Cardiac arrest temperature: the effect of ethyl alcohol and carbon dioxide on rats, guinea-pigs and isolated rat hearts.

abstract：:Nitric oxide is a potent anti-apoptotic and cardioprotective molecule in healthy animals. However, recent study demonstrates that overexpression of eNOS exacerbates the liver injury in diabetic animals. whether diabetes may also alter NO's biologic activity in ischaemic/reperfused heart remains unknown. The present ex...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu Y,Xia C,Wang R,Zhang J,Yin T,Ma Y,Tao L

更新日期：2017-08-01 00:00:00

abstract：:1. Pyruvate has been shown to enhance the contractile performance of cardiac muscle when provided as an alternative substrate to glucose. The aims of the present study were to determine whether the inotropic effects of pyruvate are due to increased mobilization of intracellular Ca2+ ([Ca2+]i) and to compare the effect...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mellors LJ,Kotsanas G,Wendt IR

更新日期：1999-11-01 00:00:00

abstract：:1. The endogenous production of and/or the bioavailability of nitric oxide (NO) is decreased in pulmonary hypertensive diseases. L-arginine (L-arg) is the substrate for NO synthase (NOS). L-arg is transported into cells via the cationic amino acid transporters (CAT), of which there are two isoforms in endothelial cell...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cui H,Chen B,Chicoine LG,Nelin LD

更新日期：2011-12-01 00:00:00

abstract：:1. Free radical-induced lipid peroxidation and changes in protein and nucleic acid structures can result in various human ailments, including ageing, neurodegenerative disorders and cancer. High body fat or dietary fat further enhances the free radical-mediated pathogenesis of various diseases. 2. In the present study...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ajith TA,Riji T,Anu V

更新日期：2008-05-01 00:00:00

abstract：:1. Oxidative stress is believed to be an important mediator of neuronal cell death but the precise mechanism by which this occurs is unknown. 2. We have developed an in vitro model of neuronal oxidative stress to study the pathways by which free radicals kill neurones. 3. We have shown that oxidative stress, cystine d...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ratan RR,Baraban JM

更新日期：1995-04-01 00:00:00

abstract：:1. There are hundreds of commercially available microcomputer statistics packages, ranging from the very cheap and elementary to the very expensive and complex, and from the very general to the very specialized. This review covers only those that appear to be popular with biomedical investigators who deal with fairly ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ludbrook J

更新日期：1995-12-01 00:00:00

abstract：:Agmatine, an endogenous ligand of imidazoline receptors, is reported to exhibit anti-hyperglycaemic and many other effects. It has been established that the imidazoline I3 receptor is involved in insulin secretion. The current study characterizes the role of the imidazoline I3 receptor in the protection of pancreatic ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li Y,Cheng KC,Asakawa A,Amitani H,Takimoto Y,Runtuwene J,Inui A

更新日期：2015-09-01 00:00:00

abstract：:The effects of variation in dietary sodium intake on biochemical indices of sympathetic activity were investigated in normal subjects. Sodium restriction for 7 days (mean urinary sodium excretion 21 mmol/day, s.e.m. = 4) increased supine plasma noradrenaline concentration significantly (1.78 nmol/l, s.e.m. = 0.23) com...

journal_title：Clinical and experimental pharmacology & physiology

authors： Watson RD,Esler MD,Leonard P,Korner PI

更新日期：1984-03-01 00:00:00

abstract：:This study investigates the effect of chronic consumption of a high-fat diet rich in corn oil (CO-HFD) on atrial cells ultrastructure, antioxidant levels and markers of intrinsic cell death of both control and type 1 diabetes mellitus (T1DM)-induced rats. Adult male rats (10 rats/group) were divided into four groups: ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Eid RA,Eleawa SM,Alkhateeb MA,Aldera H,Zaki MSA,Al-Shraim M,Saeed MA,El-Kott AF,Alaa Eldeen M,Alassiri M,Alshehri MM,Salem Al-Shudiefat AA,Khalil MA

更新日期：2019-12-01 00:00:00

abstract：:1. Several selective antagonists are available to differentiate between muscarinic receptors. 2. Further subdivision of M1 and M2 muscarinic receptors appears possible and is supported by studies with cloned receptors. 3. Reasons for differences between affinity constants determined in functional and binding studies a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mitchelson F,Choo LK,Darroch S

更新日期：1989-06-01 00:00:00

abstract：:1. The concentration of renin and angiotensinogen (Ao) and the activity of angiotensin I-converting enzyme (ACE) was measured in the ascites fluid of nephrotic rats obtained 8 days after puromycin aminonucleoside (PAN) injection. 2. Ascites fluid, serum and urine proteins of these rats were analysed by sodium dodecyl ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cruz C,Correa-Rotter R,Mézquita C,Medina-Campos ON,Pedraza-Chaverrí J

更新日期：1998-07-01 00:00:00

abstract：:1. The present report documents evidence suggesting that endothelin (ET) is a mediator and modulator of post-ganglionic sympathetic neuronal development. 2. Endothelin is produced by post-ganglionic neurons and by cells adjacent to these neurons. 3. Post-ganglionic sympathetic neurons express functional receptors for ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Damon DH

更新日期：1999-12-01 00:00:00

abstract：:1. In rats, inhibition of type IV phosphodiesterase (PDE4) attenuates acute renal failure and early (hours) mortality induced by high-dose endotoxin. Because it is unlikely that protection of renal function accounts for improved early survivability, most likely PDE4 inhibition exerts multiple beneficial effects in end...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tofovic SP,Zacharia LC,Carcillo JA,Jackson EK

更新日期：2000-10-01 00:00:00

abstract：:Contrast media are considered to cause acute kidney injury by activating various factors that induce renal vasoconstriction. We analysed the renal microvascular haemodynamic response using the Doppler flow wire method. Then changes in urinary liver-type fatty acid-binding protein levels following contrast medium admin...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kurihara O,Seino Y,Shibata Y,Matsushita M,Komiyama H,Kato K,Murakami D,Munakata R,Takano M,Miyauchi Y,Hata N,Shimizu W

更新日期：2016-11-01 00:00:00

abstract：:1. In the present study, we attempted to clarify whether the antidiabetic drug miglitol, an alpha-glucosidase inhibitor, has a protective effect against anginal ischaemia. We had reported previously that miglitol reduces myocardial infarct size through inhibition of glycogenolysis during ischaemia in rabbits. However,...

journal_title：Clinical and experimental pharmacology & physiology

authors： Uno Y,Minatoguchi S,Arai M,Wang N,Chen XH,Hashimoto K,Lu C,Takemura G,Fujiwara H

更新日期：2005-10-01 00:00:00

abstract：:1. The aim of this study was to compare the effect of acute versus chronic ADH administration on the handling of sodium, potassium and water by the nephron. Simultaneous clearance and free-flow micropuncture experiments were performed on rats, infused with hypotonic Ringer solution, following either 1-3 h ('acute') or...

journal_title：Clinical and experimental pharmacology & physiology

authors： Field MJ,Seow F,Lawrence JR

更新日期：1989-02-01 00:00:00

abstract：:1. The ulcerogenesis of gastric haemorrhagic damage during sepsis is unclear. The present study first proposes that gastric haemorrhagic ulcer is modulated by mucosal glutathione, histamine and oxyradicals in lipopolysaccharide (LPS)-induced sepsis in rats. The protective effects of several drugs on the ulcerogenic pa...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hung CR

更新日期：2000-04-01 00:00:00

abstract：:1. Left ventricular (LV) hypertrophy has been implicated in the reduction of baroreflex sensitivity present in hypertension. The aim of the current study was to investigate the mean arterial pressure-heart rate reflex (MAP-HR) in a model which induced left ventricular hypertrophy but no sustained blood pressure elevat...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kingwell BA,Krause L,Julius S

更新日期：1994-01-01 00:00:00

abstract：:1. Erlotinib, a small-molecule epidermal growth factor receptor-tyrosine kinase (EGFR-TK) inhibitor, has been approved for the management of advanced non-small cell lung cancer. The aim of the present study was to investigate whether erlotinib exerts potent antitumour activities through the reactive oxygen species (RO...

journal_title：Clinical and experimental pharmacology & physiology

authors： Qian X,Li J,Ding J,Wang Z,Zhang W,Hu G

更新日期：2009-05-01 00:00:00

abstract：:1. The effects on the coronary and systemic haemodynamics of intravenous and intracoronary injections of two benzfuran derivatives, amiodarone and its brominated analogue (L8040), were studied in open-chest anaesthetized dogs. The effects of L8040 on cardiac intracellular potentials after 6 weeks of 20 mg/kg intraperi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Singh BN,Jewitt DE,Downey JM,Kirk ES,Sonnenblick EH

更新日期：1976-09-01 00:00:00

abstract：:Angiogenesis is a process through which new capillaries are formed from pre-existing ones, which contributes significantly to the pathogenesis of numerous diseases, such as cancer and chronic inflammatory disorders. The β-D-mannuronic acid (M2000) is a novel non-steroidal anti-inflammatory drug (NSAID) with immunosupp...

journal_title：Clinical and experimental pharmacology & physiology

authors： Rastegari-Pouyani M,Mostafaie A,Mansouri K,Mortazavi-Jahromi SS,Mohammadi-Motlagh HR,Mirshafiey A

更新日期：2018-04-01 00:00:00

abstract：:1. The effect of pretreatment with nifedipine on naloxone-stimulated corticotrophin-releasing hormone (CRH)-induced adrenocorticotrophin (ACTH) release in humans was investigated. The mean peak plasma ACTH and cortisol levels and the mean peak change in cortisol levels from basal were significantly lower in the nifedi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hockings GI,Grice JE,Walters MM,Jackson RV

更新日期：1991-05-01 00:00:00

abstract：:1. Rabbits were treated with the antiparasitic drug ivermectin at subcutaneous doses of 0.2, 1 and 2.5 mg/kg and blood collected weekly for 4 weeks thereafter for measuring some blood parameters. At a dose of 0.2 or 1 mg/kg the drug had no significant effect on any of the parameters measured. At a dose of 2.5 mg/kg, t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ali BH

更新日期：1990-10-01 00:00:00

abstract：:1. Mammalian heart muscle is extremely sensitive to the external calcium concentration. It reacts to alterations of the external calcium concentration with an immediate adaptation of contractile force. 2. In mammalian heart there is a network of large transverse tubules throughout the cell. These structures are regula...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lüllmann H,Peters T

更新日期：1977-01-01 00:00:00

abstract：:1. This paper reports on the in vitro and in vivo characteristics of a non-peptide vasopressin V1 receptor antagonist 1-(1-[4-(3-acetylaminopropoxy)benzoyl]-4-piperidyl)-3,4-dihydro-2( 1H)- quinolinone (OPC-21268). 2. OPC-21268 caused a concentration-dependent displacement of the selective V1 receptor antagonist radio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Burrell LM,Phillips PA,Stephenson J,Risvanis J,Hutchins AM,Johnston CI

更新日期：1993-05-01 00:00:00

abstract：:The effect of pancuronium in the rabbit ear artery was investigated in order to measure the inhibition it produces at the prejunctional muscarinic receptor on sympathetic nerve endings in this tissue. Pancuronium (0.1-0.2 mmol/l) produced an enhancement of responses to transmural electrical stimulation but this effect...

journal_title：Clinical and experimental pharmacology & physiology

authors： Leung E,Mitchelson F

更新日期：1983-11-01 00:00:00

abstract：:1. The effect of enalapril on handling of an Na load and on body Na during 96 h of zero Na intake was measured in hypertensive rats (GH and SHR) and their normotensive controls (N and WKY) by a whole body counting method. 2. Enalapril treatment led to a greater fall in body Na in the first 24 h after the Na load (as e...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ledingham JM,Simpson FO

更新日期：1992-05-01 00:00:00

abstract：:1. The spinal sympathetic outflow (C7-T2) of pithed male Wistar rats was electrically stimulated (30-50 V, 0.5 ms, 0.1-1.0 Hz) and heart rate and arterial blood pressure were recorded. D-Tubocurarine (1 mg/kg) and atropine (1 mg/kg) were administered intravenously (i.v.) to reduce voluntary and parasympathetic nerve a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Rechtman MP,King RG,Boura AL

更新日期：1988-12-01 00:00:00

abstract：:1. This study investigated the effect of progesterone, which, under certain circumstances, can antagonize both the mineralocorticoid and glucocorticoid activities of steroid hormones, on the development and maintenance of adrenocorticotrophic hormone (ACTH)-induced hypertension in conscious sheep. 2. Progesterone (500...

journal_title：Clinical and experimental pharmacology & physiology

authors： Spence CD,Reid AF,Coghlan JP,Mills EH,Whitworth JA,Scoggins BA

更新日期：1989-08-01 00:00:00

abstract：:1. Iron overload contributes to the pathogenesis of various diseases and directly induces tissue injury. In the present study, we investigated the relationship between heart and liver injury induced by iron overload and cellular endoplasmic reticulum (ER) stress to explore the molecular mechanism of iron overload-indu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lou LX,Geng B,Chen Y,Yu F,Zhao J,Tang CS

更新日期：2009-07-01 00:00:00