Abstract：
BACKGROUND:More effective mosquito control strategies are urgently required due to the increasing prevalence of insecticide resistance. The sterile insect technique (SIT) and the release of insects carrying a dominant lethal allele (RIDL) are two proposed methods for environmentally-friendly, species-targeted population control. These methods may be more suitable for developing countries if producers reduce the cost of rearing insects. The cost of control programs could be reduced by producing all-male mosquito populations to circumvent the isolation of females before release without reducing male mating competitiveness caused by transgenes. RESULTS:An RNAi construct targeting the RNA recognition motif of the Aedes aegypti transformer-2 (tra-2) gene does not trigger female-to-male sex conversion as commonly observed among dipterous insects. Instead, homozygous insects show greater mortality among m-chromosome-bearing sperm and mm zygotes, yielding up to 100% males in the subsequent generations. The performance of transgenic males was not significantly different to wild-type males in narrow-cage competitive mating experiments. CONCLUSION:Our data provide preliminary evidence that the knockdown of Ae. aegypti tra-2 gene expression causes segregation distortion acting at the level of gametic function, which is reinforced by sex-specific zygotic lethality. This finding could promote the development of new synthetic sex distorter systems for the production of genetic sexing mosquito strains.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Hoang KP,Teo TM,Ho TX,Le VSdoi
10.1186/s13071-016-1331-xsubject
Has Abstractpub_date
2016-01-28 00:00:00pages
49issn
1756-3305pii
10.1186/s13071-016-1331-xjournal_volume
9pub_type
杂志文章abstract：BACKGROUND:Leishmania major and Leishmania infantum are among the main species that are responsible for cutaneous leishmaniosis (CL) and visceral leishmaniosis (VL), respectively. The leishmanioses represent the second-largest parasitic killer in the world after malaria. Recently, we succeeded in generating a plasmid D...
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journal_title：Parasites & vectors
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abstract：BACKGROUND:Digenean trematodes are parasitic platyhelminths that use several hosts in their life cycles and are thereby embedded in various ecosystems affected by local environmental conditions. Their presence in a habitat will reflect the presence of different host species and, as such, they can serve as ecological in...
journal_title：Parasites & vectors
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journal_title：Parasites & vectors
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journal_title：Parasites & vectors
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journal_title：Parasites & vectors
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journal_title：Parasites & vectors
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journal_title：Parasites & vectors
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journal_title：Parasites & vectors
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journal_title：Parasites & vectors
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journal_title：Parasites & vectors
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journal_title：Parasites & vectors
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journal_title：Parasites & vectors
pub_type： 杂志文章
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journal_title：Parasites & vectors
pub_type： 杂志文章
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journal_title：Parasites & vectors
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journal_title：Parasites & vectors
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journal_title：Parasites & vectors
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更新日期：2013-12-12 00:00:00
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journal_title：Parasites & vectors
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journal_title：Parasites & vectors
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更新日期：2013-07-26 00:00:00
abstract：:Since the implementation of Roll Back Malaria, the widespread use of insecticide-treated nets (ITNs) and indoor residual spraying (IRS) is thought to have played a major part in the decrease in mortality and morbidity achieved in malaria-endemic regions. In the past decade, resistance to major classes of insecticides ...
journal_title：Parasites & vectors
pub_type： 杂志文章,评审
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更新日期：2020-06-10 00:00:00
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journal_title：Parasites & vectors
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更新日期：2020-04-07 00:00:00
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journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-7-224
更新日期：2014-05-14 00:00:00
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journal_title：Parasites & vectors
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更新日期：2015-10-08 00:00:00
