Abstract:
BACKGROUND:Perioperative immune function plays an important role in the prognosis of patients. Several studies have indicated that low-dose opioid receptor blockers can improve immune function. METHODS:Sixty-nine patients undergoing video-assisted thoracoscopic resection of the lung cancer were randomly assigned to either the naloxone group (n = 35) or the non-naloxone group (n = 34) for postoperative analgesia during the first 48 h after the operation. Both groups received sufentanil and palonosetron via postoperative analgesia pump, while 0.05 μg·kg- 1·h- 1 naloxone was added in naloxone group. The primary outcomes were the level of opioid growth factor (OGF) and immune function assessed by natural killer cells and CD4+/CD8+ T-cell ratio. Second outcomes were assessed by the intensity of postoperative pain, postoperative rescue analgesia dose, postoperative nausea and vomiting (PONV). RESULTS:The level of OGF in the naloxone group increased significantly at 24 h (p<0.001) and 48 h after the operation (P < 0.01). The natural killer cells (P < 0.05) and CD4+/CD8+ T-cell ratio (P < 0.01) in the naloxone group increased significantly at 48 h after the operation. The rest VAS scores were better with naloxone at 12 and 24 h after operation(P < 0.05), and the coughing VAS scores were better with naloxone at 48 h after the operation(P < 0.05). The consumption of postoperative rescue analgesics in the naloxone group was lower (0.00(0.00-0.00) vs 25.00(0.00-62.50)), P < 0.05). Postoperative nausea scores at 24 h after operation decreased in naloxone group(0.00 (0.00-0.00) vs 1.00 (0.00-2.00), P < 0.01). CONCLUSION:Infusion of 0.05 μg·kg- 1·h- 1 naloxone for patients undergoing sufentanil-controlled analgesia for postoperative pain can significantly increase the level of OGF, natural killer cells, and CD4+/CD8+ T-cell ratio compared with non-naloxone group, and postoperative pain intensity, request for rescue analgesics, and opioid-related side effects can also be reduced. TRIAL REGISTRATION:The trial was registered at the Chinese Clinical Trial Registry on January 26, 2019 (ChiCTR1900021043).
journal_name
BMC Anesthesioljournal_title
BMC anesthesiologyauthors
Lin Y,Miao Z,Wu Y,Ge FF,Wen QPdoi
10.1186/s12871-019-0912-6subject
Has Abstractpub_date
2019-12-19 00:00:00pages
236issue
1issn
1471-2253pii
10.1186/s12871-019-0912-6journal_volume
19pub_type
杂志文章,随机对照试验abstract:BACKGROUND:In the immediate postoperative period, obese patients are more likely to exhibit hypoxaemia due to atelectasis and impaired respiratory mechanics, changes which can be attenuated by non-invasive ventilation (NIV). The aim of the study was to evaluate the duration of any effects of early initiation of short t...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-11-10
更新日期:2011-05-23 00:00:00
abstract:BACKGROUND:To determine the median effective concentration of sufentanil as an analgesic during wake-up tests after sevoflurane anesthesia during surgery for adolescent idiopathic scoliosis (AIS). METHODS:This is a randomised controlled trial. Sixty patients aged 13-18 years scheduled for AIS surgery were randomized i...
journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12871-015-0003-2
更新日期:2015-03-08 00:00:00
abstract:BACKGROUND:Goal-directed fluid therapy (GDFT) based on dynamic indicators of fluid responsiveness has been shown to decrease postoperative complications and hospital length of stay (LOS) in patients undergoing major abdominal surgery. The usefulness of this approach still needs to be clarified in low-to-moderate risk a...
journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12871-019-0707-9
更新日期:2019-03-09 00:00:00
abstract:BACKGROUND:Carbohydrate-rich liquid drinks (CRLDs) have been recommended to attenuate insulin resistance by shortening the preoperative fasting interval. The aim of our study the effect of preoperative oral administration of CRLDs on the well-being and clinical status of patients. METHODS:A randomized, double blind, p...
journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2253-14-93
更新日期:2014-10-17 00:00:00
abstract:BACKGROUND:Anesthesia management for patients with severe ankylosing spondylitis scheduled for total hip arthroplasty is challenging due to a potential difficult airway and difficult neuraxial block. We report 4 cases with ankylosing spondylitis successfully managed with a combination of lumbar plexus, sacral plexus an...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-017-0358-7
更新日期:2017-06-26 00:00:00
abstract:BACKGROUND:Current pain assessment and treatment does not address every patient's requirements. Although the Polish national guidelines for post-operative pain management have been published, many patients experience severe pain in the postoperative period. The main goal of our study was to assess pain severity among p...
journal_title:BMC anesthesiology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12871-018-0551-3
更新日期:2018-07-18 00:00:00
abstract:BACKGROUND:In patients with subarachnoid hemorrhage (SAH), vasospasm remains one of the major complications. The application of intravenous magnesium sulfate (MgSO4) has been under discussion to prevent cerebral ischemia. Our aim was to examine the impact of early MgSO4 administration on local cerebral microcirculation...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-017-0435-y
更新日期:2017-10-17 00:00:00
abstract:BACKGROUND:The timing of laryngeal mask airway (LMA) removal remains undefined. This study aimed to assess the optimal timing for LMA removal and whether topical anesthesia with lidocaine could reduce airway adverse events. METHODS:This randomized controlled trial assessed one-to-six-year-old children with ASA I-II sc...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-021-01235-7
更新日期:2021-01-08 00:00:00
abstract:BACKGROUND:Transpulmonary thermodilution (TPTD) derived parameters are used to direct fluid management in ICU-patients. Extravascular lung water EVLW and its ratio to pulmonary blood volume (pulmonary vascular permeability index PVPI) have been associated with mortality. In single indicator TPTD pulmonary blood volume ...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-14-81
更新日期:2014-09-24 00:00:00
abstract:BACKGROUND:Low-flow sevoflurane anesthesia has been shown to influence renal function in rats, but not in adult humans. Presently, no study has assessed the effects of sevoflurane on renal function in low birth weight infants. Our aim was to study the renal function in low birth weight infants undergoing surgery with l...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-15-6
更新日期:2015-01-21 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:BMC anesthesiology
pub_type: 已发布勘误
doi:10.1186/s12871-020-01196-3
更新日期:2020-11-09 00:00:00
abstract:BACKGROUND:Embolic stroke is a common complication of atrial myxoma, whereas multiple cerebral aneurysms associated with atrial myxoma is rare. The pathogenesis of the cerebral vascular disease related to an atrial myxoma is still not well known, and there are no guidelines to guide treatment and anesthesia management ...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-020-01055-1
更新日期:2020-07-04 00:00:00
abstract:BACKGROUND:To investigate the optimal dose of pretreated-dexmedetomidine in fentanyl-induced cough (FIC) suppression. METHODS:Patients of 180 undergoing elective surgery with general anesthesia, aged 18-65 years, BMI 18.5-30 kg/m2, ASA I or II, were equally randomized into four groups (n = 45) to receive intravenous p...
journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12871-019-0765-z
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:The objectives of the present study was to evaluate the effect of fluid challenge (FC) on ventriculo-arterial (V-A) coupling, its determinants: arterial elastance and ventricular elastance, and ability to predict fluid responsiveness. METHODS:Thirty patients admitted to cardio-thoracic ICU in whom the physi...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-020-01087-7
更新日期:2020-07-17 00:00:00
abstract:BACKGROUND:We report a case of severe upper airway obstruction due to a retropharyngeal hematoma that presented nearly one day after a precipitating traumatic injury. Retropharyngeal hematomas are rare, but may cause life-threatening airway compromise. CASE PRESENTATION:A 50 year-old man developed severe dyspnea with ...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-7-2
更新日期:2007-03-12 00:00:00
abstract:BACKGROUND:General anesthesia has been linked to impaired brain development in immature animals and young children. In this study the influence of orthopedic surgery under general anesthesia on the intelligence of school age children has been evaluated. METHODS:A total of 209 subjects aged 6-12 years were recruited an...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-017-0462-8
更新日期:2017-12-19 00:00:00
abstract:BACKGROUND:Obstetric dfficult airway is a leading cause of maternal morbidity and mortality. The laryngeal mask airway (LMA) is often used as a rescue airway device after failed intubation, however, little is known about predictors of difficult LMA insertion, particularly in obstetrics. Since Mallampati scores of III/I...
journal_title:BMC anesthesiology
pub_type: 临床试验,杂志文章
doi:10.1186/s12871-019-0796-5
更新日期:2019-07-08 00:00:00
abstract:BACKGROUND:Cataract surgery is one of the most common procedures performed worldwide in the elderly. Various medications can provide effective anesthesia and analgesia for cataract surgery, but undesirable side effects limit the utility of each medication or combination of medications. Dexmedetomidine may serve as an a...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-020-00973-4
更新日期:2020-04-04 00:00:00
abstract:BACKGROUND:Lumbar puncture for spinal or epidural anesthesia is commonly performed by palpating bony landmarks, but identification of the desired intervertebral level is often inaccurate. It is unclear whether such inaccuracy is related to patient factors, such as body mass index and degree of lumbar flexion. We hypoth...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-15-9
更新日期:2015-01-21 00:00:00
abstract:BACKGROUND:Sugammadex is a modified gamma-cyclodextrin that acts by selectively encapsulating free amino-steroidal neuromuscular relaxants. Several case reports have been published on the use of sugammadex in patients with neuromuscular disorders that include neuromuscular junction diseases, myopathies, neuropathies, a...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-019-0887-3
更新日期:2019-11-19 00:00:00
abstract:BACKGROUND:A mouth gag is usually used during tonsillectomy and adenotonsillectomy surgeries, cleft palate repair, obstructive sleep apnea surgery, and intraoral tumor excision. The placement of the gag causes hemodynamic changes similar to laryngoscopy. The aim of this study was to evaluate the effect of mouth gag pla...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-020-01079-7
更新日期:2020-07-03 00:00:00
abstract:BACKGROUND:Increase of pulmonary vascular resistance (PVR) is an efficient method of modulating pulmonary and systemic blood flows (Qp/Qs) for patients with left-to-right (L-R) shunt, and is also closely associated with insufficient oxygen exchange for pulmonary hypoperfusion. So that it might be a preferred regime of ...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-019-0852-1
更新日期:2019-10-09 00:00:00
abstract:BACKGROUND:Data on the best norepinephrine bolus dose for management of hypotension are limited. The aim of this study was to compare the efficacy and safety of two norepinephrine bolus doses in the rescue management of maternal hypotension during cesarean delivery. METHODS:This randomized, controlled trial included m...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-020-01004-y
更新日期:2020-04-17 00:00:00
abstract:BACKGROUND:Spinal block is a common procedure for lower limbs surgery. Fentanyl, a synthetic opioid and dexmedetomidine, a selective α2 agonist have been used as adjuvants in spinal anesthesia to prolong intraoperative and postoperative analgesia. The aim of current study is to compare the efficacy of dexmedetomidine a...
journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12871-018-0531-7
更新日期:2018-06-06 00:00:00
abstract:BACKGROUND:Compared to conventional tidal volume ventilation, low tidal-volume ventilation reduces mortality in cased of acute respiratory distress syndrome. The aim of the present study is to determine whether low tidal-volume ventilation reduces the production of inflammatory mediators in the lungs and improves physi...
journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12871-016-0209-y
更新日期:2016-07-30 00:00:00
abstract:BACKGROUND:Children require anesthesia for MRI to maintain immobility and reduce discomfort; clear indications about the best anesthesiologic management are lacking and each center developed its own protocol. Moreover, children with neuropsychiatric disorders more likely require sedation and are described in literature...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-019-0897-1
更新日期:2019-12-18 00:00:00
abstract:BACKGROUND:Current evidence regarding the efficacy of ethanol locks in preventing catheter-related bloodstream infection (CRBI) is inconclusive. METHODS:Electronic databases, including PubMed, Web of Science, Embase, and the Cochrane Library (until April 2018),were systematically searched for relevant studies. Two rev...
journal_title:BMC anesthesiology
pub_type: 杂志文章,meta分析
doi:10.1186/s12871-018-0548-y
更新日期:2018-07-24 00:00:00
abstract:BACKGROUND:Post-operative delirium (POD) is a common post-operative complication in elderly individuals and imposes a significant health and financial burden. Identifying predictive biomarkers may help understand the pathophysiology of POD. Our objective is to summarize the evidence of pre-operative biomarkers and imag...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-019-0693-y
更新日期:2019-02-23 00:00:00
abstract:BACKGROUND:Abnormal laryngeal structures are likely to be associated with a difficult laryngoscopy procedure. Currently, laryngeal structures can be measured by ultrasonography, however, little research has been performed on the potential role of ultrasound on the evaluation of a difficult laryngoscopy. The present stu...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-020-01053-3
更新日期:2020-06-02 00:00:00
abstract:BACKGROUND:The Zeus® (Dräger, Lübeck, Germany), an automated closed-circuit anesthesia machine, uses high fresh gas flows (FGF) to wash-in the circuit and the lungs, and intermittently flushes the system to remove unwanted N₂. We hypothesized this could increase desflurane consumption to such an extent that agent consu...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-8-4
更新日期:2008-07-17 00:00:00