The inhibitory effect of tongxieyaofang on rats with post infectious irritable bowel syndrome through regulating colonic par-2 receptor.

Abstract:

BACKGROUND:The aims of this study were to evaluate the effect and mechanism of a traditional Chinese medicine formula: Tongxieyaofang (TXYF) on Rats with Post Infectious Irritable Bowel Syndrome (PI-IBS). METHODS:SD male rats in adult were used to model PI-IBS and treated with TXYF at three dosage for 14 consecutive days, and then visceral sensation and the frequency of stool in PI-IBS rats were investigated. In addition, the contents of SP, TNF- α and IL-6 in colonic mucosal were analyzed by ELISA. Moreover faecal serine protease activity and PAR-2 mRNA expression were measured by ultraviolet spectrophotometry and RT-PCR, respectively. RESULTS:Our study showed that TXYF attenuated visceral hyperalgesia and inhibited stool frequency in Campylobacter-stimulated Post Infectious Irritable Bowel Syndrome (PI-IBS) rats. Furthermore, TXYF decreased the colonic SP, TNF- α and IL-6 content in PI-IBS rats. In addition, the up-regulated colonic mucosa PAR-2 mRNA expression in PI-IBS rats was significantly suppressed by orally TXYF. CONCLUSIONS:TXYF attenuated PI-IBS symptom by attenuating behavioral hyperalgesia and anti-diarrhea, the underlying mechanism was mediated by inhibiting PAR-2 receptor expression, reducing the levels of SP, TNF- α and IL-6 in colonic mucosa and decreasing faecal serine protease activity.

authors

Hu X,Zhang X,Han B,Bei W

doi

10.1186/1472-6882-13-246

subject

Has Abstract

pub_date

2013-10-02 00:00:00

pages

246

issn

1472-6882

pii

1472-6882-13-246

journal_volume

13

pub_type

杂志文章
  • Preliminary study of the antioxidant properties of flowers and roots of Pyrostegia venusta (Ker Gawl) Miers.

    abstract:BACKGROUND:Free radical stress leads to tissue injury and can eventually to arthritis, atherosclerosis, diabetes mellitus, neurodegenerative diseases and carcinogenesis. Several studies are ongoing worldwide to find natural antioxidants of plant origin. We assessed the in-vitro antioxidant activities and screened the p...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-11-69

    authors: Roy P,Amdekar S,Kumar A,Singh V

    更新日期:2011-08-23 00:00:00

  • Inhibitory effect of Yukmijihwang-tang, a traditional herbal formula against testosterone-induced benign prostatic hyperplasia in rats.

    abstract:BACKGROUND:Yukmijihwang-tang, a traditional herbal formula, has been used for treating disorder, diabetic mellitus and neurosis in China (Liu-wei-di-huang-tang in Chinese), Japan (Lokumijio-to in Japanese) and Korea for many years. In this study, we investigated the effects of Yukmijihwang-tang water extract (YJT) on t...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-12-48

    authors: Shin IS,Lee MY,Ha HK,Seo CS,Shin HK

    更新日期:2012-04-20 00:00:00

  • Samsoeum water extract attenuates allergic airway inflammation via modulation of Th1/Th2 cytokines and decrease of iNOS expression in asthmatic mice.

    abstract:BACKGROUND:Samsoeum has long been used in Korea and other Asian countries as a traditional medicine to treat various diseases. In the present study, we investigated the antiasthma effect of the herbal medicine Samsoeum water extract (SSEW) using an in vivo ovalbumin (OVA)-induced asthmatic model. METHODS:Female BALB/c...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0561-3

    authors: Jeon WY,Shin IS,Shin HK,Lee MY

    更新日期:2015-03-10 00:00:00

  • Studies on the purification of polypeptide from sika antler plate and activities of antitumor.

    abstract:BACKGROUND:We isolated a novel monomeric peptide from antler plate polypeptide (APP) of sika deer and found that it inhibited rat breast cancer cell proliferation and telomerase activity. METHODS:The molecular mass and purity of this polypeptide was determined by ultra performance liquid chromatography (UPLC) and Bruk...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0845-7

    authors: Hu W,Qi L,Tian YH,Hu R,Wu L,Meng XY

    更新日期:2015-09-18 00:00:00

  • Antrodia cinnamomea extract inhibits the proliferation of tamoxifen-resistant breast cancer cells through apoptosis and skp2/microRNAs pathway.

    abstract:BACKGROUND:Breast cancer is the most common cancer in women and affects 1.38 million women worldwide per year. Antiestrogens such as tamoxifen, a selective estrogen receptor (ER) modulator, are widely used in clinics to treat ER-positive breast tumors. However, remissions of breast cancer are often followed by resistan...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-018-2204-y

    authors: Lin YS,Lin YY,Yang YH,Lin CL,Kuan FC,Lu CN,Chang GH,Tsai MS,Hsu CM,Yeh RA,Yang PR,Lee IY,Shu LH,Cheng YC,Liu HT,Lee KD,Chang DC,Wu CY

    更新日期:2018-05-09 00:00:00

  • Inhibitory effects of ChondroT and its constituent herbs on RANKL-induced osteoclastogenesis.

    abstract:BACKGROUND:ChondroT is a complex herbal medicine consisting of water extracts of Ostericum koreanum (Maxim.) Kitag., Lonicera japonica Thunb., Angelica gigas Nakai, Clematis manshurica Rupr., and Phellodendron amurense Rupr. (6:4:4:4:3). Previous studies have reported that ChondroT possesses chondroprotective and anti-...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-019-2737-8

    authors: Guo RH,Kim SJ,Choi CH,Na CS,Kang BY,Kim YR

    更新日期:2019-11-20 00:00:00

  • A protocol of histone modification-based mechanistic study of acupuncture in patients with stable angina pectoris.

    abstract:BACKGROUND:Angina pectoris (Angina) is a medical condition related to myocardial ischemia. Although acupuncture has been widely accepted as a clinical approach for angina, there is no sufficient evidence of its effectiveness against this syndrome, and its mechanisms have not yet been well elucidated. We develop this pr...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12906-015-0653-0

    authors: Wang N,Lu SF,Chen H,Wang JF,Fu SP,Hu CJ,Yang Y,Liang FR,Zhu BM

    更新日期:2015-04-30 00:00:00

  • Correction to: Acacia hydaspica R. Parker ameliorates cisplatin induced oxidative stress, DNA damage and morphological alterations in rat pulmonary tissue.

    abstract::Following publication of the original article [1], the author reported that Tables 3 and 4 were incorrect due to a production error. ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,已发布勘误

    doi:10.1186/s12906-019-2658-6

    authors: Afsar T,Razak S,Almajwal A,Khan MR

    更新日期:2019-11-07 00:00:00

  • In vitro determination of the anti-aging potential of four southern African medicinal plants.

    abstract:BACKGROUND:Aging is an inevitable process for all living organisms. During this process reactive oxygen species generation is increased which leads to the activation of hyaluronidase, collagenase and elastase, which can further contribute to skin aging. Four southern African medicinal plants; Clerodendrum glabrum, Scho...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-304

    authors: Ndlovu G,Fouche G,Tselanyane M,Cordier W,Steenkamp V

    更新日期:2013-11-05 00:00:00

  • Establishing key components of yoga interventions for musculoskeletal conditions: a Delphi survey.

    abstract:BACKGROUND:Evidence suggests yoga is a safe and effective intervention for the management of physical and psychosocial symptoms associated with musculoskeletal conditions. However, heterogeneity in the components and reporting of clinical yoga trials impedes both the generalization of study results and the replication ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-196

    authors: Ward L,Stebbings S,Sherman KJ,Cherkin D,Baxter GD

    更新日期:2014-06-18 00:00:00

  • Effects of hydroalcoholic extract of Solidago chilensis Meyen on nociception and hypernociception in rodents.

    abstract:BACKGROUND:Solidago chilensis (syn. microglossa) is a plant from the Asteraceae family widely distributed in South America and used to treat inflammatory diseases. In 2009, it was listed as one of the native medicinal herbal plants used in the Brazilian public health system. In addition to its anti-inflammatory propert...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-019-2478-8

    authors: Malpezzi-Marinho ELA,Molska GR,Freire LIGP,Silva CI,Tamura EK,Berro LF,Parada CA,Marinho EAV

    更新日期:2019-03-20 00:00:00

  • Induction of apoptosis and G2/M arrest by ampelopsin E from Dryobalanops towards triple negative breast cancer cells, MDA-MB-231.

    abstract:BACKGROUND:Several compounds isolated from Dryobalanops have been reported to exhibit cytotoxic effects to several cancer cell lines. This study investigated the cytotoxic effects, cell cycle arrest and mode of cell death in ampelopsin E-treated triple negative cells, MDA-MB-231. METHODS:Cytotoxicity of ampelopsin E, ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1328-1

    authors: Rahman NA,Yazan LS,Wibowo A,Ahmat N,Foo JB,Tor YS,Yeap SK,Razali ZA,Ong YS,Fakurazi S

    更新日期:2016-09-08 00:00:00

  • An evaluation of the completeness of safety reporting in reports of complementary and alternative medicine trials.

    abstract:BACKGROUND:Adequate reporting of safety in publications of randomized controlled trials (RCTs) is a pre-requisite for accurate and comprehensive profile evaluation of conventional as well as complementary and alternative medicine (CAM) treatments. Clear and concise information on the definition, frequency, and severity...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-11-67

    authors: Turner LA,Singh K,Garritty C,Tsertsvadze A,Manheimer E,Wieland LS,Galipeau J,Moher D

    更新日期:2011-08-22 00:00:00

  • Hand-foot-mouth disease and use of steroids, intravenous immunoglobulin, and traditional Chinese herbs in a tertiary hospital in Shantou, China.

    abstract:BACKGROUND:In contrast to the guidelines of World Health Organization (WHO) and United States-Centers for Disease Control and prevention (US-CDC), the Chinese national guidelines recommend the use of steroids, intravenous immunoglobulin (IVIG), or traditional Chinese herbs (TCHs) in hand-foot-mouth disease (HFMD) manag...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-018-2259-9

    authors: Zhang D,Chen J,Ba-Thein W

    更新日期:2018-06-20 00:00:00

  • In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii.

    abstract:BACKGROUND:The aim of this research was to determine the intensity and mechanisms of the cytotoxic actions of five extracts isolated from the endemic plant species Helichrysum zivojinii Černjavski & Soška (family Asteraceae) against specific cancer cell lines. In order to evaluate the sensitivity of normal immunocompet...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-36

    authors: Matić IZ,Aljančić I,Žižak Ž,Vajs V,Jadranin M,Milosavljević S,Juranić ZD

    更新日期:2013-02-18 00:00:00

  • Twelve Chinese herbal preparations for the treatment of depression or depressive symptoms in cancer patients: a systematic review and meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:Patients with cancer are vulnerable to depression or other depressive conditions. The aim of this paper was to evaluate the efficacy and safety of Chinese herbal medicine (CHM) for the treatment of depression or depressive symptoms in cancer patients. METHODS:CENTRAL, MEDLINE, EMBASE, PsycINFO, CNKI, VIP, S...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12906-019-2441-8

    authors: Li M,Chen Z,Liu Z,Zhang N,Liu J,Wang H,Wang W,Liang Y,Chen J,Liu Z,Li Y,Zhai S

    更新日期:2019-01-23 00:00:00

  • Antimicrobial potential of two traditional herbometallic drugs against certain pathogenic microbial species.

    abstract:BACKGROUND:Mineral based preparations are widely used for centuries as antimicrobial agents. However, the efficacy and the mode of action of mineral based preparations are uncertain due to the insufficient antimicrobial studies. Arogyawardhana Vati (AV) and Manikya Rasa (MR) are such two Rasashastra herbo-minerallic dr...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1336-1

    authors: Wijenayake AU,Abayasekara CL,Pitawala HM,Bandara BM

    更新日期:2016-09-15 00:00:00

  • Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic activities against Anisakis simplex and Hymenolepis nana of yakuchinone A from Alpinia oxyphylla.

    abstract:BACKGROUND:Alpinia oxyphylla is a common remedy in traditional Chinese medicine. Yakuchinone A is a major constituent of A. oxyphylla and exhibits anti-inflammatory, antitumor, antibacterial, and gastric protective activities. METHODS:Antioxidant and antitumor characteristics of yakuchinone A in skin cancer cells as w...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-237

    authors: Lin RJ,Yen CM,Chou TH,Chiang FY,Wang GH,Tseng YP,Wang L,Huang TW,Wang HC,Chan LP,Ding HY,Liang CH

    更新日期:2013-09-26 00:00:00

  • The use of complementary and alternative medicine by patients with diabetes mellitus in Bahrain: a cross-sectional study.

    abstract:BACKGROUND:CAM use is widespread, especially among patients with diabetes. The Gulf States have a high prevalence of diabetes, alongside a long tradition of CAM use. The aim of this study is to establish the prevalence of CAM use among patients with diabetes mellitus in Bahrain and to examine the characteristics of the...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-10-35

    authors: Khalaf AJ,Whitford DL

    更新日期:2010-07-14 00:00:00

  • Impact of phenolic composition on hepatoprotective and antioxidant effects of four desert medicinal plants.

    abstract:BACKGROUND:Flavonoids and other polyphenols play a protective role in liver diseases and possess a high antioxidant capacity. OBJECTIVE:To compare and evaluate the antioxidant and hepatotoprotective activities of 4 deserts plants, Fagonia indica Burm. f., Calotropis procera R.Br., Zygophylum hamiense Schweinf. and Sal...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0919-6

    authors: Shehab NG,Abu-Gharbieh E,Bayoumi FA

    更新日期:2015-11-09 00:00:00

  • Gene expression profiling reveals underlying molecular mechanism of hepatoprotective effect of Phyllanthus niruri on thioacetamide-induced hepatotoxicity in Sprague Dawley rats.

    abstract:BACKGROUND:The liver plays an essential role in the body by regulating several important metabolic functions. Liver injury is associated with the distortion of these functions causing many health problems. Pharmaceutical drugs treat liver disorders but cause further damage to it. Hence, herbal drugs are used worldwide ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-160

    authors: Amin ZA,Alshawsh MA,Kassim M,Ali HM,Abdulla MA

    更新日期:2013-07-05 00:00:00

  • Aqueous extracts of Liriope platyphylla induced significant laxative effects on loperamide-induced constipation of SD rats.

    abstract:BACKGROUND:Liriope platyphylla has long been reported as a therapeutic drug for treatment of various human chronic diseases including inflammation, diabetes, neurodegenerative disorders, obesity, and atopic dermatitis. To investigate the laxative effects of L. platyphylla, alterations in excretion parameters, histologi...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-333

    authors: Kim JE,Lee YJ,Kwak MH,Ko J,Hong JT,Hwang DY

    更新日期:2013-11-26 00:00:00

  • Is 'mainstreaming AYUSH' the right policy for Meghalaya, northeast India?

    abstract:BACKGROUND:National policy on medical pluralism in India encourages the mainstreaming of AYUSH (Ayurveda, Yoga, Unani, Siddha, and Homeopathy) systems and the revitalization of local health traditions (LHT). In Meghalaya state in the northeast, the main LHT is its indigenous tribal traditional medicine. This paper pres...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0818-x

    authors: Albert S,Porter J

    更新日期:2015-08-18 00:00:00

  • Anti-inflammatory effects of Neurotoxin-Nna, a peptide separated from the venom of Naja naja atra.

    abstract:BACKGROUND:Neurotoxin-Nna (NT), an analgesic peptide separated from the venom of Naja naja atra, has reported to have an exceptional specificity to block transmission of the nerve impulse by binding to the α- subunit of the nicotinic acetylcholine receptor in the membrane. However, little information is available on th...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-86

    authors: Ruan Y,Yao L,Zhang B,Zhang S,Guo J

    更新日期:2013-04-15 00:00:00

  • Antihyperglycemic action of rhodiola-aqeous extract in type1-like diabetic rats.

    abstract:BACKGROUND:Rhodiola rosea (Rhodiola) is a plant in the Crassulaceae family that grows in cold regions of the world. It is mainly used in clinics as an adaptogen. Recently, it has been mentioned that Rhodiola increases plasma β-endorphin to lower blood pressure. Thus, the present study aims to investigate the antidiabet...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-20

    authors: Niu CS,Chen LJ,Niu HS

    更新日期:2014-01-13 00:00:00

  • Anti-allodynic effect of intrathecal processed Aconitum jaluense is associated with the inhibition of microglial activation and P2X7 receptor expression in spinal cord.

    abstract:BACKGROUND:For their analgesic and anti-arthritic effects, Aconitum species have been used in folk medicine in some East Asian countries. Although their analgesic effect is attributed to its action on voltage-dependent sodium channels, they also suppress purinergic receptor expression in dorsal root ganglion neurons in...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1201-2

    authors: Yang J,Park KS,Yoon JJ,Bae HB,Yoon MH,Choi JI

    更新日期:2016-07-13 00:00:00

  • Active chemical fractions of stem bark extract of Khaya grandifoliola C.DC and Entada africana Guill. et Perr. synergistically protect primary rat hepatocytes against paracetamol-induced damage.

    abstract:BACKGROUND:Khaya grandifoliola (Meliaceae) and Entada africana (Fabaceae) are traditionally used in Bamun (a western tribe of Cameroon) traditional medicine for the treatment of liver related diseases. In this study, the synergistic hepatoprotective effect of respective active fractions of the plants were investigated ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1169-y

    authors: Njayou FN,Kouam AF,Simo BF,Tchana AN,Moundipa PF

    更新日期:2016-07-07 00:00:00

  • Cytotoxicity of four Aframomum species (A. arundinaceum, A. alboviolaceum, A. kayserianum and A. polyanthum) towards multi-factorial drug resistant cancer cell lines.

    abstract:BACKGROUND:The search for natural products as potential cytotoxic agents has yielded promising candidates. However multidrug resistance (MDR) is still a major hurdle for patients receiving chemotherapy. In the present study, we evaluated the cytotoxicity of the methanol extracts of four dietary Aframomum plant species ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-340

    authors: Kuete V,Ango PY,Yeboah SO,Mbaveng AT,Mapitse R,Kapche GD,Ngadjui BT,Efferth T

    更新日期:2014-09-19 00:00:00

  • KOTMIN13, a Korean herbal medicine alleviates allergic inflammation in vivo and in vitro.

    abstract:BACKGROUND:The ethanol extract of KOTMIN13, composed of Inula japonica Flowers, Trichosanthes kirilowii Semen, Peucedanum praeruptorum Radix, and Allium macrostemon Bulbs, was investigated for its anti-asthmatic and anti-allergic activities. METHODS:The anti-asthmatic effects of KOTMIN13 were evaluated on ovalbumin (O...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1155-4

    authors: Lee E,Kim SG,Park NY,Park HH,Jeong KT,Choi J,Lee IH,Lee H,Kim KJ,Lee E

    更新日期:2016-06-06 00:00:00

  • Mining the deep Red-Sea brine pool microbial community for anticancer therapeutics.

    abstract:BACKGROUND:Microbial species in the brine pools of the Red Sea and the brine pool-seawater interfaces are exposed to high temperature, high salinity, low oxygen levels and high concentrations of heavy metals. As adaptations to these harsh conditions require a large suite of secondary metabolites, these microbes have a ...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-019-2554-0

    authors: Esau L,Zhang G,Sagar S,Stingl U,Bajic VB,Kaur M

    更新日期:2019-06-20 00:00:00