Abstract：
BACKGROUND:Flavonoid-rich extracts from the mature roots of Scutellaria baicalensis have been shown to exhibit antiproliferative effects on various cancer cell lines. We assessed the ability of an ethanolic extract of S. baicalensis root to inhibit the proliferation of malignant glioma cells. METHODS:Cell lines derived from primary and recurrent brain tumors from the same patient and cells selected for resistance to the chemotherapeutic agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) were used to identify antiproliferative effects of this extract when used alone and in conjunction with BCNU. RESULTS AND DISCUSSION:Results indicated that Scutellaria baicalensis not only inhibits cellular growth in recurrent and drug resistant brain tumor cell lines, but also demonstrates an increased inhibitory effect when used in conjunction with BCNU. CONCLUSION:The results of this study support the efficacy of S. baicalensis as an anticancer agent for glioblastomas multiforme and a potential adjuvant treatment to current chemotherapeutic agents used in the treatment of both primary and recurrent GBMs. Further studies of the effects of individual flavonoids alone and in combination with each other and with currently used therapies are needed.
journal_name
BMC Complement Altern Medjournal_title
BMC complementary and alternative medicineauthors
Scheck AC,Perry K,Hank NC,Clark WDdoi
10.1186/1472-6882-6-27subject
Has Abstractpub_date
2006-08-16 00:00:00pages
27issn
1472-6882pii
1472-6882-6-27journal_volume
6pub_type
杂志文章abstract：BACKGROUND:Clinacanthus nutans extracts have been consumed by the cancer patients with the hope that the extracts can kill cancers more effectively than conventional chemotherapies. Our previous study reported its anti-inflammatory effects were caused by inhibiting Toll-like Receptor-4 (TLR-4) activation. However, we a...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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abstract：BACKGROUND:Weight gain is common after breast cancer (BC) treatment and may increase the risk of disease recurrence. Complementary medicine (CM) use is high amongst BC patients. This paper describes the use of CM from a cross-sectional self-administered survey on prevalence and management of weight after BC. METHODS:U...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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abstract：BACKGROUND:Morella serata is a South African medicinal plant used in the treatment of microbial infections and to enhance male sexual performance. There is dearth of information in scientific literature on its efficacy and safety. METHODS:In the present study, the root extracts were investigated for the phytochemicals...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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更新日期：2018-04-02 00:00:00
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-12-266
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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pub_type： 杂志文章,随机对照试验
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更新日期：2015-05-08 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-6-6
更新日期：2006-03-14 00:00:00
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journal_title：BMC complementary and alternative medicine
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更新日期：2017-11-16 00:00:00
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journal_title：BMC complementary and alternative medicine
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更新日期：2018-06-07 00:00:00
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journal_title：BMC complementary and alternative medicine
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doi：10.1186/s12906-016-1328-1
更新日期：2016-09-08 00:00:00
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章,随机对照试验
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更新日期：2014-07-01 00:00:00
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journal_title：BMC complementary and alternative medicine
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更新日期：2017-09-05 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-14-358
更新日期：2014-09-25 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-019-2735-x
更新日期：2019-11-12 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章,meta分析
doi：10.1186/1472-6882-13-124
更新日期：2013-06-03 00:00:00
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-14-112
更新日期：2014-03-28 00:00:00
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-14-118
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:Radiotherapy is of critical importance in the treatment of breast cancer. However, not all patients derive therapeutic benefit and some breast cancers are resistant to the treatment, and are thus evidenced with prospective distant metastatic spread and local recurrence. In this study, we investigated the pot...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-016-1088-y
更新日期：2016-03-31 00:00:00
