Toll-like receptor activation by helminths or helminth products to alleviate inflammatory bowel disease.

Abstract:

:Helminth infection may modulate the expression of Toll like receptors (TLR) in dendritic cells (DCs) and modify the responsiveness of DCs to TLR ligands. This may regulate aberrant intestinal inflammation in humans with helminthes and may thus help alleviate inflammation associated with human inflammatory bowel disease (IBD). Epidemiological and experimental data provide further evidence that reducing helminth infections increases the incidence rate of such autoimmune diseases. Fine control of inflammation in the TLR pathway is highly desirable for effective host defense. Thus, the use of antagonists of TLR-signaling and agonists of their negative regulators from helminths or helminth products should be considered for the treatment of IBD.

journal_name

Parasit Vectors

journal_title

Parasites & vectors

authors

Sun S,Wang X,Wu X,Zhao Y,Wang F,Liu X,Song Y,Wu Z,Liu M

doi

10.1186/1756-3305-4-186

subject

Has Abstract

pub_date

2011-09-27 00:00:00

pages

186

issn

1756-3305

pii

1756-3305-4-186

journal_volume

4

pub_type

杂志文章,评审
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    abstract:BACKGROUND:The Anopheles gambiae Giles complex is the most widely studied and the most important insect vector group. We explored the use of the palp ratio method as a field tool to identify A. melas and A. gambiae in Ghana. METHODS:Human landing catches were conducted to collect mosquitoes in the coastal area of West...

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    doi:10.1186/s13071-015-0913-3

    authors: Annan AA,Kruppa TF,Adjei O,Garms R

    更新日期:2015-05-28 00:00:00

  • Rhodnius prolixus interaction with Trypanosoma rangeli: modulation of the immune system and microbiota population.

    abstract:BACKGROUND:Trypanosoma rangeli is a protozoan that infects a variety of mammalian hosts, including humans. Its main insect vector is Rhodnius prolixus and is found in several Latin American countries. The R. prolixus vector competence depends on the T. rangeli strain and the molecular interactions, as well as the insec...

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    authors: Vieira CS,Mattos DP,Waniek PJ,Santangelo JM,Figueiredo MB,Gumiel M,da Mota FF,Castro DP,Garcia ES,Azambuja P

    更新日期:2015-03-01 00:00:00

  • Molecular signatures of the rediae, cercariae and adult stages in the complex life cycles of parasitic flatworms (Digenea: Psilostomatidae).

    abstract:BACKGROUND:Parasitic flatworms (Trematoda: Digenea) represent one of the most remarkable examples of drastic morphological diversity among the stages within a life cycle. Which genes are responsible for extreme differences in anatomy, physiology, behavior, and ecology among the stages? Here we report a comparative tran...

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    doi:10.1186/s13071-020-04424-4

    authors: Nesterenko MA,Starunov VV,Shchenkov SV,Maslova AR,Denisova SA,Granovich AI,Dobrovolskij AA,Khalturin KV

    更新日期:2020-11-10 00:00:00

  • A new allele conferring resistance to Lysinibacillus sphaericus is detected in low frequency in Culex quinquefasciatus field populations.

    abstract:BACKGROUND:The Cqm1 α-glucosidase of Culex quinquefasciatus larvae acts as the midgut receptor for the binary toxin of the biolarvicide Lysinibacillus sphaericus. Mutations within the cqm1 gene can code for aberrant polypeptides that can no longer be properly expressed or bind to the toxin, leading to insect resistance...

    journal_title:Parasites & vectors

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    doi:10.1186/s13071-016-1347-2

    authors: Menezes HS,Chalegre KD,Romão TP,Oliveira CM,de-Melo-Neto OP,Silva-Filha MH

    更新日期:2016-02-04 00:00:00

  • Investigations on the occurrence of tapeworm infections in German horse populations with comparison of different antibody detection methods based on saliva and serum samples.

    abstract:BACKGROUND:Effective and sustainable worm control in horses would benefit from detailed information about the current regional occurrence of tapeworms. Different diagnostic methods are currently available to detect Anoplocephala spp. infections in horses. However, the format as well as the sensitivity and specificity o...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-020-04318-5

    authors: Jürgenschellert L,Krücken J,Austin CJ,Lightbody KL,Bousquet E,von Samson-Himmelstjerna G

    更新日期:2020-09-10 00:00:00

  • Direct and indirect effects of predation and parasitism on the Anopheles gambiae mosquito.

    abstract:BACKGROUND:A good understanding of mosquito ecology is imperative for integrated vector control of malaria. In breeding sites, Anopheles larvae are concurrently exposed to predators and parasites. However, to our knowledge, there is no study on combined effects of predators and parasites on development and survival of ...

    journal_title:Parasites & vectors

    pub_type: 杂志文章,评审

    doi:10.1186/s13071-020-3915-8

    authors: Ong'wen F,Onyango PO,Bukhari T

    更新日期:2020-01-30 00:00:00

  • Susceptibility to insecticides and resistance mechanisms in three populations of Aedes aegypti from Peru.

    abstract:BACKGROUND:Epidemics of dengue, chikungunya and Zika are a growing threat to areas where Aedes aegypti are present. The efficacy of chemical control of Ae. aegypti is threatened by the increasing frequency of insecticide resistance. The objective of this study was to determine the susceptibility status as well as the b...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-019-3739-6

    authors: Pinto J,Palomino M,Mendoza-Uribe L,Sinti C,Liebman KA,Lenhart A

    更新日期:2019-10-22 00:00:00

  • Microfilarial reduction following ProHeart® 6 and ProHeart® SR-12 treatment in dogs experimentally inoculated with a resistant isolate of Dirofilaria immitis.

    abstract:BACKGROUND:Emerging resistance of heartworms (Dirofilaria immitis) to macrocyclic lactone (ML) preventives is an increasing concern for veterinarians, pet owners and animal health companies that supply heartworm preventives, with recent reports of resistant isolates identified from the Mississippi Delta region of the U...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-017-2430-z

    authors: McTier TL,Pullins A,Inskeep GA,Gagnon G,Fan H,Schoell A,Bidgood T,Login J,Meeus P

    更新日期:2017-11-09 00:00:00

  • What does not kill it makes it weaker: effects of sub-lethal concentrations of ivermectin on the locomotor activity of Anopheles aquasalis.

    abstract:BACKGROUND:Malaria remains a major public health concern. Vector control measures based solely on insecticide treated nets (ITNs) and indoor residual spraying (IRS) have demonstrated not to be feasible for malaria elimination. It has been shown that ivermectin affects several aspects of Anopheles species biology. Along...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-017-2563-0

    authors: Sampaio VS,Rivas GBDS,Kobylinski K,Pinilla YT,Pimenta PFP,Lima JBP,Bruno RV,Lacerda MVG,Monteiro WM

    更新日期:2017-12-28 00:00:00

  • A perspective on the need and current status of efficient sex separation methods for mosquito genetic control.

    abstract::Major efforts are currently underway to develop novel, complementary methods to combat mosquito-borne diseases. Mosquito genetic control strategies (GCSs) have become an increasingly important area of research on account of their species-specificity, track record in targeting agricultural insect pests, and their envir...

    journal_title:Parasites & vectors

    pub_type: 杂志文章,评审

    doi:10.1186/s13071-018-3222-9

    authors: Papathanos PA,Bourtzis K,Tripet F,Bossin H,Virginio JF,Capurro ML,Pedrosa MC,Guindo A,Sylla L,Coulibaly MB,Yao FA,Epopa PS,Diabate A

    更新日期:2018-12-24 00:00:00

  • Evidence of multiple insecticide resistance mechanisms in Anopheles gambiae populations in Bangui, Central African Republic.

    abstract:BACKGROUND:Knowledge of insecticide resistance status in the main malaria vectors is an essential component of effective malaria vector control. This study presents the first evaluation of the status of insecticide resistance in Anopheles gambiae populations from Bangui, the Central African Republic. METHODS:Anopheles...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-016-1965-8

    authors: Olé Sangba ML,Sidick A,Govoetchan R,Dide-Agossou C,Ossè RA,Akogbeto M,Ndiath MO

    更新日期:2017-01-13 00:00:00

  • Activated microglia contribute to neuronal apoptosis in Toxoplasmic encephalitis.

    abstract:BACKGROUND:A plethora of evidence shows that activated microglia play a critical role in the pathogenesis of the central nervous system (CNS). Toxoplasmic encephalitis (TE) frequently occurs in HIV/AIDS patients. However, knowledge remains limited on the contributions of activated microglia to the pathogenesis of TE. ...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-7-372

    authors: Zhang YH,Chen H,Chen Y,Wang L,Cai YH,Li M,Wen HQ,Du J,An R,Luo QL,Wang XL,Lun ZR,Xu YH,Shen JL

    更新日期:2014-08-15 00:00:00

  • A new baseline for fascioliasis in Venezuela: lymnaeid vectors ascertained by DNA sequencing and analysis of their relationships with human and animal infection.

    abstract:BACKGROUND:Human and animal fascioliasis poses serious public health problems in South America. In Venezuela, livestock infection represents an important veterinary problem whereas there appear to be few human cases reported, most of which are passively detected in health centres. However, results of recent surveys sug...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-4-200

    authors: Bargues MD,González LC,Artigas P,Mas-Coma S

    更新日期:2011-10-14 00:00:00

  • Differentiating Entamoeba histolytica, Entamoeba dispar and Entamoeba moshkovskii using nested polymerase chain reaction (PCR) in rural communities in Malaysia.

    abstract:BACKGROUND:In this study, a total of 426 human faecal samples were examined for the presence of Entamoeba histolytica, Entamoeba dispar, Entamoeba moshkovskii infection via a combination of microscopic examination and nested polymerase chain reaction (PCR) targeting 16S ribosomal RNA of Entamoeba species. METHODS:Faec...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-5-187

    authors: Ngui R,Angal L,Fakhrurrazi SA,Lian YL,Ling LY,Ibrahim J,Mahmud R

    更新日期:2012-09-04 00:00:00

  • The first detected airline introductions of yellow fever mosquitoes (Aedes aegypti) to Europe, at Schiphol International airport, the Netherlands.

    abstract:BACKGROUND:Air-borne introduction of exotic mosquitoes to Schiphol airport in the Netherlands has been considered plausible based upon findings of mosquitoes in aircraft cabins during 2008, 2010 and 2011. Beginning in 2013, surveillance efforts at Schiphol had focused on promptly detecting accidental introductions at t...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-017-2555-0

    authors: Ibañez-Justicia A,Gloria-Soria A,den Hartog W,Dik M,Jacobs F,Stroo A

    更新日期:2017-12-08 00:00:00

  • First report of L1014F-kdr mutation in Culex pipiens complex from Morocco.

    abstract:BACKGROUND:Mosquitoes of the Culex pipiens complex, competent vectors for West Nile virus (WNV) and Rift Valley fever virus (RVFV) are widely targeted by insecticide treatments. The intensive application of chemical insecticides led to the development of resistance in many insects including Culex pipiens mosquitoes. Th...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-016-1931-5

    authors: Bkhache M,Tmimi FZ,Charafeddine O,Faraj C,Failloux AB,Sarih M

    更新日期:2016-12-16 00:00:00

  • Establishment of an in vitro chicken epithelial cell line model to investigate Eimeria tenella gamete development.

    abstract:BACKGROUND:Eimeria tenella infection leads to acute intestinal disorders responsible for important economic losses in poultry farming worldwide. The life-cycle of E. tenella is monoxenous with the chicken as the exclusive host; infection occurs in caecal epithelial cells. However, in vitro, the complete life-cycle of t...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-018-2622-1

    authors: Bussière FI,Niepceron A,Sausset A,Esnault E,Silvestre A,Walker RA,Smith NC,Quéré P,Laurent F

    更新日期:2018-01-18 00:00:00

  • Oral dosing with papaya latex is an effective anthelmintic treatment for sheep infected with Haemonchus contortus.

    abstract:BACKGROUND:The cysteine proteinases in papaya latex have been shown to have potent anthelmintic properties in monogastric hosts such as rodents, pigs and humans, but this has not been demonstrated in ruminants. METHODS:In two experiments, sheep were infected concurrently with 5,000 infective larvae of Haemonchus conto...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-4-36

    authors: Buttle DJ,Behnke JM,Bartley Y,Elsheikha HM,Bartley DJ,Garnett MC,Donnan AA,Jackson F,Lowe A,Duce IR

    更新日期:2011-03-15 00:00:00

  • High-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation (HITS-CLIP) reveals Argonaute-associated microRNAs and targets in Schistosoma japonicum.

    abstract:BACKGROUND:Schistosomiasis, caused by schistosomes, is one of the most prevalent and serious parasitic diseases in tropical and subtropical countries. This pathogen has a complex life cycle and harbors a unique repertoire of genes expressed at different life-stages. Understanding the gene regulation of schistosomes wil...

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    doi:10.1186/s13071-015-1203-9

    authors: Zhao J,Luo R,Xu X,Zou Y,Zhang Q,Pan W

    更新日期:2015-11-14 00:00:00

  • Spatial risk analysis for the introduction and circulation of six arboviruses in the Netherlands.

    abstract:BACKGROUND:Arboviruses are a growing public health concern in Europe, with both endemic and exotic arboviruses expected to spread further into novel areas in the next decades. Predicting where future outbreaks will occur is a major challenge, particularly for regions where these arboviruses are not endemic. Spatial mod...

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    authors: Esser HJ,Liefting Y,Ibáñez-Justicia A,van der Jeugd H,van Turnhout CAM,Stroo A,Reusken CBEM,Koopmans MPG,de Boer WF

    更新日期:2020-09-10 00:00:00

  • Malaria surveillance from both ends: concurrent detection of Plasmodium falciparum in saliva and excreta harvested from Anopheles mosquitoes.

    abstract:BACKGROUND:Malaria is the most important vector-borne disease in the world. Epidemiological and ecological studies of malaria traditionally utilize detection of Plasmodium sporozoites in whole mosquitoes or salivary glands by microscopy or serological or molecular assays. However, these methods are labor-intensive, and...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-019-3610-9

    authors: Ramírez AL,van den Hurk AF,Mackay IM,Yang ASP,Hewitson GR,McMahon JL,Boddey JA,Ritchie SA,Erickson SM

    更新日期:2019-07-18 00:00:00

  • Oncomelania hupensis retains its ability to transmit Schistosoma japonicum 13 years after migration from permissive to non-permissive areas.

    abstract:BACKGROUND:The East Route Project (ERP) of the South-to-North Water Diversion Project (SNWDP) stretches across schistosomiasis endemic and non-endemic areas in China, which may lead to the dispersal of Oncomelania hupensis, the intermediate host of Schistosoma japonicum, from permissive areas along the Yangtze River Ba...

    journal_title:Parasites & vectors

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    doi:10.1186/s13071-020-4004-8

    authors: Sun CS,Luo F,Liu X,Miao F,Hu W

    更新日期:2020-03-19 00:00:00

  • Sensitivity to permethrin in a Dermacentor reticulatus population from eastern Poland in laboratory study.

    abstract:BACKGROUND:The action of chemical compounds on the Palaearctic tick D. reticulatus (Fabricius) (Acari: Amblyomminae) has been poorly investigated so far. Therefore, the effects of application of permethrin on engorged D. reticulatus females have been assessed, and the survival rate for the different developmental stage...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-7-18

    authors: Buczek A,Bartosik K,Kuczyński P

    更新日期:2014-01-10 00:00:00

  • Variation in species composition and infection rates of Anopheles mosquitoes at different altitudinal transects, and the risk of malaria in the highland of Dirashe Woreda, south Ethiopia.

    abstract:BACKGROUND:The transmission of malaria is heterogeneous, and varies due to altitude. The information on whether the transmission of malaria is indigenous or imported to highland areas is scarce. Therefore, this study aimed to assess the species composition and infection rates of Anopheles at different altitudinal trans...

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    pub_type: 杂志文章

    doi:10.1186/s13071-017-2288-0

    authors: Daygena TY,Massebo F,Lindtjørn B

    更新日期:2017-07-19 00:00:00

  • Parasite fauna of wild Antillean manatees (Trichechus manatus manatus) of the Andean Region, Colombia.

    abstract:BACKGROUND:Antillean manatees (Trichechus manatus manatus) are large herbivorous aquatic mammals living in limited areas of South, Central and North America. As with other aquatic mammals, Antillean manatees can be infected by a variety of protozoan and metazoan parasites, some of them with zoonotic potential, which af...

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    pub_type: 杂志文章

    doi:10.1186/s13071-019-3448-1

    authors: Vélez J,Hirzmann J,Arévalo-González K,Lange MK,Seipp A,Gärtner U,Taubert A,Caballero S,Hermosilla C

    更新日期:2019-04-27 00:00:00

  • Field efficacy and safety of a novel oral chewable tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against naturally acquired gastrointestinal nematode infections in dogs presented as veterinary patients in Europe and the USA.

    abstract:BACKGROUND:Gastrointestinal nematodes are parasites that commonly infect dogs, and infections can be subclinical or may cause considerable clinical disease. Some species are zoonotic and may also cause clinical disease in humans. Year-round treatment of dogs is recommended to eliminate existing infections, which also i...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-020-3947-0

    authors: Becskei C,Kryda K,Fias D,Follis SL,Wozniakiewicz M,Mahabir SP,Farkas R

    更新日期:2020-03-01 00:00:00

  • The bionomics of the malaria vector Anopheles rufipes Gough, 1910 and its susceptibility to deltamethrin insecticide in North Cameroon.

    abstract:BACKGROUND:Following the recent discovery of the role of Anopheles rufipes Gough, 1910 in human malaria transmission in the northern savannah of Cameroon, we report here additional information on its feeding and resting habits and its susceptibility to the pyrethroid insecticide deltamethrin. METHODS:From 2011 to 2015...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-018-2809-5

    authors: Awono-Ambene PH,Etang J,Antonio-Nkondjio C,Ndo C,Eyisap WE,Piameu MC,Mandeng ES,Mbakop RL,Toto JC,Patchoke S,Mnzava AP,Knox TB,Donnelly M,Fondjo E,D Bigoga J

    更新日期:2018-04-18 00:00:00

  • Efficacy and speed of kill of a topically applied formulation of dinotefuran-permethrin-pyriproxyfen against weekly tick infestations with Rhipicephalus sanguineus (sensu lato) on dogs.

    abstract:BACKGROUND:Rhipicephalus sanguineus (sensu lato) is a vector of canine babesiosis, anaplasmosis and ehrlichiosis. In order to reduce the chance of transmission of these diseases, an ectoparasiticide should rapidly repel or kill new infestations with this tick. The primary objective of the present study was to evaluate ...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-016-1561-y

    authors: Blair J,Fourie JJ,Varloud M,Horak IG

    更新日期:2016-05-16 00:00:00

  • Factors associated with Toxoplasma gondii infection in confined farrow-to-finish pig herds in western France: an exploratory study in 60 herds.

    abstract:BACKGROUND:Infection by Toxoplasma gondii postnatally can occur after ingestion of contaminated meat or water (tissue cysts/oocysts). In Europe, percentage of meat borne infections is estimated between 30 and 63 %, out of which pork makes the most important source. The aim of this study was to (i) investigate the serop...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-016-1753-5

    authors: Djokic V,Fablet C,Blaga R,Rose N,Perret C,Djurkovic-Djakovic O,Boireau P,Durand B

    更新日期:2016-08-24 00:00:00

  • Loop-mediated isothermal amplification (LAMP) assay for the diagnosis of fasciolosis in sheep and its application under field conditions.

    abstract:BACKGROUND:Loop-mediated isothermal amplification (LAMP) is a very specific, efficient, and rapid gene amplification procedure in which the reaction can run at a constant temperature. In the current study we have developed a LAMP assay to improve the diagnosis of Fasciola spp. in the faeces of sheep. FINDINGS:After th...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-016-1355-2

    authors: Martínez-Valladares M,Rojo-Vázquez FA

    更新日期:2016-02-05 00:00:00