Abstract:
BACKGROUND:Postmenopausal women experience estrogen deficiency-related menopausal symptoms (e.g., hot flashes and mood swings) and a dramatic increase in the incidence of chronic diseases. Although estrogen-replacement therapy (ERT) can reduce mortality from cardiovascular disease and improve osteoporosis and menopausal symptoms, its side effects have limited recent use. This study investigated the estrogen-like activity of aqueous extract from Agrimonia pilosa Ledeb. METHODS:The estrogenic activity of A. pilosa was investigated by using several in vitro assays. The binding activity of A. pilosa on estrogen receptors was examined using a fluorescence polarization-based competitive binding assay. The proliferative activity of A. pilosa was also examined using MCF-7 cells. Furthermore, the effect of A. pilosa on the expression of 3 estrogen-dependent genes was assessed. RESULTS:Using liquid chromatography-mass spectrometry, the 3 major peaks of A. pilosa aqueous extract were identified as apigenin-hexose, luteolin-glucuronide, and apigenin-glucuronide. The aqueous extract induced the proliferation of estrogen receptor-positive MCF-7 cells (p < 0.05). A. pilosa-stimulated proliferation was blocked on adding the estrogen antagonist ICI 182,780. Moreover, A. pilosa treatment increased the mRNA expression of the estrogen-responsive genes pS2 and PR (p < 0.05). CONCLUSIONS:These results suggest A. pilosa can be used to improve estrogen deficiency-related menopausal symptoms or to treat diseases in postmenopausal women.
journal_name
BMC Complement Altern Medjournal_title
BMC complementary and alternative medicineauthors
Lee YM,Kim JB,Bae JH,Lee JS,Kim PS,Jang HH,Kim HRdoi
10.1186/1472-6882-12-260subject
Has Abstractpub_date
2012-12-21 00:00:00pages
260issn
1472-6882pii
1472-6882-12-260journal_volume
12pub_type
杂志文章abstract:BACKGROUND:Despite substantial advances in pain research and treatment, millions of people continue to suffer from pain and this has been attributed mainly to the unavailability of effective and safer analgesics. The use of plants as medicines is still widespread and plants constitute a large source of novel phytocompo...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-017-1750-z
更新日期:2017-04-26 00:00:00
abstract:BACKGROUNDS:Although the physical and mental enhancement effect of essential oils have been proved, the beneficial effect of essential oil in central fatigue remains unclear. In this study, we extracted essential oils from nine aromatic plants to make a compound essential oil, and detected the therapeutic effect of cen...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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journal_title:BMC complementary and alternative medicine
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abstract:BACKGROUND:Anoectochilus formosanus has been used as a Chinese folk medicine and is known as the "King of medicine" in Chinese society due to its versatile pharmacological effects such as anti-hypertension, anti-diabetes, anti-heart disease, anti-lung and liver diseases, anti-nephritis and anti-Rheumatoid arthritis. Ki...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-016-1054-8
更新日期:2016-02-25 00:00:00
abstract:BACKGROUND:Abalone has long been used as a valuable food source in East Asian countries. Although the nutritional importance of abalone has been reported through in vitro and in vivo studies, there is little evidence about the potential anti-tumor effects of abalone visceral extract. The aim of the present study is to ...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-10-60
更新日期:2010-10-20 00:00:00
abstract:BACKGROUND:Whole-body electrical myostimulation (WB-EMS) is a relatively recent training methodology that has been extraordinarily used in recent years. However, there is a lack of consensus on the effectiveness of WB-EMS in the situations in which its use has been largely popularized. The objective of this systematic ...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章,meta分析
doi:10.1186/s12906-019-2485-9
更新日期:2019-04-24 00:00:00
abstract:BACKGROUND:Originating from Africa, India, and the Middle East, frankincense oil has been important both socially and economically as an ingredient in incense and perfumes for thousands of years. Frankincense oil is prepared from aromatic hardened gum resins obtained by tapping Boswellia trees. One of the main componen...
journal_title:BMC complementary and alternative medicine
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更新日期:2009-03-18 00:00:00
abstract:BACKGROUND:Gamijinhae-tang (GJHT) has long been used in Korea to treat respiratory diseases. The therapeutic effect of GJHT is likely associated with its anti-inflammatory activity. However, the precise mechanisms underlying its effects are unknown. This study was conducted to evaluate the protective effects of GJHT in...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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journal_title:BMC complementary and alternative medicine
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更新日期:2016-12-08 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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更新日期:2014-06-06 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-7-38
更新日期:2007-11-29 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-017-2038-z
更新日期:2017-12-19 00:00:00
abstract:BACKGROUND:Dichrostachys cinerea (L.) Wight et Arn. (Mimosaceae) is largely used in ethno-medically across Africa, and mainly employed for the treatment of asthma in Ivory Coast and Gabon. The paper analyses the relaxation induced by the methanolic extract of D. cinerea (Edici) in the guinea-pig trachea preparations (G...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-11-23
更新日期:2011-03-17 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-018-2390-7
更新日期:2018-12-05 00:00:00
abstract:BACKGROUND:Neurotoxin-Nna (NT), an analgesic peptide separated from the venom of Naja naja atra, has reported to have an exceptional specificity to block transmission of the nerve impulse by binding to the α- subunit of the nicotinic acetylcholine receptor in the membrane. However, little information is available on th...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-13-86
更新日期:2013-04-15 00:00:00
abstract:BACKGROUND:Catharanthus roseus, a medicinal plant, is known to produce secondary metabolites, vincristine and vinblastine, which are terpenoid indole alkaloids. Previously we have reported that Eutypella spp - CrP14 isolated from stem cutting of this plant had shown significant antiproliferative activity when tested in...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-016-1299-2
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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journal_title:BMC complementary and alternative medicine
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-13-346
更新日期:2013-12-09 00:00:00
abstract:BACKGROUND:Native bees of the tribe Meliponini produce a distinct kind of propolis called geopropolis. Although many pharmacological activities of propolis have already been demonstrated, little is known about geopropolis, particularly regarding its antimicrobial activity against oral pathogens. The present study aimed...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-11-108
更新日期:2011-11-04 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-016-1160-7
更新日期:2016-06-08 00:00:00
abstract:BACKGROUND:Honey, alone or in combination, has been used for wound healing since ancient times and has reemerged as a topic of interest in the last decade. Pectin has recently been investigated for its use in various biomedical applications such as drug delivery, skin protection, and scaffolding for cells. The aim of t...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-017-1769-1
更新日期:2017-05-16 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-016-1058-4
更新日期:2016-02-29 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-016-1413-5
更新日期:2016-11-03 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-015-0836-8
更新日期:2015-09-02 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-019-2701-7
更新日期:2019-10-28 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-017-2046-z
更新日期:2017-12-16 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-018-2176-y
更新日期:2018-04-03 00:00:00