Abstract：
INTRODUCTION:Superficial CNS siderosis was previously almost unknown but is now diagnosed with increasing frequency owing to magnetic resonance imaging. Patients may present with sensory deafness, gait ataxia, various sensorimotor signs and, eventually, cognitive decline. They typically have a history of traumatic brain or spinal cord injury or previous neurosurgery, or may harbour congenital malformations. However, knowledge about treatment outcomes remains scarce. METHODS:We present a series of nine consecutive patients from a large tertiary neuroscience centre in order to highlight the challenges related to the diagnosis and treatment of superficial siderosis. RESULTS:A potential bleeding aetiology was identified in all patients, but removal of the offending bleeding source was achieved only in three (33%). Symptom progression was halted in just one patient (11%), which suggests that neurodegeneration due to haemosiderin-associated iron toxicity becomes irreversible with time. CONCLUSION:Surgical therapy in superficial CNS siderosis is rarely achieved. We suggest that prospective, large-scale multicentre studies are needed to search for non-surgical therapies that reverse (or prevent) ongoing neurotoxicity due to accumulating iron toxicity. FUNDING:not relevant. TRIAL REGISTRATION:not relevant.
journal_name
Dan Med Jjournal_title
Danish medical journalauthors
Kondziella D,Lindelof M,Haziri D,Larsen VA,Kruse Asubject
Has Abstractpub_date
2015-05-01 00:00:00issue
5issn
2245-1919pii
A5079journal_volume
62pub_type
杂志文章abstract：INTRODUCTION:In order to optimise the selection process for admission to specialist training in family medicine, we developed a new design for structured applications and selection interviews. The design contains semi-structured interviews, which combine individualised elements from the applications with standardised b...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-09-01 00:00:00
abstract：INTRODUCTION:Treatment of infections in neonates with gentamicin is a balance between optimising bactericidal effect and minimising adverse effects. Previously, at the Neonatal Intensive Care Unit (NICU) at Kolding Hospital, Denmark, neonates suspected of having infections were treated daily with gentamicin 5 mg/kg for...
journal_title：Danish medical journal
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更新日期：2017-06-01 00:00:00
abstract：:The epidemiology and prognosis of ''fainting'' or syncope has puzzled physicians over the years. Is fainting dangerous? This is a question often asked by the patient--and the answer is ''it depends on a lot of things''. The diverse pathophysiology of syncope and the underlying comorbidites of the patients play an esse...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2013-09-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
abstract：INTRODUCTION:Since 1992 the Danish Patient Insurance Association (DPIA) has been receiving claims from patients who had suffered an injury during examination or treatment in Danish healthcare. We have presently collected more than 85,000 patient cases in our database, which we make accessible to research that can promo...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-08-01 00:00:00
abstract：INTRODUCTION:This prospective cohort study in consecutive shoulder patients sought to determine the minimal, clinically important difference of the Danish version of the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire and to evaluate patient responsiveness to it. The study was undertaken at the Outpatie...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-04-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to examine the use of quantitative fluorescein angiographic analysis as a means of estimating rates of perfusion of the retina in eyes with a circulatory deficit secondary to carotid artery stenosis. MATERIAL AND METHODS:The study included 21 eyes with ocular ischaemic syndrome (...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-10-01 00:00:00
abstract：INTRODUCTION:Psychiatric disorders are common among patients with irritable bowel syndrome (IBS) which may make a psychiatric evaluation appropriate. The Hospital Anxiety and Depression Scale (HADS) has been recommended internationally for screening. The Common Mental Disorder Questionnaire (CMDQ) is a novel Danish ins...
journal_title：Danish medical journal
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2014-02-01 00:00:00
abstract：:Kidney cancer (Renal Cell Carcinoma (RCC)) is one of the most deadly malignancies due to frequent late diagnosis and poor treatment options. Histologically, RCC embraces a wide variety of different subtypes with the clear cell variant (ccRCC) being the most common, accounting for 75-90% of all RCCs. At present, the su...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-10-01 00:00:00
abstract：INTRODUCTION:Due to the coronavirus disease 2019 (COVID-19) exposure in Denmark, first-line referral centres were established to handle all patients suspected of COVID-19 or other upper respiratory tract infection. Here we report the first experiences from a first-line referral centre from Amager-Hvidovre Hospital, sit...
journal_title：Danish medical journal
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doi：
更新日期：2020-08-07 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-04-01 00:00:00
abstract：INTRODUCTION:Mechanical restraint and other forms of coercion may be used under certain circumstances at psych-iatric wards. The use of coercion receives considerable focus, yet little is known about its diurnal distribution. We examined the initiation of mechanical restraint, sedative drug administration, physical ret...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-08-01 00:00:00
abstract：INTRODUCTION:With the increasing use of cross-sectional imaging, the incidence of non-symptomatic pancreatic cystic neoplasms is increasing. Surgical management of pancreatic cystic neoplasms possess significant risks of perioperative morbidity and mortality. Our aim was to evaluate endoscopic ultrasound (EUS)-guided a...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-08-01 00:00:00
abstract：INTRODUCTION:The incidence of cutaneous malignant melanoma is rapidly increasing in Denmark like in other Northern and Western European countries. Our objective was to investigate the characteristics of current patients suffering from cutaneous malignant melanoma. METHODS:We evaluated patient and tumour characteristic...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2015-10-01 00:00:00
abstract：INTRODUCTION:Recent studies have reported an asso-ciation between the day of week of surgery and post-operative mortality, meaning that patients undergoing surgery at the end of the week or during weekends may be at higher risk. The aim of this study was to investigate the influence of the day of week of surgery on mor...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2019-07-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-06-01 00:00:00
abstract：INTRODUCTION:(99m)Tc-pertechnetate scintigraphy is much used in the evaluation of patients with nodular goitre. We investigated the ability of experienced observers to estimate the thyroid 24-h (131)I uptake (RAIU) and the thyroid volume by visual evaluation of the scintigram. MATERIAL AND METHODS:Two endocrinologists...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-02-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-03-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2015-03-01 00:00:00
abstract：INTRODUCTION:The use of positron emission tomography with 2-deoxy-2-18F-fluoro-D-glucose integrated with CT (18F-FDG-PET/CT) in oncology is common. Unexpected incidental findings are occasionally recognised and can represent clinically relevant lesions or conditions. This study aims to assess the occurrence, clinical s...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-09-07 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2014-04-01 00:00:00
abstract：:Today, sentinel lymph node dissection (SLND) has replaced axillary lymph node dissection (ALND) as standard procedure for staging of the axilla in the treatment of breast cancer. SLND can accurately stage the axilla by removing on average only two lymph nodes. Only in case of metastatic spread to sentinel nodes an ALN...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2012-07-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2015-03-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2013-06-01 00:00:00
abstract：INTRODUCTION:The health authorities have recommended that face-to-face consultations be substituted by telephone consultations to reduce the risk of virus transmission in out-patient clinics during the coronavirus disease 2019 (COVID-19) pandemic. The aim of the present study was to assess the frequency of such telepho...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-06-23 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2018-01-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2016-10-01 00:00:00
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journal_title：Danish medical journal
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2013-12-01 00:00:00
abstract：INTRODUCTION:Surveying sexual behaviour of the general population serves to identify key points of preventive interventions, monitor the effect and interpret changes in patterns of disease. Validated questionnaires describing sexual behaviour can be adapted to some extent from other countries, but national adaption, re...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：:Surgeons are increasingly using ultrasonography (US) in their clinical management of patients. However, US is a very user-dependent imaging modality and proper skills of the US operator are needed to ensure quality in patient care. This thesis explores the validity evidence for assessment of competence in abdominal an...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-11-01 00:00:00
