Treatment as prevention: preparing the way.

abstract：INTRODUCTION:We aimed to quantify and identify associated factors of linkage to HIV care following home-based HIV counselling and testing (HBHCT) in the ongoing ANRS 12249 treatment-as-prevention (TasP) cluster-randomized trial in rural KwaZulu-Natal, South Africa. METHODS:Individuals ≥16 years were offered HBHCT; tho...

journal_title：Journal of the International AIDS Society

authors： Plazy M,Farouki KE,Iwuji C,Okesola N,Orne-Gliemann J,Larmarange J,Lert F,Newell ML,Dabis F,Dray-Spira R,Anrs 12249 Tasp Study Group.

更新日期：2016-06-01 00:00:00

abstract：INTRODUCTION:Viral load testing is essential to manage HIV disease, especially in infants and children. Early infant diagnosis is performed using nucleic-acid testing in children under 18 months. Resource-limited health systems face severe challenges to scale-up both viral load and early infant diagnosis to unprecedent...

journal_title：Journal of the International AIDS Society

authors： Vubil A,Nhachigule C,Loquiha O,Meggi B,Mabunda N,Bollinger T,Sacks JA,Jani I,Vojnov L

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:HIV infection impairs maintenance of immunological memory, yet few studies of HIV-positive adults receiving 7-valent pneumococcal conjugate vaccine (PCV7) have followed them beyond the first year. We determined and compared the durability of serological responses and the clinical outcomes of HIV-positive a...

journal_title：Journal of the International AIDS Society

authors： Cheng A,Chang SY,Tsai MS,Su YC,Liu WC,Sun HY,Hung CC

更新日期：2016-01-29 00:00:00

abstract：INTRODUCTION:Rilpivirine (RPV) is a new once-daily, non-nucleoside, reverse transcriptase inhibitor (NNRTI). In treatment-naïve patients, RPV has shown non-inferior antiviral activity to efavirenz but data in treatment-experienced patients are more limited. We assessed the efficacy and safety of RPV in treatment-experi...

journal_title：Journal of the International AIDS Society

authors： Gazaignes S,Resche-Rigon M,Yang C,Gatey C,Munier AL,Desseaux K,Rozenbaum W,Molina JM

更新日期：2014-11-02 00:00:00

abstract：BACKGROUND:This retrospective survey describes types of cancers diagnosed in HIV-infected subjects in Asia, and assesses risk factors for cancer in HIV-infected subjects using contemporaneous HIV-infected controls without cancer. METHODS:TREAT Asia HIV Observational Database (TAHOD) sites retrospectively reviewed clin...

journal_title：Journal of the International AIDS Society

authors： Petoumenos K,Hui E,Kumarasamy N,Kerr SJ,Choi JY,Chen YM,Merati T,Zhang F,Lim PL,Sungkanuparph S,Pujari S,Ponnampalavanar S,Ditangco R,Lee CK,Grulich A,Law MG,TREAT Asia HIV Observational Database.

更新日期：2010-12-10 00:00:00

abstract：INTRODUCTION:Cardiovascular disease (CVD) is the leading cause of death in England and Wales. As people living with HIV (PLWH) age, proactive management of CVD risk factors is crucial. The long-awaited draft guidelines for CVD from the National Institute of Clinical Excellence (NICE) propose lipid modification (with st...

journal_title：Journal of the International AIDS Society

authors： Ahmed N,Bradley S,Pearson P,Edwards S,Waters L

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Transgender women are the population most vulnerable to HIV in Latin America, with prevalence between 18 and 38%. Although the region has improved antiretroviral coverage, there is an urgent need to strengthen HIV prevention for key populations to meet regional targets set by governments. We conducted an a...

journal_title：Journal of the International AIDS Society

authors： Silva-Santisteban A,Eng S,de la Iglesia G,Falistocco C,Mazin R

更新日期：2016-07-17 00:00:00

abstract：INTRODUCTION:Despite significant gains in access to early infant diagnosis (EID) over the past decade, most HIV-exposed infants still do not get tested for HIV in the first two months of life. For those who are tested, the long turnaround time between when the sample is drawn and when the results are returned leads to ...

journal_title：Journal of the International AIDS Society

authors： Essajee S,Vojnov L,Penazzato M,Jani I,Siberry GK,Fiscus SA,Markby J

更新日期：2015-12-02 00:00:00

abstract：INTRODUCTION:Consistent use of PrEP reduces HIV transmission from sexual practices amongst men who have sex with men (MSM) up to 92% [1]. Lisbon MSM cohort study estimates point that 59.3% of their participants at entrance (1593 HIV negative MSM enrolled between April 2011 and May 2013) were eligible for PrEP [2], acco...

journal_title：Journal of the International AIDS Society

authors： Rocha LM,Campos MJ,Brito J,Fuertes R,Rojas J,Pinto N,Mendão L,Esteves J

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Changes in combination antiretroviral therapy (cART) throughout childhood challenge the continuity of paediatric HIV treatment. This study aimed to evaluate the prevalence of treatment interruption (TI), including lamivudine (3TC) monotherapy, and the relationship of TI to virologic and immunologic paramet...

journal_title：Journal of the International AIDS Society

authors： Rakhmanina N,Lam KS,Hern J,Young HA,Walters A,Castel AD

更新日期：2016-10-27 00:00:00

abstract：BACKGROUND:The aim of our study was to assess the extent of late presentation for HIV care in Northern Greece during the period 2000 to 2010 and to explore correlations aiming to provide guidance for future interventions. METHODS:HIV-positive patients with no prior history of HIV care at presentation and with a CD4 T ...

journal_title：Journal of the International AIDS Society

authors： Metallidis S,Pilalas D,Skoura L,Haidich AB,Tsachouridou O,Papaioannou M,Chrysanthidis T,Bakaimi I,Antoniadou ZA,Margariti A,Malisiovas N,Nikolaidis P

更新日期：2012-10-11 00:00:00

abstract：INTRODUCTION:Scientific research has demonstrated the clinical benefits of earlier initiation of antiretroviral treatment (ART), and that ART can markedly reduce HIV transmission to sexual partners. Ensuring universal access to ART for those who need it has long been a core principle of the HIV response, and extending ...

journal_title：Journal of the International AIDS Society

authors： Grubb IR,Beckham SW,Kazatchkine M,Thomas RM,Albers ER,Cabral M,Lange J,Vella S,Kurian M,Beyrer C,IAS Treatment for Key Affected Populations Working Group.

更新日期：2014-07-18 00:00:00

abstract：INTRODUCTION:The Good Participatory Practice (GPP): Guidelines for Biomedical HIV Prevention Trials, second edition (2011) were developed to provide clinical trial sponsors and implementers with a formal stakeholder engagement framework. As one of the largest African research institutes, Wits Reproductive Health and HI...

journal_title：Journal of the International AIDS Society

authors： Baron D,Essien T,Pato S,Magongo M,Mbandazayo N,Scorgie F,Rees H,Delany-Moretlwe S

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:Setting and monitoring progress towards targets for HIV control is critical in ensuring responsive programmes. Here, we explore how to apply targets for reduction in HIV incidence to local settings and which indicators give the strongest signal of a change in incidence in the population and are therefore m...

journal_title：Journal of the International AIDS Society

authors： Anderson SJ,Garnett GP,Enstone J,Hallett TB

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Injection drug use remains a major risk factor for HIV transmission in Georgia. The study aims to characterize the prevalence of HIV among injection drug users in Georgia. METHODS:A cross-sectional, anonymous bio-behavioural survey to assess knowledge and behaviour in injection drug users in combination wit...

journal_title：Journal of the International AIDS Society

authors： Chikovani I,Goguadze K,Ranade S,Wertlieb M,Rukhadze N,Gotsadze G

更新日期：2011-02-15 00:00:00

abstract：:Improved knowledge, better programmes and policies, effective treatment and other scientific developments have reduced levels of new HIV infections globally. Evidence shows that programmes that prevent HIV among sex workers and their clients are most successful when all aspects of vulnerability are addressed and when ...

journal_title：Journal of the International AIDS Society

authors： Overs C,Loff B

更新日期：2013-08-29 00:00:00

abstract：INTRODUCTION:Guidelines regarding antiretroviral therapy (ART) initiation in HIV infection have varied over time, with the 2015 World Health Organization recommendation suggesting ART initiation at the time of diagnosis regardless of CD4 T-cell counts. Herein, we investigated the influence of socio-demographic and clin...

journal_title：Journal of the International AIDS Society

authors： Mehraj V,Cox J,Lebouché B,Costiniuk C,Cao W,Li T,Ponte R,Thomas R,Szabo J,Baril JG,Trottier B,Côté P,LeBlanc R,Bruneau J,Tremblay C,Routy JP,Montreal Primary HIV-Infection Study Group.

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:Switching to a rilpivirine, tenofovir and emtricitabine (RTE) single-tablet regimen (STR) has been evaluated in a limited number of virologically suppressed patients. The aim of this study was to describe clinical outcomes in HIV-positive patients switched from a suppressive antiretroviral regimen to RTE S...

journal_title：Journal of the International AIDS Society

authors： Gianotti N,Poli A,Nozza S,Spagnuolo V,Tambussi G,Bossolasco S,Cinque P,Maillard M,Cernuschi M,Galli L,Lazzarin A,Castagna A

更新日期：2015-07-30 00:00:00

abstract：INTRODUCTION:There are limited data characterizing the burden of HIV among men who have sex with men (MSM) in Malawi. Epidemiologic research and access to HIV prevention, treatment and care services have been traditionally limited in Malawi by criminalization and stigmatization of same-sex practices. To inform the deve...

journal_title：Journal of the International AIDS Society

authors： Wirtz AL,Jumbe V,Trapence G,Kamba D,Umar E,Ketende S,Berry M,Strömdahl S,Beyrer C,Baral SD

更新日期：2013-12-02 00:00:00

abstract：INTRODUCTION:In 2012, the Supreme Court of Canada ruled that people living with HIV (PLWH) must disclose their HIV status to sexual partners prior to sexual activity that poses a "realistic possibility" of HIV transmission for consent to sex to be valid. The Supreme Court deemed that the duty to disclose could be avert...

journal_title：Journal of the International AIDS Society

authors： Patterson SE,Milloy MJ,Ogilvie G,Greene S,Nicholson V,Vonn M,Hogg R,Kaida A

更新日期：2015-12-22 00:00:00

abstract：INTRODUCTION:Lamivudine (3TC) and emtricitabine (FTC) are considered interchangeable by HIV-1 guidelines in first-line tenofovir/efavirenz (TDF/EFV) and TDF/nevirapine (NVP) combination antiretroviral therapy (cART). Data from trials on equivalence of 3TC and FTC are inconsistent. We examined the effectiveness of 3TC a...

journal_title：Journal of the International AIDS Society

authors： Rokx C,Fibriani A,van de Vijver D,Verbon A,Schutten M,Gras L,Rijnders BJ

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:This descriptive, non-interventional study on HIV-1-infected patients treated with DRV/r in the usual clinical setting, with a single-arm prospective observational design, collected data on utilization of darunavir/ritonavir (DRV/r) under the conditions described in marketing authorization in usual clinica...

journal_title：Journal of the International AIDS Society

authors： Antinori A,Borderi M,Cauda R,Bini T,Chirianni A,Squillace N,Mancusi D,Termini R

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:HIV testing is an essential prerequisite for accessing treatment with antiretroviral therapy or prevention using pre-exposure prophylaxis. Internet distribution of HIV self-tests is a novel approach, and data on the programmatic cost of this approach are limited. We analyse the costs and cost-effectiveness...

journal_title：Journal of the International AIDS Society

authors： Shrestha RK,Chavez PR,Noble M,Sansom SL,Sullivan PS,Mermin JH,MacGowan RJ

更新日期：2020-01-01 00:00:00

abstract：:Prevention of HIV infection has recently acquired new effective tools, based on the provision of antiretrovirals, to both decrease the "source" of HIV infection and/or to decrease host susceptibility to HIV infection. The milestone concept of using antiretrovirals for prevention has been tested already in the 1990s, t...

journal_title：Journal of the International AIDS Society

authors： Vella S

更新日期：2014-11-02 00:00:00

abstract：BACKGROUND:The majority of new HIV infections are acquired through heterosexual transmission. There is urgent need for prevention methods to compliment behavior change and condom use. Topical microbicide represent a potential strategy for reduction of HIV transmission in women. METHODS:Monthly Colposcopy evaluations w...

journal_title：Journal of the International AIDS Society

authors： Chirenje ZM,Mâsse BR,Maslankowski LA,Ramjee G,Coletti AS,Tembo TN,Magure TM,Soto-Torres L,Kelly C,Hillier S,Karim A

更新日期：2012-08-27 00:00:00

abstract：BACKGROUND:Despite the centrality of family in Indian society, relatively little is known about family-based communication concerning sexual behaviour and HIV/AIDS in rural Indian families. To date, very few family-based adolescent HIV-prevention interventions have been developed for rural Indian youth. This study cond...

journal_title：Journal of the International AIDS Society

authors： Soletti AB,Guilamo-Ramos V,Burnette D,Sharma S,Bouris A

更新日期：2009-11-19 00:00:00

abstract：INTRODUCTION:Rilpivirine (RPV) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) that was recently approved for the treatment of antiretroviral-naïve individuals with HIV-1 viral load of <100,000 copies/ml. As transmission of the drug resistance mutations to this NNRTI may affect treatment o...

journal_title：Journal of the International AIDS Society

authors： Parczewski M,Urbańska A,Maciejewska K,Witak-Jȩdra M,Leszczyszyn-Pynka M

更新日期：2014-04-17 00:00:00

abstract：INTRODUCTION:The HIV Strategy in New South Wales (NSW) Australia aims to virtually eliminate HIV transmission by 2020. We estimated the 2016 HIV diagnosis and care cascade for the state of NSW, with a focus on introducing population-based data to improve data quality and assess progress towards the UNAIDS 90-90-90 targ...

journal_title：Journal of the International AIDS Society

authors： Keen P,Gray RT,Telfer B,Guy R,Schmidt HM,Whittaker B,Holden J,Holt M,Kelleher A,Wilson D,Callander D,Cooper DA,Prestage G,Selvey C,Grulich AE,NSW HIV Prevention Partnership Project.

更新日期：2018-04-01 00:00:00

abstract：INTRODUCTION:Current healthcare systems fail to provide adequate HIV services to men. In Zambia, 25% of adult men living with HIV were unaware of their HIV status in 2018, and 12% of those who were unaware of their HIV statu were not receiving antiretroviral therapy (ART) due to pervasive barriers to HIV testing servic...

journal_title：Journal of the International AIDS Society

authors： Mwango LK,Stafford KA,Blanco NC,Lavoie MC,Mujansi M,Nyirongo N,Tembo K,Sakala H,Chipukuma J,Phiri B,Nzangwa C,Mwandila S,Nkwemu KC,Saadani A,Mwila A,Herce ME,Claassen CW

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:The universal test and treat strategy (UTT) was developed to maximize the proportion of all HIV-positive individuals on antiretroviral treatment (ART) and virally suppressed, assuming that it will lead to a reduction in HIV incidence at the population level. The evolution over time of the cross-sectional H...

journal_title：Journal of the International AIDS Society

authors： Larmarange J,Diallo MH,McGrath N,Iwuji C,Plazy M,Thiébaut R,Tanser F,Bärnighausen T,Pillay D,Dabis F,Orne-Gliemann J,ANRS 12249 TasP Study Group.

更新日期：2018-07-01 00:00:00