Abstract:
OBJECTIVE:CT-diagnosed emphysema is associated with poor prognosis in chronic obstructive pulmonary disease (COPD). Its clinical impacts on prognoses of asthma with chronic airflow obstruction (CAO) are not well known. We sought to compare mortalities and prognostic factors in COPD and asthma with CAO by the presence or absence of CT-diagnosed emphysema. DESIGN:Retrospective cohort study. SETTING:Referral centre hospital for respiratory disease. PARTICIPANTS:1272 patients aged over 40 years with CAO (January 2000 to December 2011). CAO was defined as a forced expiratory volume in 1 s/forced vital capacity <0.7 after bronchodilator use throughout the observation period. PRIMARY AND SECONDARY OUTCOME MEASUREMENTS:Overall mortality served as the primary endpoint. We compared mortalities and prognostic factors of COPD and asthma subgroups with or without emphysema. Secondary endpoints were the prevalence of COPD and asthma in patients with CAO. RESULTS:Overall, diagnoses included COPD with emphysema in 517 (40.6%) patients, COPD without emphysema in 104 (8.2%) patients, asthma with emphysema in 178 (13.9%) patients, asthma without emphysema in 169 (13.3%) patients, other respiratory diseases (RD) with emphysema in 128 (10.1%) patients, and other RD without emphysema in 176 (13.8%) patients. Patients with asthma without emphysema had the best prognosis followed by those with asthma with emphysema, COPD without emphysema and COPD with emphysema. Each subgroup had distinct prognostic factors. Presence of emphysema was an independent risk factor for de novo lung cancer among patients with CAO. CONCLUSIONS:Patients with asthma with CAO have a better prognosis than patients with COPD. The presence of CT-diagnosed emphysema predicts poor prognosis in COPD and asthma with CAO.
journal_name
BMJ Openjournal_title
BMJ openauthors
Kurashima K,Fukuda C,Nakamoto K,Takaku Y,Hijikata N,Hoshi T,Kanauchi T,Ueda M,Takayanagi N,Sugita Y,Araki Rdoi
10.1136/bmjopen-2013-003541subject
Has Abstractpub_date
2013-11-04 00:00:00pages
e003541issue
11issn
2044-6055pii
bmjopen-2013-003541journal_volume
3pub_type
杂志文章相关文献
BMJ Open文献大全abstract:OBJECTIVES:An increasing number of studies had shown that air pollution exposure may aggravate blood glucose control in patients with diabetes, an independent risk factor for colorectal cancer (CRC) proposed by some researchers. This study aimed to investigate the impact of exposure to ambient particulate matter with a...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-036955
更新日期:2020-10-28 00:00:00
abstract:INTRODUCTION:Personalised cancer screening aims to improve benefits, reduce harms and being more cost-effective than age-based screening. The objective of the DECIDO study is to assess the acceptability and feasibility of offering risk-based personalised breast cancer screening and its integration in regular clinical p...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-044597
更新日期:2020-12-23 00:00:00
abstract:OBJECTIVES:Retirement villages (RV) have expanded rapidly, now housing perhaps one in eight people aged 75+ years in New Zealand. Health service initiatives might better support residents and offer cost advantages, but little is known of resident demographics, health status or needs. This study describes village reside...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-035876
更新日期:2020-09-18 00:00:00
abstract::The serial interval is the time between symptom onsets in an infector-infectee pair. The generation time, also known as the generation interval, is the time between infection events in an infector-infectee pair. The serial interval and the generation time are key parameters for assessing the dynamics of a disease. A n...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2020-040263
更新日期:2020-11-23 00:00:00
abstract:INTRODUCTION:Preterm babies are among the highest users of parenteral nutrition (PN) of any patient group, but there is wide variation in commencement, duration, and composition of PN and uncertainty around which groups will benefit from early introduction. Recent studies in critically unwell adults and children sugges...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-029065
更新日期:2019-07-09 00:00:00
abstract:INTRODUCTION:The importance of cardiovascular health in relation to pregnancy outcome is increasingly acknowledged. Women who develop certain pregnancy complications, in particular preeclampsia, are at higher risk for future cardiovascular disease. Independent of its outcome, pregnancy requires a substantial adaptive r...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033083
更新日期:2019-11-10 00:00:00
abstract:OBJECTIVE:The risk of fetal death increases steeply after 42 gestational weeks. Since 2009, Denmark has had a more proactive policy including prevention of prolonged pregnancy, and early intervention in women with diabetes, preeclampsia, high body mass index and of a higher age group. The aim of this study was to descr...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005785
更新日期:2014-08-14 00:00:00
abstract:INTRODUCTION:Research indicates that experiencing the suicide of a relative can have a significant impact on family members' emotional health. However, research incorporating the impact of suicide bereavement on family members' physical health is sparse. This paper details the protocol for a mixed-methods study of suic...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-014707
更新日期:2017-03-30 00:00:00
abstract:OBJECTIVES:To investigate the effect of adding point-of-care (POC) susceptibility testing to POC culture on appropriate use of antibiotics as well as clinical and microbiological cure for patients with suspected uncomplicated urinary tract infection (UTI) in general practice. DESIGN:Open, individually randomised contr...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2017-018028
更新日期:2017-10-16 00:00:00
abstract:INTRODUCTION:Since the emergence in 1997 of the Wellness Recovery Action Plan, a number of other tools developed by users and/or ex-users of mental health services have been published and implemented. All these tools aim to promote self-determination in mental health recovery processes. A scoping review will be carried...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-043957
更新日期:2020-11-12 00:00:00
abstract:OBJECTIVES:Accreditation in France relies on a mandatory 4-year cycle of self-assessment and a peer review of 82 standards, among which 14 focus priority standards (FPS). Hospitals are also required to measure yearly quality indicators (QIs-5 in 2010). On advice given by the accreditation committee of HAS (Haute Autori...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003289
更新日期:2013-08-30 00:00:00
abstract:OBJECTIVES:To determine the prevalence of potentially inappropriate prescribing (PIP) in a cohort of community-dwelling middle-aged people and assess the relationship between PIP and emergency department (ED) visits, general practitioner (GP) visits and quality of life (QoL). DESIGN:Prospective cohort study. SETTING:...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-016562
更新日期:2017-10-16 00:00:00
abstract:OBJECTIVE:Post-randomisation exclusions in randomised controlled trials are common and may include participants identified as not meeting trial eligibility criteria after randomisation. We report how a decision might be reached and reported on, to include or exclude these participants. We illustrate using a motivating ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-039546
更新日期:2020-12-02 00:00:00
abstract:OBJECTIVE:To project the proportion of population 65+ years with severe long-term activity limitations from 2017 to 2047. DESIGN:Large population study. SETTING:Population living in private households of the European Union (EU) and neighbouring countries. PARTICIPANTS:Participants from the EU Statistics on Income an...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-017654
更新日期:2017-10-23 00:00:00
abstract:INTRODUCTION:The significant increase in the rate of morbidity and mortality due to cardiovascular diseases has become a health challenge globally. Lack of enough knowledge on the underlying causes in Iran and taking the unique characteristics of the Shiraz metropolitan city (the capital city of Fars Province) into con...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2018-026317
更新日期:2019-04-03 00:00:00
abstract:OBJECTIVES:The aim was to study whether a workplace-registered frequent short-term sick leave spell pattern was an early indicator of future disability pension or future long-term sick leave among municipal eldercare workers. SETTING:The municipal healthcare sector in the city of Aarhus, which is the second largest ci...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003941
更新日期:2014-02-07 00:00:00
abstract:INTRODUCTION:Multiple sclerosis (MS) is a severe debilitating disease that affects patients' quality of life. Up to 90% of patients with MS will develop lower urinary tract dysfunction within the first 18 years of the disease. If oral pharmacotherapy with anticholinergics, behavioural modifications and pelvic floor phy...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-013225
更新日期:2017-02-03 00:00:00
abstract:OBJECTIVE:Evidence-based clinical resources (EBCRs) have the potential to improve diagnostic and therapeutic accuracy. The majority of US teaching medical institutions have incorporated them into clinical training. Many EBCRs are subscription based, and their cost is prohibitive for most clinicians and trainees in low-...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-026947
更新日期:2019-08-08 00:00:00
abstract:OBJECTIVE:To assess the effect that accreditation training in fetal growth surveillance and evidence-based protocols had on stillbirth rates in England and Wales. DESIGN:Analysis of mortality data from Office of National Statistics. SETTING:England and Wales, including three National Health Service (NHS) regions (Wes...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003942
更新日期:2013-12-17 00:00:00
abstract:INTRODUCTION:Opioid use patterns of individuals with non-cancer pain are influenced by the behavioural dynamics of the individual in managing and properly following the prescription. The use of assessment tools for measuring the risk of behaviour suggestive of opioid abuse is important for health professionals who prov...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-021948
更新日期:2018-10-02 00:00:00
abstract:INTRODUCTION:Despite the frequent use of therapies in acute bronchitis, the evidence of their benefit is lacking, since only a few clinical trials have been published, with low sample sizes, poor methodological quality and mainly in children. The objective of this study is to compare the effectiveness of three symptoma...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2018-028159
更新日期:2019-05-16 00:00:00
abstract:OBJECTIVES:Although several rehabilitation programmes following hip arthroscopy for femoracetabular impingement (FAI) syndrome have been described, there are no clinical trials evaluating whether formal physiotherapy-prescribed rehabilitation improves recovery compared with self-directed rehabilitation. The objective o...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2016-014658
更新日期:2017-06-23 00:00:00
abstract:OBJECTIVES:Assessment of the relations between recorded gonorrhoea rates and clinical testing activity and disposable diagnostic tests. METHODS:In Denmark, two sources of information on the epidemiology of gonorrhoea are available: (1) a mandatory clinical notification system (since 1867) comprising summary informatio...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-008013
更新日期:2015-11-30 00:00:00
abstract:INTRODUCTION:Current pharmacological treatment options for hyperemesis gravidarum have been introduced based on scarce evidence and are often not sufficiently effective. Several case reports suggest that mirtazapine, an antidepressant, may be an effective treatment for hyperemesis gravidarum, but so far there are no co...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-034712
更新日期:2020-03-24 00:00:00
abstract:OBJECTIVES:To evaluate the impact of an expansion of liaison psychiatry services (LPS) on patient management, outcomes and treatment costs for emergency department (ED) attendances for self-harm. DESIGN:Retrospective before and after cohort study using routinely collected Self-Harm Surveillance Register data. SETTING...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-016906
更新日期:2017-08-21 00:00:00
abstract:INTRODUCTION:Recurrent urinary tract infections (RUTIs) have a significant negative impact on quality of life and healthcare costs. To date, daily prophylactic antibiotics are the only treatment which have been shown to help prevent RUTIs. D-mannose is a type of sugar which is believed to inhibit bacterial adherence to...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-037128
更新日期:2021-01-13 00:00:00
abstract:OBJECTIVES:(1) To explain general practitioners' (GPs') approaches to prostate-specific antigen (PSA) testing and overdiagnosis; (2) to explain how GPs reason about their PSA testing routines and (3) to explain how these routines influence GPs' personal experience as clinicians. SETTING:Primary care practices in Austr...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-006367
更新日期:2015-03-17 00:00:00
abstract:OBJECTIVE:Since 2011 China's central government has committed to establishing a new 'general practitioner' (GP)-centred primary care system. To this end there have been great efforts to train an additional 300 000 GPs by 2020. This paper examines the perspective of practitioners in Henan, China, regarding general pract...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-036240
更新日期:2020-02-03 00:00:00
abstract:INTRODUCTION:Premature rupture of membranes (PROM) occurs at term in 8% of pregnancies. Several studies have demonstrated that the risk of chorioamnionitis and neonatal sepsis increases with duration of PROM. Decreasing the time interval between PROM and delivery is associated with lower rates of maternal infections. I...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-026090
更新日期:2019-06-20 00:00:00
abstract:OBJECTIVES:The Acne Priority Setting Partnership (PSP) was set up to identify and rank treatment uncertainties by bringing together people with acne, and professionals providing care within and beyond the National Health Service (NHS). SETTING:The UK with international participation. PARTICIPANTS:Teenagers and adults...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-008085
更新日期:2015-07-17 00:00:00