Hypoxia-inducible factor 1 alpha and nuclear-related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease.

abstract：:1. The effects of clomiphene (CLM) on cardiac outward K+ current components from rat isolated ventricular myocytes were investigated using the whole-cell patch-clamp technique. Clomiphene (10 micromol/L) significantly inhibited both peak (Ipeak) and end-pulse (Ilate) outward currents (elicited by a 500 msec voltage st...

journal_title：Clinical and experimental pharmacology & physiology

authors： Borg JJ,Hancox JC,Hogg DS,James AF,Kozlowski RZ

更新日期：2004-01-01 00:00:00

abstract：:1. Medullary blood flow (MBF) is important in the long-term control of arterial pressure. However, it is unclear which vascular elements regulate MBF. 2. Exogenous endothelin (ET)-1 decreases cortical more than medullary blood flow. We hypothesized that ET-1 would therefore constrict afferent (AA) and efferent arterio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Denton KM,Shweta A,Finkelstein L,Flower RL,Evans RG

更新日期：2004-08-01 00:00:00

abstract：:1. It has previously been shown that perfusion with high O2-affinity-erythrocytes decreases venous PO2 (PVO2) and decreases O2 uptake (VO2) in contracting muscle at the same O2 delivery (arterial O2 concentration x flow). A linear VO2-PVO2 relationship has been obtained with a VO2-axis intercept, suggesting that, duri...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kohzuki H,Misawa H,Kishi T,Ohga Y,Sakata S,Takaki M

更新日期：1999-08-01 00:00:00

abstract：:We compared the intraocular pressure (IOP)-lowering effect and safety profile of latanoprost (Xalatan) with its generic variant, Glautan (Unipharm, Tel Aviv, Israel). After 1 and 4 weeks of treatment, a randomized, prospective, cross-over comparison was carried out that included patients with open-angle glaucoma or oc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Golan S,Rosenfeld E,Shemesh G,Kurtz S

更新日期：2015-02-01 00:00:00

abstract：:Age-related endothelial dysfunction is closely associated with the local production of reactive oxygen species (ROS) within and in the vicinity of the vascular endothelium. Oxidant-induced DNA damage can activate the nuclear enzyme poly(ADP-ribose) polymerase 1 (PARP-1), leading to endothelial dysfunction in various p...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang GH,Chao M,Hui LH,Xu DL,Cai WL,Zheng J,Gao M,Zhang MX,Wang J,Lu QH

更新日期：2015-12-01 00:00:00

abstract：:The authors have previously demonstrated that a low and intermittent peripheral dose of rapamycin (1 mg/kg three times/week) to rats inhibited mTORC1 signalling, but avoided the hyperlipidemia and diabetes-like syndrome associated with higher doses of rapamycin. The dosing regimen reduced food intake, body weight, adi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Toklu HZ,Bruce EB,Sakarya Y,Carter CS,Morgan D,Matheny MK,Kirichenko N,Scarpace PJ,Tümer N

更新日期：2016-09-01 00:00:00

abstract：:1. Total fluid and saline intakes were greater in spontaneously hypertensive rats (SHR) than in normotensive rats (NTR). 2. Total fluid and saline intake were significantly elevated in prehypertensive SHR, 5 weeks old, compared with age-matched NTR, and the intakes fell with age in both strains but remained considerab...

journal_title：Clinical and experimental pharmacology & physiology

authors： May CN,Parsons BJ

更新日期：1983-01-01 00:00:00

abstract：:This study aimed to evaluate the changes in left and right ventricular functions of children with obstructive sleep apnoea-hypopnoea syndrome (OSAHS) and to determine the efficacy of surgical treatment for OSAHS in children. The subjects included 20 normal controls and 55 children of OSAHS with adenoid and/or tonsil h...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mu H,Liu J,Gong K,Li D,Zhang J

更新日期：2015-06-01 00:00:00

abstract：:1. Gastric emptying studies in small laboratory animals are hampered by the deficiency of a technique that is non-invasive and repeatable. The aim of the present study was to adapt the non-invasive [13C]-octanoic acid breath test, which has been validated in humans, to assess both liquid and solid gastric emptying in ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Symonds EL,Butler RN,Omari TI

更新日期：2000-09-01 00:00:00

abstract：:1. It is known that the alpha(4)-subunit is likely to occur in the brain predominantly in alpha(4)beta(3)delta receptors at extrasynaptic sites. Recent studies have revealed that the alpha(1)-, alpha(4)-, gamma(2)- and delta-subunits may colocalize extrasynaptically in dentate granule cells of the hippocampus. In the ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang MD,Rahman M,Johansson IM,Bäckström T

更新日期：2010-07-01 00:00:00

abstract：:Ageing is associated with increased prevalences of both atrial and ventricular arrhythmias, reflecting disruption of the normal sequence of ion channel activation and inactivation generating the propagated cardiac action potential. Experimental models with specific ion channel genetic modifications have helped clarify...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jeevaratnam K,Chadda KR,Salvage SC,Valli H,Ahmad S,Grace AA,Huang CL

更新日期：2017-12-01 00:00:00

abstract：:The effects of variation in dietary sodium intake on biochemical indices of sympathetic activity were investigated in normal subjects. Sodium restriction for 7 days (mean urinary sodium excretion 21 mmol/day, s.e.m. = 4) increased supine plasma noradrenaline concentration significantly (1.78 nmol/l, s.e.m. = 0.23) com...

journal_title：Clinical and experimental pharmacology & physiology

authors： Watson RD,Esler MD,Leonard P,Korner PI

更新日期：1984-03-01 00:00:00

abstract：:1. In the rectum and distal nephron, sodium reabsorption is mediated by the amiloride-sensitive epithelial sodium channel (ENaC). The ENaC-mediated sodium transport is electrogenic and creates an amiloride-sensitive transepithelial potential difference (PD). 2. We have evaluated the salt- and angiotensin (Ang)II-depen...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang Q,Horisberger JD,Maillard M,Brunner HR,Rossier BC,Burnier M

更新日期：2000-01-01 00:00:00

abstract：:In the context of the ongoing debate on the mechanism of blood pressure (BP) regulation and pathophysiology of arterial hypertension ("renocentric" vs "neural" concepts), attention is focused on the putative regulatory role of changes in renal medullary blood flow (MBF). Experimental evidence is analysed with regard t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sadowski J,Bądzyńska B

更新日期：2020-08-01 00:00:00

abstract：:1. Investigations of the role of cAMP in the stimulation of the steroidogenesis of zona glomerulosa (ZG) cells by increased extracellular K+ concentration are reviewed. 2. Possible reasons for discrepancies in the results of different investigators on whether K+ increases the cAMP content or output of ZG tissue or dis...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tait JF,Tait SA

更新日期：1999-12-01 00:00:00

abstract：:The kidney has a unique environment that results in relatively low tissue oxygen tension (Po2). However, recent studies have shown that renal hypoxia is more severe during hypertension and may reflect changes in the way O2 is used. The present review summarizes studies that explore the relationship between renal oxyge...

journal_title：Clinical and experimental pharmacology & physiology

authors： Welch WJ

更新日期：2006-10-01 00:00:00

abstract：:1. Quantitative autoradiography and homogenate radioligand binding of [125I]-Bolton Hunter substance P ([125I]-BHSP) were used to compare brain NK1 receptors in young (2 months) and aged (18-20 months) rats. 2. The autoradiographic distribution and density of [125I]-BHSP binding sites was similar in all cortical regio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Geraghty DP,Maguire CM

更新日期：2002-12-01 00:00:00

abstract：:1. Direct cortical stimulation of motor and sensory areas of the cortex in experimental animals and some neurosurgical patients has provided much useful physiological information. Some of the benefits of this approach can be provided in awake volunteer subjects using new techniques which activate the motor cortex thor...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gandevia SC

更新日期：1996-10-01 00:00:00

abstract：:An efficient animal model is fundamental for studies on the underlying mechanisms of constrictive pericarditis (CP). A novel CP rat model was established by pericardial injection composing of lipopolysaccharides (LPS) and talcum powder without thoracotomy. Pathological changes were confirmed by histological staining. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Qiao W,Xiao YJ,Wang X,Sun LJ,Chen YX,Ren WD

更新日期：2020-12-21 00:00:00

abstract：:1. The effects of ouabain and acetazolamide on the secretion of pancreatic juice stimulated by secretin in anaesthetized dogs were investigated. 2. Intra-arterial injection of ouabain (1-10 micrograms) and acetazolamide (1-10 mg) caused dose-dependent decreases in the volume of pancreatic juice. When both drugs were a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iwatsuki K,Horiuchi A,Yonekura Y,Chiba S

更新日期：1989-03-01 00:00:00

abstract：:1. Hypertension plays a critical role in the progression of chronic kidney disease (CKD) to end-stage renal disease (ESRD), but it has also been postulated that antihypertensive drugs that block the renin-angiotensin system (RAS) show class-specific renoprotective actions beyond their blood pressure (BP)-lowering effe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kujal P,Chábová VČ,Vernerová Z,Walkowska A,Kompanowska-Jezierska E,Sadowski J,Vaňourková Z,Husková Z,Opočenský M,Skaroupková P,Schejbalová S,Kramer HJ,Rakušan D,Malý J,Netuka I,Vaněčková I,Kopkan L,Cervenka L

更新日期：2010-12-01 00:00:00

abstract：:1. The turnover rate of inositol(1,4,5)trisphosphate (Ins(1,4,5)P3) in noradrenaline-stimulated adult rat left atria was calculated from changes in specific activity and was found to equal 110 ct/min per mg tissue. In contrast, the isomers of inositol mono- and bisphosphates accumulated at a rate of 508 ct/min per mg....

journal_title：Clinical and experimental pharmacology & physiology

authors： Anderson KE,Myers D,Woodcock EA

更新日期：1993-05-01 00:00:00

abstract：:1. The present study examined the cytosolic Ca(2+) regulatory machinery involved in the vasorelaxation produced by petasin, a sesquiterpene isolated from Petasites formosanus. 2. Aortic rings isolated from Sprague-Dawley rats were exposed to petasin (0.01-100 micromol/L) to elucidate its vascular effects on isometric ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang GJ,Lin YL,Chen CH,Wu XC,Liao JF,Ren J

更新日期：2010-03-01 00:00:00

abstract：:The aim of the present study was to determine the effects of increased cAMP levels in response to pituitary adenylate cyclase-activating polypeptide 27 (PACAP27) on atrial atrial natriuretic peptide (ANP) secretion in rabbit atria. A perfused beating atrial model was used in the present study and cAMP efflux and ANP l...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang Y,Liu LP,Liang ZL,Li XL,Jin YZ,Cui X

更新日期：2008-10-01 00:00:00

abstract：:Cardiac output and rhythm depend on the release and the take-up of calcium from the sarcoplasmic reticulum (SR). Excessive diastolic calcium leak from the SR due to dysfunctional calcium release channels (RyR2) contributes to the formation of delayed after-depolarizations, which underlie the fatal arrhythmias that occ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Walweel K,Oo YW,Laver DR

更新日期：2017-01-01 00:00:00

abstract：:1. The effect of endothelin on phosphatidylinositol turnover in rat atria was investigated by measuring the generation of inositol phosphates following [3H]-inositol labelling. 2. In the presence of 10 mmol/L LiCl, endothelin caused dose-dependent increases in the accumulation of inositol mono, bis and trisphosphates ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kuraja IJ,Woodcock EA

更新日期：1990-04-01 00:00:00

abstract：:Following the potent efficacy of β-D-Mannuronic acid in a breast cancer murine model, we evaluated the efficacy of this novel non-steroidal anti-inflammatory drug in breast cancer patients in the present clinical trial. The study was an 8-week randomized, controlled, phase II clinical trial (IRCT: 2017012213739N7 (in ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kashefi S,Omranipour R,Mahmoodzadeh H,Ahmadi H,Alikhassi A,Hosseini M,Cuzzocrea S,Rehm BHA,Matsuo H,Mirshafiey A

更新日期：2019-06-01 00:00:00

abstract：:1. Econazole is used clinically as an antifungal drug with many different in vitro effects. However, the effects of econazole on prostate cancer cells are unknown. The effects of econazole on intracellular Ca2+ concentrations ([Ca2+]i) in and the proliferation of human PC3 prostate cancer cells was explored in the pre...

journal_title：Clinical and experimental pharmacology & physiology

authors： Huang JK,Liu CS,Chou CT,Liu SI,Hsu SS,Chang HT,Hsieh CH,Chang CH,Chen WC,Jan CR

更新日期：2005-09-01 00:00:00

abstract：:1. The haemodynamic and metabolic effects of oral intake of approximately 30 mg/kg per day N-nitro-L-arginine (NOLA) were examined in sham and adrenocorticotrophin (ACTH, 0.5 mg/kg per day) treated conscious Sprague-Dawley rats (n = 33). 2. NOLA administration produced an increase in systolic blood pressure of 24 +/- ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li M,Dusting GJ,Whitworth JA

更新日期：1992-10-01 00:00:00

abstract：:1. This study was designed to elucidate the effects of guar gum, a dietary fibre, on changes in prostanoid contents induced by 1,2-dimethylhydrazine, a carcinogenic agent, in rat colonic mucosa. 2. Prostanoid contents were determined using high performance liquid chromatography; five prostanoids, namely 6-keto-prostag...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kanamori S,Sugiyama S,Goto H,Hayakawa T,Shimomura Y,Ozawa T

更新日期：1995-10-01 00:00:00