Abstract:
BACKGROUND:The GABARAP family members (GABARAP, GABARAPL1/GEC1 and GABARAPL2 /GATE-16) are involved in the intracellular transport of receptors and the autophagy pathway. We previously reported that GABARAPL1 expression was frequently downregulated in cancer cells while a high GABARAPL1 expression is a good prognosis marker for patients with lymph node-positive breast cancer. METHODS:In this study, we asked using qRT-PCR, western blotting and epigenetic quantification whether the expression of the GABARAP family was regulated in breast cancer by epigenetic modifications. RESULTS:Our data demonstrated that a specific decrease of GABARAPL1 expression in breast cancers was associated with both DNA methylation and histone deacetylation and that CREB-1 recruitment on GABARAPL1 promoter was required for GABARAPL1 expression. CONCLUSIONS:Our work strongly suggests that epigenetic inhibitors and CREB-1 modulators may be used in the future to regulate autophagy in breast cancer cells.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Hervouet E,Claude-Taupin A,Gauthier T,Perez V,Fraichard A,Adami P,Despouy G,Monnien F,Algros MP,Jouvenot M,Delage-Mourroux R,Boyer-Guittaut Mdoi
10.1186/s12885-015-1761-4subject
Has Abstractpub_date
2015-10-17 00:00:00pages
729issn
1471-2407pii
10.1186/s12885-015-1761-4journal_volume
15pub_type
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