Abstract:
BACKGROUND:Adiponectin is a biomarker that is associated with type 2 diabetes and hypertension. Lower circulating level is a risk factor. Higher levels are protective. African Americans have a higher prevalence of type 2 diabetes and hypertension and lower levels of adiponectin when compared to other racial/ethnic groups. Little is known about the association of adiponectin on these health outcomes among African Americans. The purpose of the study was to assess the association of adiponectin on type 2 diabetes and hypertension likelihood among African American men and women in the Jackson Heart Study. METHODS:Separate multivariate logistic regressions were conducted stratified by sex based on cross-sectional data with type 2 diabetes and hypertension as the outcomes. Adiponectin was divided into four quartiles with the highest quartile as the reference. Data was collected from 2000-2004 on 3,663 participants. Data analysis was conducted in calendar year 2014. Two- tailed P < .05 was established as level of significance. RESULTS:In the adjusted multivariate models, adiponectin level was inversely associated with type 2 diabetes among women (odds ratio [OR], 95% confidence interval [CI] = 1.47, [1.02, 2.11], P = .04). There was no association among men. Women with the lowest level of adiponectin were less likely to be hypertensive (OR, 95% CI = 0.66, [0.46, 0.95], p = .02). There was no association among men. CONCLUSION:Findings reveal differential associations between levels of adiponectin with type 2 diabetes and hypertension likelihood among African American women. More research is needed to elucidate this differential association.
journal_name
BMC Cardiovasc Disordjournal_title
BMC cardiovascular disordersauthors
Davis SK,Gebreab SY,Xu R,Riestra P,Khan RJ,Sumner AE,Hickson D,Bidulescu Adoi
10.1186/s12872-015-0005-5subject
Has Abstractpub_date
2015-02-25 00:00:00pages
13issn
1471-2261pii
10.1186/s12872-015-0005-5journal_volume
15pub_type
杂志文章abstract:BACKGROUND:To investigate the relationships of plasma renin, angiotensin, and aldosterone levels to blood pressure variability and target organ damage in children with essential hypertension. METHODS:A case-control study was conducted on 132 children diagnosed with essential hypertension (103 males and 29 females with...
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,评审
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更新日期:2018-02-07 00:00:00
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pub_type: 杂志文章,meta分析,评审
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
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更新日期:2009-03-03 00:00:00