当前位置： SCI文献检索 > NeuroImage-Clinical期刊下所有文献 > Task-independent effects are potential confounders in longitudinal imaging studies of learning in schizophrenia.

Task-independent effects are potential confounders in longitudinal imaging studies of learning in schizophrenia.

Abstract：

:Learning impairment is a core deficit in schizophrenia that impacts on real-world functioning and yet, elucidating its underlying neural basis remains a challenge. A key issue when interpreting learning-task experiments is that task-independent changes may confound interpretation of task-related signal changes in neuroimaging studies. The nature of these task-independent changes in schizophrenia is unknown. Therefore, we examined task-independent "time effects" in a group of participants with schizophrenia contrasted with healthy participants in a longitudinal fMRI learning-experiment designed to allow for examination of non-specific effects of time. Flanking the learning portions of the experiment with a task-of-no-interest allowed us to extract task-independent BOLD changes. Task-independent effects occurred in both groups, but were more robust in the schizophrenia group. There was a significant interaction effect between group and time in a distributed activity pattern that included inferior and superior temporal regions, frontal areas (left anterior insula and superior medial gyri), and parietal areas (posterior cingulate cortices and precuneus). This pattern showed task-independent linear decrease in BOLD amplitude over the two scanning sessions for the schizophrenia group, but showed either opposite effect or no activity changes for the control group. There was a trend towards a correlation between task-independent effects and the presence of more negative symptoms in the schizophrenia group. The strong interaction between group and time suggests that both the scanning experience as a whole and the transition between task-types evokes a different response in persons with schizophrenia and may confound interpretation of learning-related longitudinal imaging experiments if not explicitly considered.

journal_name

Neuroimage Clin

journal_title

NeuroImage. Clinical

authors

Korostil M,Fatima Z,Kovacevic N,Menon M,McIntosh AR

doi

10.1016/j.nicl.2015.11.016

subject

Has Abstract

pub_date

2015-11-23 00:00:00

pages

159-71

issn

2213-1582

pii

S2213-1582(15)30033-4

journal_volume

10

pub_type

杂志文章

相关文献

NeuroImage-Clinical文献大全
  • Disconnected neuromagnetic networks in children born very preterm: Disconnected MEG networks in preterm children.

    abstract：:Many children born very preterm (≤32 weeks) experience significant cognitive difficulties, but the biological basis of such problems has not yet been determined. Functional MRI studies have implicated altered functional connectivity; however, little is known regarding the spatiotemporal organization of brain networks ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2015.08.016

    authors： Ye AX,AuCoin-Power M,Taylor MJ,Doesburg SM

    更新日期：2015-09-01 00:00:00

  • Diffusion tensor imaging reveals changes in microstructural integrity along compressed nerve roots that correlate with chronic pain symptoms and motor deficiencies in elderly stenosis patients.

    abstract：:Age-related degenerative changes in the lumbar spine frequently result in nerve root compression causing severe pain and disability. Given the increasing incidence of lumbar spinal disorders in the aging population and the discrepancies between the use of current diagnostic imaging tools and clinical symptoms, novel m...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.101880

    authors： Hughes SW,Hellyer PJ,Sharp DJ,Newbould RD,Patel MC,Strutton PH

    更新日期：2019-01-01 00:00:00

  • The associations of depression and hypertension with brain volumes: Independent or interactive?

    abstract：:Independent studies on major depressive disorder (MDD) and hypertension, suggest overlapping abnormalities in brain regions associated with emotional and autonomic processing. However, the unique and interactive effects of MDD and hypertension have never been studied in a single sample. Brain volume in these areas may...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.nicl.2015.03.020

    authors： Meurs M,Groenewold NA,Roest AM,van der Wee NJ,Veltman DJ,van Tol MJ,de Jonge P

    更新日期：2015-03-28 00:00:00

  • Spectral EEG abnormalities during vibrotactile encoding and quantitative working memory processing in schizophrenia.

    abstract：:Schizophrenia is associated with a number of cognitive impairments such as deficient sensory encoding or working memory processing. However, it is largely unclear how dysfunctions on these various levels of cortical processing contribute to alterations of stimulus-specific information representation. To test this, we ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2016.04.004

    authors： Ludwig S,Spitzer B,Jacobs AM,Sekutowicz M,Sterzer P,Blankenburg F

    更新日期：2016-04-12 00:00:00

  • Neural correlates of attention bias to masked facial threat cues: Examining children at-risk for social anxiety disorder.

    abstract：Background:Behavioral inhibition (BI) is an early-appearing temperament trait and a robust predictor of social anxiety disorder (SAD). Both BI and anxiety may have distinct patterns of emotion processing marked by heightened neural responses to threat cues. BI and anxious children display similar frontolimbic patterns ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2018.04.003

    authors： Auday ES,Taber-Thomas BC,Pérez-Edgar KE

    更新日期：2018-04-12 00:00:00

  • Fibromyalgia interacts with age to change the brain.

    abstract：:Although brain plasticity in the form of gray matter increases and decreases has been observed in chronic pain, factors determining the patterns of directionality are largely unknown. Here we tested the hypothesis that fibromyalgia interacts with age to produce distinct patterns of gray matter differences, specificall...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2013.08.015

    authors： Ceko M,Bushnell MC,Fitzcharles MA,Schweinhardt P

    更新日期：2013-09-06 00:00:00

  • Examining the relationship between measures of autistic traits and neural synchrony during movies in children with and without autism.

    abstract：:Children who have been diagnosed with autism spectrum disorder (ASD) often show a marked deficit in measures of social cognition. In autistic adults, measures of social cognition have been shown to relate to differences in brain synchronization (as measured by fMRI) when individuals are processing naturalistic stimuli...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102477

    authors： Lyons KM,Stevenson RA,Owen AM,Stojanoski B

    更新日期：2020-01-01 00:00:00

  • The association between intra- and juxta-cortical pathology and cognitive impairment in multiple sclerosis by quantitative T2* mapping at 7 T MRI.

    abstract：:Using quantitative T2* at 7 Tesla (T) magnetic resonance imaging, we investigated whether impairment in selective cognitive functions in multiple sclerosis (MS) can be explained by pathology in specific areas and/or layers of the cortex. Thirty-one MS patients underwent neuropsychological evaluation, acquisition of 7 ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2016.11.001

    authors： Louapre C,Govindarajan ST,Giannì C,Madigan N,Nielsen AS,Sloane JA,Kinkel RP,Mainero C

    更新日期：2016-11-03 00:00:00

  • Associations of hippocampal subfields in the progression of cognitive decline related to Parkinson's disease.

    abstract：OBJECTIVE:Hippocampal atrophy has been associated with mild cognitive impairment (MCI) in Parkinson's disease (PD). However, literature on how hippocampal atrophy affects the pathophysiology of cognitive impairment in PD has been limited. Previous studies assessed the hippocampus as an entire entity instead of their in...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2016.12.008

    authors： Foo H,Mak E,Chander RJ,Ng A,Au WL,Sitoh YY,Tan LC,Kandiah N

    更新日期：2016-12-12 00:00:00

  • Disrupted modular organization of primary sensory brain areas in schizophrenia.

    abstract：:Abnormal brain resting-state functional connectivity has been consistently observed in patients affected by schizophrenia (SCZ) using functional MRI and other neuroimaging techniques. Graph theoretical methods provide a framework to investigate these defective functional interactions and their effects on the organizat...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2018.02.035

    authors： Bordier C,Nicolini C,Forcellini G,Bifone A

    更新日期：2018-03-01 00:00:00

  • Relevance of brain lesion location for cognition in vascular mild cognitive impairment.

    abstract：BACKGROUND:Vascular mild cognitive impairment (VMCI) is a potentially transitional state between normal aging and vascular dementia. The presence of macroscopic white matter lesions (WML) of moderate or severe extension on brain MRI is the hallmark of the VMCI. OBJECTIVE:To assess the clinical relevance of the frequen...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.nicl.2019.101789

    authors： Giorgio A,Di Donato I,De Leucio A,Zhang J,Salvadori E,Poggesi A,Diciotti S,Cosottini M,Ciulli S,Inzitari D,Pantoni L,Mascalchi M,Federico A,Dotti MT,De Stefano N,VMCI-Tuscany Study Group.

    更新日期：2019-01-01 00:00:00

  • White matter integrity in small vessel disease is related to cognition.

    abstract：:Cerebral small vessel disease, including white matter hyperintensities (WMH) and lacunes of presumed vascular origin, is common in elderly people and is related to cognitive impairment and dementia. One possible mechanism could be the disruption of white matter tracts (both within WMH and normal-appearing white matter...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2015.02.003

    authors： Tuladhar AM,van Norden AG,de Laat KF,Zwiers MP,van Dijk EJ,Norris DG,de Leeuw FE

    更新日期：2015-02-16 00:00:00

  • Computational analysis in epilepsy neuroimaging: A survey of features and methods.

    abstract：:Epilepsy affects 65 million people worldwide, a third of whom have seizures that are resistant to anti-epileptic medications. Some of these patients may be amenable to surgical therapy or treatment with implantable devices, but this usually requires delineation of discrete structural or functional lesion(s), which is ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章,评审

    doi：10.1016/j.nicl.2016.02.013

    authors： Kini LG,Gee JC,Litt B

    更新日期：2016-02-23 00:00:00

  • Combined FET PET/MRI radiomics differentiates radiation injury from recurrent brain metastasis.

    abstract：Background:The aim of this study was to investigate the potential of combined textural feature analysis of contrast-enhanced MRI (CE-MRI) and static O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET for the differentiation between local recurrent brain metastasis and radiation injury since CE-MRI often remains inconclusive. ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2018.08.024

    authors： Lohmann P,Kocher M,Ceccon G,Bauer EK,Stoffels G,Viswanathan S,Ruge MI,Neumaier B,Shah NJ,Fink GR,Langen KJ,Galldiks N

    更新日期：2018-08-19 00:00:00

  • Mirror neuron activations in encoding of psychic pain in borderline personality disorder.

    abstract：:Borderline personality disorder (BPD) is characterized by pronounced emotional instability in interpersonal relations. Previous studies have shown increased activity in the amygdala, an imaging phenotype of negative affect. However, clinical accounts of BPD have drawn attention to deficits in social cognition and thei...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.101737

    authors： Sosic-Vasic Z,Eberhardt J,Bosch JE,Dommes L,Labek K,Buchheim A,Viviani R

    更新日期：2019-01-01 00:00:00

  • Chronic tinnitus and the limbic system: Reappraising brain structural effects of distress and affective symptoms.

    abstract：:Chronic tinnitus has been associated with brain structural changes in both the auditory system as well as limbic system. While there is considerable inconsistency across brain structural findings, growing evidence suggests that distress and other non-auditory symptoms modulate effects. In this study we addressed this ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.101976

    authors： Besteher B,Gaser C,Ivanšić D,Guntinas-Lichius O,Dobel C,Nenadić I

    更新日期：2019-01-01 00:00:00

  • Microstructural imaging in temporal lobe epilepsy: Diffusion imaging changes relate to reduced neurite density.

    abstract：PURPOSE:Previous imaging studies in patients with refractory temporal lobe epilepsy (TLE) have examined the spatial distribution of changes in imaging parameters such as diffusion tensor imaging (DTI) metrics and cortical thickness. Multi-compartment models offer greater specificity with parameters more directly relate...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102231

    authors： Winston GP,Vos SB,Caldairou B,Hong SJ,Czech M,Wood TC,Wastling SJ,Barker GJ,Bernhardt BC,Bernasconi N,Duncan JS,Bernasconi A

    更新日期：2020-01-01 00:00:00

  • Psychopathy is associated with shifts in the organization of neural networks in a large incarcerated male sample.

    abstract：:Psychopathy is a personality disorder defined by antisocial behavior paired with callousness, low empathy, and low interpersonal emotions. Psychopathic individuals reliably display complex atypicalities in emotion and attention processing that are evident when examining task performance, activation within specific neu...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.102083

    authors： Tillem S,Harenski K,Harenski C,Decety J,Kosson D,Kiehl KA,Baskin-Sommers A

    更新日期：2019-01-01 00:00:00

  • Physical activity is associated with left corticospinal tract microstructure in bipolar depression.

    abstract：:Psychomotor retardation and reduced daily activities are core features of the depressive syndrome including bipolar disorder (BD). It was the aim of this study to investigate white matter microstructure of the motor system in BD during depression and its association with motor activity. We hypothesized reduced physica...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2018.09.033

    authors： Bracht T,Steinau S,Federspiel A,Schneider C,Wiest R,Walther S

    更新日期：2018-01-01 00:00:00

  • Functional connectome fingerprint of sleep quality in insomnia patients: Individualized out-of-sample prediction using machine learning.

    abstract：OBJECTIVES:Insomnia disorder has been reclassified into short-term/acute and chronic subtypes based on recent etiological advances. However, understanding the similarities and differences in the neural mechanisms underlying the two subtypes and accurately predicting the sleep quality remain challenging. METHODS:Using ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102439

    authors： Ma X,Wu D,Mai Y,Xu G,Tian J,Jiang G

    更新日期：2020-01-01 00:00:00

  • Connectivity of precuneus to the default mode and dorsal attention networks: A possible invariant marker of long-term tinnitus.

    abstract：:Resting state functional connectivity studies of tinnitus have provided inconsistent evidence concerning its neural bases. This may be due to differences in the methodology used, but it is also likely related to the heterogeneity of the tinnitus population. In this study, our goal was to identify resting state functio...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2017.07.015

    authors： Schmidt SA,Carpenter-Thompson J,Husain FT

    更新日期：2017-07-22 00:00:00

  • The diffeomorphometry of temporal lobe structures in preclinical Alzheimer's disease.

    abstract：:This paper examines morphometry of MRI biomarkers derived from the network of temporal lobe structures including the amygdala, entorhinal cortex and hippocampus in subjects with preclinical Alzheimer's disease (AD). Based on template-centered population analysis, it is demonstrated that the structural markers of the a...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2013.09.001

    authors： Miller MI,Younes L,Ratnanather JT,Brown T,Trinh H,Postell E,Lee DS,Wang MC,Mori S,O'Brien R,Albert M,BIOCARD Research Team.

    更新日期：2013-09-16 00:00:00

  • Emotion self-regulation training in major depressive disorder using simultaneous real-time fMRI and EEG neurofeedback.

    abstract：:Simultaneous real-time fMRI and EEG neurofeedback (rtfMRI-EEG-nf) is an emerging neuromodulation approach, that enables simultaneous volitional regulation of both hemodynamic (BOLD fMRI) and electrophysiological (EEG) brain activities. Here we report the first application of rtfMRI-EEG-nf for emotion self-regulation t...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102331

    authors： Zotev V,Mayeli A,Misaki M,Bodurka J

    更新日期：2020-01-01 00:00:00

  • Subacute functional connectivity correlates with cognitive recovery six months after stroke.

    abstract：BACKGROUND AND PURPOSE:Cognitive impairment is a common consequence of stroke, and the rewiring of the surviving brain circuits might contribute to cognitive recovery. Studies investigating how the functional connectivity of networks change across time and whether their remapping relates to cognitive recovery in stroke...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102538

    authors： Vicentini JE,Weiler M,Casseb RF,Almeida SR,Valler L,de Campos BM,Li LM

    更新日期：2020-12-17 00:00:00

  • Lower 123I-FP-CIT binding to the striatal dopamine transporter, but not to the extrastriatal serotonin transporter, in Parkinson's disease compared with dementia with Lewy bodies.

    abstract：:In this retrospective cross-sectional study we compared 123I‑N‑ω‑fluoropropyl‑2β‑carbomethoxy‑3β‑(4‑iodophenyl)nortropane (123I-FP-CIT) binding to the striatal dopamine and the extrastriatal serotonin transporter (DAT and SERT, respectively) between Parkinson's disease (PD) and dementia with Lewy bodies (DLB) to gain ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2018.04.009

    authors： Joling M,Vriend C,van der Zande JJ,Lemstra AW,van den Heuvel OA,Booij J,Berendse HW

    更新日期：2018-04-06 00:00:00

  • Preliminary evidence for differential olfactory and trigeminal processing in combat veterans with and without PTSD.

    abstract：:Structural and functional changes in the olfactory system are increasingly implicated in the expression of PTSD. Still, very little is known about the neurobiological networks of trauma-related odor sensitivity or how they relate to other objective and subjective measures of olfaction and PTSD. The purpose of this stu...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2017.09.018

    authors： Cortese BM,Schumann AY,Howell AN,McConnell PA,Yang QX,Uhde TW

    更新日期：2017-09-28 00:00:00

  • Hippocampal volume predicts antidepressant efficacy in depressed patients without incomplete hippocampal inversion.

    abstract：BACKGROUND:Incomplete hippocampal inversion (IHI), also called malrotation, is a frequent atypical anatomical pattern of the hippocampus. Because of the crucial implication of the hippocampus in Major Depressive Disorder (MDD) and the neurodevelopmental hypothesis of MDD, we aimed to assess the prevalence of IHI in pat...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2016.04.009

    authors： Colle R,Cury C,Chupin M,Deflesselle E,Hardy P,Nasser G,Falissard B,Ducreux D,Colliot O,Corruble E

    更新日期：2016-04-27 00:00:00

  • Functional connectivity of the Precuneus reflects effectiveness of visual restitution training in chronic hemianopia.

    abstract：:Visual field defects in chronic hemianopia can improve through visual restitution training, yet not all patients benefit equally from this long and exhaustive procedure. Here, we asked if resting-state functional connectivity prior to visual restitution could predict training success. In two training sessions of eight...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102292

    authors： Halbertsma HN,Elshout JA,Bergsma DP,Norris DG,Cornelissen FW,van den Berg AV,Haak KV

    更新日期：2020-01-01 00:00:00

  • High serum high-density lipoprotein-cholesterol is associated with memory function and gyrification of insular and frontal opercular cortex in an elderly memory-clinic population.

    abstract：:The issue of whether serum lipid marker values are cognitively and neurologically significant for elderly individuals attending a memory clinic has been controversial. We investigated the associations of serum lipid markers with the memory function and cortical structure in 52 patients aged ≥75 years who had attended ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.101746

    authors： Kinno R,Mori Y,Kubota S,Nomoto S,Futamura A,Shiromaru A,Kuroda T,Yano S,Ishigaki S,Murakami H,Baba Y,Ono K

    更新日期：2019-01-01 00:00:00

  • Brain connectivity tracks effects of chemotherapy separately from behavioral measures.

    abstract：:Several studies in cancer research have suggested that cognitive dysfunction following chemotherapy, referred to in lay terms as "chemobrain", is a serious problem. At present, the changes in integrative brain function that underlie such dysfunction remain poorly understood. Recent developments in neuroimaging suggest...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.101654

    authors： Kardan O,Reuter-Lorenz PA,Peltier S,Churchill NW,Misic B,Askren MK,Jung MS,Cimprich B,Berman MG

    更新日期：2019-01-01 00:00:00