Abstract:
BACKGROUND:Our preliminary studies indicated that electroacupuncture (EA) at the ST36 and Ashi acupoints could promote regeneration of the rabbit gastrocnemius (GM) by improving microcirculation perfusion, promoting the recovery of myofiber structures, and inhibiting excessive fibrosis. However, the effects of EA on recovery of the electrophysiological properties of the GM after contusion are not yet clear. Thus, the purpose of this study was to investigate the effects of EA at the Zusanli (ST36) and Ashi acupoints with regard to recovery of the electrophysiological properties of the rabbit GM after contusion. METHODS:Forty-five rabbits were randomly divided into three groups: normal, contusion, and EA. After an acute GM contusion was produced (in rabbits in the contusion and EA groups), rabbits in the EA group were treated with electrostimulation at the ST36 and Ashi acupoints with 0.4 mA (2 Hz) for 15 min. The contusion group received no EA treatment. At different time points (7, 14, and 28 days) after contusion, we performed surface electromyography (EMG) and measured the nerve conduction velocity (NCV) of the GM and the GM branch of the tibial nerve. We also examined acetylcholinesterase (AchE) and Agrin expression in the neuromuscular junction (NMJ) via immunohistochemistry. RESULTS:Compared with the contusion group, the EMG amplitude and NCV in rabbits in the EA group were significantly higher at all time points after contusion. AchE and Agrin expression in the EA group were significantly higher than those in the contusion group. CONCLUSIONS:Our results showed that EA at the ST36 and Ashi acupoints effectively promoted recovery of the electrophysiological properties of the rabbit GM after contusion. The effects of EA were realized by promotion of the regeneration of myofibers and nerve fibers, as well as acceleration of NMJ reconstruction by upregulation of AchE and Agrin expression in the motor endplate area.
journal_name
BMC Complement Altern Medjournal_title
BMC complementary and alternative medicineauthors
Liu S,Wang R,Luo D,Xu Q,Xiao C,Lin P,Yu Z,Zhao X,Cai R,Ma J,Zhang Q,Wang Ydoi
10.1186/s12906-015-0601-zsubject
Has Abstractpub_date
2015-03-19 00:00:00pages
69issn
1472-6882pii
10.1186/s12906-015-0601-zjournal_volume
15pub_type
杂志文章abstract:BACKGROUND:The purpose of this study was to investigate the inhibitory effects of long-term electroacupuncture at BaiHui (DU20) and ZuSanLi (ST36) on cardiovascular remodeling in spontaneously hypertensive rats (SHR) and underlying mechanisms. METHODS:6-weeks-old SHR or Wistar male rats were randomly, divided into 6 g...
journal_title:BMC complementary and alternative medicine
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abstract:BACKGROUND:Flavonoid-rich aqueous fraction of methanolic extract of Hibiscus sabdariffa calyx was evaluated for its anti-hepatotoxic activities in streptozotocin-induced diabetic Wistar rats. METHODS:Diabetes Mellitus was induced in Wistar rats by a single i.p injection of 80 mg/kg b.w. streptozotocin (STZ) dissolved ...
journal_title:BMC complementary and alternative medicine
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更新日期:2013-11-05 00:00:00
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更新日期:2014-12-17 00:00:00
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更新日期:2018-06-14 00:00:00
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更新日期:2014-10-07 00:00:00
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更新日期:2010-07-20 00:00:00
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更新日期:2013-11-09 00:00:00
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更新日期:2009-12-12 00:00:00
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更新日期:2014-09-25 00:00:00
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更新日期:2018-01-31 00:00:00
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更新日期:2013-08-15 00:00:00
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更新日期:2019-06-20 00:00:00
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更新日期:2018-01-29 00:00:00
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更新日期:2017-03-07 00:00:00