Abstract:
BACKGROUND:The Interleukin 28B (IL28B) rs12979860 polymorphisms was recently reported to be associated with the human T-cell leukemia virus type 1 (HTLV-1) proviral load (PvL) and the development of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). METHODS:In an attempt to examine this hypothesis, we assessed the association of the rs12979860 genotypes with HTLV-1 PvL levels and clinical status in 112 unrelated Brazilian subjects (81 HTLV-1 asymptomatic carriers, 24 individuals with HAM/TSP and 7 with Adult T cell Leukemia/Lymphoma (ATLL)). RESULTS:All 112 samples were successfully genotyped and their PvLs compared. Neither the homozygote TT nor the heterozygote CT mutations nor the combination genotypes (TT/CT) were associated with a greater PvL. We also observed no significant difference in allele distribution between asymptomatic carriers and patients with HTLV-1 associated HAM/TSP. CONCLUSIONS:Our study failed to support the previously reported positive association between the IL28B rs12979860 polymorphisms and an increased risk of developing HAM/TSP in the Brazilian population.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Sanabani SS,Nukui Y,Pereira J,da Costa AC,de Oliveira AC,Pessôa R,Leal FE,Segurado AC,Kallas EG,Sabino ECdoi
10.1186/1471-2334-12-374subject
Has Abstractpub_date
2012-12-23 00:00:00pages
374issn
1471-2334pii
1471-2334-12-374journal_volume
12pub_type
杂志文章abstract:BACKGROUND:Molecular strain typing of tuberculosis isolates has led to increased understanding of the epidemiological characteristics of the disease and improvements in its control, diagnosis and treatment. However, molecular cluster investigations, which aim to detect previously unidentified cases, remain challenging....
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1475-5
更新日期:2016-04-12 00:00:00
abstract:BACKGROUND:Surgical site infections following coronary artery bypass graft (CABG) procedures pose substantial burden on patients and healthcare systems. This study aims to describe the incidence of surgical site infections and causative pathogens following CABG surgery over the period 2003-2012, and to identify risk fa...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-318
更新日期:2014-06-10 00:00:00
abstract:BACKGROUND:Dengue cases have been classified according to disease severity into dengue fever (DF) and dengue hemorrhagic fever (DHF). Although DF is considered a non-severe manifestation of dengue, it has been recently demonstrated that DF represents a heterogeneous group of patients with varied clinical complications ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-350
更新日期:2013-07-28 00:00:00
abstract:BACKGROUND:Recently we developed and validated generic quality indicators that define 'appropriate antibiotic use' in hospitalized adults treated for a (suspected) bacterial infection. Previous studies have shown that with appropriate antibiotic use a reduction of 13% of length of hospital stay can be achieved. Our mai...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12879-015-0867-2
更新日期:2015-03-19 00:00:00
abstract:BACKGROUND:Although resistance to isoniazid (INH) is the most common form of drug resistance seen among Mycobacterium tuberculosis isolates, there have been few studies on the efficacy and optimal duration of treatment for patients with INH-resistant tuberculosis (TB). METHODS:We evaluated retrospectively the treatmen...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-8-6
更新日期:2008-01-23 00:00:00
abstract:BACKGROUND:Few studies have assessed the time to blood culture positivity as a predictor of clinical outcome in fungal bloodstream infections (BSIs). The purpose of this study was to evaluate the time to positivity (TTP) of blood cultures in patients with Candida albicans BSIs and to assess its impact on clinical outco...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-486
更新日期:2013-10-20 00:00:00
abstract:BACKGROUND:Rapid diagnostic tests (RDTs) are alternative methods for microscopy in the diagnosis of malaria in resource limited settings. Among commercially available RDTs, CareStart™ Malaria test was found to show reliable results. This study evaluated the performance of CareStart™ Malaria Combo test kit in Northweste...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2503-9
更新日期:2017-06-06 00:00:00
abstract:BACKGROUND:Recent data have shown that HTLV-1 is prevalent among HIV positive patients in Mozambique, although the impact of HTLV-1 infection on HIV disease progression remains controversial. Our aim was to determine the phenotypic profile of T lymphocytes subsets among Mozambican patients co-infected by HIV and HTLV-1...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-9-211
更新日期:2009-12-22 00:00:00
abstract:BACKGROUND:Mycoplasma pneumoniae (M. pneumoniae) is one of the most common causes of community acquired pneumonia (CAP). Establishing an early diagnosis of M. pneumoniae pneumonia in patients with acute respiratory distress syndrome (ARDS) may have important therapeutic implications. METHODS:We describe diagnosis and ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05085-5
更新日期:2020-05-24 00:00:00
abstract:BACKGROUND:Tuberculosis (TB) is the major cause of death in Human Immunodeficiency Virus (HIV)-infected individuals. However, diagnosis of TB in HIV remains challenging particularly when HIV infection is advanced. Several gene signatures and serum protein biomarkers have been identified that distinguish active TB from ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3127-4
更新日期:2018-05-15 00:00:00
abstract:BACKGROUND:Understanding the underlying epidemiology that shapes Neisseria gonorrhoeae (GC), and Chlamydia trachomatis (CT) infections can contribute to data driven policies directed towards curbing the proliferation of these pathogens in Ghana. Information on the symptoms and risk factors for STIs will help to identif...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4035-y
更新日期:2019-05-16 00:00:00
abstract:BACKGROUND:The emergence of extensively drug-resistant tuberculosis (XDR-TB) has raised public health concern for global TB control. Although multi drug-resistant tuberculosis (MDR- TB) prevalence and associated genetic mutations in Morocco are well documented, scarce information on XDR TB is available. Hence, the eval...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3009-9
更新日期:2018-02-27 00:00:00
abstract:BACKGROUND:Mycoplasmas are present worldwide in a large number of animal hosts. Due to their small genome and parasitic lifestyle, Mycoplasma spp. require complex isolation media. Nevertheless, already over 100 different species have been identified and characterized and their number increases as more hosts are sampled...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-5-46
更新日期:2005-06-14 00:00:00
abstract:BACKGROUND:Bacterial infections in the genital tract frequently result in morbidity through a variety of inflammation based symptoms. One component of the bacteria that may trigger host inflammatory response is their DNA. CpG motifs in this DNA are known targets for Toll-like receptor 9 (TLR9), which is a pathogen-reco...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1016-7
更新日期:2015-07-16 00:00:00
abstract:BACKGROUND:Infection with carbapenem-resistant Acinetobacter baumannii has been associated with high morbidity and mortality in solid organ transplant recipients. The main objective of this study was to assess the influence of carbapenem resistance and other potential risk factors on the outcome of A. baumannii infecti...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-351
更新日期:2012-12-13 00:00:00
abstract:BACKGROUND:Urinary tract infection is an infection affecting infants and children. The aim of this study was to determine the etiology of urinary tract infection along with their antimicrobial resistance. METHODS:This cross-sectional study was conducted from June 2015 to January 2016 at Siddhi Memorial Hospital, Bhakt...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3997-0
更新日期:2019-05-14 00:00:00
abstract:BACKGROUND:Osteomyelitis is a difficult-to-cure infection with a high relapse rate despite combined medical and surgical therapies. Some severity factors, duration of antimicrobial therapy and type of surgical procedure might influence osteomyelitis relapse. METHODS:116 patients with osteomyelitis were followed for ≥1...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3550-6
更新日期:2018-12-07 00:00:00
abstract:BACKGROUND:There currently is a severe Zika Virus (ZIKV) epidemic in Brazil and other South American countries. Due to international travel, this poses severe public health risk of ZIKV importation to other countries. We estimate the prevalence of ZIKV in an import region by the time a microcephaly case is detected, si...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-2076-z
更新日期:2016-12-12 00:00:00
abstract:BACKGROUND:Syndromic management of STIs has been advocated as simplified and cheap approach. Youth have been reported to be at increased risk of acquiring STIs which can facilitate HIV transmission. We have investigated the relationship between the syndromic management and specific aetiology diagnosis and its relations...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-6-22
更新日期:2006-02-10 00:00:00
abstract:BACKGROUND:Fusobacterium species (spp.) bacteremia is uncommon and has been associated with a variety of clinical presentations. We conducted a retrospective, population based study to determine the relative proportion of species in this genus causing bacteremia and the risk factors for infection and adverse clinical o...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-264
更新日期:2013-06-05 00:00:00
abstract:BACKGROUND:The role of the surface capsular polysaccharides (CPs) of Mycobacterium tuberculosis (Mtb) in the pathogenesis of infection and disease, as well their potential for use as diagnostic reagents and vaccine antigens, are unknown. METHODS:Serum antibody to two CPs of Mtb, arabinomannan (AM) and glucan (Glu), we...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-276
更新日期:2013-06-19 00:00:00
abstract:BACKGROUND:The Belgian HIV epidemic is largely concentrated among men who have sex with men and Sub-Saharan Africans. We studied the continuum of HIV care of those diagnosed with HIV living in Belgium and its associated factors. METHODS:Data on new HIV diagnoses 2007-2010 and HIV-infected patients in care in 2010-2011...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-1230-3
更新日期:2015-11-03 00:00:00
abstract:BACKGROUND:The technique most frequently used to genotype HCV is quantitative RT-PCR. This technique is unable to provide an accurate genotype/subtype for many samples; we decided to develop an in-house method with the goal of accurately identifying the genotype of all samples. As a Belgium National Centre of reference...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4386-4
更新日期:2019-08-22 00:00:00
abstract:BACKGROUND:There is an established correlation between maternal education and reduction in childhood mortality. One proposed link is that an increase in maternal education will lead to an increase in health care access and vaccine uptake. Vaccinations are a central preventative child health tool, therefore demonstratin...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12879-017-2890-y
更新日期:2017-12-28 00:00:00
abstract:BACKGROUND:West Nile virus (WNV) infections have become increasingly prevalent in certain European countries, including Hungary. Although most human infections do not cause severe symptoms, in approximately 1% of cases WNV infections can lead to severe WNV neuroinvasive disease (WNND) and death. The goal of our study w...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05760-7
更新日期:2021-01-13 00:00:00
abstract:BACKGROUND:Mycobacterium tuberculosis can enter into a dormant state which has resulted in one third of the world's population being infected with latent tuberculosis making the study of latency and reactivation of utmost importance. M. tuberculosis encodes five resuscitation promoting factors (Rpfs) that bear strong s...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-7-146
更新日期:2007-12-17 00:00:00
abstract:BACKGROUND:Acute hepatitis A is a fecal-oral transmitted disease related to inadequate sanitary conditions. In addition to its traditional classification, several outbreaks in the men who have sex with men (MSM) population have resulted in acute hepatitis A being recognized as a sexually transmitted disease. However, f...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2555-x
更新日期:2017-06-20 00:00:00
abstract:BACKGROUND:Systematic reviews suggest that the incidence of diagnosed tuberculosis is two- to- three times higher in those with diabetes mellitus than in those without. Few studies have previously reported the association between diabetes or hyperglycaemia and the prevalence of active tuberculosis and none in a populat...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-2066-1
更新日期:2016-12-05 00:00:00
abstract:BACKGROUND:Antiretroviral therapy (ART) agents potentially associated with adverse metabolic profiles are commonly used in low- and middle-income countries. We assessed risk factors for cardiovascular disease (CVD)-related morbidity and mortality in a cohort of HIV-infected, ART-treated adults in Rio de Janeiro, Brazil...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1735-4
更新日期:2016-08-08 00:00:00
abstract:BACKGROUND:Cutaneous leishmaniasis is one of the neglected tropical diseases in the Ethiopian highlands and studies on assessment of knowledge, attitude and practice of the community in endemic areas are scanty. The study aimed to assess the knowledge, attitude towards cutaneous leishmaniasis and treatment seeking prac...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4506-1
更新日期:2019-10-16 00:00:00