Antidiabetic activities of aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves in streptozotocin-induced diabetic rats.

Abstract:

BACKGROUND:Moringa stenopetala has been used in traditional health systems to treat diabetes mellitus. The aim of this study was to investigate the antidiabetic activity of aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves in streptozotocin (STZ) induced diabetic rats. METHODS:The aqueous ethanol extract and n-butanol fraction of Moringa stenopetala leaves hydroalcoholic (500 mg/kg body weight) and metformin (150 mg/kg body weight) were administered to diabetic rats. Blood glucose, lipid profiles, liver and kidney function were examined after 14 days of experiment. Histopathological profile of the pancreas was also observed in diabetic rats at the end of study. An oral sucrose challenge test was also carried out to assess the post prandial effect of the extract. RESULTS:Oral administration of the aqueous ethanol and n-butanol extracts of Moringa stenopetala leaves (500 mg/kg body weight) and metformin (150 mg/kg) significantly reduced blood glucose level (P<0.05), improved serum lipid profiles, liver enzymes and kidney functions in diabetic rats after 14 days. The extracts also improved damage of islet of Langerhan's in diabetic rats. The plant material reduced the post-prandial glucose level (P<0.001) at the dose of 750 mg/kg. CONCLUSION:These findings revealed that both the aqueous ethanol and n-butanol extracts of Moringa stenopetala leaves possess antihyperglycemic and antihyperlipidemic properties, and alleviate STZ-induced pancreatic damage in diabetic rats. The beneficial effects of plant material in inhibition of diabetes-induced complications are being investigated.

authors

Toma A,Makonnen E,Mekonnen Y,Debella A,Adisakwattana S

doi

10.1186/s12906-015-0779-0

subject

Has Abstract

pub_date

2015-07-18 00:00:00

pages

242

issn

1472-6882

pii

10.1186/s12906-015-0779-0

journal_volume

15

pub_type

杂志文章
  • Traditional medicine practices among community members with diabetes mellitus in Northern Tanzania: an ethnomedical survey.

    abstract:BACKGROUND:Diabetes is a growing burden in sub-Saharan Africa where traditional medicines (TMs) remain a primary form of healthcare in many settings. In Tanzania, TMs are frequently used to treat non-communicable diseases, yet little is known about TM practices for non-communicable diseases like diabetes. METHODS:Betw...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1262-2

    authors: Lunyera J,Wang D,Maro V,Karia F,Boyd D,Omolo J,Patel UD,Stanifer JW,Comprehensive Kidney Disease Assessment For Risk factors, epidemiology, Knowledge, and Attitudes (CKD AFRiKA) Study.

    更新日期:2016-08-11 00:00:00

  • Acupuncture as a therapeutic treatment option for threatened miscarriage.

    abstract:BACKGROUND:Threatened miscarriage involves vaginal bleeding in a pregnancy that remains viable. This is a common early pregnancy complication with increased risk factors for early pregnancy loss, preterm premature rupture of membranes (PPROM), preterm delivery, low birth weight babies and maternal antepartum haemorrhag...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-12-20

    authors: Betts D,Smith CA,Hannah DG

    更新日期:2012-03-22 00:00:00

  • Antioxidant potential of bitter cumin (Centratherum anthelminticum (L.) Kuntze) seeds in in vitro models.

    abstract:BACKGROUND:Bitter cumin (Centratherum anthelminticum (L.) Kuntze), is a medicinally important plant. Earlier, we have reported phenolic compounds, antioxidant, and anti-hyperglycemic, antimicrobial activity of bitter cumin. In this study we have further characterized the antioxidative activity of bitter cumin extracts ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-11-40

    authors: Ani V,Naidu KA

    更新日期:2011-05-20 00:00:00

  • Fermented barley and soybean (BS) mixture enhances intestinal barrier function in dextran sulfate sodium (DSS)-induced colitis mouse model.

    abstract:BACKGROUND:Inflammatory bowel disease (IBD) is characterized by chronic or relapsing immune system activation and inflammation within the gastrointestinal tract. The lack of safety and efficacy of standard therapies, the use of food supplements for managing IBD is increasing, and many studies have reported that various...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1479-0

    authors: Woo JK,Choi S,Kang JH,Kim DE,Hurh BS,Jeon JE,Kim SY,Oh SH

    更新日期:2016-12-03 00:00:00

  • Effects of hydroalcoholic extract of Solidago chilensis Meyen on nociception and hypernociception in rodents.

    abstract:BACKGROUND:Solidago chilensis (syn. microglossa) is a plant from the Asteraceae family widely distributed in South America and used to treat inflammatory diseases. In 2009, it was listed as one of the native medicinal herbal plants used in the Brazilian public health system. In addition to its anti-inflammatory propert...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-019-2478-8

    authors: Malpezzi-Marinho ELA,Molska GR,Freire LIGP,Silva CI,Tamura EK,Berro LF,Parada CA,Marinho EAV

    更新日期:2019-03-20 00:00:00

  • Anti-inflammatory activities of astringent persimmons (Diospyros kaki Thunb.) stalks of various cultivar types based on the stages of maturity in the Gyeongnam province.

    abstract:BACKGROUND:Natural products play a significant role in human health in relation to the prevention and treatment of inflammatory conditions. One of the plants with great medicinal potentials is Diospyros kaki which is mainly cultivated in Asian countries including Korea, Japan, and China. Astringent D. kaki is a wild sp...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-019-2659-5

    authors: Choi J,Kim MJ,Komakech R,Jung H,Kang Y

    更新日期:2019-09-23 00:00:00

  • The effectiveness of integrative medicine interventions on pain and anxiety in cardiovascular inpatients: a practice-based research evaluation.

    abstract:BACKGROUND:Pain and anxiety occurring from cardiovascular disease are associated with long-term health risks. Integrative medicine (IM) therapies reduce pain and anxiety in small samples of hospitalized cardiovascular patients within randomized controlled trials; however, practice-based effectiveness research has been ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-486

    authors: Johnson JR,Crespin DJ,Griffin KH,Finch MD,Rivard RL,Baechler CJ,Dusek JA

    更新日期:2014-12-13 00:00:00

  • Preclinical evaluation of safety and potential of black hellebore extracts for cancer treatment.

    abstract:BACKGROUND:The therapeutic use of Helleborus niger L. is manifold due to its specific phytochemical composition. Two compound groups, the ranunculin derivates including protoanemonin and the steroidal saponins, are also associated with toxicity (genotoxicity, disintegration of membrane structures). Therefore, in vitro ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-019-2517-5

    authors: Felenda JE,Turek C,Mörbt N,Herrick A,Müller MB,Stintzing FC

    更新日期:2019-05-21 00:00:00

  • Effect of the Chinese traditional prescription Suo Quan Wan on TRPV1 expression in the bladder of rats with bladder outlet obstruction.

    abstract:BACKGROUND:Suo Quan Wan (SQW) is a Chinese traditional prescription that has been used in clinical treatment of lower urinary tract symptoms for centuries. However, scientific basis of SQW efficacy and mechanism is still needed. This study investigated the effect of SQW on bladder function and transient receptor potent...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0898-7

    authors: Lai H,Tan B,Liang Z,Yan Q,Lian Q,Wu Q,Huang P,Cao H

    更新日期:2015-12-01 00:00:00

  • The inhibitory effect of tongxieyaofang on rats with post infectious irritable bowel syndrome through regulating colonic par-2 receptor.

    abstract:BACKGROUND:The aims of this study were to evaluate the effect and mechanism of a traditional Chinese medicine formula: Tongxieyaofang (TXYF) on Rats with Post Infectious Irritable Bowel Syndrome (PI-IBS). METHODS:SD male rats in adult were used to model PI-IBS and treated with TXYF at three dosage for 14 consecutive d...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-246

    authors: Hu X,Zhang X,Han B,Bei W

    更新日期:2013-10-02 00:00:00

  • In vitro biological assessment of Berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects.

    abstract:BACKGROUND:Berberis vulgaris is a well known plant with traditional herbal medical history. The aims of this study was to bioscreen and compare the in vitro biological activity (antioxidant, cholinergic, antidaibetic and the anticancer) of barberry crude extract and berberine active compound. METHODS:The effect of B. ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-218

    authors: Abd El-Wahab AE,Ghareeb DA,Sarhan EE,Abu-Serie MM,El Demellawy MA

    更新日期:2013-09-05 00:00:00

  • Impact of phenolic composition on hepatoprotective and antioxidant effects of four desert medicinal plants.

    abstract:BACKGROUND:Flavonoids and other polyphenols play a protective role in liver diseases and possess a high antioxidant capacity. OBJECTIVE:To compare and evaluate the antioxidant and hepatotoprotective activities of 4 deserts plants, Fagonia indica Burm. f., Calotropis procera R.Br., Zygophylum hamiense Schweinf. and Sal...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0919-6

    authors: Shehab NG,Abu-Gharbieh E,Bayoumi FA

    更新日期:2015-11-09 00:00:00

  • Copaifera langsdorffii oleoresin and its isolated compounds: antibacterial effect and antiproliferative activity in cancer cell lines.

    abstract:BACKGROUND:Natural products display numerous therapeutic properties (e.g., antibacterial activity), providing the population with countless benefits. Therefore, the search for novel biologically active, naturally occurring compounds is extremely important. The present paper describes the antibacterial action of the Cop...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0961-4

    authors: Abrão F,de Araújo Costa LD,Alves JM,Senedese JM,de Castro PT,Ambrósio SR,Veneziani RC,Bastos JK,Tavares DC,Martins CH

    更新日期:2015-12-21 00:00:00

  • Complementary and alternative medicine use among patients with cancer in Mongolia: a National hospital survey.

    abstract:BACKGROUND:Complementary and alternative medicine (CAM) use is popular in former Soviet Central Asian countries including Mongolia. However, no studies are available on CAM use among patients with cancer in countries of this region. The aim of this research is to describe the prevalence and patterns of CAM use by patie...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1576-8

    authors: Oyunchimeg B,Hwang JH,Ahmed M,Choi S,Han D

    更新日期:2017-01-19 00:00:00

  • Current challenges and future directions for naturopathic medicine in Australia: a qualitative examination of perceptions and experiences from grassroots practice.

    abstract:BACKGROUND:Naturopaths are an increasingly significant part of the healthcare sector in Australia, yet despite their significant role there has been little research on this practitioner group. Currently the naturopathic profession in Australia is undergoing a period of rapid professional growth and change. However, to ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-15

    authors: Wardle JL,Adams J,Lui CW,Steel AE

    更新日期:2013-01-14 00:00:00

  • Non-alcoholic fatty liver disease among sasang constitutional types: a population-based study in Korea.

    abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and is highly prevalent in populations with metabolic conditions such as obesity and type II diabetes. Specific types of Sasang constitution can act as a risk factor for metabolic diseases, but there are no studies ad...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0925-8

    authors: Lee SK,Yoon DW,Lee SW,Kim JY,Kim JK,Shin C

    更新日期:2015-11-07 00:00:00

  • Factors associated with herbal use among urban multiethnic primary care patients: a cross-sectional survey.

    abstract:BACKGROUND:The use of herbal supplements in the United States has become increasingly popular. The prevalence of herbal use among primary care patients varies in previous studies; the pattern of herbal use among urban racially/ethnically diverse primary care patients has not been widely studied. The primary objectives ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-4-18

    authors: Kuo GM,Hawley ST,Weiss LT,Balkrishnan R,Volk RJ

    更新日期:2004-12-02 00:00:00

  • Role of ellagic acid in regulation of apoptosis by modulating novel and atypical PKC in lymphoma bearing mice.

    abstract:BACKGROUND:Protein kinase C regulates various cellular processes including cell proliferation, cell adhesion, apoptosis, angiogenesis, invasion, and metastasis. Activation of different PKC isozymes results in distinct cellular responses. Novel PKCs are mainly involved in apoptotic process. Atypical PKC subfamily plays ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0810-5

    authors: Mishra S,Vinayak M

    更新日期:2015-08-15 00:00:00

  • Effect of transcutaneous acupoint electrical stimulation on propofol sedation: an electroencephalogram analysis of patients undergoing pituitary adenomas resection.

    abstract:BACKGROUND:Transcutaneous acupoint electrical stimulation (TAES) as a needleless acupuncture has the same effect like traditional manual acupuncture. The combination of TAES and anesthesia has been proved valid in enhancing the anesthetic effects but its mechanisms are still not clear. METHODS:In this study, we invest...

    journal_title:BMC complementary and alternative medicine

    pub_type: 临床试验,杂志文章

    doi:10.1186/s12906-016-1008-1

    authors: Liu X,Wang J,Wang B,Wang YH,Teng Q,Yan J,Wang S,Wan Y

    更新日期:2016-01-27 00:00:00

  • Antioxidant potential, in vitro cytotoxicity and apoptotic effect induced by crude organic extract of Anthracophyllum lateritium against RD sarcoma cells.

    abstract:BACKGROUND:Macrofungi have an established history of use in traditional oriental medicine. Anthracophyllum lateritium is a terrestrial macrofungus found in the dry zone forest reserves in Sri Lanka. Yet there are no scientific reports on bioactive properties of this species. Hence, the current study was aimed at determ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0924-9

    authors: Fernando DM,Wijesundera RL,Soysa P,de Silva D,Nanayakkara CM

    更新日期:2015-11-06 00:00:00

  • Thai plants with high antioxidant levels, free radical scavenging activity, anti-tyrosinase and anti-collagenase activity.

    abstract:BACKGROUND:Ultraviolet radiation from sunlight induces overproduction of reactive oxygen species (ROS) resulting in skin photoaging and hyperpigmentation disorders. Novel whitening and anti-wrinkle compounds from natural products have recently become of increasing interest. The purpose of this study was to find product...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1994-7

    authors: Chatatikun M,Chiabchalard A

    更新日期:2017-11-09 00:00:00

  • Antimicrobial activity against oral pathogens and immunomodulatory effects and toxicity of geopropolis produced by the stingless bee Melipona fasciculata Smith.

    abstract:BACKGROUND:Native bees of the tribe Meliponini produce a distinct kind of propolis called geopropolis. Although many pharmacological activities of propolis have already been demonstrated, little is known about geopropolis, particularly regarding its antimicrobial activity against oral pathogens. The present study aimed...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-11-108

    authors: Liberio SA,Pereira AL,Dutra RP,Reis AS,Araújo MJ,Mattar NS,Silva LA,Ribeiro MN,Nascimento FR,Guerra RN,Monteiro-Neto V

    更新日期:2011-11-04 00:00:00

  • Gualou Xiebai decoction inhibits cardiac dysfunction and inflammation in cardiac fibrosis rats.

    abstract:BACKGROUND:Gualou Xiebai Decoction (GXD) is a well-known traditional Chinese recipe. It has been used to treat cardiovascular disorders for nearly two thousand years. But there is a lack of reports on cardiac fibrosis and underlying mechanism. METHODS:Myocardial infarction was performed by ligation of left anterior de...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1012-5

    authors: Ding YF,Peng YR,Shen H,Shu L,Wei YJ

    更新日期:2016-02-04 00:00:00

  • Anti-inflammatory and immuno-modulatory studies on LC-MS characterised methanol extract of Gentiana kurroo Royle.

    abstract:BACKGROUND:In ayurvedic traditional medicine Gentiana kurroo Royle (family; Gentianaceae) is used to treat several metabolic diseases. This plant is rich in various compounds belonging to flavonoids and glycosides. Till now little work has been carried out on immunomodulatory and anti-inflammatory potential of this pla...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1593-7

    authors: Mubashir K,Ganai BA,Ghazanfar K,Akbar S,Rah B,Tantry M,Masood A

    更新日期:2017-01-28 00:00:00

  • In vitro determination of the anti-aging potential of four southern African medicinal plants.

    abstract:BACKGROUND:Aging is an inevitable process for all living organisms. During this process reactive oxygen species generation is increased which leads to the activation of hyaluronidase, collagenase and elastase, which can further contribute to skin aging. Four southern African medicinal plants; Clerodendrum glabrum, Scho...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-304

    authors: Ndlovu G,Fouche G,Tselanyane M,Cordier W,Steenkamp V

    更新日期:2013-11-05 00:00:00

  • Anti-inflammatory effects of Sanguisorbae Radix water extract on the suppression of mast cell degranulation and STAT-1/Jak-2 activation in BMMCs and HaCaT keratinocytes.

    abstract:BACKGROUND:Sanguisorbae Radix (SR) is a well-known herbal medicine used to treat inflammatory disease and skin burns in Asia. In addition, it is used to treat many types of allergic skin diseases, including urticaria, eczema, and allergic dermatitis. SR has been reported to exhibit anti-wrinkle, anti-oxidant, and anti-...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1317-4

    authors: Yang JH,Yoo JM,Cho WK,Ma JY

    更新日期:2016-09-06 00:00:00

  • Activity guided isolation and modification of juglone from Juglans regia as potent cytotoxic agent against lung cancer cell lines.

    abstract:BACKGROUND:Juglans regia has been found to exhibit significant anticancer activity against various human cancer cell lines. This study was undertaken to isolate the active chemical constituent (Juglone) and to investigate its cytotoxic activity along with its various analogs against different human cancer cell lines. ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0920-0

    authors: Zhang XB,Zou CL,Duan YX,Wu F,Li G

    更新日期:2015-11-03 00:00:00

  • Euphorbia humifusa Willd exerts inhibition of breast cancer cell invasion and metastasis through inhibition of TNFα-induced MMP-9 expression.

    abstract:BACKGROUND:Breast cancer is the most common type of malignancy in women worldwide. Euphorbia humifusa Willd (EuH) is a plant that is widely used as a traditional medicine. However, no systemic studies on the anti-cancer effects of EuH have been reported. The aim of this study is to evaluate the anti-metastatic effect o...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1404-6

    authors: Shin SY,Kim CG,Jung YJ,Jung Y,Jung H,Im J,Lim Y,Lee YH

    更新日期:2016-10-24 00:00:00

  • Topical application of Acheflan on rat skin injury accelerates wound healing: a histopathological, immunohistochemical and biochemical study.

    abstract:BACKGROUND:Dermal wound healing involves a cascade of complex events including angiogenesis and extracellular matrix remodeling. Several groups have focused in the study of the skin wound healing activity of natural products. The phytomedicine Acheflan®, and its main active constituent is the oil from Cordia verbenacea...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0745-x

    authors: Perini JA,Angeli-Gamba T,Alessandra-Perini J,Ferreira LC,Nasciutti LE,Machado DE

    更新日期:2015-06-30 00:00:00

  • Inhalation of honey reduces airway inflammation and histopathological changes in a rabbit model of ovalbumin-induced chronic asthma.

    abstract:BACKGROUND:Honey is widely used in folk medicine to treat cough, fever, and inflammation. In this study, the effect of aerosolised honey on airway tissues in a rabbit model of ovalbumin (OVA)-induced asthma was investigated. The ability of honey to act either as a rescuing agent in alleviating asthma-related symptoms o...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-176

    authors: Kamaruzaman NA,Sulaiman SA,Kaur G,Yahaya B

    更新日期:2014-05-29 00:00:00