Abstract:
BACKGROUND:The aims of this study were to evaluate the effect and mechanism of a traditional Chinese medicine formula: Tongxieyaofang (TXYF) on Rats with Post Infectious Irritable Bowel Syndrome (PI-IBS). METHODS:SD male rats in adult were used to model PI-IBS and treated with TXYF at three dosage for 14 consecutive days, and then visceral sensation and the frequency of stool in PI-IBS rats were investigated. In addition, the contents of SP, TNF- α and IL-6 in colonic mucosal were analyzed by ELISA. Moreover faecal serine protease activity and PAR-2 mRNA expression were measured by ultraviolet spectrophotometry and RT-PCR, respectively. RESULTS:Our study showed that TXYF attenuated visceral hyperalgesia and inhibited stool frequency in Campylobacter-stimulated Post Infectious Irritable Bowel Syndrome (PI-IBS) rats. Furthermore, TXYF decreased the colonic SP, TNF- α and IL-6 content in PI-IBS rats. In addition, the up-regulated colonic mucosa PAR-2 mRNA expression in PI-IBS rats was significantly suppressed by orally TXYF. CONCLUSIONS:TXYF attenuated PI-IBS symptom by attenuating behavioral hyperalgesia and anti-diarrhea, the underlying mechanism was mediated by inhibiting PAR-2 receptor expression, reducing the levels of SP, TNF- α and IL-6 in colonic mucosa and decreasing faecal serine protease activity.
journal_name
BMC Complement Altern Medjournal_title
BMC complementary and alternative medicineauthors
Hu X,Zhang X,Han B,Bei Wdoi
10.1186/1472-6882-13-246subject
Has Abstractpub_date
2013-10-02 00:00:00pages
246issn
1472-6882pii
1472-6882-13-246journal_volume
13pub_type
杂志文章abstract:BACKGROUND:Free radical stress leads to tissue injury and can eventually to arthritis, atherosclerosis, diabetes mellitus, neurodegenerative diseases and carcinogenesis. Several studies are ongoing worldwide to find natural antioxidants of plant origin. We assessed the in-vitro antioxidant activities and screened the p...
journal_title:BMC complementary and alternative medicine
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doi:10.1186/1472-6882-11-69
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更新日期:2015-03-10 00:00:00
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doi:10.1186/s12906-015-0845-7
更新日期:2015-09-18 00:00:00
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更新日期:2019-11-20 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-04-30 00:00:00
abstract::Following publication of the original article [1], the author reported that Tables 3 and 4 were incorrect due to a production error. ...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章,已发布勘误
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journal_title:BMC complementary and alternative medicine
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更新日期:2019-03-20 00:00:00
abstract:BACKGROUND:Several compounds isolated from Dryobalanops have been reported to exhibit cytotoxic effects to several cancer cell lines. This study investigated the cytotoxic effects, cell cycle arrest and mode of cell death in ampelopsin E-treated triple negative cells, MDA-MB-231. METHODS:Cytotoxicity of ampelopsin E, ...
journal_title:BMC complementary and alternative medicine
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doi:10.1186/s12906-016-1328-1
更新日期:2016-09-08 00:00:00
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更新日期:2011-08-22 00:00:00
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更新日期:2018-06-20 00:00:00
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更新日期:2013-02-18 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章,meta分析
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更新日期:2019-01-23 00:00:00
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journal_title:BMC complementary and alternative medicine
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更新日期:2010-07-14 00:00:00
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更新日期:2013-07-05 00:00:00
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更新日期:2013-11-26 00:00:00
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journal_title:BMC complementary and alternative medicine
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更新日期:2015-08-18 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-13-86
更新日期:2013-04-15 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-14-20
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journal_title:BMC complementary and alternative medicine
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更新日期:2016-07-13 00:00:00
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更新日期:2016-07-07 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-14-340
更新日期:2014-09-19 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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更新日期:2016-06-06 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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更新日期:2019-06-20 00:00:00