Abstract:
BACKGROUND:In diagnosing celiac disease (CD), serological tests are highly valuable. However, their role in following up children with CD after prescription of a gluten-free diet is unclear. This study aimed to compare the performance of antibody tests in predicting small-intestinal mucosal status in diagnosis vs. follow-up of pediatric CD. METHODS:We conducted a prospective cohort study at a tertiary-care center. 148 children underwent esophohagogastroduodenoscopy with biopsies either for symptoms ± positive CD antibodies (group A; n = 95) or following up CD diagnosed ≥ 1 year before study enrollment (group B; n = 53). Using biopsy (Marsh ≥ 2) as the criterion standard, areas under ROC curves (AUCs) and likelihood-ratios were calculated to estimate the performance of antibody tests against tissue transglutaminase (TG2), deamidated gliadin peptide (DGP) and endomysium (EMA). RESULTS:AUCs were higher when tests were used for CD diagnosis vs. follow-up: 1 vs. 0.86 (P = 0.100) for TG2-IgA, 0.85 vs. 0.74 (P = 0.421) for TG2-IgG, 0.97 vs. 0.61 (P = 0.004) for DPG-IgA, and 0.99 vs. 0.88 (P = 0.053) for DPG-IgG, respectively. Empirical power was 85% for the DPG-IgA comparison, and on average 33% (range 13-43) for the non-significant comparisons. Among group B children, 88.7% showed mucosal healing (median 2.2 years after primary diagnosis). Only the negative likelihood-ratio of EMA was low enough (0.097) to effectively rule out persistent mucosal injury. However, out of 12 EMA-positive children with mucosal healing, 9 subsequently turned EMA-negative. CONCLUSIONS:Among the CD antibodies examined, negative EMA most reliably predict mucosal healing. In general, however, antibody tests, especially DPG-IgA, are of limited value in predicting the mucosal status in the early years post-diagnosis but may be sufficient after a longer period of time.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Vécsei E,Steinwendner S,Kogler H,Innerhofer A,Hammer K,Haas OA,Amann G,Chott A,Vogelsang H,Schoenlechner R,Huf W,Vécsei Adoi
10.1186/1471-230X-14-28subject
Has Abstractpub_date
2014-02-13 00:00:00pages
28issn
1471-230Xpii
1471-230X-14-28journal_volume
14pub_type
杂志文章abstract:BACKGROUND:Several association studies with small sample sizes of two SNPs in IL28BB (rs12979860 and rs8099917) showed inconsistent results, so in this study, we aim to evaluate the association between the two SNPs and infection susceptibility of Hepatitis B Virus (HBV) in Asian population, especially in Chinese popula...
journal_title:BMC gastroenterology
pub_type: 杂志文章,meta分析
doi:10.1186/s12876-015-0286-2
更新日期:2015-05-12 00:00:00
abstract:BACKGROUND:HBV and HCV reactivation have been widely reported in patients undergoing immunosuppressive therapy (IT); however, few data are available on the risk of reactivation in patients with psoriasis receiving IT. The aim of our study was to assess the prevalence of HBV and HCV infection in patients with psoriasis ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-014-0214-x
更新日期:2014-12-19 00:00:00
abstract:BACKGROUND:This case seeks to highlight to endoscopists a rare benign disorder that may be encountered during endoscopy. Clinicians may be tempted to biopsy, which could lead to a catastrophic gastrointestinal haemorrhage. CASE PRESENTATION:A 66-year-old asymptomatic Caucasian male was referred for colonoscopy with a ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1118-6
更新日期:2019-11-27 00:00:00
abstract:BACKGROUND:The use of thickeners is a standard therapy for decreasing episodes of regurgitation or vomiting in infants. However, it remains to be investigated whether thickener is effective for vomiting and/or chronic respiratory symptoms in children with cerebral palsy. METHODS:We enrolled 18 neurologically impaired ...
journal_title:BMC gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-230X-8-11
更新日期:2008-04-16 00:00:00
abstract:BACKGROUND:Inadequate response to proton pump inhibitor (PPI) therapy in patients with gastroesophageal reflux disease (GERD) is reported in up to 40%. Patients with non erosive reflux disease (NERD) have lower response rates compared to patients with erosive reflux disease (ERD); pH metry contributes to GERD diagnosis...
journal_title:BMC gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1186/1471-230X-13-12
更新日期:2013-01-16 00:00:00
abstract:BACKGROUND:Studies on Epstein-Barr virus (EBV) have focused mostly on neoplastic disease. Few studies have considered immunocompetent patients who are not severely immunocompromised. Liver cirrhosis is associated with various levels of immune dysfunction. In the current study, we determined EBV infection rates, the inf...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1021-1
更新日期:2019-06-18 00:00:00
abstract:BACKGROUND:An intravascular ultrasound catheter (IVUSc) was developed for intracardiac ultrasound to assess interventions with compelling results. However, intrahepatic vascular exploration was rarely tested and was always associated with X-ray techniques. The aim of this study was to demonstrate the feasibility to nav...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-021-01600-3
更新日期:2021-01-09 00:00:00
abstract:BACKGROUND:Controversy exists regarding the role of PD1 and its ligand PD-L1 in chronic hepatitis B infection. In some studies, persistent HBV infection has been attributed to high levels of PD-1 and PD-L1 expression on HBV-specific T-cells and antigen-presenting cells (APCs) respectively. Other studies revealed that t...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-109
更新日期:2012-08-16 00:00:00
abstract:BACKGROUND:Endoscopic nasobiliary drainage (ENBD) is widely used for biliary decompression in patients with biliary disease. However, it is difficult to reposition a nasobiliary catheter from the mouth to nostril. We developed a new device, which has a curved flexible loop and bar-handle, for repositioning of ENBD cath...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1148-0
更新日期:2019-12-21 00:00:00
abstract:BACKGROUND:Apoptosis inhibitor of macrophage (AIM) and adipocytokines are involved in the metabolic syndrome, which has been putatively associated with the progression of chronic hepatitis C (CHC). However, the association between these cytokines and CHC is not fully elucidated. The aim of this study is to test whether...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-14-27
更新日期:2014-02-13 00:00:00
abstract:BACKGROUND:Low 25-Hydroxy-vitamin-D; "25(OH)-D3" serum and vitamin D receptor (VDR) levels were recently correlated to advanced fibrosis. However, VDR mechanism in liver fibrosis modulations is not well understood. In this study, we aimed to evaluate changes in liver NK cells cytotoxicity due to modulations in VDR in C...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01248-5
更新日期:2020-04-10 00:00:00
abstract:BACKGROUND:Recent improvements in stone extraction implements and apparatus have lessened the complexity of the endoscopic bile duct stone treatment. However, despite confirmation of complete removal, cases of residual stones have been reported, which can result in recurrent biliary symptoms, cholangitis, and pancreati...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01428-3
更新日期:2020-08-24 00:00:00
abstract:BACKGROUND:Recent evidence cautions against the use of non-selective beta-blockers (NSBB) in patients with refractory ascites or spontaneous bacterial peritonitis while other data suggests a survival benefit in patients with advanced liver disease. The aim of this study was to describe the use and impact of NSBB in pat...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1155-1
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:Intestinal ischemia-reperfusion injury (IRI) can occur in clinical scenarios such as organ transplantation, trauma and cardio-pulmonary bypass, as well as in neonatal necrotizing enterocolitis or persistent ductus arteriosus. Pharmacological protection by pretreating ("preconditioning") with opioids attenuat...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-13-69
更新日期:2013-04-22 00:00:00
abstract:BACKGROUND:Patients often experience severe weight loss after oesophagectomy. Enteral nutrition via a feeding jejunostomy tube (FT) is commonly practised. This study aimed to assess the effect of severe weight loss postoperatively and enteral nutrition via an FT on long-term prognosis after oesophagectomy. METHODS:Thi...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01543-1
更新日期:2020-12-03 00:00:00
abstract:BACKGROUND:Portal vein thrombosis (PVT) occurs frequently in hepatocellular carcinoma (HCC) and is often diagnosed in the course of a routine patient evaluation and surveillance for liver cancer. The purpose of this study is to investigate the relationship between folate status and portal vein thrombosis. METHODS:HCC ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01525-3
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:Real-time tissue sonoelastography (EG) is a new non-invasive technique that visualizes differences in tissue strain. We evaluated the usefulness of EG in patients with ulcerative colitis (UC) by investigating the association between EG and colonoscopic findings and disease activity. METHODS:Thirty-seven UC ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-11-29
更新日期:2011-03-31 00:00:00
abstract:BACKGROUND:Irritable bowel syndrome (IBS) is a very common functional bowel disorder. However, the difference of depression and anxiety comorbidities among different IBS subtypes is still not well evaluated. This study aims to investigate the difference in the level and prevalence of depression and anxiety among health...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01593-5
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:Irritable bowel syndrome (IBS) is defined as a multifactorial disorder associated with visceral hypersensitivity, altered gut motility and dysfunction of the brain-gut axis. Gut microbiota and its metabolites are proposed as possible etiological factors of IBS. Short chain fatty acids (SCFAs) induce both inh...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-021-01613-y
更新日期:2021-01-26 00:00:00
abstract:BACKGROUND:Capillary patterns (CP) observed by magnifying Narrow Band Imaging (NBI) are useful for differentiating non-adenomatous from adenomatous colorectal polyps. However, there are few studies concerning the effectiveness of magnifying NBI for determining the depth of invasion in early colorectal neoplasms. We aim...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-10-33
更新日期:2010-03-27 00:00:00
abstract:BACKGROUND:Stress is a common contributing factor for irritable bowel syndrome (IBS). This study was to evaluate the efficacy of the centralized health education program in improving the quality of life (QOL) of middle school students with IBS who experienced the Wenchuan earthquake on May 12, 2008. METHODS:A multi-ce...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12876-018-0845-4
更新日期:2018-07-27 00:00:00
abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of liver diseases, ranging from pure steatosis to nonalcoholic steatohepatitis (NASH), and eventually to liver cirrhosis with its complications. Identifying advanced fibrosis in patients is crucial to evaluating prognosis and possible therapeu...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-10-67
更新日期:2010-06-28 00:00:00
abstract:BACKGROUND:In China, the incidence of Inflammatory bowel disease (IBD) has shown a significant growth trend. Analysis of the epidemiology, clinical manifestations, diagnostic means, and treatment of IBD will further improve the clinician's understanding of IBD, improve knowledge and further enable early diagnosis and s...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-015-0405-0
更新日期:2016-01-12 00:00:00
abstract:BACKGROUND:High dose intravenous proton pump inhibitor after endoscopic therapy for peptic ulcer bleeding has been recommended as adjuvant therapy. Whether oral proton pump inhibitor can replace intravenous proton pump inhibitor in this setting is unknown. This study aims to compare the clinical efficacy of oral and in...
journal_title:BMC gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-230X-12-66
更新日期:2012-06-08 00:00:00
abstract:BACKGROUND:Saturated fatty acids are thought to be of relevance for the development of non-alcoholic fatty liver disease and obesity. However, the underlying mechanisms are poorly understood. In previous studies we found that food-derived carbohydrates such as fructose alter the intestinal serotonergic system while ind...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-13-169
更新日期:2013-12-09 00:00:00
abstract:BACKGROUND:Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive disorder caused by mutations in TYMP gene, encoding nuclear thymidine phosphorylase (TP). MNGIE mainly presents with gastrointestinal symptoms and is mostly misdiagnosed in many patients as malabsorption syndrome, inf...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01280-5
更新日期:2020-05-08 00:00:00
abstract:BACKGROUND:To evaluate the safety, efficacy and outcomes of fast-track rehabilitation applied to gastric cancer proximal, distal and total gastrectomy. METHODS:Eighty consecutive patients undergoing gastric cancer resection performed by a single surgeon, received perioperative multimodal rehabilitation. Demographic an...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-14-147
更新日期:2014-08-18 00:00:00
abstract:BACKGROUND:Most of the previous studies regarding the effects of gel-forming fibres have considered the gastric emptying of liquid or solid meals after the addition of pectin or guar gum. The influence of locust bean gum, on gastric emptying of nutrient semisolid meals in humans has been less well studied, despite its ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-3-12
更新日期:2003-06-06 00:00:00
abstract:BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) rarely metastasizes to the brain; therefore, the features of brain metastasis of PDAC are still unknown. We encountered simultaneous metastases to the brain and lung in a PDAC patient after curative surgery. Case presentation A 68-year-old man with PDAC in the tail of ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01587-3
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:The role of the crural diaphragm during increased intra-abdominal pressure is not exactly known. We investigated the hypothesis that the crural diaphragm undergoes reflex phasic contraction on elevation of the intra-abdominal pressure with a resulting increase of the lower esophageal pressure and prevention ...
journal_title:BMC gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1186/1471-230X-4-24
更新日期:2004-09-30 00:00:00