Abstract:
BACKGROUND:Compared to conventional tidal volume ventilation, low tidal-volume ventilation reduces mortality in cased of acute respiratory distress syndrome. The aim of the present study is to determine whether low tidal-volume ventilation reduces the production of inflammatory mediators in the lungs and improves physiological status during hepatic surgery. METHODS:We randomly assigned patients undergoing hepatectomy into 2 groups: conventional tidal-volume vs. low tidal-volume (12 vs. 6 mL•kg(-1) ideal body weight) ventilation with a positive end-expiratory pressure of 3 cm H2O. Arterial blood and airway epithelial lining fluid were sampled immediately after intubation and every 3 h thereafter. RESULTS:Twenty-five patients were analyzed. No significant changes were found in hemodynamics or acid-base status during the study. Interleukin-8 was significantly elevated in epithelial lining fluid from the low tidal-volume group. Oxygenation evaluated immediately after admission to the post-surgical care unit was significantly worse in the low tidal-volume group. CONCLUSIONS:Low tidal-volume ventilation with low positive end-expiratory pressure may lead to pulmonary inflammation during major surgery such as hepatectomy. TRIAL REGISTRATION:The effect of ventilatory tidal volume on lung injury during hepatectomy that requires transient liver blood flow interruption. UMIN000021371 (03/07/2016); retrospectively registered.
journal_name
BMC Anesthesioljournal_title
BMC anesthesiologyauthors
Sato H,Nakamura K,Baba Y,Terada S,Goto T,Kurahashi Kdoi
10.1186/s12871-016-0209-ysubject
Has Abstractpub_date
2016-07-30 00:00:00pages
47issue
1issn
1471-2253pii
10.1186/s12871-016-0209-yjournal_volume
16pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Surgical stress index (SSI) is an established indicator for intraoperative nociception. Opioids are used to block stimulus of cranial pinning in neurosurgery. We investigated the effect of different infusion rates of sufentanil on SSI during cranial pinning in children under general anaesthesia. METHODS:For...
journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12871-017-0448-6
更新日期:2017-12-08 00:00:00
abstract::BACKGROUND: We report a case of a patient with apparent resistance to local anesthetics. While similar cases of failure of regional anesthetics are often attributed to technical failure, the overall clinical presentation and history of this patient suggests a true resistance to local anesthetics. CASE PRESENTATION: Th...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-4-1
更新日期:2004-01-16 00:00:00
abstract:BACKGROUND:To identify changes in cefoperazone/sulbactam penetration into cerebrospinal fluid (CSF) after craniotomy and to investigate preliminarily whether cefoperazone/sulbactam CSF concentration can reach therapeutic level when administered intravenously after neurosurgical operation. METHODS:Neurosurgical patient...
journal_title:BMC anesthesiology
pub_type: 临床试验,杂志文章
doi:10.1186/s12871-015-0012-1
更新日期:2015-03-13 00:00:00
abstract:BACKGROUND:The sensory innervation of the shoulder is complex and there are variations in the branching patterns of the sensory fibres. Articular branches from the axillary nerve to the subacromial bursa are described in more than 50% of investigated shoulders but the isolated contribution of sensory input from the axi...
journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12871-020-0952-y
更新日期:2020-01-31 00:00:00
abstract:BACKGROUND:Most trauma patients admitted to the hospital alive and die later on, decease during the initial care in the emergency department or the intensive care unit (ICU). However, a number of patients pass away after having been discharged from the ICU during the initial hospital stay. On first sight these cases co...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-020-01159-8
更新日期:2020-09-23 00:00:00
abstract:BACKGROUND:Obstetric dfficult airway is a leading cause of maternal morbidity and mortality. The laryngeal mask airway (LMA) is often used as a rescue airway device after failed intubation, however, little is known about predictors of difficult LMA insertion, particularly in obstetrics. Since Mallampati scores of III/I...
journal_title:BMC anesthesiology
pub_type: 临床试验,杂志文章
doi:10.1186/s12871-019-0796-5
更新日期:2019-07-08 00:00:00
abstract:BACKGROUND:The infusion of large amounts of Ringer's lactate prolongs the functional gastrointestinal recovery time and increases the number of complications after open abdominal surgery. We performed an open-labelled clinical trial to determine whether hydroxyethyl starch or Ringer's lactate exerts these adverse effec...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-015-0053-5
更新日期:2015-05-06 00:00:00
abstract:BACKGROUND:The aim of the present study was to verify whether propofol impaired learning and memory through the interplay of N-methyl-D-aspartate (NMDA) receptor with brain-derived neurotrophic factor (BDNF)-tyrosine kinase B (TrkB) signaling pathway. METHODS:120 Sprague-Dawley (SD) rats were randomly assigned into ei...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-018-0491-y
更新日期:2018-04-05 00:00:00
abstract:BACKGROUND:Low-flow sevoflurane anesthesia has been shown to influence renal function in rats, but not in adult humans. Presently, no study has assessed the effects of sevoflurane on renal function in low birth weight infants. Our aim was to study the renal function in low birth weight infants undergoing surgery with l...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-15-6
更新日期:2015-01-21 00:00:00
abstract:BACKGROUND:Post-operative delirium (POD) is a common post-operative complication in elderly individuals and imposes a significant health and financial burden. Identifying predictive biomarkers may help understand the pathophysiology of POD. Our objective is to summarize the evidence of pre-operative biomarkers and imag...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-019-0693-y
更新日期:2019-02-23 00:00:00
abstract:BACKGROUND:Goal-directed fluid therapy (GDFT) based on dynamic indicators of fluid responsiveness has been shown to decrease postoperative complications and hospital length of stay (LOS) in patients undergoing major abdominal surgery. The usefulness of this approach still needs to be clarified in low-to-moderate risk a...
journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12871-019-0707-9
更新日期:2019-03-09 00:00:00
abstract:BACKGROUND:Even the best cancer surgery is usually associated with minimal residual disease. Whether these remaining malignant cells develop into clinical recurrence is at least partially determined by adequacy of host defense, especially natural killer cell function. Anesthetics impair immune defenses to varying degre...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-9-1
更新日期:2009-02-03 00:00:00
abstract:BACKGROUND:Persistently variable success has been experienced in locally translating even well-grounded national clinical practice guidelines, including in the perioperative setting. We have sought greater applicability and acceptance of clinical practice guidelines and protocols with our novel Perioperative Risk Optim...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-016-0187-0
更新日期:2016-03-22 00:00:00
abstract:BACKGROUND:The Zeus® (Dräger, Lübeck, Germany), an automated closed-circuit anesthesia machine, uses high fresh gas flows (FGF) to wash-in the circuit and the lungs, and intermittently flushes the system to remove unwanted N₂. We hypothesized this could increase desflurane consumption to such an extent that agent consu...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-8-4
更新日期:2008-07-17 00:00:00
abstract:BACKGROUND:Ultrasound gels may contain propylene glycol and glycerol, which are neurotoxic in high concentrations. If the needle passes through gel during regional anesthesia, gel may be injected near the nerve. It is unknown if this practice poses a risk for neurotoxicity. Using an animal model, we assessed the histol...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-13-18
更新日期:2013-09-03 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the effect of the steep Trendelenburg position (STP) with pneumoperitoneum on whole-blood viscosity (WBV) in patients undergoing robot-assisted laparoscopic prostatectomy (RALP). The study also analyzed the associations of clinical patient-specific and time-dependent ...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-019-0919-z
更新日期:2020-01-07 00:00:00
abstract:BACKGROUND:Since blood pressure tends to be unstable during induction of anesthesia in patients undergoing cardiovascular surgery, an artery catheter is often inserted before induction to continuously monitor arterial pressure during induction of anesthesia. ClearSight System™ enables noninvasive continuous measurement...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-020-01091-x
更新日期:2020-07-20 00:00:00
abstract:BACKGROUND:Enhanced recovery after surgery programs (ERAS) using thoracic epidural anesthesia and perioperative patient conditioning with omega-3 fatty acids (n3FA), glucose control (GC) and on-demand fluid therapy, respectively, showed beneficial effects. In the MOFA- study these components were used together in patie...
journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12871-019-0823-6
更新日期:2019-08-17 00:00:00
abstract:BACKGROUND:The effect of local infiltration after breast surgery is controversial. This prospective double blind randomized study sought to document the analgesic effect of local anaesthetic infiltration after breast cancer surgery. METHODS:Patients scheduled for mastectomy or tumorectomy and axillary nodes dissection...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-11-23
更新日期:2011-11-24 00:00:00
abstract:BACKGROUND:Preoperative oral carbohydrates has been suggested to attenuate insulin resistance and decrease postoperative complications. In this study, a vitamin-rich carbohydrate beverage was administered before surgery in an animal model to investigate its effects on the surgical stress response and S-100β levels. ME...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-019-0748-0
更新日期:2019-05-15 00:00:00
abstract:BACKGROUND:Delayed gastric emptying and the resultant "full stomach" is the most important risk factor for perioperative pulmonary aspiration. Using point-of-care gastric sonography, we aimed to investigate the prevalence of full stomach and its risk factors in elective surgical patients with type 2 diabetes. METHODS:...
journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12871-019-0848-x
更新日期:2019-10-10 00:00:00
abstract:BACKGROUND:The anaesthetic management of patients with Morquio syndrome is complicated by a number of factors including odontoid hypoplasia, atlantoaxial instability, thoracic kyphosis, and deposition of mucopolysaccharides in the soft tissue of the oropharnyx. CASE PRESENTATION:Herein we describe the anaesthetic cons...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-10-2
更新日期:2010-02-26 00:00:00
abstract:BACKGROUND:Local anesthetic Bupivacaine commonly used in gastric cancer resection operation has been reported to suppress the progression of gastric cancer. However, the specific mechanism by which Bupivacaine functions is largely unexplored. METHODS:The viability and metastasis of gastric cancer cells were assessed b...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-020-01179-4
更新日期:2020-10-30 00:00:00
abstract:BACKGROUND:Mismanagement of remifentanil leads to severe side effects such as opioid-induced tolerance and hyperalgesia. Recently studies revealed an alternative withdrawal method to limit these side effects. A gradual withdrawal of remifentanil seems to be associated with less pain. The hypothesis of this double-blind...
journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12871-019-0731-9
更新日期:2019-04-25 00:00:00
abstract:BACKGROUND:Spinal block is a common procedure for lower limbs surgery. Fentanyl, a synthetic opioid and dexmedetomidine, a selective α2 agonist have been used as adjuvants in spinal anesthesia to prolong intraoperative and postoperative analgesia. The aim of current study is to compare the efficacy of dexmedetomidine a...
journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12871-018-0531-7
更新日期:2018-06-06 00:00:00
abstract::BACKGROUND: Propofol is widely used for both short-term anesthesia and long-term sedation. It has unusual pharmacokinetics because of its high lipid solubility. The standard approach to describing the pharmacokinetics is by a multi-compartmental model. This paper presents the first detailed human physiologically based...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-5-4
更新日期:2005-04-22 00:00:00
abstract:BACKGROUND:Blood biomarkers are increasingly used to diagnose, guide therapy in, and risk-stratify community-acquired pneumonia (CAP) patients in emergency departments (EDs). How pre-analytic factors affect these markers' initial levels in this population is unknown. METHODS:In this secondary analysis of consecutive E...
journal_title:BMC anesthesiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2253-14-102
更新日期:2014-11-15 00:00:00
abstract:BACKGROUND:This study investigated the effect of different degrees of passive leg raising (PLR) on the internal jugular vein (IJV) cross-sectional area (CSA) and on the success rate of IJV cannulation in patients waiting for thoracic surgery, to analyze whether body mass index (BMI), gender, age, fasting time and preop...
journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12871-019-0751-5
更新日期:2019-05-17 00:00:00
abstract:BACKGROUND:The frequency of malpositioning of gastric tubes in the trachea has been reported to be 0.3-15%, which may cause severe complications, such as pneumonia, if not detected promptly. If a gastric tube can be guided into the esophagus under direct vision with a video laryngoscope, misplacement of the gastric tub...
journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2253-14-82
更新日期:2014-09-25 00:00:00
abstract:BACKGROUND:Effectiveness of the donation request is generally measured by consent rates, rather than by relatives' satisfaction with their decision. Our aim was to elicit Dutch ICU staffs' views and experiences with the donation request, to investigate their awareness of (dis)satisfaction with donation decisions by rel...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-14-52
更新日期:2014-07-11 00:00:00