Review article: the diagnosis and treatment of haematinic deficiency in gastrointestinal disease.

abstract：BACKGROUND:Guidelines recommend that patients with gastro-oesophageal reflux disease are adequately treated with acid-suppressive therapy before undergoing anti-reflux surgery. Little is known of the use of acid-suppressive drugs before anti-reflux surgery. AIM:To determine the use of proton pump inhibitors and H2 -re...

journal_title：Alimentary pharmacology & therapeutics

authors： Lødrup A,Pottegård A,Hallas J,Bytzer P

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver condition. A major current research effort is ongoing to find potential strategies to treat NAFLD-non-alcoholic steatohepatitis (NASH), with special attention to the gut microbiota. Multiple animal studies and pilot clinical t...

journal_title：Alimentary pharmacology & therapeutics

authors： Koopman N,Molinaro A,Nieuwdorp M,Holleboom AG

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Recently, the therapeutic landscape with regard to anti-HCV therapy has changed dramatically. The new directly acting anti-virals (DAAs) have demonstrated improved sustained virological response (SVR) compared with pegylated-interferon and ribavirin. AIM:To examine and present the latest data with regard to...

journal_title：Alimentary pharmacology & therapeutics

authors： Joshi D,Carey I,Agarwal K

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Liver biopsy is the gold standard in evaluating liver diseases but is susceptible to complications. Safety data on aspiration needle biopsies remain limited. AIM:To evaluate the safety of percutaneous liver biopsy performed with Klatskin needle. METHODS:Clinical and biochemical data were retrospectively re...

journal_title：Alimentary pharmacology & therapeutics

authors： Takyar V,Etzion O,Heller T,Kleiner DE,Rotman Y,Ghany MG,Fryzek N,Williams VH,Rivera E,Auh S,Liang TJ,Hoofnagle JH,Koh C

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Oral tacrolimus, approved for the prophylaxis of organ rejection in liver or kidney transplants, has been reported to be effective in anecdotal cases of refractory inflammatory bowel disease. AIM:To evaluate the usefulness of low-dose oral tacrolimus in refractory inflammatory bowel disease. METHODS:Thirty...

journal_title：Alimentary pharmacology & therapeutics

authors： Baumgart DC,Wiedenmann B,Dignass AU

更新日期：2003-05-15 00:00:00

abstract：BACKGROUND:Hepatitis B (HBV)-infected patients have a higher morbidity and mortality when super-infected by hepatitis A (HAV). AIM:To evaluate the immunogenicity and safety of a commercial inactivated HAV vaccine in Chinese patients with chronic HBV infection. METHODS:Sixty-five HBV-infected patients (30 carriers, 22...

journal_title：Alimentary pharmacology & therapeutics

authors： Tsang SW,Sung JJ

更新日期：1999-11-01 00:00:00

abstract：:As the relative efficacy of therapeutic agents in the treatment of gastro-oesophageal reflux disease is related to how consistently and completely gastric acid secretion is suppressed, intragastric pH monitoring is a useful tool in stratifying therapies. If there is no acid in the stomach, there can be none to reflux ...

journal_title：Alimentary pharmacology & therapeutics

authors： Kahrilas PJ

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Gastrointestinal (GI) symptoms are common in soldiers in combat or high-pressure operational situations and often lead to compromised performance. Underlying mechanisms are unclear, but neuroendocrine dysregulation, immune activation and increased intestinal permeability may be involved in stress-related GI ...

journal_title：Alimentary pharmacology & therapeutics

authors： Li X,Kan EM,Lu J,Cao Y,Wong RK,Keshavarzian A,Wilder-Smith CH

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:With the global efforts to eradicate hepatitis C virus (HCV), treatment during pregnancy is becoming a priority for research as this, and maternal cure should reduce vertical transmission. However, as information on the efficacy and safety of direct-acting antivirals (DAAs) in pregnancy is generally lacking,...

journal_title：Alimentary pharmacology & therapeutics

authors： Freriksen JJM,van Seyen M,Judd A,Gibb DM,Collins IJ,Greupink R,Russel FGM,Drenth JPH,Colbers A,Burger DM

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Many patients are not symptom-free after eradication therapy for Helicobacter pylori and continue to use proton pump inhibitors or H2-receptor antagonists (H2-RAs). AIM:To ascertain whether a cohort of patients treated for H. pylori were still taking either proton pump inhibitors or H2-RAs more than 4 years...

journal_title：Alimentary pharmacology & therapeutics

authors： Tan AC,Hartog GD,Mulder CJ

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:ONO-2952 is a novel and selective inhibitor of translocator protein 18 kDa that reduces stress-induced defecation and visceral hyperalgesia in rat models. AIM:To evaluate the efficacy and safety of ONO-2952 in females with irritable bowel syndrome with diarrhoea in an exploratory proof-of-concept study. ME...

journal_title：Alimentary pharmacology & therapeutics

authors： Whitehead WE,Duffy K,Sharpe J,Nabata T,Bruce M

更新日期：2017-01-01 00:00:00

abstract：:In a double-blind, placebo-controlled study of SK&F 94482 (BMY-25368) (400-mg, post-evening meal, for 7 days in 11 healthy subjects), there was a significant 75% decrease in median integrated 24-h intragastric acidity during dosing with the drug (218 mmol h/L) compared with placebo (883 mmol h/L; P = 0.003). The singl...

journal_title：Alimentary pharmacology & therapeutics

authors： Gavey CJ,Smith JT,Nwokolo CU,Pounder RE

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:The effect of anti-viral treatment on downstream costs for hepatitis C virus (HCV)-infected patients is unknown. AIM:To evaluate follow-up costs in patients with chronic HCV, stratified by liver disease severity. METHODS:Using a US private insurance database, mean all-cause per-patient-per-month (PPPM) US ...

journal_title：Alimentary pharmacology & therapeutics

authors： Gordon SC,Hamzeh FM,Pockros PJ,Hoop RS,Buikema AR,Korner EJ,Terrault NA

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Renewed interest in the use of antibiotics to prevent travellers' diarrhoea has occurred with the availability of non-absorbed (<0.4%) rifaximin, and with evidence that a subgroup of travellers with diarrhoea have progression of their illnesses to postinfectious irritable bowel syndrome. AIM:To summarize re...

journal_title：Alimentary pharmacology & therapeutics

authors： DuPont HL

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:The incidence of 'true' re-infection with Helicobacter pylori after successful eradication remains uncertain. AIM:To determine the worldwide rates, risk factors and clinical implications of 'true' re-infection of Helicobacter pylori. 'True' re-infection of H. pylori is defined as the situation where tests f...

journal_title：Alimentary pharmacology & therapeutics

authors： Zhang YY,Xia HH,Zhuang ZH,Zhong J

更新日期：2009-01-01 00:00:00

abstract：AIM:To evaluate and compare two 1-week low-dose triple therapies based on lansoprazole, amoxycillin and a macrolide in eradicating Helicobacter pylori. METHODS:Seventy consecutive patients, suffering from dyspeptic symptoms with H. pylori infection, were randomly allocated to one of two treatment groups: (A) (LAC; n =...

journal_title：Alimentary pharmacology & therapeutics

authors： Cammarota G,Tursi A,Papa A,Montalto M,Veneto G,Cuoco L,Fedeli G,Gasbarrini G

更新日期：1996-12-01 00:00:00

abstract：:Trospium chloride is a muscarinergic antagonist acting on oesophageal smooth muscle and on ganglionic and/or myenteric neurons. The effect of this drug on oesophageal motility was tested in 16 healthy male subjects in a double-blind randomized cross-over examination of trospium chloride or placebo following phentolami...

journal_title：Alimentary pharmacology & therapeutics

authors： Frieling T,Enck P,Dohmann R,Wienbeck M,Lübke HJ

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:More convenient therapies are needed to treat Helicobacter pylori infection successfully. Clarithromycin and amoxycillin are effective against H. pylori both in vivo and in vitro. Recent success with a high dose amoxycillin-metronidazole combination therapy led us to evaluate clarithromycin-amoxycillin dual ...

journal_title：Alimentary pharmacology & therapeutics

authors： al-Assi MT,Genta RM,Karttunen TJ,Graham DY

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:The long-term outcome of percutaneous acetic acid injection (PAI) and percutaneous ethanol injection (PEI) for treating small hepatocellular carcinoma (HCC) remains unclear. AIM:To compare the long-term outcome of PAI vs. PEI for treating small HCC. METHODS:From July 1998 to July 2004, 125 patients with sm...

journal_title：Alimentary pharmacology & therapeutics

authors： Tsai WL,Cheng JS,Lai KH,Lin CP,Lo GH,Hsu PI,Yu HC,Lin CK,Chan HH,Chen WC,Chen TA,Li WL,Liang HL

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:In Sweden, the most common causes of liver cirrhosis are alcohol overconsumption and hepatitis C. However, recent data on the clinical characteristics of Swedish patients with cirrhosis are scarce. AIMS:To determine the incidence, clinical presentation, aetiological spectrum and survival rates of liver cirr...

journal_title：Alimentary pharmacology & therapeutics

authors： Nilsson E,Anderson H,Sargenti K,Lindgren S,Prytz H

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Direct-acting antiviral (DAA) regimens have shown high efficacy and tolerability for patients with HCV genotype 1/1b (GT1/1b) in clinical trials. However, robust real-world evidence of interferon (IFN)-free DAA treatment for HCV GT1-infected patients in Asia is still lacking. AIM:To systematically review an...

journal_title：Alimentary pharmacology & therapeutics

authors： Ji F,Wei B,Yeo YH,Ogawa E,Zou B,Stave CD,Li Z,Dang S,Furusyo N,Cheung RC,Nguyen MH

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Lymphocytic gastritis (LG) is an uncommon entity with varying symptoms and endoscopic appearances. This condition, as well as two forms of H. pylori-negative gastritis [chronic active gastritis (CAG) and chronic inactive gastritis (CIG)], appears to be more common in patients with coeliac disease (CD) based ...

journal_title：Alimentary pharmacology & therapeutics

authors： Lebwohl B,Green PH,Genta RM

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Steroid-refractory ulcerative colitis (UC) remains a challenging condition warranting surgery upon failure of pharmacological treatment. Calcineurin inhibitors or infliximab are alternatives in this situation. Data on the efficacy and safety of tacrolimus in this setting are limited. AIM:To study the short-...

journal_title：Alimentary pharmacology & therapeutics

authors： Schmidt KJ,Herrlinger KR,Emmrich J,Barthel D,Koc H,Lehnert H,Stange EF,Fellermann K,Büning J

更新日期：2013-01-01 00:00:00

abstract：AIM:To evaluate the efficacy of omeprazole plus clarithromycin and furazolidone in Helicobacter pylori eradication and duodenal ulcer healing in Brazilian patients. METHODS:Forty H. pylori-positive patients with duodenal ulcer were randomized to receive 20 mg omeprazole o.m. or b.d. for 1 month plus 500 mg clarithromy...

journal_title：Alimentary pharmacology & therapeutics

authors： Dani R,Queiroz DM,Dias MG,Franco JM,Magalhães LC,Mendes GS,Moreira LS,De Castro LP,Toppa NH,Rocha GA,Cabral MM,Salles PG

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Transplacental transfer of tumour necrosis factor-alpha (TNF-α) inhibitors has been shown in mothers receiving therapy for inflammatory bowel disease (IBD). AIM:To examine reports of adverse events of these medications in pregnancy. METHODS:Individual Safety Reports of adverse events (Jan 2003-June 2012) w...

journal_title：Alimentary pharmacology & therapeutics

authors： Deepak P,Stobaugh DJ

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus may lead to increased serum ammonia and systemic inflammation thereby promoting hepatic encephalopathy (HE). AIM:To investigate the potential association between diabetes mellitus/glycaemic control and the presence of covert HE as well as the development of overt HE in a prospective settin...

journal_title：Alimentary pharmacology & therapeutics

authors： Labenz C,Nagel M,Kremer WM,Hilscher M,Schilling CA,Toenges G,Kuchen R,Schattenberg JM,Galle PR,Wörns MA

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Attachment of Giardia lamblia trophozoites to enterocytes is essential for colonization of the small intestine and is considered a prerequisite for Giardia-induced enterocyte damage. Inhibition of attachment may therefore have therapeutic potential. METHODS:Enterocyte-like differentiated Caco-2 cells were u...

journal_title：Alimentary pharmacology & therapeutics

authors： Katelaris PH,Naeem A,Farthing MJ

更新日期：1994-04-01 00:00:00

abstract：AIM:To investigate the efficacy of two omeprazole triple therapies for the eradication of Helicobacter pylori, ulcer healing and ulcer relapse during a 6-month treatment-free period in patients with active duodenal ulcer. METHODS:This was a double-blind, randomized study in 15 centres across Canada. Patients (n = 149)...

journal_title：Alimentary pharmacology & therapeutics

authors： Zanten SJ,Bradette M,Farley A,Leddin D,Lind T,Unge P,Bayerdörffer E,Spiller RC,O'Morain C,Sipponen P,Wrangstadh M,Zeijlon L,Sinclair P

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Ursodeoxycholic acid (UDCA) prolongs transplantation-free survival in primary biliary cirrhosis (PBC). However, the optimal therapeutic dose has not been established. AIM:To compare the effects of UDCA administered in daily doses of 10 vs. 20 mg/kg on symptoms, liver biochemistry and biliary UDCA enrichment...

journal_title：Alimentary pharmacology & therapeutics

authors： Van Hoogstraten HJ,De Smet MB,Renooij W,Breed JG,Engels LG,Den Ouden-Muller JW,Rijk MC,Smit AM,Zwertbroek R,Hop WC,van Berge Henegouwen GP,Schalm SW,van Buuren HR

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:In rheumatoid arthritis and psoriasis female sex has been shown to be associated with discontinuation of anti-tumour necrosis factor-α (TNF-α) therapy. AIM:To retrospectively assess the association between sex and TNF-α drug persistence in patients with inflammatory bowel disease (IBD). METHODS:All IBD pat...

journal_title：Alimentary pharmacology & therapeutics

authors： Schultheiss JPD,Brand EC,Lamers E,van den Berg WCM,van Schaik FDM,Oldenburg B,Fidder HH

更新日期：2019-08-01 00:00:00