TCC pract...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1058-4

    authors: Lu WA,Chen YS,Kuo CD

    更新日期:2016-02-29 00:00:00

  • Effect of root-extracts of Ficus benghalensis (Banyan) in memory, anxiety, muscle co-ordination and seizure in animal models.

    abstract:BACKGROUND:Ficus benghalensis L. (Banyan) is a commonly found tree in Eastern Nepal. Its different plant parts are used for various neurological ailments. This study was performed in mice to see its effects in various neuropharmacological parameters. METHODS:Passive-avoidance (memory), Open-field (anxiety), Pentobarbi...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1413-5

    authors: Panday DR,Rauniar GP

    更新日期:2016-11-03 00:00:00

  • Anticancer and apoptotic effects on cell proliferation of diosgenin isolated from Costus speciosus (Koen.) Sm.

    abstract:BACKGROUND:Diosgenin, a naturally occurring steroid saponin found abundantly in C. speciosus, is a well-known precursor of various synthetic steroidal drugs that are extensively used in the pharmaceutical industry. METHODS:The present study was conducted to evaluate the in vitro anticancer and apoptotic effects on cel...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0836-8

    authors: Selim S,Al Jaouni S

    更新日期:2015-09-02 00:00:00

  • Anti-inflammatory and cytotoxic activities of the extracts, fractions, and chemical constituents isolated from Luehea ochrophylla Mart.

    abstract:BACKGROUND:Stem bark of Luehea ochrophylla (L. ochrophylla) is used by the traditional Brazilian medicine for treatment of rheumatic diseases and tumors. This study aimed to investigate inhibition of acute and chronic inflammations and cytotoxic activity of extracts, fractions, and isolated compounds from L. ochrophyll...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-019-2701-7

    authors: Araújo CRR,de Melo Silva T,Dos Santos MG,Ottoni MHF,de Souza Fagundes EM,de Sousa Fontoura H,de Melo GEBA,de Carvalho Alcântara AF

    更新日期:2019-10-28 00:00:00

  • Inhibition of autophagy enhances synergistic effects of Salidroside and anti-tumor agents against colorectal cancer.

    abstract:BACKGROUND:Various plant extracts have been suggested to be used as auxiliary agents in chemotherapy considering their anti-proliferative effect on cancer cells. However, recent reports reveal that plant extracts may function as inducers of autophagy of cancer cells. In general, autophagy confers survival advantage for...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-2046-z

    authors: Li H,Chen C

    更新日期:2017-12-16 00:00:00

  • Purification and MIC analysis of antimicrobial proteins from Cucumis sativus L. seeds.

    abstract:BACKGROUND:Cucumis sativus L. (cucumber), from the family Cucurbitaceae, is a therapeutic plant with various pharmacological benefits, broadly utilized as a part of complementary medicine (e.g., Unani, Ayurveda, Siddha, and Traditional Chinese). In light of past research discoveries, this plant had been chosen to consi...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-018-2176-y

    authors: Al Akeel R,Mateen A,Alharbi KK,Alyousef AA,Al-Mandeel HM,Syed R

    更新日期:2018-04-03 00:00:00