Abstract:
:1. The effects of the alpha-beta-adrenergic antagonist labetalol on the activation of human platelets by adrenaline and other aggregating stimuli have been investigated. 2. Labetalol inhibited platelet aggregation and secretion induced by collagen and the second phase of aggregation caused by ADP, platelet activating factor, adrenaline and ionophore A23187. Adrenaline-induced platelet activation was inhibited by the lowest labetalol concentration. The response to Na arachidonate was minimally affected and the arachidonate-induced thromboxane B2 generation was only partially prevented. 3. The pre-incubation with low concentration of ionophore A23187 overcame labetalol's inhibition of collagen-induced platelet aggregation. 4. Labetalol did not influence intraplatelet cyclic AMP levels. 5. The present investigation provided evidences that the modulation of human platelet function by labetalol could be related also to a decreased Ca2+ availability.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Anfossi G,Trovati M,Lanzio M,Mularoni E,Massucco P,Emanuelli Gdoi
10.1111/j.1440-1681.1988.tb01099.xsubject
Has Abstractpub_date
1988-06-01 00:00:00pages
437-48issue
6eissn
0305-1870issn
1440-1681journal_volume
15pub_type
杂志文章abstract::1. Hepatic resection with concomitant periods of ischaemia and reperfusion (I/R) is required to perform reduced-size liver (RSL) transplantation procedures, such as living donor or split liver transplantation. Although a great deal of progress has been made using these types of surgical procedures, a significant numbe...
journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1681.2007.04640.x
更新日期:2007-09-01 00:00:00
abstract::1. Activation of peripheral chemoreceptors with KCN in the working heart-brainstem preparation from young male Wistar rats (70-90 g) increases phrenic (PNA; +105 +/- 18%) and thoracic (tSNA; +44 +/- 6%) sympathetic nerve activity compared with baseline and reduces heart rate (HR; from 377 +/- 27 to 83 +/- 6 b.p.m.). 2...
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-03-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章,随机对照试验
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更新日期:2011-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-07-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1992.tb00444.x
更新日期:1992-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-10-01 00:00:00
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doi:10.1111/j.1440-1681.1983.tb00177.x
更新日期:1983-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1046/j.1440-1681.1999.02981.x
更新日期:1999-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1995-08-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
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更新日期:1995-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.1977.tb02675.x
更新日期:1977-07-01 00:00:00
abstract::1. Epidermal growth factor is a potent mitogen that causes natriuresis, diuresis and inhibition of arginine vasopressin-induced water reabsorption. 2. The aim of this study was to determine any interaction between epidermal growth factor and the V1 (vascular) and/or V2 (antidiuretic) arginine vasopressin receptor subt...
journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
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更新日期:1994-03-01 00:00:00
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abstract::1. Structural changes in resistance vessels were studied sequentially (a) by hindquarter perfusion and (b) by planimetry of renal arterioles less than or equal to 20 micrometers radius, for 10 weeks during development of DOCA (deoxycorticosterone acetate)/salt hypertension in uninephrectomized rats and 5 weeks after c...
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更新日期:1982-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.1994.tb02494.x
更新日期:1994-03-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1994.tb02433.x
更新日期:1994-01-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
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更新日期:1984-11-01 00:00:00