Abstract：
BACKGROUND:Pulse pressure (PPV) and stroke volume (SVV) variations may not be reliable in the setting of pulmonary hypertension and/or right ventricular (RV) failure. We hypothesized that RV afterload increase attenuates SVV and PPV during hypovolemia in a rabbit model of pulmonary embolism (PE) secondary to RV dysfunction. METHODS:Seven anesthetized and mechanically ventilated rabbits were studied during four experimental conditions: normovolemia, blood withdrawal, pulmonary embolism and fluid loading of a colloidal solution. Central venous, RV and left ventricular (LV) pressures, and infra-diaphragmatic aortic blood flow (AoF) and pressure were measured. SV was estimated by the integral of systolic AoF. We analyzed RV and LV function through stroke work output curves. PPV and SVV were obtained by the variation of beat-to-beat PP and SV, respectively. We assessed RV and LV diastolic and systolic function by the time rate of relaxation (tau) and the ratio of the first derivative of ventricular pressure and the highest isovolumic developed pressure (dP/dt/DP), respectively. The vasomotor tone was estimated by the dynamic arterial elastance (Eadyn = PPV/SVV). RESULTS:PPV and SVV increased significantly during hemorrhage and returned to baseline values after PE which was associated to biventricular right-downward of the stroke work curves and a decrease of AoF and SV (P < 0.05). RV systo-diastolic function and LV systolic function were impaired. All the animals were nonresponders after volume expansion. Eadyn did not show any significant change during the different experimental conditions. CONCLUSIONS:The dynamic preload indicators (SVV and PPV) were significantly reduced after a normotensive PE in hypovolemic animals, mainly by the systo-diastolic dysfunction of the RV associated with LV systolic impairment, which makes the animals nonresponsive to volume loading. This normalization of dynamic preload indices may prevent the detrimental consequence of fluid loading.
journal_name
BMC Anesthesioljournal_title
BMC anesthesiologyauthors
Bouchacourt JP,Riva J,Grignola JCdoi
10.1186/s12871-017-0329-zsubject
Has Abstractpub_date
2017-03-03 00:00:00pages
35issue
1issn
1471-2253pii
10.1186/s12871-017-0329-zjournal_volume
17pub_type
杂志文章abstract：BACKGROUND:Intracranial-pressure (ICP) monitoring is useful for patients with increased ICP following hemorrhagic stroke. In this study, the changes in pressure gradients between the two cerebral hemispheres were investigated after hemorrhagic stroke of one side, and after a craniotomy. METHODS:Twenty-four patients wi...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/1471-2253-14-112
更新日期：2014-12-03 00:00:00
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journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-020-01228-y
更新日期：2021-01-11 00:00:00
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journal_title：BMC anesthesiology
pub_type： 杂志文章,随机对照试验
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更新日期：2016-07-30 00:00:00
abstract：BACKGROUND:In Sweden, airway guidelines aimed toward improving patient safety have been recommended by the Swedish Society of Anaesthesia and Intensive Care Medicine. Adherence to evidence-based airway guidelines is known to be generally poor in Sweden. The aim of this study was to determine whether airway guidelines a...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/1471-2253-14-25
更新日期：2014-04-07 00:00:00
abstract：BACKGROUND:The primary goal of this study was to determine whether administration of intrathecal morphine reduces postoperative pain. The secondary goal was to determine the effect of intrathecal morphine upon circulating levels of the weakly analgesic endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG...
journal_title：BMC anesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12871-018-0489-5
更新日期：2018-02-27 00:00:00
abstract：BACKGROUND:Patients in intensive care units (ICUs) are often physically unable to communicate with their physicians. Thus, the sharing of information about the on-going treatment of the patients in ICUs is directly related to the communication attitudes governing a patient's relatives and the physician. This study aims...
journal_title：BMC anesthesiology
pub_type： 杂志文章,多中心研究
doi：10.1186/s12871-017-0388-1
更新日期：2017-07-17 00:00:00
abstract：BACKGROUND:In what way volume, concentration and dose affect block duration is controversial. The purpose of the present study is to investigate the effect of dose, volume and concentration of mepivacaine on the duration of sensory and motor blockade in ultrasound-guided single shot axillary brachial plexus blockade. ...
journal_title：BMC anesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12871-015-0110-0
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abstract：BACKGROUND:To identify changes in cefoperazone/sulbactam penetration into cerebrospinal fluid (CSF) after craniotomy and to investigate preliminarily whether cefoperazone/sulbactam CSF concentration can reach therapeutic level when administered intravenously after neurosurgical operation. METHODS:Neurosurgical patient...
journal_title：BMC anesthesiology
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doi：10.1186/s12871-015-0012-1
更新日期：2015-03-13 00:00:00
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journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-019-0852-1
更新日期：2019-10-09 00:00:00
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doi：10.1186/s12871-019-0799-2
更新日期：2019-07-09 00:00:00
abstract：BACKGROUND:Neuropathic pain is evasive to treat once developed, however evidence suggests that local administration of anesthetics near the time of injury reduces the development of neuropathic pain. As abnormal electrical signaling in the damaged nerve contributes to the initiation and maintenance of neuropathic pain,...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-015-0113-x
更新日期：2015-10-06 00:00:00
abstract：BACKGROUND:Few studies have investigated the effect of dexmedetomidine on postoperative nausea and vomiting (PONV) in patients underwent gynecological laparoscopic surgery. We investigated if adding dexmedetomidine to a morphine-based patient-controlled analgesia (PCA) could decrease the incidence of PONV in this high-...
journal_title：BMC anesthesiology
pub_type： 杂志文章,随机对照试验
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更新日期：2020-01-08 00:00:00
abstract：BACKGROUND:Perioperative immune function plays an important role in the prognosis of patients. Several studies have indicated that low-dose opioid receptor blockers can improve immune function. METHODS:Sixty-nine patients undergoing video-assisted thoracoscopic resection of the lung cancer were randomly assigned to ei...
journal_title：BMC anesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12871-019-0912-6
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pub_type： 杂志文章,随机对照试验
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更新日期：2016-11-16 00:00:00
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journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/1471-2253-11-2
更新日期：2011-02-16 00:00:00
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pub_type： 杂志文章,随机对照试验
doi：10.1186/s12871-019-0751-5
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journal_title：BMC anesthesiology
pub_type： 杂志文章
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更新日期：2007-03-12 00:00:00
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pub_type： 临床试验,杂志文章
doi：10.1186/s12871-016-0201-6
更新日期：2016-07-25 00:00:00
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journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-017-0419-y
更新日期：2017-09-05 00:00:00
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journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-020-01091-x
更新日期：2020-07-20 00:00:00
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journal_title：BMC anesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12871-015-0124-7
更新日期：2015-10-13 00:00:00
abstract：BACKGROUND:Data on the best norepinephrine bolus dose for management of hypotension are limited. The aim of this study was to compare the efficacy and safety of two norepinephrine bolus doses in the rescue management of maternal hypotension during cesarean delivery. METHODS:This randomized, controlled trial included m...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-020-01004-y
更新日期：2020-04-17 00:00:00
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journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-016-0283-1
更新日期：2016-11-21 00:00:00
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journal_title：BMC anesthesiology
pub_type： 杂志文章,评审
doi：10.1186/s12871-018-0605-6
更新日期：2018-11-06 00:00:00
abstract：BACKGROUND:Children require anesthesia for MRI to maintain immobility and reduce discomfort; clear indications about the best anesthesiologic management are lacking and each center developed its own protocol. Moreover, children with neuropsychiatric disorders more likely require sedation and are described in literature...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-019-0897-1
更新日期：2019-12-18 00:00:00
abstract：BACKGROUND:The quality of patients' recovery following surgery and anesthesia has been a matter of focus and concern over the past decade. The Quality of Recovery-40 (QoR-40) questionnaire was developed and validated for post-anesthesia patient evaluation. The QoR-40, however, is English-based and was tested and valida...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-016-0229-7
更新日期：2016-08-18 00:00:00
