Abstract：
BACKGROUND:Liver steatosis was caused by lipid accumulation in the liver. Alisma orientale (AO) is recognized as a promising candidate with therapeutic efficacy for the treatment of nonalcoholic fatty liver disease (NAFLD). HepG2 hepatocyte cell line is commonly used for liver disease cell model. METHOD:The HepG2 cells were cultured with the NEFAs mixture (oleic and palmitic acids, 2:1 ratio) for 24 h to induce hepatic steatosis. Then different doses of Alisma orientale extract (AOE) was treated to HepG2 for 24 h. Incubated cells were used for further experiments. RESULTS:The AOE showed inhibitory effects on lipid accumulation in the Oil Red O staining and Nile red staining tests with no cytotoxicity at a concentration of 300 μg/mL. Fatty acid synthase (FASN) and acetyl-CoA carboxylase 1 (ACC1) mRNA and protein expression level were down-regulated after AOE treatment. Bcl-2 associated X protein (Bax) and c-Jun N-terminal kinase (JNK) mRNA expression level were decreased as well as p-JNK (activated form of JNK), Bax, cleaved caspase-9, caspase-3 protein expression level. Anti-apopototic B-cell lymphoma 2 (Bcl-2) protein level increased after AOE treatment. In addition, inflammatory protein expression including p-p65, p65, COX-2 and iNOS were inhibited by AOE treatment. CONCLUSION:The results suggest that AOE has anti-steatosis effects that involve lipogenesis, anti-lipoapoptosis, and anti-inflammation in the NEFA-induced NAFLD pathological cell model.
journal_name
BMC Complement Altern Medjournal_title
BMC complementary and alternative medicineauthors
Jeong HS,Cho YH,Kim KH,Kim Y,Kim KS,Na YC,Park J,Lee IS,Lee JH,Jang HJdoi
10.1186/s12906-016-1181-2subject
Has Abstractpub_date
2016-07-25 00:00:00pages
239issn
1472-6882pii
10.1186/s12906-016-1181-2journal_volume
16pub_type
杂志文章abstract：BACKGROUND:The purpose of this study was to investigate the inhibitory effects of long-term electroacupuncture at BaiHui (DU20) and ZuSanLi (ST36) on cardiovascular remodeling in spontaneously hypertensive rats (SHR) and underlying mechanisms. METHODS:6-weeks-old SHR or Wistar male rats were randomly, divided into 6 g...
journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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abstract：:ᅟ. ...
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journal_title：BMC complementary and alternative medicine
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更新日期：2017-04-11 00:00:00
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journal_title：BMC complementary and alternative medicine
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更新日期：2017-09-11 00:00:00
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journal_title：BMC complementary and alternative medicine
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更新日期：2019-01-29 00:00:00
