HUWE1 mutations in Juberg-Marsidi and Brooks syndromes: the results of an X-chromosome exome sequencing study.

abstract：OBJECTIVE:CT-diagnosed emphysema is associated with poor prognosis in chronic obstructive pulmonary disease (COPD). Its clinical impacts on prognoses of asthma with chronic airflow obstruction (CAO) are not well known. We sought to compare mortalities and prognostic factors in COPD and asthma with CAO by the presence o...

journal_title：BMJ open

authors： Kurashima K,Fukuda C,Nakamoto K,Takaku Y,Hijikata N,Hoshi T,Kanauchi T,Ueda M,Takayanagi N,Sugita Y,Araki R

更新日期：2013-11-04 00:00:00

abstract：OBJECTIVES:Regular physical exercise may preserve β cell function in newly diagnosed adults with type 1 diabetes (T1D). However, clinical trials to test this theory require the recruitment and retention of adults with new-onset T1D, which can be challenging. We sought to determine the overall experiences of newly diagn...

journal_title：BMJ open

authors： Henshall C,Narendran P,Andrews RC,Daley A,Stokes KA,Kennedy A,Greenfield S

更新日期：2018-07-17 00:00:00

abstract：OBJECTIVE:To describe the prevalence of statin utilisation by people aged over 50 years in Ireland and the factors associated with the likelihood of using a statin, focusing particularly on those using statins for primary prevention of cardiovascular disease (CVD). METHODS:This is a cross-sectional analysis of cardiov...

journal_title：BMJ open

authors： Byrne P,Cullinan J,Murphy C,Smith SM

更新日期：2018-02-08 00:00:00

abstract：INTRODUCTION:Idiopathic Environmental Intolerance (IEI) attributed to electromagnetic fields (EMF) refers to self-reported sensitivity mainly characterised by the attribution of non-specific physical symptoms to low-level EMF exposure emitted from sources such as mobile phones. Scientific studies have not provided evid...

journal_title：BMJ open

authors： Bogers RP,Bolte JF,Houtveen JH,Lebret E,van Strien RT,Schipper CM,Alkadhimi M,Baliatsas C,van Kamp I

更新日期：2013-08-29 00:00:00

abstract：OBJECTIVE:We sought to examine the effect of smoking cessation on subsequent development of depressive disorders. DESIGN:This was a retrospective cohort study. METHODS:We used administrative claim and health check data from fiscal years 2010 to 2014, obtained from the largest health insurance association in Fukuoka, ...

journal_title：BMJ open

authors： Fujita T,Babazono A,Harano Y,Jiang P

更新日期：2019-03-23 00:00:00

abstract：INTRODUCTION:For patients with advanced cancer, research shows that pain is frequent, burdensome and undertreated. Evidence-based approaches to support cancer pain management have been developed but have not been implemented within the context of the UK National Health Service. This protocol is for a pragmatic multicen...

journal_title：BMJ open

authors： Allsop MJ,Wright-Hughes A,Black K,Hartley S,Fletcher M,Ziegler LE,Bewick BM,Meads D,Hughes ND,Closs SJ,Hulme C,Taylor S,Flemming K,Hackett J,O'Dwyer JL,Brown JM,Bennett MI

更新日期：2018-03-22 00:00:00

abstract：INTRODUCTION:Physical activity (PA) has diverse benefits for physical and mental health and can reduce symptoms of mental illness. Adults with mental illness face practical, psychosocial and socioeconomic barriers to adopting and maintaining PA, and it is unclear how to effectively promote PA in this group. Supervised ...

journal_title：BMJ open

authors： Chapman JJ,Suetani S,Siskind D,Kisely S,Breakspear M,Byrne JH,Patterson S

更新日期：2018-09-08 00:00:00

abstract：OBJECTIVES:It is unclear how newer methods of respiratory support for infants born extremely preterm (EP; 22-27 weeks gestation) have affected in-hospital sequelae. We aimed to determine changes in respiratory support, survival and morbidity in EP infants since the early 1990s. DESIGN:Prospective longitudinal cohort s...

journal_title：BMJ open

authors： Cheong JLY,Olsen JE,Huang L,Dalziel KM,Boland RA,Burnett AC,Haikerwal A,Spittle AJ,Opie G,Stewart AE,Hickey LM,Anderson PJ,Doyle LW,Members of the Victorian Infant Collaborative Study Group.

更新日期：2020-09-10 00:00:00

abstract：PURPOSE:Despite the growing evidence that physical activity and familial factors play a role in low back pain (LBP), there is a lack of robust longitudinal studies that (1) investigate the types and dosages of physical activity that are protective or harmful for LBP, (2) employ objective measures of physical activity a...

journal_title：BMJ open

authors： Carvalho-E-Silva AP,Pinheiro MB,Ferreira ML,Hübscher M,Calais-Ferreira L,Ferreira PH

更新日期：2020-07-28 00:00:00

abstract：OBJECTIVE:To assess scientific publication and map research gaps on access to medicines (ATM) in Latin American and the Caribbean low-income and middle-income countries (LMIC). DESIGN:Scoping review. Two independent reviewers assessed studies for inclusion and extracted data from each study. INFORMATION SOURCES:Searc...

journal_title：BMJ open

authors： Emmerick IC,Oliveira MA,Luiza VL,Azeredo TB,Bigdeli M

更新日期：2013-05-03 00:00:00

abstract：OBJECTIVES:Hospice care (HC) is seen as a comprehensive approach, that enhances quality of end-of-life (EOL) care, for terminally ill patients. Despite its positive aspects, HC enrolment is disproportionate for rural patients, who are less likely to use HC in comparison to their urban counterparts. The purpose of this ...

journal_title：BMJ open

authors： Ko E,Fuentes D,Singh-Carlson S,Nedjat-Haiem F

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:Major ECG abnormalities have been associated with increased risk of cardiovascular disease (CVD) burden in asymptomatic populations. However, sex differences in occurrence of major ECG abnormalities have been poorly studied, particularly across ethnic groups. The objectives were to investigate (1) sex differ...

journal_title：BMJ open

authors： Bolijn R,Ter Haar CC,Harskamp RE,Tan HL,Kors JA,Postema PG,Snijder MB,Peters RJG,Kunst AE,van Valkengoed IGM

更新日期：2020-09-03 00:00:00

abstract：OBJECTIVES:To examine the effect of the new legislation on partial sickness benefit on subsequent work participation of Finns with long-term sickness absence. Additionally, we investigated whether the effect differed by sex, age or diagnostic category. DESIGN:A register-based quasi-experimental study compared the inte...

journal_title：BMJ open

authors： Kausto J,Viikari-Juntura E,Virta LJ,Gould R,Koskinen A,Solovieva S

更新日期：2014-12-24 00:00:00

abstract：INTRODUCTION:The rising popularity of social media, since their inception around 20 years ago, has been echoed in the growth of health-related research using data derived from them. This has created a demand for literature reviews to synthesise this emerging evidence base and inform future activities. Existing reviews ...

journal_title：BMJ open

authors： Taylor J,Pagliari C

更新日期：2018-12-14 00:00:00

abstract：INTRODUCTION:Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits fibrinolysis by blocking lysine-binding sites on plasminogen, which contribute to reduced bleeding, the need for transfusion and mortality. Although there is reliable evidence of the efficacy of TXA, its effects on other...

journal_title：BMJ open

authors： Murao S,Nakata H,Yamakawa K

更新日期：2020-06-22 00:00:00

abstract：OBJECTIVES:A Demographic and Health Platform was established in Magude in 2015, prior to the deployment of a project aiming to evaluate the feasibility of malaria elimination in southern Mozambique, named the Magude project. This platform aimed to inform the design, implementation and evaluation of the Magude project, ...

journal_title：BMJ open

authors： Galatas B,Nhacolo A,Marti H,Munguambe H,Jamise E,Guinovart C,Cirera L,Amone F,Macete E,Bassat Q,Rabinovich R,Alonso P,Aide P,Saute F,Sacoor C

更新日期：2020-05-05 00:00:00

abstract：INTRODUCTION:Providing patients with access to electronic health records (EHRs) has emerged as a promising solution to improve quality of care and safety. As the efforts to develop and implement EHR-based data sharing platforms mature and scale up worldwide, there is a need to evaluate the impact of these interventions...

journal_title：BMJ open

authors： Neves AL,Carter AW,Freise L,Laranjo L,Darzi A,Mayer EK

更新日期：2018-08-13 00:00:00

abstract：OBJECTIVE:To investigate the appropriateness of cases presenting to the emergency department (ED) following ambulance-based secondary telephone triage. DESIGN:A pragmatic retrospective cohort analysis of all the planned and unplanned ED presentations within 48 hours of a secondary telephone triage. SETTING:The second...

journal_title：BMJ open

authors： Eastwood K,Smith K,Morgans A,Stoelwinder J

更新日期：2017-10-15 00:00:00

abstract：OBJECTIVE:To investigate the gap between real-world data and clinical research initiated by doctors in China, explore the potential reasons for this gap and collect different stakeholders' suggestions. DESIGN:This qualitative study involved three types of hospital personnel based on three interview outlines. The data ...

journal_title：BMJ open

authors： Jin F,Yao C,Yan X,Dong C,Lai J,Li L,Wang B,Tan Y,Zhu S

更新日期：2020-12-29 00:00:00

abstract：OBJECTIVE:Township hospitals (THs) are important components of the three-tier rural healthcare system of China. However, the efficiency and productivity of THs have been questioned since the healthcare reform was implemented in 2009. The objective of this study is to analyse the efficiency and productivity changes in T...

journal_title：BMJ open

authors： Cheng Z,Cai M,Tao H,He Z,Lin X,Lin H,Zuo Y

更新日期：2016-11-11 00:00:00

abstract：OBJECTIVES:This study was designed to investigate the effect of alcohol intoxication on clinical presentation of hospitalised adult trauma patients at a Level I trauma centre using propensity score matching. DESIGN:Cross-sectional study. SETTING:Taiwan. PARTICIPANTS:Detailed data of 929 hospitalised adult trauma pat...

journal_title：BMJ open

authors： Peng SH,Hsu SY,Kuo PJ,Rau CS,Cheng YA,Hsieh CH

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:There has not previously been a systematic comparison of awards for research funding in infectious diseases by sex. We investigated funding awards to UK institutions for all infectious disease research from 1997 to 2010, across disease categories and along the research and development continuum. DESIGN:Syst...

journal_title：BMJ open

authors： Head MG,Fitchett JR,Cooke MK,Wurie FB,Atun R

更新日期：2013-12-09 00:00:00

abstract：INTRODUCTION:Fracture healing can fail in up to 10% of cases despite appropriate treatment. While lithium has been the standard treatment for bipolar disorder, it may also have a significant impact to increase bone healing in patients with long bone fractures. To translate this knowledge into clinical practice, a rando...

journal_title：BMJ open

authors： Nam D,Balasuberamaniam P,Milner K,Kunz M,Vachhani K,Kiss A,Whyne C

更新日期：2020-01-07 00:00:00

abstract：INTRODUCTION:Poor air quality (AQ) is a global public health issue and AQ events can span across countries. Using emergency department (ED) syndromic surveillance from England and France, we describe changes in human health indicators during periods of particularly poor AQ in London and Paris during 2014. METHODS:Usin...

journal_title：BMJ open

authors： Hughes HE,Morbey R,Fouillet A,Caserio-Schönemann C,Dobney A,Hughes TC,Smith GE,Elliot AJ

更新日期：2018-04-19 00:00:00

abstract：INTRODUCTION:Expectant mothers in low-income and middle-income countries often lack access to vital information about pregnancy, preparation for birth and best practices when caring for their newborn. Innovative solutions are needed to bridge this knowledge gap and dramatically improve maternal and neonatal health in t...

journal_title：BMJ open

authors： Su Y,Yuan C,Zhou Z,Heitner J,Campbell B

更新日期：2016-08-10 00:00:00

abstract：OBJECTIVES:Cardiac rehabilitation (CR) improves outcomes after myocardial infarction (MI), but it is underused in China. The purpose of this study was to develop a set of quality indicators (QIs) to improve clinical practices and to confirm the measurability and performance of the developed QIs for CR in Chinese patien...

journal_title：BMJ open

authors： Zheng X,Zhang M,Zheng Y,Zhang Y,Wang J,Zhang P,Yang X,Li S,Ding R,Siqin G,Hou X,Chen L,Zhang M,Sun Y,Wu J,Yu B

更新日期：2020-12-30 00:00:00

abstract：OBJECTIVE:To examine the impact of caesarean section on breastfeeding indicators-early initiation of breastfeeding, exclusive breastfeeding under 6 months and children ever breastfed (at least once)-in sub-Saharan Africa. DESIGN:Secondary analysis of Demographic and Health Surveys (DHS). SETTING:Thirty-three low-inco...

journal_title：BMJ open

authors： Yisma E,Mol BW,Lynch JW,Smithers LG

更新日期：2019-09-04 00:00:00

abstract：OBJECTIVES:To examine the damage location distribution of five main body region injuries of maximum abbreviated injury score (MAIS) 3-6 injured occupants for nearside struck vehicle in front-to-side impact crashes. DESIGN AND SETTING:MAIS 3-6 injured occupants information was extracted from the US-National Automotive ...

journal_title：BMJ open

authors： Tang Y,Cao L,Kan S

更新日期：2014-05-08 00:00:00

abstract：OBJECTIVE:The aim of this pilot study was to determine risk factors, including Staphylococcus aureus nasal carriage, for dermatitis in submariners during a submarine patrol. PARTICIPANTS AND METHODS:36 submariners undertaking a submerged 6-week patrol participated in the study. Severity of dermatitis and its impact wa...

journal_title：BMJ open

authors： Flaxman A,Allen E,Lindemann C,Yamaguchi Y,O'Shea MK,Fallowfield JL,Lindsay M,Gunner F,Knox K,Wyllie DH

更新日期：2016-06-02 00:00:00

abstract：INTRODUCTION:Desert dust is estimated to constitute about 35% of aerosol in the troposphere. Desertification, climatic variability and global warming all can contribute to increased dust formation. This study aims to examine possible health effects of desert dust exposure on pregnant women and their children. The purpo...

journal_title：BMJ open

authors： Kanatani KT,Adachi Y,Sugimoto N,Noma H,Onishi K,Hamazaki K,Takahashi Y,Ito I,Egawa M,Sato K,Go T,Kurozawa Y,Inadera H,Konishi I,Nakayama T,Japan Environment & Children's Study Group.

更新日期：2014-06-23 00:00:00