Exaggerated response to restraint stress in rats congenic for the chromosome 1 blood pressure quantitative trait locus.

Abstract:

:1. To understand the roles of a putative hypertension gene in the chromosome 1 quantitative trait locus (QTL) region, the response to restraint stress was studied in strains congenic for this QTL. 2. To establish congenic strains, the QTL region was introgressed from stroke-prone spontaneously hypertensive rats (SHRSP)/Izm to Wistar-Kyoto/Izm (WKY/Izm) rats by repeated backcrossing. Two congenic strains (WKYpch1.0 and WKYpch1.1) were established to cover the whole QTL region between D1Wox29 and D1Arb21 (approximately 40 cM) and a smaller region between D1Smu11 and D1Arb21 (approximately 10 cM), respectively. After telemetry probes were implanted, rats were exposed to restraint stress to investigate the blood pressure response. 3. Basal blood pressure measured by radiotelemetry differed significantly between WKY rats and WKYpch1.0 (103 +/- 10 and 116 +/- 4 mmHg, respectively; P = 0.002 by anova). When exposed to restraint stress, WKYpch1.0 showed a greater increase in blood pressre than did WKY rats. The exaggerated response in the WKYpch1.0 strain was abolished by chemical sympathectomy using guanethidine. The WKYpch1.1 rats did not differ significantly from WKY rats either in basal blood pressure or in the response to restraint stress. 4. In conclusion, a QTL for high blood pressure was successfully introgressed in the established congenic strain, WKYpch1.0. A gene (or genes) in the chromosome 1 QTL region modulates the cardiovascular responses to restraint stress in these congenic rats, probably through the sympathetic nervous system.

authors

Cui ZH,Ikeda K,Kawakami K,Gonda T,Nabika T,Masuda J

doi

10.1046/j.1440-1681.2003.03860.x

keywords:

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

464-9

issue

7

eissn

0305-1870

issn

1440-1681

pii

3860

journal_volume

30

pub_type

杂志文章
  • Blood pressure regulation in baroreceptor-denervated rats.

    abstract::1. Arterial baroreceptor denervation produces acute hypertension, but chronically denervated animals have an average arterial pressure that is similar to that of baroreceptor intact animals. 2. Although cardiopulmonary baroreceptors and renal compensations have been suggested to mediate the restoration of a normal ave...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.1997.tb01787.x

    authors: Sved AF,Schreihofer AM,Kost CK Jr

    更新日期:1997-01-01 00:00:00

  • Angiotensin II-nitric oxide interaction in glomerular arterioles.

    abstract::1. Resistance changes of the afferent and efferent arterioles determine blood flow and filtration rate in the kidney. The tone of both vessels results from the influence of nerves and humoral and paracrine factors, through a balance of constrictor and dilator systems. Angiotensin (Ang) II and nitric oxide (NO) are imp...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.2005.04203.x

    authors: Patzak A,Lai E,Persson PB,Persson AE

    更新日期:2005-05-01 00:00:00

  • MicroRNAs in common diseases and potential therapeutic applications.

    abstract::1. Evidence gathered in recent years has revealed microRNAs (miRNAs) fine-tune gene expression and play an important role in various cellular processes, including cell growth, differentiation, proliferation and apoptosis. 2. The present review summarizes current knowledge of miRNA pathways in the pathogenesis of cance...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.2009.05269.x

    authors: Tsai LM,Yu D

    更新日期:2010-01-01 00:00:00

  • Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus.

    abstract::Diabetes mellitus and depressive disorders are both common chronic diseases that increase functional disability and social burden. Cognitive impairment is a potentially debilitating feature of depression. Previous evidence indicates that the antidiabetic drug metformin could be suitable for diabetic patients with cogn...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/1440-1681.12265

    authors: Guo M,Mi J,Jiang QM,Xu JM,Tang YY,Tian G,Wang B

    更新日期:2014-09-01 00:00:00

  • Changes in postoperative night bispectral index of patients undergoing thoracic surgery with different types of anaesthesia management: a randomized controlled trial.

    abstract::This study hypothesized that different types of anaesthesia management would result in similar postoperative sleep quality. In this prospective single-blind investigation, 219 patients undergoing elective thoracic surgery were randomized into three arms: general anaesthesia, as the control group (group C); general ana...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/1440-1681.12530

    authors: Tan WF,Guo B,Ma H,Li XQ,Fang B,Lv HW

    更新日期:2016-03-01 00:00:00

  • The inhibition of nitric oxide-mediated relaxations in rat aorta and anococcygeus muscle by diphenylene iodonium.

    abstract::1. The effects of diphenylene iodonium (DPI), an inhibitor of reduced nicotinamide adenine dinucleotide phosphate-dependent oxidases (which generate superoxide anions), were studied on nitric oxide (NO)-mediated responses in isolated preparations of the rat aorta and anococcygeus muscle. 2. In aortic rings, the endoth...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1993.tb01661.x

    authors: Rand MJ,Li CG

    更新日期:1993-03-01 00:00:00

  • Opioid mechanisms controlling renal function.

    abstract::1. Over the past 50 years considerable evidence has been reported suggesting that endogenous opioids participate in the control of renal function. 2. Exogenous administration of opioids produces profound changes in the renal excretion of water and sodium. 3. Opioids produce changes in urine output and urine sodium exc...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.1995.tb02324.x

    authors: Kapusta DR

    更新日期:1995-12-01 00:00:00

  • Effects of post-treatment with low-dose propofol on inflammatory responses to lipopolysaccharide-induced shock in conscious rats.

    abstract::1. In the present study, we used a low dose of propofol (5 mg/kg per h) to investigate its effects on the pro-inflammatory cytokines (tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-10) and changes in nitric oxide (NO) following lipopolysaccharide (LPS) for a period of 12 h in conscious rats. 2. Expe...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2005.04155.x

    authors: Hsu BG,Yang FL,Lee RP,Peng TC,Chen HI

    更新日期:2005-01-01 00:00:00

  • New insights into the treatment of hypertension.

    abstract::1. The choice of initial pharmacological therapy is one area where the different hypertension management guidelines vary in recommending either the use of diuretics and beta-blockers as preferred drugs or choosing from any of the five major classes of antihypertensives. 2. Improvement in cardiovascular morbidity and m...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.1997.tb02733.x

    authors: Tomlinson B

    更新日期:1997-12-01 00:00:00

  • Changes in redox ratio and protein glycation in precataractous lens from fructose-fed rats: effects of exogenous L-carnitine.

    abstract::1. Rats fed high dietary fructose are documented to form an acquired model of insulin resistance. The present study measured the effects of administration of L-carnitine (CA) on lens protein glycation, oxidative stress and redox homeostasis in rats fed a high-fructose diet. 2. Animals were divided into four groups: (i...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2007.04815.x

    authors: Balasaraswathi K,Rajasekar P,Anuradha CV

    更新日期:2008-02-01 00:00:00

  • Decreased oxidative stress in prehepatic portal hypertensive rat livers following the induction of diabetes.

    abstract::1. Oxidative stress (OS) is a biological entity indicated as being responsible for several pathologies, including diabetes. Diabetes can also be associated with human cirrhosis. Portal hypertension (PH), a major syndrome in cirrhosis, produces hyperdynamic splanchnic circulation and hyperaemia. The present study was d...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2004.03963.x

    authors: Evelson P,Llesuy S,Filinger E,Rodriguez RR,Lemberg A,Scorticati C,Susemihl M,Villareal I,Polo JM,Peredo H,Perazzo JC

    更新日期:2004-03-01 00:00:00

  • Development of peripheral autonomic synapses: neurotransmitter receptors, neuroeffector associations and neural influences.

    abstract::1. The functional innervation of autonomic target tissues occurs early during development, at a time when both the nerves and post-synaptic target tissues are still differentiating. 2. Physiological responses appear soon after the arrival of the first fibres when uptake and release mechanisms within the nerves are alr...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1440-1681.1999.03092.x

    authors: Hill CE,Phillips JK,Sandow SL

    更新日期:1999-08-01 00:00:00

  • Inhibition of 11β-hydroxysteroid dehydrogenase 1 by carbenoxolone affects glucose homeostasis and obesity in db/db mice.

    abstract::1. One of the major causes of metabolic syndrome is elevated 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in the liver and adipose tissue. High 11β-HSD1 expression contributes significantly to the diabetic phenotype in db/db mice. The purpose of the present study was to test the effect of the pharmacological inhibiti...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2011.05640.x

    authors: Dhanesha N,Joharapurkar A,Shah G,Kshirsagar S,Dhote V,Sharma A,Jain M

    更新日期:2012-01-01 00:00:00

  • Species differences in binding of submandibular nuclear proteins to renin promoter DNA.

    abstract::1. Renin is highly expressed in submandibular gland (SMG) of mouse, which has two genes, Ren-1d and Ren-2d, but not at all in rat SMG. Differences in nuclear protein binding to renin promoter DNA were, therefore, explored. 2. Rat -169 to +23 renin DNA formed complexes with both mouse and rat extract, whereas a corresp...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1993.tb01684.x

    authors: Loudon JA,Fukamizu A,Murakami K,Morris BJ

    更新日期:1993-05-01 00:00:00

  • Dose-dependent effect of alcohol on insulin-like growth factor systems in male rats.

    abstract::1. Chronic alcohol treatment has been reported to be associated with liver and kidney damage. The insulin-like growth factor (IGF) is the major growth factor related to alcohol consumption. However, the effect of alcohol on the IGF system in the liver and kidney has not been fully elucidated. Thus, the present study w...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2004.03945.x

    authors: Park SH,Heo JS,Kang CW

    更新日期:2004-01-01 00:00:00

  • The possible involvement of adrenoceptors in the intestinal effect of morphine in mice.

    abstract::The inhibitory effect of morphine on intestine was observed by following the intestinal transit of a charcoal meal. This inhibitory effect of morphine was antagonized by naloxone. In addition, the inhibitory effect of morphine was also suppressed by prior administration of yohimbine and phentolamine. However, prazosin...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1984.tb00873.x

    authors: Wong CL

    更新日期:1984-11-01 00:00:00

  • Increase in serum total angiotensin-converting enzyme activity with enalapril therapy in humans: a controlled trial.

    abstract::1. In a controlled, randomized double-blind trial, 15 patients with essential hypertension were treated with enalapril 5-20 mg/day, or doxazosin 1-8 mg/day, during a 7 week dose titration phase. This was followed by 7 weeks of combined treatment with doxazosin and enalapril. 2. Blood was taken after a 2 week placebo r...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1440-1681.1992.tb00456.x

    authors: Stokes GS,Monaghan JC,Marwood JF,Okoro EO,Johnston H

    更新日期:1992-05-01 00:00:00

  • Comparative bioavailability of two cefadroxil products using serum and urine data in healthy human volunteers.

    abstract::1. The aim of the present study was to assess the bioequivalence of two cefadroxil products, namely Ultracef (a reference product) in the form of a 500 mg capsule (produced by Bristol-Myers Squibb Laboratories, Princeton, NJ, USA) and Roxil (a test product) in the form of a 500 mg capsule (produced by Tabuk Pharmaceut...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1440-1681.2004.04012.x

    authors: Otoom S,Hasan M,Najib N

    更新日期:2004-07-01 00:00:00

  • Effects of locally administered argatroban on restenosis after balloon angioplasty: experimental and clinical study.

    abstract::1. This study was undertaken to evaluate the preventive effects of locally administered argatroban, a competitive inhibitor of thrombin-induced platelet activation, on restenosis after balloon angioplasty. 2. A hydrogel-coated balloon catheter was immersed three times in argatroban/saline solution (1 mg/mL) for 60 s, ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1997.tb02694.x

    authors: Imanishi T,Arita M,Tomobuchi Y,Hamada M,Hano T,Nishio I

    更新日期:1997-11-01 00:00:00

  • Renin and the (pro)renin receptor in the renal collecting duct: Role in the pathogenesis of hypertension.

    abstract::The intrarenal renin-angiotensin system (RAS) plays a critical role in the pathogenesis and progression of hypertension and kidney disease. In angiotensin (Ang) II-dependent hypertension, collecting duct renin synthesis and secretion are stimulated despite suppression of juxtaglomerular (JG) renin. This effect is medi...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/1440-1681.12319

    authors: Gonzalez AA,Prieto MC

    更新日期:2015-01-01 00:00:00

  • Effects of dietary fibre on dimethylhydrazine-induced changes in prostanoid concentrations in rat colonic mucosa.

    abstract::1. This study was designed to elucidate the effects of guar gum, a dietary fibre, on changes in prostanoid contents induced by 1,2-dimethylhydrazine, a carcinogenic agent, in rat colonic mucosa. 2. Prostanoid contents were determined using high performance liquid chromatography; five prostanoids, namely 6-keto-prostag...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1995.tb01928.x

    authors: Kanamori S,Sugiyama S,Goto H,Hayakawa T,Shimomura Y,Ozawa T

    更新日期:1995-10-01 00:00:00

  • The association between serum albumin/prealbumin level and disease severity in non-CF bronchiectasis.

    abstract::Non-cystic fibrosis (non-CF) bronchiectasis is a chronic pulmonary disease that can lead to malnutrition. Serum prealbumin and albumin level are related to inflammatory and nutritional status. Thus, we aimed to confirm our hypothesis that low serum albumin and prealbumin level, as well as body mass index (BMI), is cor...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.13331

    authors: Li L,Li Z,Bi J,Li H,Wang S,Shao C,Song Y

    更新日期:2020-09-01 00:00:00

  • Taurine prevents high-fat diet-induced-hepatic steatosis in rats by direct inhibition of hepatic sterol regulatory element-binding proteins and activation of AMPK.

    abstract::This study investigated if the protective effect of taurine against high fat diet-induced hepatic steatosis involves modulating the hepatic activity of 5' AMP-activated protein kinase (AMPK) and levels/activity of the sterol regulatory element-binding proteins-1/2 (SREBP1/2). Rats were divided into four groups (n = 12...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.13387

    authors: Morsy MD,Aboonq MS,ALsleem MA,Abusham AA

    更新日期:2020-07-21 00:00:00

  • Protective effects of L-carnitine on myoglobinuric acute renal failure in rats.

    abstract::1. Muscle injury (rhabdomyolysis) is one of the causes of acute renal failure (ARF). Iron, free radicals and nitric oxide (NO) play a critical role in the pathogenesis of glycerol-induced myoglobinuric ARF. L-Carnitine is an anti-oxidant and prevents the accumulation of end-products of lipid peroxidation. Therefore, t...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2006.04336.x

    authors: Aydogdu N,Atmaca G,Yalcin O,Taskiran R,Tastekin E,Kaymak K

    更新日期:2006-01-01 00:00:00

  • Characterisation of a rat model of mechanical low back pain at an advanced stage using immunohistochemical methods.

    abstract::Chronic low back pain (LBP) has high prevalence in the adult population which is associated with enormous disability. Hence, our aim was to further characterise our LBP rat model by using immunohistological and immunohistochemical methods at an advanced stage (day 49) of the model. Male Sprague-Dawley rats were anaest...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.13402

    authors: Park TSW,Khan N,Kuo A,Nicholson JR,Corradini L,Smith MT

    更新日期:2020-09-05 00:00:00

  • Multiple oscillators, dynamic synchronization and sympathetic control.

    abstract::1. Intermittent bursts of activity are a robust feature of the discharges of sympathetic nerves. There are at least two major mechanisms producing such discharges: (i) phasic inputs influencing sympathetic circuits; and (ii) oscillators embedded within sympathetic networks. The functional significance of patterned and...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1440-1681.2001.03414.x

    authors: Gilbey MP

    更新日期:2001-01-01 00:00:00

  • Noradrenergic reinnervation of the rat vas deferens after vasovasostomy following vasectomy.

    abstract::1. Anastomosis (vasovasostomy) of epididymal and prostatic halves of vasa deferentia was carried out in rats in which unilateral or bilateral medial transection (vasectomy) had been performed 4 weeks previously. 2. Noradrenaline levels in epididymal halves of vasa deferentia, 8 weeks after anastomosis with prostatic h...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1987.tb00984.x

    authors: DeGaris RM,Pennefather JN

    更新日期:1987-05-01 00:00:00

  • MicroRNA-217 suppresses homocysteine-induced proliferation and migration of vascular smooth muscle cells via N-methyl-D-aspartic acid receptor inhibition.

    abstract::Hyperhomocysteine has become a critical risk for atherosclerosis and can stimulate proliferation and migration of vascular smooth muscle cells (VSMCs). N-methyl-D-aspartic acid receptor (NMDAR) is a receptor of homocysteine and mediates the effects of homocysteine on VSMCs. Bioinformatics analysis has shown NMDAR is a...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.12611

    authors: Duan H,Li Y,Yan L,Yang H,Wu J,Qian P,Li B,Wang S

    更新日期:2016-10-01 00:00:00

  • Blood pressure responses to dietary sodium manipulation during normotensive human pregnancy.

    abstract::Short-term salt loading and salt restriction in a group of normal pregnant women produced no changes in lying, sitting or standing blood pressures or heart rates. Home blood pressures showed no trend to change over the periods of altered salt intake. Although plasma volume and plasma renin activity changed with altere...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1985.tb02654.x

    authors: McEniery PJ,Hunyor SN,Cooper KA,Gallery ED,Gyory AZ,Boyce ES

    更新日期:1985-05-01 00:00:00

  • Hypertension mechanisms causing stroke.

    abstract::1. Although it is well established that hypertension is the main risk factor for stroke, the complexity of cerebrovascular problems related to hypertension is not generally appreciated. 2. Hypertension can cause stroke through many mechanisms. A high intraluminal pressure will lead to extensive alteration in endotheli...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1440-1681.1999.03081.x

    authors: Johansson BB

    更新日期:1999-07-01 00:00:00